Abstract:
:Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its clinicopathological and genetic features are poorly understood. The aim of our study was to elucidate the frequency and prognostic significance of molecular subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with DLBCL-like morphology and classified them into germinal center B-cell like (GCB)/non-GCB subgroups by immunohistochemistry (IHC) for CD10, bcl-6 and MUM1, or into double-expressor (DE)/non-DE subgroups by IHC for bcl-2 and c-myc. Translocations involving BCL2, BCL6, MYC, IGH, IGK, IGL, and MALT1 were also investigated using break-apart fluorescence in situ hybridization (FISH). The 25 cases were classified into two entities-DLBCL, not otherwise specified (NOS) (n = 23; 92%) and high grade B-cell lymphoma, double hit (n = 2; 8%)-according to the recent WHO classification. None of them showed histological evidence of Epstein-Barr virus infection or high-grade transformation from low grade B-cell lymphoma. Ten cases were GCB-type and four cases were DE-type, but these subtypes did not contribute to clinicopathological differences. Translocations involving BCL2, BCL6, MYC, IGH, IGK, IGL, and MALT1 were detected in 3 (12%), 3 (12%), 10 (40%), 14 (56%), 3 (12%), 3 (12%), and 0 (0%) of 25 cases, respectively. Of note, the presence of IGH translocation was significantly associated with better overall survival (P = .0053) and progression free survival (P = .0259). Similarly, the translocation involving at least one of the IGs (IGH, IGK, and/or IGL) was associated with more favorable prognosis in DLBCLs or even in DLBCL, NOS. This is the first report to reveal that a small subset of colorectal DLBCL corresponds to double-hit lymphoma. In addition, translocations involving at least one of the IGs may be a favorable prognostic factor in colorectal DLBCL. Testing the translocation involving rearrangement of IGs as well as MYC and BCL2/BCL6 may thus be useful for diagnosis and prognosis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Hori Y,Yamamoto H,Nozaki Y,Torisu T,Fujiwara M,Taguchi K,Nishiyama K,Nakamura S,Kitazono T,Oda Ydoi
10.1016/j.humpath.2019.09.003subject
Has Abstractpub_date
2020-02-01 00:00:00pages
67-78eissn
0046-8177issn
1532-8392pii
S0046-8177(19)30168-6journal_volume
96pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Twelve cases of pure adenoid cystic carcinoma of the breast were reviewed. Patients ranged in age from 34 to 69 years. Seven carcinomas were in the right breast, and five in the left; five of the 12 were located in the central region of the breast, five in the upper outer quadrant, and the two in the upper inner and l...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(87)80413-6
更新日期:1987-12-01 00:00:00
abstract::Seminoma and sarcoidosis do not seem to be associated diseases, judging from epidemiologic data. The presence of these two diseases in the patient whose case is reported may have been coincidental. It was observed, however, that when the testis tumor appeared in this patient, the longstanding sarcoid lesions significa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80041-6
更新日期:1984-04-01 00:00:00
abstract::Recent studies have indicated that some cases of fulminant hepatitis that were ostensibly type B were actually acute viral hepatitis, types B and delta, or persistent hepatitis, type B with superimposed acute delta infection. Histologic characterization of the various types has not yet been undertaken. Within ten to 3...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(85)80012-5
更新日期:1985-03-01 00:00:00
abstract::Primitive neuroectodermal tumors are morphologically similar malignant tumors arising in intracranial and peripheral sites of the nervous system, showing varying degrees of cellular differentiation with a tendency to disseminate along cerebrospinal fluid pathways. They occur primarily in children and young adults. Und...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(83)80006-9
更新日期:1983-06-01 00:00:00
abstract::In this report, we present the clinicopathologic features of 13 cases of the invasive micropapillary variant of urothelial carcinoma. This is a rare and aggressive variant of bladder cancer recognized by the current World Health Organization classification of urologic tumors. The micropapillary component varied from 5...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.11.018
更新日期:2010-08-01 00:00:00
abstract::Papillary renal cell carcinoma (PRCC) is currently divided in 2 subtypes. We reviewed a large cohort of PRCC and correlated subtype, morphological features and diagnostic marker expression with overall survival (OS) to uncover differences between the 2 subtypes. Three hundred seventy-six renal tumors initially diagnos...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.08.006
更新日期:2019-01-01 00:00:00
abstract::CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCCs) that were CDX2 positive. CDX2 expression in ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.12.029
更新日期:2017-06-01 00:00:00
abstract::Inflammatory pseudotumors (IPs), mostly benign lesions characterized by fibrotic ground tissue and polyclonal mononuclear infiltrate, may affect all organ systems. IPs originating in the central nervous system (IP-CNS) are very rare, and their distinct histopathologic features are poorly characterized. Three otherwise...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1053/hupa.2003.35
更新日期:2003-03-01 00:00:00
abstract::Histopathologic lesions in the central nervous system (CNS) of 400 autopsy cases of the acquired immunodeficiency syndrome (AIDS) collected from 1982 to 1990 were studied. Lesions most closely associated with human immunodeficiency virus (HIV) infection in the CNS (perivascular macrophages, nodular encephalomyelitis, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90215-3
更新日期:1993-11-01 00:00:00
abstract::The Mix1 homeobox-like (MIXL1) gene encodes a paired class homeobox transcription factor that is involved in embryogenesis. Previous studies have shown that the MIXL1 gene product is expressed in B- and T-cell progenitors of normal bone marrow and, in some cell lines derived from hematopoietic neoplasms. The status of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.020
更新日期:2007-03-01 00:00:00
abstract::Pseudovascular adenoid squamous cell carcinoma (PASCC) is a variant epithelial neoplasm with the ability to simulate the growth pattern of angiosarcoma. It has been documented in the breast, skin, and, recently, lung. We describe three additional examples of pulmonary PASCC occurring in two men and one woman. The pati...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90145-7
更新日期:1994-04-01 00:00:00
abstract::Surfactant-associated (SA) glycoproteins are lung-specific proteins produced in the human lung by alveolar type II cells and Clara cells. The distribution of these proteins was studied immunohistochemically in lung tissue obtained postmortem from 12 stillborn fetuses and 49 infants with hyaline membrane disease (HMD)....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90200-o
更新日期:1990-04-01 00:00:00
abstract::The assessment of hormone receptors, including estrogen receptor and progesterone receptor, has become a standard practice in breast cancer management. However, the need for multiple sections to evaluate each receptor individually by conventional immunohistochemistry may preclude the analysis on some core biopsies wit...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.06.002
更新日期:2013-03-01 00:00:00
abstract::Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90161-h
更新日期:1991-03-01 00:00:00
abstract::In situ carcinomas must penetrate their own basement membrane to be classified as invasive, and subsequently infiltrate surrounding connective tissue and cross vascular basement membranes to metastasize hematogenously. Accordingly, in many studies, integral basement membrane components, including type IV collagen, lam...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80251-8
更新日期:2000-03-01 00:00:00
abstract::Neoglycoproteins are readily available conjugates of a histochemically inert carrier protein and histochemically crucial carbohydrate moieties which are covalently attached to the carrier protein by chemical synthesis. Biotinylation renders these conjugates detectable in formalin-fixed, paraffin-embedded tissue sectio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90045-2
更新日期:1989-04-01 00:00:00
abstract::Giant cell tumors (GCTs) of the bone are primary skeletal neoplasms that behave intermediately between a true benign and an overtly malignant neoplasm. For two decades, controversial reports have found estrogen receptor (ER) expression in isolated cells or small numbers of samples from these tumors. In this report, we...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.31476
更新日期:2002-02-01 00:00:00
abstract::The distinction between Spitz nevus and melanoma is currently possible, applying a set of definite histological criteria. However, in certain lesions deviating from the stereotypical morphology of classic Spitz nevi ("atypical Spitz tumors"), the differentiation between benign and malignant cases appears problematic b...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.02.001
更新日期:2006-07-01 00:00:00
abstract::Bone Marrow Transplant (BMT) is a critical therapeutic intervention for a variety of diseases occurring in the pediatric patient. Complications of allogeneic BMT include graft-versus-host disease (GVHD), infection, drug toxicity, thrombotic microangiopathy, and veno-occlusive disease. With solid organ transplantation,...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90132-6
更新日期:1999-07-01 00:00:00
abstract::Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80205-1
更新日期:2000-01-01 00:00:00
abstract::Patients with small cell lung carcinoma (SCLC) rarely demonstrate long-term survival. We previously reported that gene expression profiling identified a subset of SCLC with good prognosis in surgical cases. To find an easier way to routinely identify SCLC belonging to this subset, we conducted the present study with a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.01.001
更新日期:2014-05-01 00:00:00
abstract::Malignant mixed tumors of the parotid gland are rare. Metastasizing lesions are even more rare. To the best of our knowledge, this is the first case reported in the English literature in which the scalp nodule was the primary manifestation of the malignant nature of the parotid tumor. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(77)80100-7
更新日期:1977-11-01 00:00:00
abstract::The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; rang...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(92)90238-x
更新日期:1992-02-01 00:00:00
abstract::A 61-year-old woman was admitted to the hospital because of general fatigue. Laboratory examinations showed hyponatremia, plasma hypo-osmolarity, and inappropriate increased concentration of the plasma antidiuretic hormone (ADH) in the presence of concentrated urine. Magnetic resonance imaging revealed a mass lesion i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90094-5
更新日期:1996-05-01 00:00:00
abstract::Pancreatic cancer (PaCA) is a deadly disease with few systemic therapeutic options. The head of the pancreas is the most innervated part and most common location of cancer. However, little is known about the contribution of the nerve-cancer interaction to facilitate pancreatic progression. To quantify PaCA axonogenesi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.02.001
更新日期:2016-06-01 00:00:00
abstract::Snail1 and ZEB1 are transcriptional repressors that drive tumor initiation and metastasis in animal models. Snail1 and ZEB1 are frequently coexpressed in tumor cell lines, suggesting that these factors may cooperate to promote tumor progression. However, coexpression of these transcriptional repressors in primary huma...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.11.004
更新日期:2011-08-01 00:00:00
abstract::Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present st...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.01.020
更新日期:2013-08-01 00:00:00
abstract::We have previously reported that MUC2 apomucin was highly expressed in noninvasive tumors of the pancreas (intraductal papillary tumor [IdPT]) and liver (bile duct cystadenocarcinoma [BdCC]), which show more favorable outcomes than invasive carcinomas. In contrast, MUC2 was rarely expressed in invasive carcinomas of t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90134-9
更新日期:1997-03-01 00:00:00
abstract::We applied a panel of antibodies to formalin-fixed, paraffin-embedded sections of 55 renal cell carcinomas using a three-stage immunoperoxidase technique. The antibody panel included two anti-keratins, AE1 and CAM5.2, anti-epithelial membrane antigen (EMA), anti-vimentin, anti-S100 protein, and the anti-leukocyte mark...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80016-9
更新日期:1988-08-01 00:00:00
abstract::Gastrointestinal stromal tumors are a group of mesenchymal tumors arising from the wall of the gastrointestinal tract that are characterized by activating mutations in KIT or PDGFRA. Their proper recognition is important clinically because of their potential responsiveness to targeted therapies. We report a case of du...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.09.017
更新日期:2009-04-01 00:00:00