Abstract:
:We have begun a systematic study of human papillomavirus (HPV) infection in colposcopically and/or morphologically normal epithelium of the uterine cervix. Paired biopsies were taken from the lesions (cervical intraepithelial neoplasia [CIN], condyloma, invasive carcinoma) and from the normal-appearing adjacent epithelium 3 to 5 mm from the edge of the lesion. Myometrium or ectocervical epithelium from patients who had undergone hysterectomy for reasons other than genital dysplasia or malignancy served as controls. One biopsy was examined histologically. DNA from the second biopsy was digested with Pst I, and the presence or absence of HPV was determined by Southern blotting using HPV-16 DNA as a probe. HPV was not detected in any of the 12 control samples. Of 30 patients with CIN and/or condyloma, five of 18 who were HPV-positive had either HPV-16 (three cases) or virus resembling HPV-31 (two cases) in the lesion and adjacent epithelium. Of seven patients with invasive carcinoma, four had HPV in the lesion and adjacent epithelium; two of these four patients had typical HPV-16. Such infection of apparently normal epithelium has major implications for our understanding of the pathogenesis, treatment, and follow-up of patients with cervical neoplasia.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Colgan TJ,Percy ME,Suri M,Shier RM,Andrews DF,Lickrish GMdoi
10.1016/0046-8177(89)90039-7subject
Has Abstractpub_date
1989-04-01 00:00:00pages
316-9issue
4eissn
0046-8177issn
1532-8392pii
0046-8177(89)90039-7journal_volume
20pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::In 112 unselected autopsies of adult patients without known pancreatic disease (except adult-onset diabetes mellitus), the pancreas was examined to establish the incidence and degree of such minor pancreatic lesions as lipomatosis, fibrosis, alterations of ducts and ductal epithelium, inflammatory infiltrates, focal n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80294-4
更新日期:1984-07-01 00:00:00
abstract::We report the case of an exuberant ulcerative angiomatoid nasal lesion in a cocaine abuser. The lesion was made up of polymorphous endothelial cells with occasional mitoses, arranged in a lobular pattern with infiltrative-looking areas. There were extensive areas of thrombosis with focal recanalization. Intravascular ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80226-9
更新日期:2000-02-01 00:00:00
abstract::Thirty cases of ductal carcinoma in situ (DCIS) of the breast, showing histological microcalcifications, were studied to clarify their mechanism of formation. Undecalcified sections revealed three types of calcium precipitates: type I and II granular calcifications (GCs) and laminar calcifications (LCs). In type I GCs...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90372-x
更新日期:1996-02-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is a common salivary gland neoplasm with a lengthy clinical course and often late local recurrences after surgical resection. This is accounted for histologically by its infiltrative capacity and distinct propensity for perineural invasion. The expression of biological markers may help e...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.128249
更新日期:2002-09-01 00:00:00
abstract::Nested urothelial carcinoma (UC) is a rare histologic variant of UC, characterized by deceptively bland histologic features resembling von Brunn's nests but usually with a poor outcome. In our experience, this variant is frequently misclassified or underrecognized as its clinicopathologic spectrum is not well defined....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.07.015
更新日期:2010-02-01 00:00:00
abstract::δ-Like ligand 4 (DLL4), a ligand for the Notch family of receptors, forecasts the prognosis of several human malignancies. However, the expression and role of DLL4 in breast cancer remain largely unknown. In the present study, we first evaluated whether the overexpression of DLL4 could be used as an indicator of axill...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.04.025
更新日期:2014-11-01 00:00:00
abstract::The clinicopathologic features and immunohistochemical profiles of 14 cases of a distinctive mesenchymal tumor that arises in the superficial lamina propria of the cervix and vagina and is histologically distinguishable from mesodermal (fibroepithelial) stromal polyp, including the cellular (pseudosarcomatous) variant...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.25588
更新日期:2001-07-01 00:00:00
abstract::Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(92)90110-o
更新日期:1992-03-01 00:00:00
abstract::The evolution of sequential histological changes from normal cells through invasive cancer affords the cancer biologist the opportunity to identify separate molecular steps involved in cancer progression. As one studies the development of human carcinoma, it becomes apparent that multiple genetic alterations affecting...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(94)90056-6
更新日期:1994-10-01 00:00:00
abstract::The significance of the quantity of acidophil bodies (AB) in nonalcoholic steatohepatitis (NASH) is not certain. We quantified AB in liver biopsies and examined the association with the diagnosis of NASH and other histologic features. We reviewed 157 liver biopsies from the NASH Clinical Research Network Database coll...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.01.001
更新日期:2016-06-01 00:00:00
abstract::Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80251-7
更新日期:1982-12-01 00:00:00
abstract::Histologic prognostic parameters in papillary renal cell carcinoma (PRCC) are unclear. The aims were to review the clinicopathological features of PRCC, including Fuhrman grade and International Society of Urological Pathology (ISUP) nucleolar grade, and to identify parameters that may be independent prognostic indica...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.07.001
更新日期:2015-10-01 00:00:00
abstract::Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present st...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.01.020
更新日期:2013-08-01 00:00:00
abstract::Invasive squamous cell carcinoma (SCC) of the cervix involves the progression of premalignant cervical intraepithelial neoplasia (CIN) and is associated with persistent human papillomavirus infection. Most CINs will regress, and the challenge is to identify the lesions likely to progress to invasive cancer. We evaluat...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.09.019
更新日期:2017-01-01 00:00:00
abstract::This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(78)80005-7
更新日期:1978-01-01 00:00:00
abstract::Infiltrating ductal carcinoma of the breast is histologically heterogeneous and may be subdivided into three main types (A, B, and C) which correlate with the likelihood of long-term survival. Examples of each type were tested against three monoclonal antibodies (H59, H71, and H72) prepared against the breast cancer c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80375-1
更新日期:1987-11-01 00:00:00
abstract::Pleomorphic adenomas of the breast (PAB) are uncommon tumors. We studied the clinicopathologic features of 10 cases of PAB, seven of which were assessed immunohistochemically. Nine patients were women, with a median age at diagnosis of 65 years. Eight patients presented with a palpable mass; two had a nipple discharge...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(91)90102-u
更新日期:1991-12-01 00:00:00
abstract::There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurren...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.04.016
更新日期:2017-07-01 00:00:00
abstract::The approach to the collection and transport of meaningful and accurate microbiologic specimens depends upon the nature of the suspected infectious entity and upon the location of the pathogenic process, as well as the possession of appropriate instrumentation and containers. New information and newly developed collec...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(76)80040-8
更新日期:1976-05-01 00:00:00
abstract::Angiogenesis is important for tumor growth and progress, and the intratumor density of microvessels is a significant prognostic factor in many tumor types. The role in thyroid cancer has not been well studied, and we therefore examined a series of 128 papillary carcinomas with respect to microvessel density (MVD) and ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/1-ip.2000.6548
更新日期:2000-04-01 00:00:00
abstract::Mucin core proteins (MUCs) are expressed in tissue-specific patterns in the gastrointestinal tract and expression is deregulated in Barrett's metaplasia. Based on differential expression, MUCs have been used to classify adenocarcinomas into distinct phenotypes (eg, intestinal, gastric, pancreaticobiliary, etc). Becaus...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.10.020
更新日期:2014-03-01 00:00:00
abstract::The types of collagen present in a case of elastofibroma dorsi were determined using type specific, characterized collagen antibodies. The presence of type II collagen (normally present only in articular cartilage and in selected ocular structures) is discussed with regard to the pathogenesis of this lesion, and the u...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80107-4
更新日期:1981-02-01 00:00:00
abstract::Cervical intraepithelial neoplasia (CIN) is historically viewed as a progressive biologic continuum leading to cervical cancer. However, it has been questioned whether CIN1 lesions ever progress. To this end, we evaluated the number of patients with a CIN3 and a previous CIN1 diagnosis. Subsequently, metachronous CIN1...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.10.014
更新日期:2014-02-01 00:00:00
abstract::α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are speci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.04.025
更新日期:2013-10-01 00:00:00
abstract::We studied c-erbB-2, p53, and nm23 gene products in 112 primary breast carcinomas. Fifty patients were aged 35 years or younger, and 62 were aged 36 to 50. Clinicopathological criteria including clinical stage, hormone receptor status, histological types, histological grades, and lymph node status, were reviewed. Dise...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90111-3
更新日期:1998-04-01 00:00:00
abstract::Fluorescent (FISH) and chromogenic (CISH) in situ hybridization have recently become part of the diagnostic armamentarium of breast pathologists. HER2 gene testing by FISH and/or CISH has become an integral part of the diagnostic workup for patients with breast cancer. In this era of high throughput technologies, thes...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2007.04.011
更新日期:2007-08-01 00:00:00
abstract::Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonali...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.125381
更新日期:2002-08-01 00:00:00
abstract::The diagnosis of melanoma metastatic to lymph node remains a difficult problem given its histological diversity. We examined the staining patterns of S-100, NK1/C3, HMB-45, and MART-1 (DC10) in melanoma metastases to lymph nodes. Immunohistochemical stains were performed on tissue sections of 126 formalin-fixed lymph ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2003.09.019
更新日期:2004-02-01 00:00:00
abstract::p16INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. Although most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.06.014
更新日期:2017-08-01 00:00:00
abstract::Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.10.023
更新日期:2018-01-01 00:00:00