Abstract:
:Histological criteria for the diagnosis of reflux esophagitis include basal zone hyperplasia, stromal papillae elongation, and inflammatory infiltrate. However, endoscopic esophageal biopsy specimens may include little or no lamina propria. Intraepithelial T lymphocytes, seen in hematoxylin and eosin-stained sections as cells with irregular nuclear contours (CINC), may have a higher density in children with esophagitis. We evaluated the diagnostic accuracy of a numerical score built up by grading the "classical" parameters and its correlation with CINC density in grasp biopsy specimens obtained from children undergoing esophagogastroduodenoscopy with and without esophagitis. We analyzed esophageal biopsy specimens from 349 children (median age, 5 years) subdivided in 4 groups according to the previous routine histology report: group 1, 144 children with esophagitis; group 2, 65 controls; group 3, 51 children with dubious esophagitis; and group 4, 75 children with esophagitis on endoscopy but a normal histology report. A numerical value was assigned to each parameter; the sum of these values represented the histological score. We also evaluated intraepithelial CINC density (ie, number of CINC per high-power field). We separately analyzed histological sections with and without lamina propria. For both total score and for CINC density, we calculated a cutoff using a receiver operating characteristic curve. Cutoffs of 6 for score and of 4 for CINC density provided the best sensitivity and specificity. Sensitivity of the histological score was better in biopsy specimens containing lamina propria (94%) than in those without lamina propria (4%). Sensitivity of CINC density was satisfactory in both specimens with (78%) and without (75%) lamina propria. Specificity was satisfactory for both parameters. In conclusion, when lamina propria was present in sections of endoscopic esophageal biopsy specimens, histological score provided a better diagnostic accuracy for the diagnosis of esophagitis. However, when no lamina propria was present, as was the case in 67% of our children, CINC density had better sensitivity. In addition, this latter parameter showed esophageal mucosa damage in 34% of previously dubious cases or cases with esophagitis at endoscopy but a previous routine histology report of normal mucosa.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Esposito S,Valente G,Zavallone A,Guidali P,Rapa A,Oderda Gdoi
10.1016/j.humpath.2003.07.006subject
Has Abstractpub_date
2004-01-01 00:00:00pages
96-101issue
1eissn
0046-8177issn
1532-8392pii
S0046817703004738journal_volume
35pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.08.004
更新日期:2015-12-01 00:00:00
abstract::Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90232-4
更新日期:1996-09-01 00:00:00
abstract::The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90175-2
更新日期:1995-06-01 00:00:00
abstract::After endoscopic resection of early gastric cancer (EGC), it is imperative to accurately determine whether follow-up surgery is indicated, since this technique is used as a first line of treatment. Herein, we developed a scoring system to indicate the risk of lymph node metastasis in submucosal EGC (smEGC), and presen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.07.037
更新日期:2013-12-01 00:00:00
abstract::Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.08.006
更新日期:2018-02-01 00:00:00
abstract::Langerhans' cell histiocytosis (LCH) is a proliferative histiocytic disorder of unknown etiology. We previously reported that Epstein-Barr virus (EBV) infects and proliferates in macrophages, and investigated the possibility that EBV exhibits etiologic effects in LCH. To detect EBV expression, paraffin sections from 1...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.03.017
更新日期:2004-07-01 00:00:00
abstract::Of the approximately 635 residents in each year of pathology training, about 165 are already meeting the Pathology Board's proposed requirement for a fifth year of resident training. The cost of a fifth year of training for the other 470 residents is estimated to be approximately $20 million. Options for avoiding this...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80159-8
更新日期:1984-08-01 00:00:00
abstract::The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.07.016
更新日期:2005-10-01 00:00:00
abstract::There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurren...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.04.016
更新日期:2017-07-01 00:00:00
abstract::We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90432-4
更新日期:1998-10-01 00:00:00
abstract::CpG island methylator phenotype (CIMP) pathway in colorectal cancer is characterized by methylation of promoter regions of multiple putative tumor suppressor genes. Aberrant methylation also occurs in serrated and adenomatous polyps. We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS m...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.06.002
更新日期:2008-01-01 00:00:00
abstract::Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.03.007
更新日期:2017-06-01 00:00:00
abstract::Bcl-2 and bcl-xL are proteins known to inhibit cell death (apoptosis). Expression of these proteins in gangliogliomas has not been extensively examined. This study retrospectively evaluates bcl-2 and bcl-x immunostaining in paraffin-embedded materials in gangliogliomas. Twenty-nine gangliogliomas in 17 males and 12 fe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90097-7
更新日期:1999-06-01 00:00:00
abstract::IMP3, an oncofetal protein, is a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein family. Its relevance as a novel biomarker in lung, pancreatic, renal, and cervical adenocarcinoma was recently revealed. However, its role in breast carcinogenesis and tumor progression is not yet established. B...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.05.005
更新日期:2009-11-01 00:00:00
abstract::The DNA content and proliferative indexes of seven cases of tenosynovial giant cell tumor of tendon sheath, diffuse type (TGCT-D); 11 cases of tenosynovial giant cell tumor of tendon sheath, localized type (TGCT-L); and seven cases of pigmented villonodular synovitis (PVNS) were analyzed by flow cytometry in an attemp...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90340-9
更新日期:1992-07-01 00:00:00
abstract::An immunohistochemical survey of X-linked inhibitor of apoptosis (XIAP) expression in mammary carcinoma was performed. XIAP, the most potent of the inhibitor of apoptosis family of caspase inhibitors, has been linked to tumor aggressiveness and therapeutic resistance in several malignancies and is considered an attrac...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.016
更新日期:2007-06-01 00:00:00
abstract::Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the prese...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90165-5
更新日期:1995-06-01 00:00:00
abstract::α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are speci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.04.025
更新日期:2013-10-01 00:00:00
abstract::The histologic findings in lymph nodes were used to identify eight patients, who are not in a high-risk group, with human immunodeficiency virus (HIV) infection. In order to determine the specificity of these findings, the histologic and clinical findings in these patients were compared with the histologic and clinica...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80269-7
更新日期:1988-07-01 00:00:00
abstract::We report four unusual cases of hyalinizing trabecular thyroid tumors, three of which displayed capsular and/or blood vessel invasion and were classified as minimally invasive carcinomas. These three patients were all euthyroid women aged 18, 39, and 62 years. The youngest patient also had familial polyposis, while th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90277-1
更新日期:1994-02-01 00:00:00
abstract::Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90039-3
更新日期:1997-04-01 00:00:00
abstract::Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.02.007
更新日期:2009-08-01 00:00:00
abstract::The Renal Pathology Society proposed a pathological classification for diabetic nephropathy (DN) (RPS 2010). We retrospectively examined the renal structural-functional relationships using the RPS 2010 classification in 49 DN cases. We also evaluated the importance of the percentage of glomeruli with nodular diabetic ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.01.019
更新日期:2018-05-01 00:00:00
abstract::Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.013
更新日期:2007-05-01 00:00:00
abstract::Aquaporin 5 (AQP5) is an androgen-regulated member of a family of small hydrophobic integral transmembrane water channel proteins regulating cellular water homeostasis and growth signaling. To evaluate its clinical impact and relationship with key genomic alterations in prostate cancer, AQP5 expression was analyzed by...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.09.026
更新日期:2016-02-01 00:00:00
abstract::CRABP-II, a retinoic acid binding protein, shuffles retinoic acid from cytoplasm into nucleus and forms a complex with nuclear retinoic acid receptor to facilitate transcriptional activities of retinoic acid. In this study, we studied the expression patterns of CRABP-II in pancreatic ductal adenocarcinoma (PDAC) compa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.01.014
更新日期:2014-06-01 00:00:00
abstract::A 61-year-old white woman was found to have disseminated abdominal carcinoma at autopsy. The primary site proved to be a bile duct carcinoma arising from ductal epithelium of multiple von Meyenburg complexes of the liver. No other neoplastic lesion was found elsewhere after careful, gross, microscopic examination. Thi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80575-5
更新日期:1986-12-01 00:00:00
abstract::Graduate training is one of the most important activities in which we engage. Through PhD training programs in pathology, we continually renew the intellectual vigor of our discipline and assure its position as a vibrant force in the life sciences. To focus on this important issue, the Education Committee of the Ameri...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2004.03.014
更新日期:2004-07-01 00:00:00
abstract::Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interacti...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.03.028
更新日期:2012-12-01 00:00:00
abstract::Hepatic artery thrombosis (HAT) following orthotopic liver transplantation (OLT) can cause hepatic parenchymal necrosis and ischemic cholangiopathy. This study investigates additional histologic features that may suggest HAT in post-OLT liver specimens. For 94 liver specimens (explanted allografts and biopsies) from p...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.04.019
更新日期:2019-08-01 00:00:00