Abstract：
:α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are specific for pancreatic neuroendocrine tumor. In addition, the association of ATRX/DAXX protein loss with tumor cell proliferation has not been examined. We, therefore, immunostained ATRX and DAXX in 10 gastric, 15 duodenal, 20 rectal, 70 pancreatic, and 22 pulmonary neuroendocrine tumors with 15 nonneoplastic pancreases and 27 pancreatic adenocarcinomas to elucidate the site-specific roles of ATRX/DAXX abnormalities. At least 1 loss of ATRX and DAXX immunoreactivity was detected in all neuroendocrine tumor cases but not in any of nonneoplastic pancreatic tissues or pancreatic adenocarcinomas. The loss of DAXX protein was correlated with the Ki-67 index (ATRX, P = .904; DAXX, P = .044). The status of DAXX immunoreactivity correlated positively with World Health Organization histologic grade (P = .026). These results suggest that the status of ATRX or DAXX protein loss in neuroendocrine tumor differed among the organs in which these tumors arose, and these proteins may play site-specific roles in the development of these tumors.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Chen SF,Kasajima A,Yazdani S,Chan MS,Wang L,He YY,Gao HW,Sasano Hdoi
10.1016/j.humpath.2013.04.025subject
Has Abstractpub_date
2013-10-01 00:00:00pages
2199-203issue
10eissn
0046-8177issn
1532-8392pii
S0046-8177(13)00227-Xjournal_volume
44pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:The assessment of hormone receptors, including estrogen receptor and progesterone receptor, has become a standard practice in breast cancer management. However, the need for multiple sections to evaluate each receptor individually by conventional immunohistochemistry may preclude the analysis on some core biopsies wit...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.06.002
更新日期：2013-03-01 00:00:00
abstract：:CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.29678
更新日期：2001-12-01 00:00:00
abstract：:To determine useful factors when selecting an appropriate procedure for noninvasive ampullary neoplasia, we investigated the relationship between the location and the histomorphological/immunohistochemical characteristics of 56 noninvasive ampullary neoplasms obtained by endoscopic papillectomy (EP). All subjects were...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.05.013
更新日期：2014-09-01 00:00:00
abstract：:Liver involvement in amyloidosis is rarely associated with intrahepatic cholestasis. The cases recorded in the literature indicate that there is a tendency toward periportal deposition, leading to centrilobular cholestasis. Our case was most interesting in that the amyloid deposition was most severe in the centrilobul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80029-9
更新日期：1981-05-01 00:00:00
abstract：:NLRC3 is a member of the nucleotide-binding domain and leucine-rich repeat (NLR) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, NLRC3 expression correlation with the development and prognosis of hepatocellular carcinoma (HCC) is...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.07.031
更新日期：2018-12-01 00:00:00
abstract：:Columnar cell lesions of the breast are a spectrum of lesions in the terminal duct lobular units, which include columnar cell change, columnar cell hyperplasia, and columnar cell change or columnar cell hyperplasia with atypia. The latter was designated by the World Health Organization as flat epithelial atypia. We st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.12.003
更新日期：2010-06-01 00:00:00
abstract：:Telomerase is expressed in many human cancers and cell lines and is thought to contribute to their immortality. To date, little is known about the expression of telomerase in nonepithelial tumors. The objective of this study was to evaluate the expression of human telomerase reverse transcriptase (hTERT) in gastrointe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.07.010
更新日期：2004-10-01 00:00:00
abstract：:To examine the hypothesis that malpositions of cardiac ventricles could be explained by altered development of the interventricular septum, we studied hearts from the Johns Hopkins Hospital autopsy files with double inlet left ventricle (16 cases) or corrected transposition (nine cases). In double inlet left ventricle...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80125-6
更新日期：1981-03-01 00:00:00
abstract：:Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.01.013
更新日期：2014-06-01 00:00:00
abstract：:Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofibe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80312-3
更新日期：1984-12-01 00:00:00
abstract：:Congenital subclavian steal may result from various anomalies of the aortic arch. The most common predisposing type is the right aortic arch with an isolated left subclavian artery arising from a left ductus arteriosus. A rare variant includes isolation of the left common carotid as well as the left subclavian arterie...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80200-6
更新日期：1981-10-01 00:00:00
abstract：:Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that th...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.017
更新日期：2012-09-01 00:00:00
abstract：:Four monoclonal antibodies (MoAbs), 60.15, 61.3, 105.10, and 2.16, directed to different proteins of Mycobacterium tuberculosis were used by an indirect avidin-biotin complex peroxidase-antiperoxidase method to detect mycobacterial antigens in lung, lymph node, and joint tissue specimens of tuberculous patients. Using...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90226-8
更新日期：1989-11-01 00:00:00
abstract：:Human papillomavirus-related oropharyngeal squamous cell carcinoma has a unique biology and improved prognosis. A new focus is to identify prognostic biomarkers specifically in this human papillomavirus-positive cohort. We analyzed cyclin D1 immunostaining on a tissue microarray of patients with known clinical follow-...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.01.021
更新日期：2013-08-01 00:00:00
abstract：:Oral cancer overexpressed 1 (ORAOV1) has been reported to exhibit high amplification levels in esophageal squamous cell cancer (ESCC) and in premalignant lesions. However, ORAOV1 protein expression levels in ESCC and esophageal squamous intraepithelial neoplasia (ESIN) have not yet been reported. We have explored the ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.01.009
更新日期：2015-05-01 00:00:00
abstract：:Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for invasive cholangiocarcinoma: biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. How the carcinogenetic process differs between biliary intr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.11.018
更新日期：2008-08-01 00:00:00
abstract：:Proliferating cell nuclear antigen (PCNA) and c-myc p62 oncoprotein are two nuclear proteins expressed in proliferating and transformed cells. They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively. On the other hand, nucleolar organizer regi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90084-t
更新日期：1993-04-01 00:00:00
abstract：:Deregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. XIAP is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members. To explore the relevance of XIAP for progression and prognosis in renal cell carci...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.03.011
更新日期：2004-08-01 00:00:00
abstract：:To investigate the relationship between the tissue distribution and the types of amyloid proteins, the detailed histopathologic features of the available liver in 284 cases of amyloidosis were examined. We classified hepatic amyloidosis into three types, namely, the vascular pattern, parenchymal pattern, and stromal p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90279-1
更新日期：1995-10-01 00:00:00
abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90114-4
更新日期：1999-04-01 00:00:00
abstract：:Islets were evaluated for the presence of amyloid deposits in 169 pancreases removed at autopsy. Islet amyloid occurred in 17 of 142 (12 per cent) of nondiabetics and in 16 of 27 (59 per cent) of diabetics. When diabetics were divided into categories according to clinical severity of disease, the insulin treated diabe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80197-9
更新日期：1981-10-01 00:00:00
abstract：:A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80143-3
更新日期：1982-01-01 00:00:00
abstract：:Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers. A previous study has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2). In this study, we investigated the ex...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.03.007
更新日期：2017-06-01 00:00:00
abstract：:A membrane-bound, Ca2-dependent complex of the cofactor factor Va and the enzyme factor Xa comprises the prothrombinase coagulation complex, which catalyzes the proteolytic conversion of prothrombin to thrombin. In normal hemostasis, the platelet is presumed to supply the surface membrane and thus constitutes the site...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80334-9
更新日期：1987-02-01 00:00:00
abstract：:Three cases of veno-occlusive disease of the liver were diagnosed in four autopsied patients who had received high-dose mitomycin C therapy followed by autologous bone marrow transplantation, and the pathologic finding are reported. Review of 27 liver, examined post mortem, of patients receiving other high-dose chemot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80008-7
更新日期：1982-07-01 00:00:00
abstract：:Cellular crescents are typically inflammatory and associated with rapidly progressive glomerulonephritis. Their pathogenesis involves glomerular basement membrane rupture due to circulating or intrinsic factors. Crescents associated with diabetic glomerulosclerosis are rarely reported. Furthermore, the nature of cells...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.10.030
更新日期：2014-03-01 00:00:00
abstract：:The DNA content and proliferative indexes of seven cases of tenosynovial giant cell tumor of tendon sheath, diffuse type (TGCT-D); 11 cases of tenosynovial giant cell tumor of tendon sheath, localized type (TGCT-L); and seven cases of pigmented villonodular synovitis (PVNS) were analyzed by flow cytometry in an attemp...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90340-9
更新日期：1992-07-01 00:00:00
abstract：:Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90232-4
更新日期：1996-09-01 00:00:00
abstract：:Although early-stage cervical cancer can be treated by surgery, distant metastases can be life threatening. It has been a challenge to identify reliable biomarkers as indicators of metastasis or poor prognosis. We investigated the prognostic impact of vimentin, E-cadherin, and β-catenin expression measured by immunohi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.08.025
更新日期：2012-08-01 00:00:00
abstract：:A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.12.002
更新日期：2011-09-01 00:00:00
