Abstract：
:CRABP-II, a retinoic acid binding protein, shuffles retinoic acid from cytoplasm into nucleus and forms a complex with nuclear retinoic acid receptor to facilitate transcriptional activities of retinoic acid. In this study, we studied the expression patterns of CRABP-II in pancreatic ductal adenocarcinoma (PDAC) compared with those in normal pancreas, chronic pancreatitis, and precancerous lesions. We showed no detectable expressions of CRABP-II in normal pancreatic parenchyma, normal ductal epithelium, and chronic pancreatitis. In contrast, the expression of CRABP-II was readily detected in all PDACs including metastatic PDACs. CRABP-II staining was also observed and progressively increased from pancreatic intraepithelial neoplasia 1 to 3. In addition, when fine needle aspiration specimens were evaluated from patients with PDAC, CRABP-II was positive in 55.6% cases if cytology diagnosis was "atypia," and in 87.5% cases, if "malignancy." Our study suggests that CRABP-II is highly and specifically expressed in PDAC and is more commonly expressed in high-grade precursor cancerous lesions than in low-grade lesions. Therefore, overexpression of CRABP-II is a late event of pancreatic carcinogenesis, and it could be used as a diagnostic marker to distinguish PDAC from other benign pancreatic conditions in both resection and cytology specimens.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Xiao W,Hong H,Awadallah A,Yu S,Zhou L,Xin Wdoi
10.1016/j.humpath.2014.01.014subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1177-83issue
6eissn
0046-8177issn
1532-8392pii
S0046-8177(14)00050-1journal_volume
45pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:K homology domain containing protein overexpressed in cancer (KOC) is a member of the insulin-like growth factor (IGF) messenger RNA-binding protein family and is expressed during embryogenesis and in certain malignancies. KOC, known as L523S and IGF messenger RNA-binding protein 3, was shown to be frequently expresse...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.11.011
更新日期：2007-04-01 00:00:00
abstract：:Limitations in obtaining surgically resected or biopsy samples of small cell lung cancer (SCLC) tumors make comprehensive biological analyses difficult. The loss of thyroid transcription factor 1 (TTF-1) has been associated with the aggressive behavior of non-small cell lung cancer; however, clinicopathological featur...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.05.009
更新日期：2018-09-01 00:00:00
abstract：:In the normal liver, the transforming growth factor beta (TGF-beta) signaling pathway plays an important role in inhibiting hepatocyte growth. This effect is mediated through Smad4 (or Dpc4), a tumor-suppressor gene that affects gene transcription and controls cell growth. A loss of Smad4 is associated with carcinoma ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.128061
更新日期：2002-09-01 00:00:00
abstract：:Kaposi's sarcoma (KS) is a pleomorphic spindle cell lesion whose incidence has markedly increased among patients infected with the human immunodeficiency virus (HIV), especially among those whose primary risk factor is homo/bisexual transmission. The question as to whether KS is even a true neoplasm still remains larg...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90112-g
更新日期：1992-03-01 00:00:00
abstract：:Clinical stage I seminomas are effectively treated with surgery raising concerns as to when to give adjuvant radiation therapy given the risk of secondary malignancies. A recent randomized trial found tumor size and rete testis invasion to be the strongest predictors of relapse in clinical stage I seminomas. These 2 p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.03.011
更新日期：2005-06-01 00:00:00
abstract：:The benign epithelial neoplasm liver cell adenoma is rare, especially in childhood. We report 2 such cases, 1 of which was associated with Prader-Willi syndrome. Differential diagnosis of the liver cell adenomas on the basis of histopathologic findings proved difficult and was based on the absence of cellular and nucl...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.125771
更新日期：2002-08-01 00:00:00
abstract：:The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90175-2
更新日期：1995-06-01 00:00:00
abstract：:Oral contraceptive-associated sinusoidal ectasia is a rare lesion of unknown pathogenesis. We describe the case of a 31-year-old woman who had used oral contraceptives for 10 years and was found to have abnormal liver function tests on "routine" examination. A single 9 x 5 x 4 cm hypervascular lesion was demonstrated ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90411-u
更新日期：1992-08-01 00:00:00
abstract：:Four monoclonal antibodies (MoAbs), 60.15, 61.3, 105.10, and 2.16, directed to different proteins of Mycobacterium tuberculosis were used by an indirect avidin-biotin complex peroxidase-antiperoxidase method to detect mycobacterial antigens in lung, lymph node, and joint tissue specimens of tuberculous patients. Using...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90226-8
更新日期：1989-11-01 00:00:00
abstract：:The Sydney classification for gastritis provides guidelines for histological grading of gastric biopsies. In an ongoing study of gastric preneoplastic lesions in Chiapas, Mexico, 7 biopsies from 150 patients (4 from the antrum and 3 from the body) were obtained during endoscopy and studied histologically. The first 74...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90164-8
更新日期：1999-12-01 00:00:00
abstract：:Primary small bowel adenocarcinoma is rare. Although generally similar to colonic adenocarcinoma, some small bowel adenocarcinomas exhibit unique morphologic features, particularly those arising in association with Crohn disease. In this study, 15 sporadic small bowel adenocarcinomas and 11 Crohn enteritis-associated ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.09.014
更新日期：2014-02-01 00:00:00
abstract：:Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2015.10.003
更新日期：2016-03-01 00:00:00
abstract：:Anaplastic meningiomas (MIIIs) and meningeal hemangiopericytomas (HPCs) display significant morphologic and immunohistochemical overlap, including occasional cases of otherwise classic HPC with focal epithelial membrane antigen (EMA) positivity. The availability of several new biomarkers prompted us to examine the pot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.07.017
更新日期：2004-11-01 00:00:00
abstract：:We describe a patient with adenosquamous carcinoma of the prostate. His history suggests a common histogenesis of the glandular and squamous elements of the tumor. A 60-year-old white man had adenocarcinoma of the prostate diagnosed by biopsy and then underwent radical prostatectomy, which showed adenosquamous carcino...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90125-6
更新日期：1995-01-01 00:00:00
abstract：:In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial-mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor buddin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.012
更新日期：2018-10-01 00:00:00
abstract：:Monocytoid B-cell lymphoma (MBCL) is a newly recognized, morphologically and immunologically distinct, low-grade B-cell neoplasm that may exist as a pure morphologic entity or as a component of a composite lymphoma. To determine whether cytogenetic abnormalities exist in cases of MBCL, fresh tissue from four lymphoma ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90188-m
更新日期：1993-10-01 00:00:00
abstract：:Acute myeloid leukemia is a heterogeneous group of diseases. Mutations of the isocitrate dehydrogenase (IDH) genes represent a novel class of point mutations in acute myeloid leukemia. These mutations prevent oxidative decarboxylation of isocitrate to α-ketoglutarate and confer novel enzymatic activity, facilitating t...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2012.05.003
更新日期：2012-10-01 00:00:00
abstract：:We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90432-4
更新日期：1998-10-01 00:00:00
abstract：:AT-rich interactive domain 1A (ARID1A) is tumor suppressor gene that interacts with BRG1 adenosine triphosphatase to form a SWI/SNF chromatin remodeling protein complex. Inactivation of ARID1A has been described in several neoplasms, including epithelial ovarian and endometrial carcinomas, and has been correlated with...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.07.003
更新日期：2014-11-01 00:00:00
abstract：:Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(89)90249-9
更新日期：1989-06-01 00:00:00
abstract：:Immunoglobulin G4-related sclerosing cholangitis is histologically characterized by the infiltration of immunoglobulin G4-positive plasma cells and sclerosing change. Moreover, several cases of carcinoma accompanied by immunoglobulin G4-positive cells in tissue and increased serum immunoglobulin G4 levels have been re...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.03.001
更新日期：2012-12-01 00:00:00
abstract：:This study aimed to determine the correlations of 7 histopathologic prognostic indicators of follicular lymphoma (follicular lymphoma grade, CD10 expression, Bcl-2 expression, IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation) with progression-free survival, overall survival, and follicular ly...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.06.013
更新日期：2013-11-01 00:00:00
abstract：:We present a rare case of unilateral intratesticular cystadenocarcinoma with mucinous differentiation in a 71-year-old male patient. The orchiectomy specimen revealed a 3.5-cm well to moderately differentiated cystic neoplasm with elongated fine papillary structures lined by columnar epithelium with alternating goblet...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.11.021
更新日期：2011-09-01 00:00:00
abstract：:We investigated whether histological chorioamnionitis (HCA) is a risk factor predisposing to leukemoid reaction (LR) and whether LR is associated with the preterm parturition syndrome and the systemic fetal inflammation response syndrome. A prospective histological study on placentas was performed in preterm infants (...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.09.017
更新日期：2006-01-01 00:00:00
abstract：:Improved graft survival was observed in cadaver-kidney recipients prepared with random donor blood transfusions and in selected living-related-kidney recipients primed with transfusions from the kidney donor. This seems to justify a purposeful transfusion policy in these patients. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80031-8
更新日期：1983-03-01 00:00:00
abstract：:Despite the nearly ubiquitous expression of telomerase in almost all types of malignant human tumors, studies have shown widely varying positivity in the highest-grade glioma, the glioblastomas (GBMs), ranging from 26% to 100% of tumors analyzed. We have previously shown significant variability in positive versus nega...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.9086
更新日期：2000-08-01 00:00:00
abstract：:Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a h...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80254-3
更新日期：1984-11-01 00:00:00
abstract：:Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonali...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.125381
更新日期：2002-08-01 00:00:00
abstract：:Pauci-immune necrotizing crescentic glomerulonephritis is the histologic substrate of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Several studies in animal models have demonstrated the crucial role of complement activation in the pathogenesis of ANCA-associated vasculitis, but only small series h...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2016.05.015
更新日期：2016-10-01 00:00:00
abstract：:In contrast to long bone osteosarcoma, mandibular osteosarcoma is highly heterogeneous and morphologically overlaps with benign tumors, obscuring diagnosis and treatment selection. Molecular characterization is difficult due to the paucity of available specimens of this rare disease. We aimed to characterize the spect...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.11.012
更新日期：2016-04-01 00:00:00
