PhD graduate training programs in pathology: 2003 report from the American Society for Investigative Pathology workshop on pathology graduate education.


:Graduate training is one of the most important activities in which we engage. Through PhD training programs in pathology, we continually renew the intellectual vigor of our discipline and assure its position as a vibrant force in the life sciences. To focus on this important issue, the Education Committee of the American Society for Investigative Pathology (ASIP) organized a workshop on April 11, 2003 for pathology graduate program directors from across the United States and Canada. The goals of this workshop were to better define the current models of pathology graduate training programs, to identify key issues pertaining to the curriculum of pathology training programs and strategies to better market pathology graduate training opportunities, and to identify challenges for the future. Twenty-three program directors and other faculty interested in pathology graduate education, as well as 2 invited PhD students, attended the workshop. Workshop participants concluded that the integration of more and better disease-related education into graduate training programs would attract more and better-qualified students into pathology career pathways that will ultimately fulfill important societal needs and train future leaders of the biomedical research community. The ASIP is facilitating this goal by taking a leadership role in publicizing educational efforts in pathology and by making systematic use of its Website for sharing information about curriculum ideas and materials, as well as course syllabi.


Hum Pathol


Human pathology


Kemp JD,Bowser R,American Society for Investigative Pathology workshop.




Has Abstract


2004-07-01 00:00:00














  • Ki67 labeling index in core needle biopsies independently predicts tumor-specific survival in prostate cancer.

    abstract::A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Bubendorf L,Tapia C,Gasser TC,Casella R,Grunder B,Moch H,Mihatsch MJ,Sauter G

    更新日期:1998-09-01 00:00:00

  • Lack of human herpesvirus 8 and Epstein-Barr virus in Kikuchi's histiocytic necrotizing lymphadenitis.

    abstract::Kikuchi's histiocytic necrotizing lymphadenitis is a self-limited disorder that typically involves the cervical lymph nodes of young women. Although a viral etiology has been postulated, a definitive viral agent has not been identified. Recent reports have suggested that human herpesvirus 8 (HHV 8) or Epstein-Barr vir...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: George TI,Jones CD,Zehnder JL,Warnke RA,Dorfman RF

    更新日期:2003-02-01 00:00:00

  • Monoclonal antibody Adnab-9 defines a preneoplastic marker in epithelium at risk for adenocarcinoma of the small intestine.

    abstract::Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Tobi M,Kaila V,Hassan N,Gallinger S,Fligiel S,Hatfield J,Gesell M,Sakr W,Luk G,Odze RD

    更新日期:1999-04-01 00:00:00

  • A subset of sinonasal undifferentiated carcinoma is associated with transcriptionally active high-risk human papillomavirus by in situ hybridization: a clinical and pathologic analysis.

    abstract::Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy with a poor prognosis, and pathologically, it is a diagnosis of exclusion. Rendering this diagnosis can be challenging in practice because of the large number of diverse entities in the differential diagnosis. We encountered an index case of a sin...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Baraban E,Tong CCL,Adappa ND,Cooper K

    更新日期:2020-07-01 00:00:00

  • Intercellular contacts between stromal cells in the normal human endometrium throughout the menstrual cycle.

    abstract::Increasing differentiation in the human endometrium is associated with an apparent decrease in intercellular contacts between endometrial stromal cells ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Parmley TH,Roberts DK,Emsa NJ,Horbelt DV

    更新日期:1990-10-01 00:00:00

  • p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas.

    abstract::Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: O'Regan EM,Toner ME,Finn SP,Fan CY,Ring M,Hagmar B,Timon C,Smyth P,Cahill S,Flavin R,Sheils OM,O'Leary JJ

    更新日期:2008-03-01 00:00:00

  • Decreased expression of neuropeptides in malignant paragangliomas: an immunohistochemical study.

    abstract::Paraffin-embedded sections of 99 human adrenal and extraadrenal paragangliomas were analyzed by the indirect immunoperoxidase technique for the presence of neuron-specific enolase (NSE) and 10 neuropeptides. Each showed diffuse staining for NSE. Most tumors were positive for [Leu5]-enkephalin (76 per cent), [Met5]-enk...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Linnoila RI,Lack EE,Steinberg SM,Keiser HR

    更新日期:1988-01-01 00:00:00

  • SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma.

    abstract::Invasive squamous cell carcinoma (SCC) of the cervix involves the progression of premalignant cervical intraepithelial neoplasia (CIN) and is associated with persistent human papillomavirus infection. Most CINs will regress, and the challenge is to identify the lesions likely to progress to invasive cancer. We evaluat...

    journal_title:Human pathology

    pub_type: 杂志文章,多中心研究


    authors: Velez-Perez A,Wang XI,Li M,Zhang S

    更新日期:2017-01-01 00:00:00

  • Brainstem subarachnoid respiratory epithelial cysts: report of two cases and review of the literature.

    abstract::Two cystic lesions that were lined by pseudostratified ciliated columnar epithelium containing goblet cells are described. Both lesions were found in the subarachnoid space between the vertebrobasilar arterial system and the brainstem. One cyst was an incidental finding in a patient who died of orbital phycomycosis. T...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Schelper RL,Kagan-Hallet KS,Huntington HW

    更新日期:1986-04-01 00:00:00

  • Primary effusion Burkitt's lymphoma with t(8;22) in a patient with hepatitis C virus-related cirrhosis.

    abstract::Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficienc...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Ascoli V,Lo Coco F,Artini M,Levrero M,Fruscalzo A,Mecucci C

    更新日期:1997-01-01 00:00:00

  • Down-regulation of drs mRNA in human prostate carcinomas.

    abstract::We have previously reported that the drs gene has the ability to suppress transformation by v-src and v-K-ras in the rat cell line F2808. We have also shown that the expression of drs mRNA is markedly reduced in a variety of human cancer cell lines, suggesting that down-regulation of drs mRNA is correlated with the de...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Kim CJ,Shimakage M,Kushima R,Mukaisho K,Shinka T,Okada Y,Inoue H

    更新日期:2003-07-01 00:00:00

  • Apocrine cystic metaplasia: subgross pathology and prevalence in cancer-associated versus random autopsy breasts.

    abstract::Focal apocrine metaplasia was studied in 293 whole human breasts by a subgross sampling technique with histologic confirmation. There were 186 breasts obtained from random autopsies. Another 107 breasts were obtained that were cancer-associated; these breasts either contained an invasive cancer or were situated contra...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Wellings SR,Alpers CE

    更新日期:1987-04-01 00:00:00

  • Type XV collagen in human colonic adenocarcinomas has a different distribution than other basement membrane zone proteins.

    abstract::In situ carcinomas must penetrate their own basement membrane to be classified as invasive, and subsequently infiltrate surrounding connective tissue and cross vascular basement membranes to metastasize hematogenously. Accordingly, in many studies, integral basement membrane components, including type IV collagen, lam...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Amenta PS,Briggs K,Xu K,Gamboa E,Jukkola AF,Li D,Myers JC

    更新日期:2000-03-01 00:00:00

  • Sex-determining region Y-box 2 expression predicts poor prognosis in human ovarian carcinoma.

    abstract::Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Zhang J,Chang DY,Mercado-Uribe I,Liu J

    更新日期:2012-09-01 00:00:00

  • Retinal ependymoma: an immunohistologic and ultrastructural study.

    abstract::Glial tumors of the retina are rare. Most are syndrome associated and include pilocytic astrocytoma in neurofibromatosis type 1 and subependymal giant cell astrocytoma in tuberous sclerosis complex. Acquired, more conventional, diffuse astrocytomas are less frequent. Ependymoma is exquisitely rare. Herein, we report t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Tay A,Scheithauer BW,Cameron JD,Myhre MJ,Boerner MJ

    更新日期:2009-04-01 00:00:00

  • Toxic shock syndrome: clinicopathologic findings in a fatal case.

    abstract::A 15 year old girl presented with a painful desquamative rash, fever, and profound hypotension. Despite antimicrobial therapy and intensive supportive measures, she died 80 hours after admission. The premortem skin biopsy and autopsy findings, which included subepidermal edema and blister formation, subacute vasculiti...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Abdul-Karim FW,Lederman MM,Carter JR,Hewlett EL,Newman AJ,Greene BM

    更新日期:1981-01-01 00:00:00

  • Expression of p27, COX-2, MLH1, and MSH2 in young patients with colon carcinoma and correlation with morphologic findings.

    abstract::Despite an overall decrease in colorectal carcinoma incidence, rates of colorectal carcinoma have increased substantially in patients aged less than 40 years. Several authors have characterized morphologic features of colorectal carcinoma in young patients, with variable results. To date, there has been 1 detailed mol...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Kenney B,Deng Y,Mitchell K

    更新日期:2013-04-01 00:00:00

  • Enteroendocrine cell dysgenesis and malabsorption, a histopathologic and immunohistochemical characterization.

    abstract::Enteroendocrine cell dysgenesis was observed in 3 patients with intestinal failure of unknown cause. Enteroendocrine cell dysgenesis is a congenitally acquired life-threatening malabsorptive condition with a unique clinical phenotype paired with a histologically identifiable disease pattern. Two cases were first prese...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Cortina G,Smart CN,Farmer DG,Bhuta S,Treem WR,Hill ID,Martín MG

    更新日期:2007-04-01 00:00:00

  • Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease.

    abstract::In 112 unselected autopsies of adult patients without known pancreatic disease (except adult-onset diabetes mellitus), the pancreas was examined to establish the incidence and degree of such minor pancreatic lesions as lipomatosis, fibrosis, alterations of ducts and ductal epithelium, inflammatory infiltrates, focal n...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Stamm BH

    更新日期:1984-07-01 00:00:00

  • Endocardial fibroelastosis and myocardial calcification secondary to an anomalous right coronary artery arising from the pulmonary trunk.

    abstract::The case of an infant with endocardial fibroelastosis and a coexistent anomalous right coronary artery that originated from the pulmonary trunk is presented. The causal relation between the two conditions is discussed. ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Huang TY,Hsueh Y,Tsung SH

    更新日期:1985-09-01 00:00:00

  • Overexpression of cofilin 1 can predict progression-free survival in patients with epithelial ovarian cancer receiving standard therapy.

    abstract::The aim of this study was to examine the relation between cofilin 1 expression and progression-free survival in advanced epithelial ovarian cancer. We performed quantitative reverse transcriptase polymerase chain reaction and immunohistochemical analysis in 78 patients with advanced epithelial ovarian cancer (excludin...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Nishimura S,Tsuda H,Kataoka F,Arao T,Nomura H,Chiyoda T,Susumu N,Nishio K,Aoki D

    更新日期:2011-04-01 00:00:00

  • A prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2, based on simple clinical parameters.

    abstract::This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Koeneman MM,van Lint FHM,van Kuijk SMJ,Smits LJM,Kooreman LFS,Kruitwagen RFPM,Kruse AJ

    更新日期:2017-01-01 00:00:00

  • Human tails and pseudotails.

    abstract::A case of a tail in a 2-week-old infant is reported, and findings from a review of 33 previously reported cases of true tails and pseudotails are summarized. The true, or persistent, vestigial tail of humans arises from the most distal remnant of the embryonic tail. It contains adipose and connective tissue, central b...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Dao AH,Netsky MG

    更新日期:1984-05-01 00:00:00

  • Histopathologic features in the central nervous system of 400 acquired immunodeficiency syndrome cases: implications of rates of occurrence.

    abstract::Histopathologic lesions in the central nervous system (CNS) of 400 autopsy cases of the acquired immunodeficiency syndrome (AIDS) collected from 1982 to 1990 were studied. Lesions most closely associated with human immunodeficiency virus (HIV) infection in the CNS (perivascular macrophages, nodular encephalomyelitis, ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Rhodes RH

    更新日期:1993-11-01 00:00:00

  • Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm.

    abstract::Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for invasive cholangiocarcinoma: biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. How the carcinogenetic process differs between biliary intr...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Nakanishi Y,Zen Y,Kondo S,Itoh T,Itatsu K,Nakanuma Y

    更新日期:2008-08-01 00:00:00

  • EGFR and KRAS mutations in metastatic lung adenocarcinomas.

    abstract::In primary lung adenocarcinoma, EGFR and KRAS mutations are found in approximately 10% to 20% and 20% to 30%, respectively. Few studies have investigated these mutations in metastases. Patients with EGFR mutations have a 70% to 80% response rate to tyrosine-kinase inhibitors therapy and a longer progression-free survi...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Munfus-McCray D,Harada S,Adams C,Askin F,Clark D,Gabrielson E,Li QK

    更新日期:2011-10-01 00:00:00

  • Immunohistochemical characteristics of renomedullary interstitial cell tumor: a study of 41 tumors with emphasis on differential diagnosis of mesenchymal neoplasms.

    abstract::Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Lu Z,Al-Obaidy K,Cheng L,Perry KD,Grignon DJ,Williamson SR

    更新日期:2018-12-01 00:00:00

  • Sinonasal adenocarcinoma: evidence for histogenetic divergence of the enteric and nonenteric phenotypes.

    abstract::Adenocarcinomas of nonsalivary origin represent approximately 10% to 20% of all sinonasal malignancies and are characterized by varying histopathologic features and uncertain histogenesis. To better understand the histogenesis and phenotypic heterogeneity of these tumors, we performed immunohistochemical analyses for ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Choi HR,Sturgis EM,Rashid A,DeMonte F,Luna MA,Batsakis JG,El-Naggar AK

    更新日期:2003-11-01 00:00:00

  • Mallory bodies in scar adenocarcinoma of the lung.

    abstract::A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Michel RP,Limacher JJ,Kimoff RJ

    更新日期:1982-01-01 00:00:00

  • The molecular biology of esophageal and gastric cancer and their precursors: oncogenes, tumor suppressor genes, and growth factors.

    abstract::The evolution of sequential histological changes from normal cells through invasive cancer affords the cancer biologist the opportunity to identify separate molecular steps involved in cancer progression. As one studies the development of human carcinoma, it becomes apparent that multiple genetic alterations affecting...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Stemmermann G,Heffelfinger SC,Noffsinger A,Hui YZ,Miller MA,Fenoglio-Preiser CM

    更新日期:1994-10-01 00:00:00