Abstract：
:Bcl-2 and bcl-xL are proteins known to inhibit cell death (apoptosis). Expression of these proteins in gangliogliomas has not been extensively examined. This study retrospectively evaluates bcl-2 and bcl-x immunostaining in paraffin-embedded materials in gangliogliomas. Twenty-nine gangliogliomas in 17 males and 12 females, age 2.5 to 47 years (mean, 20.7 years), were studied. Nineteen tumors were situated primarily in the temporal lobe. All but three patients presented with seizures ranging from 3 months to 28 years' duration (mean, 11.1 years) before surgery. All tumors histologically were comprised of an atypical neuronal component and a glioma component, which most frequently resembled a low-grade astrocytoma. Cortical dysplasia was observed adjacent to eight tumors. MIB-1 (marker of cell proliferation) labeling indices (percentage of positively staining tumor cell nuclei) ranged from 0 to 7.7 (mean, 0.8). bcl-2 staining was observed in 25 tumors (86%); neuronal staining was present in 24 cases (83%), and glial cell staining in 21 tumors (72%). Bcl-xL staining was only observed in eight gangliogliomas (28%); in all eight tumors (28%), neuronal staining was seen, and focal glial cell staining was present in two cases (7%). Four tumors (14%) did not stain with either bcl-2 or bcl-xL. There appeared to be no relationship between MIB-1 immunostaining and staining with bcl-2 or bcl-xL. bcl-2 expression by immunohistochemistry was observed more frequently than bcl-xL in gangliogliomas. Expression of these proteins may reflect abnormalities of apoptosis, which could play a role in the survival of cells that may be involved in the development of gangliogliomas.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Prayson RAdoi
10.1016/s0046-8177(99)90097-7subject
Has Abstractpub_date
1999-06-01 00:00:00pages
701-5issue
6eissn
0046-8177issn
1532-8392pii
S0046-8177(99)90097-7journal_volume
30pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(92)90110-o
更新日期：1992-03-01 00:00:00
abstract：:We have previously shown that necrotic tumors retain their immunoreactivity for a range of cytokeratin antibodies. Some thyroid tumors undergo extensive necrosis after fine-needle aspiration (FNA) procedures. We evaluated the sensitivity of antibodies on necrotic thyroid tumors by examining a series of thyroid tumors ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90071-0
更新日期：1999-11-01 00:00:00
abstract：:Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.08.010
更新日期：2019-11-01 00:00:00
abstract：:A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi's sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endothelial cells. It is known that KS has a high...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90261-6
更新日期：1997-10-01 00:00:00
abstract：:We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.07.030
更新日期：2017-01-01 00:00:00
abstract：:The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.12.024
更新日期：2016-05-01 00:00:00
abstract：:Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its expression was examined by immunohistochemistry and in situ hybridization on a tissue microarray containing gastric carcinomas, adjacent nonneoplastic mucosa (NNM)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.10.017
更新日期：2010-05-01 00:00:00
abstract：:Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90104-0
更新日期：1997-02-01 00:00:00
abstract：:Preeclampsia is a leading cause for maternal and perinatal mortality and morbidity. Microarray-based transcriptional profiling has been widely used for identifying genes responsible for preeclampsia. These studies deliver multiple pictures of gene signatures, implying the complicated pathophysiology. In the present wo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.002
更新日期：2014-06-01 00:00:00
abstract：:We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90432-4
更新日期：1998-10-01 00:00:00
abstract：:Congenital subclavian steal may result from various anomalies of the aortic arch. The most common predisposing type is the right aortic arch with an isolated left subclavian artery arising from a left ductus arteriosus. A rare variant includes isolation of the left common carotid as well as the left subclavian arterie...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80200-6
更新日期：1981-10-01 00:00:00
abstract：:The presence of thyroglobulin (TG) was investigated by immunohistochemistry with one polyclonal and three distinct monoclonal anti-TG antibodies in 19 primary and 15 metastatic medullary thyroid carcinoma (MTC) cases. In two primary tumors possessing a mixed trabecular and follicular growth pattern, a significant numb...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90035-f
更新日期：1993-03-01 00:00:00
abstract：:Pulmonary vein stenosis (PVS) is a rare disorder. Accurate diagnosis often requires anatomical examination. We report four children with pulmonary vein stenosis. Autopsy showed bilateral lesions in two patients who were thought clinically to have unilateral disease. A diagnosis of PVS was made at autopsy in the third ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90011-x
更新日期：1995-08-01 00:00:00
abstract：:Adamantinoma of the long bones is a rare, typically low-grade malignant tumor that frequently involves the tibia. Radiographically, adamantinoma is characteristically a lytic, intracortical, and expansile lesion with variable margins. Histologically, adamantinoma is a bimorphic neoplasm, composed of epithelial and ost...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.11.018
更新日期：2019-09-01 00:00:00
abstract：:Kaposi's sarcoma (KS) is a pleomorphic spindle cell lesion whose incidence has markedly increased among patients infected with the human immunodeficiency virus (HIV), especially among those whose primary risk factor is homo/bisexual transmission. The question as to whether KS is even a true neoplasm still remains larg...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90112-g
更新日期：1992-03-01 00:00:00
abstract：:Epidermal growth factor receptor is a transmembrane receptor involved in oncogenesis, including the development of glioblastoma. We studied the prognostic significance of epidermal growth factor receptor amplification as determined by fluorescence in situ hybridization, quantitative polymerase chain reaction, and prot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.09.020
更新日期：2010-06-01 00:00:00
abstract：:Polymer substances are commonly applied as surface coatings on endovascular catheters and vascular devices. Adverse effects related to their use have been reported, although the overall clinical significance and appropriate methods of detection of these complications have been unclear. In this analysis, we systematica...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2016.01.018
更新日期：2016-07-01 00:00:00
abstract：:Seven cases in which interstitial fibrosis developed in patients who had acute interstitial pneumonia were studied ultrastructurally to elucidate the pathogenesis of the interstitial thickening seen by light microscopy. Interstitial fibrosis is generally thought to result from fibroblast proliferation and collagen dep...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80279-3
更新日期：1985-10-01 00:00:00
abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.017
更新日期：2014-07-01 00:00:00
abstract：:Immunofluorescent staining of tissue from a lung tumor detected 12 years after excision of a primary malignant melanoma of the skin was negative for prekeratin and positive for vimentin, indicating that the tumor was not epithelial in origin and excluding carcinoma from the differential diagnosis. Complementary conven...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80182-8
更新日期：1983-11-01 00:00:00
abstract：:Renal glomerular disease characterized by the deposition of immunoglobulin light chains or monoclonal immunoglobulins was demonstrated by immunofluorescence microscopy in 11 patients. The most common histopathologic findings were those of mesangiocapillary glomerulonephritis, but considerable variability was observed....
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80017-4
更新日期：1985-03-01 00:00:00
abstract：:Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90232-4
更新日期：1996-09-01 00:00:00
abstract：:The relationship between nuclear diameter and biologic behavior was studied in 127 cases of thyroid carcinoma. Using a sonic digitizer coupled to a minicomputer, nuclear diameters of 200 randomly selected cancer cells from each case (hematoxylineosin-stained paraffin sections) projected at X 400 magnification were tra...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80409-4
更新日期：1987-12-01 00:00:00
abstract：:SPARC (secreted protein acidic and rich in cysteine, also called osteonectin, BM-40, and 43K protein) is a matricellular protein and is associated with cell-matrix interactions during cell proliferation and extracellular remodeling. It is also implicated in the neovascularization, invasion, and metastasis of human mal...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.28244
更新日期：2001-10-01 00:00:00
abstract：:Fatty acids are implicated in tumorigenesis, but data are limited concerning endogenous fatty acid metabolism of tumor cells in adenomas and adenocarcinomas of the small intestine. The recently cloned human acyl-CoA-synthetase 5 (ACS5) is predominantly found in the small intestine and represents a key enzyme in provid...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/s0046-8177(03)00431-3
更新日期：2003-10-01 00:00:00
abstract：:Lymphoepithelial cysts with histological features characteristic of branchial cleft cysts have been reported to occur rarely in the thyroid gland. To our knowledge only six cases of this lesion have been reported. Since these reports brought this entity to our attention, we have noted that intrathyroidal lymphoepithel...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90042-6
更新日期：1994-11-01 00:00:00
abstract：:To investigate the roles of matrix metalloproteinases (MMPs) in thymic epithelial tumors, we examined the expression of MMP-2, -7, and -9; membrane-type 1 (MT1)-MMP; and tissue inhibitor of metalloproteinase-2 (TIMP-2) in 57 tumors by immunohistochemistry and in selected 15 cases by in situ hybridization. The tumors c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.07.013
更新日期：2003-12-01 00:00:00
abstract：:Perineural invasion is a histologic feature usually diagnostic of invasion in malignancies. In the breast, however, it has been associated with benign lesions such as sclerosing adenosis (SA), complex sclerosing lesion/radial scar (CSL/RS), and ductal carcinoma in situ (DCIS). This article describes perineural invasio...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.27637
更新日期：2001-08-01 00:00:00
abstract：:Hyaline globules (HG) have been observed in a large variety of unrelated categories of tumors and benign tissues. Different explanations for their formation have been proposed, varying according to tumor type and anatomic location. We have studied 80 tumor cases containing HG, by light microscopy, electron microscopy,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.20376
更新日期：2000-12-01 00:00:00
abstract：:Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.01.013
更新日期：2014-06-01 00:00:00
