Abstract：
:The synovium in two well-documented cases of alkaptonuric ochronosis was studied by transmission electron and light microscopy. A feature of alkaptonuria previously unreported in the English-language literature was the presence of phagocytosis of large collagen fibrils by synovial macrophages in both cases. The origin of these fibrils appeared to have been shards of ochronotic cartilage and areas of metaplastic cartilage. This finding suggests that active remodeling of the synovial tissues occurs in advanced ochronotic arthropathy. Numerous shards of ochronotic cartilage were embedded in the synovium. In addition, small aggregates of large collagen fibrils encrusted with apparent ochronotic pigment were occasionally noted in the interstitium. These aggregates of ochronotic collagen are best described as microshards, and they have not generally been recognized in the literature. What appeared by light microscopy to represent ochronotic pigment deposition in interstitial collagen actually represented embedded microshards of ochronotic cartilage in the interstitium. Slender and elongated microshards were most likely to be confused by light microscopy as ochronotic interstitial collagen.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Gaines JJ Jr,Tom GD,Khankhanian Ndoi
10.1016/s0046-8177(87)80385-4subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1160-4issue
11eissn
0046-8177issn
1532-8392pii
S0046-8177(87)80385-4journal_volume
18pub_type
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