Abstract：
:Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophagus, leiomyoma is the most common mesenchymal tumor. GISTs are composed of spindle (70%) or epithelioid (30%) cells, and 10%-30% are malignant showing intra-abdominal spread or liver metastases. They are immunohistochemically positive for c-kit (CD117), CD34, and sometimes for actin but are almost always negative for desmin and S100-protein. The malignant GISTs especially show activating mutations in the c-kit gene. GISTs and gastrointestinal autonomic nerve tumors (GANT) overlap. The cell of origin is not fully understood, but resemblance to the interstitial cells of Cajal, expression of some smooth muscle markers, and occurrence outside of the GI-tract suggest origin from multipotential cells that can differentiate into Cajal and smooth muscle cells.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Miettinen M,Sarlomo-Rikala M,Lasota Jdoi
10.1016/s0046-8177(99)90040-0subject
Has Abstractpub_date
1999-10-01 00:00:00pages
1213-20issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(99)90040-0journal_volume
30pub_type
杂志文章,评审相关文献
HUMAN PATHOLOGY文献大全abstract：:Langerhans cell histiocytosis (LCH) is a group of granulomatous disorders in which abnormal Langerhans cells proliferate as either a localized lesion in a single bone or disseminated disease involving two or more organs or systems. Because the different LCH forms exhibit significantly elevated levels of inflammatory m...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.05.028
更新日期：2014-01-01 00:00:00
abstract：:Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2015.10.003
更新日期：2016-03-01 00:00:00
abstract：:Improved graft survival was observed in cadaver-kidney recipients prepared with random donor blood transfusions and in selected living-related-kidney recipients primed with transfusions from the kidney donor. This seems to justify a purposeful transfusion policy in these patients. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80031-8
更新日期：1983-03-01 00:00:00
abstract：:Fluorescent (FISH) and chromogenic (CISH) in situ hybridization have recently become part of the diagnostic armamentarium of breast pathologists. HER2 gene testing by FISH and/or CISH has become an integral part of the diagnostic workup for patients with breast cancer. In this era of high throughput technologies, thes...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2007.04.011
更新日期：2007-08-01 00:00:00
abstract：:Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.09.001
更新日期：2016-12-01 00:00:00
abstract：:Botryomycosis is a rare bacterial infection of the skin and, rarely, viscera that is characterized by the formation of characteristic hyaline grains. We encountered a patient with Erysipelothrix rhusiopathiae endocarditis who developed visceral botryomycosis. He was a 54-year-old black man who presented in sepsis with...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.10.004
更新日期：2005-01-01 00:00:00
abstract：:Papillary renal cell carcinoma (PRCC), a morphologically and genetically distinct subtype of RCC, is morphologically separated into 2 subtypes, type 1 and 2, for prognostic purposes. Type 1 PRCC (single layer of small cells, scant pale cytoplasm) is more common and has a favorable prognosis compared with type 2 (pseud...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.05.016
更新日期：2008-01-01 00:00:00
abstract：:CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.29678
更新日期：2001-12-01 00:00:00
abstract：:The assessment of hormone receptors, including estrogen receptor and progesterone receptor, has become a standard practice in breast cancer management. However, the need for multiple sections to evaluate each receptor individually by conventional immunohistochemistry may preclude the analysis on some core biopsies wit...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.06.002
更新日期：2013-03-01 00:00:00
abstract：:Previously used only as a screening tool, cytology now emerges as a powerful diagnostic technique, especially since the advent of the fine needle aspiration (FNA) biopsy. This article highlights the use of ancillary techniques, primarily electron microscopy (EM), and immunohistochemistry (IHC). When coupled with routi...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(98)90003-x
更新日期：1998-12-01 00:00:00
abstract：:AT-rich interaction domain 4B (ARID4B), which belongs to the ARID family, is heavily involved in cell growth and differentiation and is closely associated with many types of tumors. However, the role of this protein in hepatocellular carcinoma (HCC) remains unknown. In this study, we used data from The Cancer Genome A...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.12.012
更新日期：2018-03-01 00:00:00
abstract：:Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.11.013
更新日期：2007-05-01 00:00:00
abstract：:Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.01.003
更新日期：2018-04-01 00:00:00
abstract：:Calcitonin and calcitonin gene-related peptide (CGRP) have been localized immunohistochemically in neuroendocrine cells of normal and diseased human lungs. Cells immunoreactive for calcitonin and CGRP first appeared in immature bronchi in the 27th gestational week. Thereafter, both peptides were found in the same bron...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90103-2
更新日期：1989-09-01 00:00:00
abstract：:Our aim was to investigate the expression of micro-RNA-200b (miR-200b) and cAMP-responsive element-binding protein 1 (CREB-1) in astrocytoma and its efficacy for predicting outcome. Both miR-200b and CREB-1 messenger RNA expression was measured in 122 astrocytomas and 30 nonneoplastic brain specimens by quantitative r...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.01.025
更新日期：2014-10-01 00:00:00
abstract：:The pathology report is a critical document that helps guide the management of patients with cancer. More and more patients read their reports, intending to participate in decisions about their care. However, a substantial subset of patients may lack the ability to comprehend this often technical and complex document....
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2014.07.008
更新日期：2014-11-01 00:00:00
abstract：:The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.12.017
更新日期：2010-11-01 00:00:00
abstract：:Pathological demonstration of varicella infection in first trimester aborted tissue is reported. A 24-year-old primigravida manifested chickenpox infection about 38 days after her last menstrual period or at 24 days age of the embryo. The conceptus survived another 4 to 5 weeks. The macerated embryo and placental tiss...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90396-3
更新日期：1998-01-01 00:00:00
abstract：:Microsatellite instability (MSI) defines a specific type of genetic instability. Although consensus diagnostic criteria for MSI definition in colorectal cancer have been established, their utility in other tumor types remain to be proven. Previously we developed a mathematical model for MSI definition in colorectal ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.10.021
更新日期：2004-03-01 00:00:00
abstract：:Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is comm...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.10.036
更新日期：2018-02-01 00:00:00
abstract：:To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.04.024
更新日期：2014-11-01 00:00:00
abstract：:Of the approximately 635 residents in each year of pathology training, about 165 are already meeting the Pathology Board's proposed requirement for a fifth year of resident training. The cost of a fifth year of training for the other 470 residents is estimated to be approximately $20 million. Options for avoiding this...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80159-8
更新日期：1984-08-01 00:00:00
abstract：:Hepatic artery thrombosis (HAT) following orthotopic liver transplantation (OLT) can cause hepatic parenchymal necrosis and ischemic cholangiopathy. This study investigates additional histologic features that may suggest HAT in post-OLT liver specimens. For 94 liver specimens (explanted allografts and biopsies) from p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.04.019
更新日期：2019-08-01 00:00:00
abstract：:The Ewing family of tumors (EFT) is characterized by high MIC2/CD99 expression and specific EWS/ETS gene rearrangements, resulting in different chimeric transcripts. Further division into peripheral primitive neuroectodermal tumors and Ewing's sarcoma is still debated and, in the absence of distinct morphological para...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90223-x
更新日期：1999-09-01 00:00:00
abstract：:We investigated the use of remote video microscopy (telepathology) to assist in the diagnosis of 52 neurosurgical frozen section cases. The TelMed system (Discovery Medical Systems, Overland Park, KS), in which the referring pathologist selects appropriate fields for transmission to the consultant, was used for the st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90142-4
更新日期：1993-08-01 00:00:00
abstract：:We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90406-2
更新日期：1996-07-01 00:00:00
abstract：:Most ovarian sex cord-stromal tumors (SCSTs) can be categorized on the basis of conventional histology, but approximately 10% of cases are unclassified because they present indeterminate or overlapping morphologic features. Immunohistochemical and molecular studies of unclassified ovarian SCST are very limited, but re...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.07.028
更新日期：2013-12-01 00:00:00
abstract：:Atypical fibro-osseous lesions, usually in the proximal femur, are a common consultative diagnostic problem. This is due to the fact that they contain a variety of patterns individually reminiscent of fibrous dysplasia, fibroxanthoma (non-ossifying fibroma), myxofibroma, lipoma, cyst, bone infarct, Paget's disease, an...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90162-a
更新日期：1993-05-01 00:00:00
abstract：:Sneddon's syndrome is a potentially fatal arterio-occlusive disorder characterized by generalized livedo racemosa and cerebrovascular lesions. Skin biopsies often fail to yield diagnostic arterial lesions. In the present series, affected vessels were found in skin biopsies from 12 of 15 patients with Sneddon's syndrom...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90323-u
更新日期：1992-06-01 00:00:00
abstract：:To investigate the relationship between the tissue distribution and the types of amyloid proteins, the detailed histopathologic features of the available liver in 284 cases of amyloidosis were examined. We classified hepatic amyloidosis into three types, namely, the vascular pattern, parenchymal pattern, and stromal p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90279-1
更新日期：1995-10-01 00:00:00
