Abstract：
:To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detection and prognostic analysis. We found that CD25 was expressed by most tumor cells in all samples, and CD56(+)CD25(+) cells were the predominant population in the mouse model, the 2 cell lines, and 10 of the 16 fresh tumor samples; in the other 6 fresh tumor samples, the predominant cell population was of the CD16(+)CD25(+) phenotype, and only a minor population showed the CD56(+)CD25(+) phenotype. The phenotype detected by immunohistochemistry staining generally was consistent with the phenotype found by flow cytometry immunophenotyping. According to the expression of CD56 and CD16, 115 cases could be classified into 3 phenotypic subtypes: CD56(-)CD16(-), CD56(+)CD16(-), and CD56(dim/-)CD16(+). Patients with tumors of the CD56(dim/-)CD16(+) phenotype had a poorer prognosis than patients with tumors of the other phenotypes. Differentiation of extranodal natural killer/T-cell lymphoma, nasal type apparently resembles the normal natural killer cell developmental pattern, and these tumors can be classified into 3 phenotypic subtypes of different aggressiveness. Expression of CD56(dim/-)CD16(+) implies a poorer prognosis.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Yu JB,Zuo Z,Zhang WY,Yang QP,Zhang YC,Tang Y,Zhao S,Mo XM,Liu WPdoi
10.1016/j.humpath.2014.04.024subject
Has Abstractpub_date
2014-11-01 00:00:00pages
2255-62issue
11eissn
0046-8177issn
1532-8392pii
S0046-8177(14)00295-0journal_volume
45pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:The control of colorectal cancer is currently dependent on early detection, and its prevention requires the recognition and treatment of its precursor lesions. The adenoma has been established as the precursor of colorectal carcinoma in the general population. Among patients with inflammatory bowel disease (IBD), dysp...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(94)90032-9
更新日期：1994-11-01 00:00:00
abstract：:Women with breast cancer have an increased risk of developing primary ovarian tumors. Because a differential diagnosis between primary and metastatic tumors may be difficult in poorly differentiated ovarian neoplasms, breast carcinoma markers may be helpful in establishing the primary site of origin. Gross cystic dise...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90084-3
更新日期：1991-04-01 00:00:00
abstract：:Primary small bowel adenocarcinoma is rare. Although generally similar to colonic adenocarcinoma, some small bowel adenocarcinomas exhibit unique morphologic features, particularly those arising in association with Crohn disease. In this study, 15 sporadic small bowel adenocarcinomas and 11 Crohn enteritis-associated ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.09.014
更新日期：2014-02-01 00:00:00
abstract：:Altered expression of oncogenes and tumor suppressor genes, the normal function of which is to regulate cell growth and differentiation, represents a central event in the pathogenesis of human cancer. Aberrant expression of these genes is often a result of a mutational event. In vitro amplification of DNA with the pol...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(94)90220-8
更新日期：1994-06-01 00:00:00
abstract：:Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.04.009
更新日期：2006-09-01 00:00:00
abstract：:We describe the pathology of 5 patients with germline PRKACA copy number gain and Cushing syndrome: 4 males and 1 female, aged 2 to 43 years, including a mother and son. Imaging showed normal or slightly enlarged adrenal glands in 4 patients and a unilateral mass in the fifth. Biochemically, the patients had corticotr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.09.005
更新日期：2015-01-01 00:00:00
abstract：:Acute rejection is an extremely common complication of lung transplantation. (1) To appreciate the interobserver variation in the interpretation of histologic findings and (2) to assess the efficacy of transbronchial biopsy (TBB) for acute rejection diagnosis and associated diseases, particularly infection, we perform...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.01.022
更新日期：2005-04-01 00:00:00
abstract：:Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(00)80205-1
更新日期：2000-01-01 00:00:00
abstract：:Encapsulated thyroid tumors of follicular cell origin with high-grade features (EFHG) are unusual neoplasms. In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma. When noninvasive, EFHG create a major therapeutic/diagnostic dilemma stemming f...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.08.011
更新日期：2010-02-01 00:00:00
abstract：:To obtain a better understanding of steroid metabolism associated with adrenocortical malignancy we studied steroidogenesis in nine cases of adrenocortical carcinoma (six with Cushing's syndrome, two without clinically significant adrenocortical hormonal abnormalities, and one with primary aldosteronism) by analyzing ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90088-x
更新日期：1993-04-01 00:00:00
abstract：:The present report is a neuropathologic study of three patients who died from a severe form of necrotizing encephalopathy following intrathecal methotrexate therapy and craniospinal irradiation for acute lymphoblastic leukemia. During the early phase the lesion presented as multifocal coalescing areas of coagulation n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80047-1
更新日期：1978-11-01 00:00:00
abstract：:Immunoreactivity to LN2 and LN3, monoclonal antibodies that recognize components of the class II major histocompatibility complex, was assessed in 72 cases of non-small cell lung carcinoma (NSCLC) (32 biopsy specimens, 40 resection specimens) and 64 cases of small cell carcinoma (56 biopsy specimens, 8 resections) of ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90013-2
更新日期：1998-12-01 00:00:00
abstract：:Atypical mesothelial hyperplasia encountered in pleural fluid or in a pleural biopsy specimen raises the suspicion that one may be dealing with a diffuse malignant mesothelioma of the pleura. We studied eight cases with cytologic or histologic changes of mesothelial atypia thought to be suspicious for diffuse malignan...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90292-w
更新日期：1991-07-01 00:00:00
abstract：:Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.03.007
更新日期：2017-06-01 00:00:00
abstract：:A case of a primary carcinoid islet cell tumor of the duodenum is reported, demonstrated by histochemistry, electron microscopy, and immunofluorescence to be composed of alpha cells containing glucagon-like material. The patient was found on admission to have hyperglycemia and a diffuse skin rash. Primary duodenal glu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(79)80032-5
更新日期：1979-05-01 00:00:00
abstract：:We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.12.010
更新日期：2007-06-01 00:00:00
abstract：:To assess the epileptogenic lesions, a series of 202 cases with temporal lobectomy were analyzed histopathologically. The severity of hippocampal neuronal loss in patients with temporal lobe epilepsy was quantitatively analyzed and compared against autopsy controls of patients who died of nonneurologic disorders. For ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.24997
更新日期：2001-06-01 00:00:00
abstract：:The case of an infant with endocardial fibroelastosis and a coexistent anomalous right coronary artery that originated from the pulmonary trunk is presented. The causal relation between the two conditions is discussed. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80138-6
更新日期：1985-09-01 00:00:00
abstract：:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80251-7
更新日期：1982-12-01 00:00:00
abstract：:Although early-stage cervical cancer can be treated by surgery, distant metastases can be life threatening. It has been a challenge to identify reliable biomarkers as indicators of metastasis or poor prognosis. We investigated the prognostic impact of vimentin, E-cadherin, and β-catenin expression measured by immunohi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.08.025
更新日期：2012-08-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.08.004
更新日期：2008-03-01 00:00:00
abstract：:Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90232-4
更新日期：1996-09-01 00:00:00
abstract：:Our previous investigations of transforming growth factor types beta 1 and beta 2 (TGF beta s) showed negative or positive autocrine growth regulation of gliomas in vitro. Near-diploid gliomas were inhibited by the TGF beta s, whereas a stimulatory response correlated with progressive anaplasia and karyotypic divergen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90118-x
更新日期：1994-05-01 00:00:00
abstract：:The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.09.027
更新日期：2016-02-01 00:00:00
abstract：:Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.10.023
更新日期：2018-01-01 00:00:00
abstract：:Although T-lineage large granular lymphocyte (LGL) leukemia has been described for over 20 years, many patients with this neoplasm go unrecognized. Chief among the difficulties in diagnosing this entity is that the morphologic features are nonspecific and that it is difficult to distinguish it from reactive processes....
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.19298
更新日期：2000-10-01 00:00:00
abstract：:Angiotropic lymphoma (AL) is an unusual variant of extranodal lymphoma, characterized by massive proliferation of neoplastic lymphoid cells almost exclusively within blood vessels. Whereas the lymphoid origin of this disease is widely accepted it still remains unclear whether AL is a distinct entity that originates in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.7636
更新日期：2000-07-01 00:00:00
abstract：:Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(99)90040-0
更新日期：1999-10-01 00:00:00
abstract：:Implementation of Grade Groups (GrGrs) has been widely accepted for reporting prostate cancer grade since the 2014 International Society of Urological Pathology consensus meeting. Despite their undisputed value for risk stratification, some GrGr are, a priori, quite heterogeneous in that they contain multiple Gleason ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.03.001
更新日期：2020-05-01 00:00:00
abstract：:A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi's sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endothelial cells. It is known that KS has a high...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90261-6
更新日期：1997-10-01 00:00:00
