Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors.

abstract：:The surgical pathologist is often called upon to make a rapid decision about the malignant potential of a soft tissue tumor. These tumors have specific stromas that support growth and endow the tumor with unique qualities, as well as being manifestations of the phenotypic expression of tumor cells. Collagen, the major...

journal_title：Human pathology

authors： Stern R

更新日期：1981-09-01 00:00:00

abstract：:Preserving small pieces of frozen tissue for possible future ancillary studies ("tumor banking") usually involves either placing a small piece of tissue in a cryovial and snap freezing it in liquid nitrogen or embedding and freezing the tissue in a block of cryopreservation medium, such as optimal cutting temperature ...

journal_title：Human pathology

authors： Loken SD,Demetrick DJ

更新日期：2005-09-01 00:00:00

abstract：:A distinctive ultrastructural finding, observed in a case of acute lymphoblastic leukemia (ALL) and previously unreported on the surface of bone marrow cells, is described. The alteration is referred to as distinctive cytoplasmic surface activity (DCSA). For further delineation, study of 130 consecutively submitted bo...

journal_title：Human pathology

authors： de Chadarévian JP,Corriveau M

更新日期：1987-04-01 00:00:00

abstract：:This report describes a vasculitis and subsequently developing angiodestructive lymphoma in an 11-year-old Japanese-Filipino girl exhibiting mosquito allergy with the background of chronic active Epstein-Barr virus (EBV) infection. She developed necrotic skin ulcer at the site of mosquito bite, and histopathological e...

journal_title：Human pathology

authors： Kanno H,Onodera H,Endo M,Maeda F,Chida S,Akasaka T,Sawai T

更新日期：2005-02-01 00:00:00

abstract：:The approach to the collection and transport of meaningful and accurate microbiologic specimens depends upon the nature of the suspected infectious entity and upon the location of the pathogenic process, as well as the possession of appropriate instrumentation and containers. New information and newly developed collec...

journal_title：Human pathology

authors： Matsen JM,Ederer GM

更新日期：1976-05-01 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) and c-myc p62 oncoprotein are two nuclear proteins expressed in proliferating and transformed cells. They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively. On the other hand, nucleolar organizer regi...

journal_title：Human pathology

authors： Korkolopoulou P,Patsouris E,Pangalis G,Tsenga A,Elemenoglou J,Thomas-Tsangli E,Spandidos D,Kittas C

更新日期：1993-04-01 00:00:00

abstract：:Inflammatory pseudotumors (IPs), mostly benign lesions characterized by fibrotic ground tissue and polyclonal mononuclear infiltrate, may affect all organ systems. IPs originating in the central nervous system (IP-CNS) are very rare, and their distinct histopathologic features are poorly characterized. Three otherwise...

journal_title：Human pathology

authors： Häusler M,Schaade L,Ramaekers VT,Doenges M,Heimann G,Sellhaus B

更新日期：2003-03-01 00:00:00

abstract：:Because infants rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourag...

journal_title：Human pathology

authors： Donnelly WH,Hawkins H

更新日期：1987-01-01 00:00:00

abstract：:The current system of pathologic classification of human breast cancers does not take into account the biologic determinants of prognosis, nor is there a consensus regarding the progression from in situ to invasive carcinoma. The present study compared the molecular phenotypes of in situ and invasive components of bre...

journal_title：Human pathology

authors： Martins D,Sousa B,Lopes N,Gomes M,Veronese L,Albergaria A,Paredes J,Schmitt F

更新日期：2011-10-01 00:00:00

abstract：:Perineural invasion is a histologic feature usually diagnostic of invasion in malignancies. In the breast, however, it has been associated with benign lesions such as sclerosing adenosis (SA), complex sclerosing lesion/radial scar (CSL/RS), and ductal carcinoma in situ (DCIS). This article describes perineural invasio...

journal_title：Human pathology

authors： Gobbi H,Jensen RA,Simpson JF,Olson SJ,Page DL

更新日期：2001-08-01 00:00:00

abstract：:It has been proposed that an epithelial injury may be one of the multiple primary events in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to characterize the tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis. W...

journal_title：Human pathology

authors： Lappi-Blanco E,Lehtonen ST,Sormunen R,Merikallio HM,Soini Y,Kaarteenaho RL

更新日期：2013-05-01 00:00:00

abstract：:Recent studies demonstrated that protease-activated receptor-2 (PAR-2) correlates with tumor progression in various tissues. On the other hand, oxidative stress arising from endometriosis has been considered a cause of carcinogenesis in ovarian clear cell carcinoma (OCCC). We previously demonstrated that oxidative str...

journal_title：Human pathology

authors： Aman M,Ohishi Y,Imamura H,Shinozaki T,Yasutake N,Kato K,Oda Y

更新日期：2017-06-01 00:00:00

abstract：:A 60-year-old man was admitted for progressive visual loss in both eyes. He was diagnosed with retinopathy and chest computed tomography revealed an invasive thymoma. In western blot analysis, serum autoantibodies against recoverin, photoreceptor-specific calcium-binding protein, and heat shock cognate protein 70 whic...

journal_title：Human pathology

authors： Yamada G,Ohguro H,Aketa K,Itoh T,Shijubo N,Takahashi H,Fujiwara O,Satoh M,Ohtsuka K,Abe S

更新日期：2003-07-01 00:00:00

abstract：:Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...

journal_title：Human pathology

authors： Pradhan D,Schoedel K,McGough RL,Ranganathan S,Rao UNM

更新日期：2018-01-01 00:00:00

abstract：:Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...

journal_title：Human pathology

authors： Nasir A,Amateau SK,Khan S,Simpson RW,Snover DC,Amin K

更新日期：2018-04-01 00:00:00

abstract：:This study assessed squamous cell papillomas of the human esophagus for the presence of human papillomavirus (HPV) and correlated the results with histological features. Twenty-three lesions obtained by endoscopic biopsy from 17 patients were studied, first by in situ hybridization (ISH) for HPV types 6-11, 16-18, 18,...

journal_title：Human pathology

authors： Carr NJ,Bratthauer GL,Lichy JH,Taubenberger JK,Monihan JM,Sobin LH

更新日期：1994-05-01 00:00:00

abstract：:Tumor budding is an acknowledged prognostic marker in colorectal cancer. This study was conducted to investigate the morphology and prognostic significance of budding in rectal cancer after neoadjuvant radiotherapy. Surgical specimens from 96 consecutive patients who underwent neoadjuvant radiotherapy and curative res...

journal_title：Human pathology

authors： Du C,Xue W,Li J,Cai Y,Gu J

更新日期：2012-07-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a group of granulomatous disorders in which abnormal Langerhans cells proliferate as either a localized lesion in a single bone or disseminated disease involving two or more organs or systems. Because the different LCH forms exhibit significantly elevated levels of inflammatory m...

journal_title：Human pathology

authors： Murakami I,Matsushita M,Iwasaki T,Kuwamoto S,Kato M,Horie Y,Hayashi K,Imamura T,Morimoto A,Imashuku S,Gogusev J,Jaubert F,Takata K,Oka T,Yoshino T

更新日期：2014-01-01 00:00:00

abstract：:Posttransplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV), and may clinically resemble acute allograft rejection. Three methods to show EBV in tissue were evaluated in 15 liver allograft biopsies from 12 patients including four with PTLD: (1) semiquantitative polymerase chain react...

journal_title：Human pathology

authors： Lones MA,Shintaku IP,Weiss LM,Thung SN,Nichols WS,Geller SA

更新日期：1997-05-01 00:00:00

abstract：:Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gene silencing. Many cancer entities feature overexpression of HDACs. Cu...

journal_title：Human pathology

authors： Klieser E,Urbas R,Stättner S,Primavesi F,Jäger T,Dinnewitzer A,Mayr C,Kiesslich T,Holzmann K,Di Fazio P,Neureiter D,Swierczynski S

更新日期：2017-07-01 00:00:00

abstract：:Two episodes of severe, relapsing sensorimotor polyneuropathy closely paralleled the course of systemic illness in a patient with immunoblastic lymphadenopathy. A review of the literature shows three other cases, although none with documented pathologic changes in muscles and nerves. Based on the pathologic findings i...

journal_title：Human pathology

authors： Cytowic RE,Challa VR,Buss DH,Angelo JN

更新日期：1982-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficienc...

journal_title：Human pathology

authors： Ascoli V,Lo Coco F,Artini M,Levrero M,Fruscalzo A,Mecucci C

更新日期：1997-01-01 00:00:00

abstract：:A six year old boy with bilateral breast enlargement was found to have a normal endocrine status. Resected tissue revealed the features of pseudogynecomastia due to a proliferation of fibrous tissue traversed by neuroid structures. Multinucleated giant cells were present within the fibrous tissue. Ultrastructural stud...

journal_title：Human pathology

authors： Lipper S,Willson CF,Copeland KC

更新日期：1981-08-01 00:00:00

abstract：:We have begun a systematic study of human papillomavirus (HPV) infection in colposcopically and/or morphologically normal epithelium of the uterine cervix. Paired biopsies were taken from the lesions (cervical intraepithelial neoplasia [CIN], condyloma, invasive carcinoma) and from the normal-appearing adjacent epithe...

journal_title：Human pathology

authors： Colgan TJ,Percy ME,Suri M,Shier RM,Andrews DF,Lickrish GM

更新日期：1989-04-01 00:00:00

abstract：:The clinical spectrum of coronavirus disease 2019 is getting wider with the exponential increase of patients worldwide. Initially described with flu-like symptoms, variable cutaneous manifestations have been reported, with only few histopathological descriptions. Detection of the virus in cutaneous samples has been as...

journal_title：Human pathology

authors： Fattori A,Cribier B,Chenard MP,Mitcov M,Mayeur S,Weingertner N

更新日期：2021-01-01 00:00:00

abstract：:Altered expression of oncogenes and tumor suppressor genes, the normal function of which is to regulate cell growth and differentiation, represents a central event in the pathogenesis of human cancer. Aberrant expression of these genes is often a result of a mutational event. In vitro amplification of DNA with the pol...

journal_title：Human pathology

authors： Loda M

更新日期：1994-06-01 00:00:00

abstract：:The pathology report is a critical document that helps guide the management of patients with cancer. More and more patients read their reports, intending to participate in decisions about their care. However, a substantial subset of patients may lack the ability to comprehend this often technical and complex document....

journal_title：Human pathology

authors： Mossanen M,True LD,Wright JL,Vakar-Lopez F,Lavallee D,Gore JL

更新日期：2014-11-01 00:00:00

abstract：:Partial monosomy 13q, a chromosomal alteration originally reported in spindle cell lipoma, has also been documented in a few cases of mammary myofibroblastoma. Subsequently, a monoallelic loss of RB1 and FOXO1, located on 13q14, was identified in some cases of cellular angiofibroma, a benign stromal tumor of the lower...

journal_title：Human pathology

authors： Magro G,Righi A,Casorzo L,Antonietta T,Salvatorelli L,Kacerovská D,Kazakov D,Michal M

更新日期：2012-11-01 00:00:00

abstract：:Using analysis of allelic loss (loss of heterozygosity [LOH]), we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma and then to embryonal carcinoma in mixed-type testicular germ cell tumors. To identify the genetic backgrounds related to the progression of nonsemin...

journal_title：Human pathology

authors： Miyai K,Ito K,Nakanishi K,Tsuda H

更新日期：2019-02-01 00:00:00

abstract：:Adenocarcinomas of nonsalivary origin represent approximately 10% to 20% of all sinonasal malignancies and are characterized by varying histopathologic features and uncertain histogenesis. To better understand the histogenesis and phenotypic heterogeneity of these tumors, we performed immunohistochemical analyses for ...

journal_title：Human pathology

authors： Choi HR,Sturgis EM,Rashid A,DeMonte F,Luna MA,Batsakis JG,El-Naggar AK

更新日期：2003-11-01 00:00:00