Abstract:
:In this report, we present the clinicopathologic features of 13 cases of the invasive micropapillary variant of urothelial carcinoma. This is a rare and aggressive variant of bladder cancer recognized by the current World Health Organization classification of urologic tumors. The micropapillary component varied from 50% to 100% of the tumor specimen; in 10 cases, the micropapillary component composed greater than 70% of the tumor, with 5 cases showing pure micropapillary carcinoma. The architectural pattern of the tumor varied from solid expansile nests with slender papillae within tissue retraction spaces to pseudoglandular growth with prominent ring-like structures (2 cases, 15%) and invasive micropapillary carcinoma with squamous differentiation (2 cases, 15%); a streaking solid architectural pattern of micropapillary carcinoma was additionally present in 2 cases (15%). At histology, the individual tumor cells had abundant eosinophilic cytoplasm and nuclei with prominent nucleoli and irregular distribution of chromatin, and frequent mitotic figures. Most neoplastic cells had nuclei of low to intermediate nuclear grade with occasional nuclear pleomorphism. Eight mixed cases had concurrent conventional high-grade urothelial carcinoma with squamous or glandular differentiation in 3 and 1 case(s), respectively. All patients had advanced-stage cancer (>pT2), and 8 (62%) had lymph node metastasis. Immunohistochemical staining demonstrated that both micropapillary and associated conventional urothelial carcinomas were positive for MUC1 and 2, cytokeratin 7, PTEN, p53, and Ki-67. Her2Neu, uroplakin, cytokeratin 20, 34betaE12, CA125, and p16 were positive in 4, 10, 8, 7, 3, and 3 cases, respectively. MUC5A, MUC6, and CDX2 were negative in all micropapillary cases. Follow-up information was available in all cases (range, 2-21 months; mean, 10 months). Eleven of patients died of disease from 2 to 14 months, and 2 patients were alive with disease at 14 and 21 months. Univariate statistical analysis showed survival differences between invasive micropapillary and conventional urothelial carcinomas (P < .0001). In summary, invasive micropapillary variant of urothelial carcinoma is an aggressive variant associated with poor prognosis that presents at an advanced clinical stage. The immunophenotype of invasive micropapillary carcinoma supports urothelial origin; the immunoreactivity to Her2Neu and PTEN might be relevant in terms of future targeting therapy. The morphologic diversity of micropapillary carcinoma may represent a diagnostic pitfall in limited samples, where its distinction from conventional urothelial carcinoma is critical for its clinical management.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Lopez-Beltran A,Montironi R,Blanca A,Cheng Ldoi
10.1016/j.humpath.2009.11.018subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1159-64issue
8eissn
0046-8177issn
1532-8392pii
S0046-8177(10)00029-8journal_volume
41pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Cytoplasmic mislocalization of p27 (CDKN1B/KIP1) is caused by activated AKT1 and has been associated with poor prognosis in various cancers. CIMP in colorectal cancer is characterized by extensive promoter methylation and is associated with MSI-MSI-H and BRAF mutations. We have recently shown a positive correlation be...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.014
更新日期:2007-04-01 00:00:00
abstract::Bioassay of hormones has a small but important role in defining the physiologic status of selected patients in whom immunoassay results do not correlate with clinical signs and symptoms. This article reviews three sensitive bioassays for hormones, which are based on 1) stimulation of adenylate cyclase in membrane prep...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(84)80050-7
更新日期:1984-02-01 00:00:00
abstract::The aim of this study is to evaluate the analysis of markers related with progression, to further characterize familial breast cancers. Here, we investigated the expression of breast cancer susceptibility gene-1, hypoxia-inducible factor-1α, vascular endothelial growth factor receptor 1, and Na+/H+ exchanger regulator...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.01.010
更新日期:2011-11-01 00:00:00
abstract::The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy wh...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.62
更新日期:2003-04-01 00:00:00
abstract::Pathological demonstration of varicella infection in first trimester aborted tissue is reported. A 24-year-old primigravida manifested chickenpox infection about 38 days after her last menstrual period or at 24 days age of the embryo. The conceptus survived another 4 to 5 weeks. The macerated embryo and placental tiss...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90396-3
更新日期:1998-01-01 00:00:00
abstract::In 1821 Napoleon died in exile on the Island of St. Helena. Although the autopsy had suggested stomach cancer as the cause of death, in 1961 an elevated arsenic concentration was found in Napoleon's hair. This finding elicited numerous theories of conspiracy, treachery, and poisoning. Most recent reports even suggeste...
journal_title:Human pathology
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.humpath.2005.02.001
更新日期:2005-04-01 00:00:00
abstract::Combined small cell and non-small cell carcinoma is relatively rare in the lung. Examination of the clonal relationship of different components in this type of tumor may give a clue to the rarity. We retrieved 6 such tumors; all 6 had small cell carcinoma and adenocarcinoma components, and 3 had an additional squamous...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/j.humpath.2003.05.001
更新日期:2003-11-01 00:00:00
abstract::A study of so-called gelatinous transformation of the bone marrow in 14 patients is presented. The condition is characterized by the presence of extracellular "gelatinous" material, fat atrophy, and associated focal marrow hypoplasia and is often mistaken as representing edema, necrosis, or amyloid. Histochemical stud...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80051-3
更新日期:1978-11-01 00:00:00
abstract::Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.017
更新日期:2012-09-01 00:00:00
abstract::Idiopathic hypereosinophilic syndrome (HES) consists of a prolonged state of eosinophilia of unknown origin with organ involvement. We describe the case of a patient who developed fatal eosinophilic myocarditis. A 23-year-old woman with an 8-month history of eosinophilia presented with symptoms of myocarditis. Histolo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.05.008
更新日期:2004-09-01 00:00:00
abstract::To examine the importance of prohibitin 1 and c-Met/hepatocyte growth factor receptor (HGFR) expression in human cervical adenocarcinomas, 85 patients (69 with invasive adenocarcinoma [ACA] and 16 with adenocarcinoma in situ [AIS]) were studied using immunohistochemistry. High prohibitin 1 expression was found in 51 (...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.10.012
更新日期:2006-02-01 00:00:00
abstract::Benign lymphocytic angiitis and granulomatosis is a T-cell lymphoproliferative disorder confined to the lung and corresponding to a low-grade angiocentric immunoproliferative lesion. Controversy remains as to whether these lesions are lymphomas. We report such a case in an 8-year-old patient with Burkitt's lymphoma in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90041-z
更新日期:1992-10-01 00:00:00
abstract::Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.08.004
更新日期:2012-05-01 00:00:00
abstract::In contrast to long bone osteosarcoma, mandibular osteosarcoma is highly heterogeneous and morphologically overlaps with benign tumors, obscuring diagnosis and treatment selection. Molecular characterization is difficult due to the paucity of available specimens of this rare disease. We aimed to characterize the spect...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.11.012
更新日期:2016-04-01 00:00:00
abstract::Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its clinicopathological and genetic features are poorly understood. The aim of our study was to elucidate the frequency and prognostic significance of molecular subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with DLBCL-li...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.09.003
更新日期:2020-02-01 00:00:00
abstract::Despite the nearly ubiquitous expression of telomerase in almost all types of malignant human tumors, studies have shown widely varying positivity in the highest-grade glioma, the glioblastomas (GBMs), ranging from 26% to 100% of tumors analyzed. We have previously shown significant variability in positive versus nega...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.9086
更新日期:2000-08-01 00:00:00
abstract::Syndecan-1, a cell-surface transmembrane heparan sulfate proteoglycan, has been reported to correlate with the biologic behavior of malignant tumors in various organs. We examined the correlation between the expression of syndecan-1 at the protein and mRNA levels and clinicopathologic features of 37 intrahepatic chola...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(03)00336-8
更新日期:2003-09-01 00:00:00
abstract::The genetic diagnosis of Gaucher disease by molecular methods is complicated by the existence of a highly homologous transcribed pseudogene (96% identity) that is found in close proximity to the true gene on chromosome 1q21. In addition, the pseudogene sequence can mimic disease-causing mutations in the true gene. Sel...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.11.006
更新日期:2004-04-01 00:00:00
abstract::The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.027
更新日期:2016-02-01 00:00:00
abstract::Histological criteria for the diagnosis of reflux esophagitis include basal zone hyperplasia, stromal papillae elongation, and inflammatory infiltrate. However, endoscopic esophageal biopsy specimens may include little or no lamina propria. Intraepithelial T lymphocytes, seen in hematoxylin and eosin-stained sections ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.07.006
更新日期:2004-01-01 00:00:00
abstract::Interferon-induced protein with tetratricopeptide repeat 1 (IFIT1) plays a key role in growth suppression and apoptosis promotion in cancer cells. Interferon was reported to induce the expression of IFIT1 and inhibit the expression of O-6-methylguanine-DNA methyltransferase (MGMT).This study aimed to investigate the e...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.01.013
更新日期:2016-06-01 00:00:00
abstract::Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a variant of anaplastic large cell lymphoma arising within seroma effusion associated with breast implants. BI-ALCL is a rare disease, recently recognized as a new provisional entity by the 2017 revised World Health Organization classification. All ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.05.007
更新日期:2019-08-01 00:00:00
abstract::Encapsulated thyroid tumors of follicular cell origin with high-grade features (EFHG) are unusual neoplasms. In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma. When noninvasive, EFHG create a major therapeutic/diagnostic dilemma stemming f...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.08.011
更新日期:2010-02-01 00:00:00
abstract::We compared the DNA content (DI) by cell image analysis with the karyotype and morphological phenotype of paraffin-embedded tissues from 51 spontaneous abortions. The study included 21 cases with triploid, 19 cases with diploid, and 11 cases with aneuploid (monosomic, trisomic, or mosaic) karyotype. Measurements were ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90209-x
更新日期:1998-09-01 00:00:00
abstract::Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.013
更新日期:2010-10-01 00:00:00
abstract::This article reviews 281 malignant germ cell tumors of the ovary from the Armed Forces Institute of Pathology and highlights their distinctive clinical and pathologic features. Emphasis is placed on the importance of a combined therapeutic approach utilizing surgery, chemotherapy, and radiation. The rationale for unil...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(77)80115-9
更新日期:1977-09-01 00:00:00
abstract::ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.009
更新日期:2008-06-01 00:00:00
abstract::Chondroblastoma (CBL) is a benign neoplasm of bone for which the genomic characteristics remain unclear. We compared the status of allelic losses of CBL with that seen in a set of chondrosarcomas (CS) to determine whether differences in their natural history and behavior are also reflected genetically. Eleven cases of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.02.014
更新日期:2006-07-01 00:00:00
abstract::Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.02.007
更新日期:2009-08-01 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(99)90040-0
更新日期:1999-10-01 00:00:00