Specimen collection and transport.

abstract：:A 3-year-old boy with congenital nemaline myopathy had generalized muscle weakness and hypotonia since birth. He developed cardiac symptoms at 2 years of age and died from congestive heart failure. At autopsy, the heart was markedly dilated, involving both ventricles. Rod bodies were recognized not only in skeletal mu...

journal_title：Human pathology

authors： Ishibashi-Ueda H,Imakita M,Yutani C,Takahashi S,Yazawa K,Kamiya T,Nonaka I

更新日期：1990-01-01 00:00:00

abstract：:Five cases of persistent neonatal hyperinsulinemic hypoglycemia (PNHH) were studied by a combined immunofluorescent and Feulgen technique under a computerized microscope which was used to measure the area and absorbance of beta cell nuclei. An increase of 16% was found in the nuclear area and absorbance of the beta ce...

journal_title：Human pathology

authors： Ariel I,Kerem E,Schwartz-Arad D,Bartfeld E,Ron N,Pizov G,Zajicek G

更新日期：1988-10-01 00:00:00

abstract：:The shortage of pathologists is being created by a combination of three factors: inadequate trainee recruitment, high trainee attrition, and accelerating practitioner attrition. The current report provides comprehensive data on the first two factors. The third factor is, by every estimate, likely to become worse over ...

journal_title：Human pathology

authors： Vance RP,Prichard RW,Smith RD

更新日期：1991-11-01 00:00:00

abstract：:Prior studies have suggested that the type of breast cancer influences the location of distant metastases ("organotropism") and that there may be discordance of estrogen receptor and human epidermal growth factor receptor 2 (Her2) expression between primaries and metastases. Our aims were to investigate the relationsh...

journal_title：Human pathology

authors： St Romain P,Madan R,Tawfik OW,Damjanov I,Fan F

更新日期：2012-03-01 00:00:00

abstract：:Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...

journal_title：Human pathology

authors： Zhao D,Wang SH,Feng Y,Hua CG,Zhao J,Tang XF

更新日期：2011-10-01 00:00:00

abstract：:A 60-year-old man developed a widely metastatic spindle cell neoplasm with admixed osteoclast-like giant cells indistinguishable from malignant giant cell tumor of soft parts. Autopsy revealed a bronchogenic sarcomatoid squamous cell carcinoma that was the primary source of the sarcomatoid metastases. The osteoclast-l...

journal_title：Human pathology

authors： Love GL,Daroca PJ Jr

更新日期：1983-11-01 00:00:00

abstract：:Refractile foreign particles within clear vacuoles were observed in capillaries of 17 patients who underwent cardiopulmonary bypass surgery, died, and were autopsied at the George Washington University Hospital from December 1978 through April 1981. The postoperative survival time ranged from less than one day to more...

journal_title：Human pathology

authors： Orenstein JM,Sato N,Aaron B,Buchholz B,Bloom S

更新日期：1982-12-01 00:00:00

abstract：:Many have wondered what might have become of the totalitarian state Lenin founded on merciless terror, had he not died so young. He was 52 and at the height of his power when he had his first stroke. Six months later he had another and then a third stroke three months after that. He died 3 months shy of his 54th birth...

journal_title：Human pathology

authors： Vinters H,Lurie L,Mackowiak PA

更新日期：2013-10-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a pleomorphic spindle cell lesion whose incidence has markedly increased among patients infected with the human immunodeficiency virus (HIV), especially among those whose primary risk factor is homo/bisexual transmission. The question as to whether KS is even a true neoplasm still remains larg...

journal_title：Human pathology

authors： Lee WA,Hutchins GM

更新日期：1992-03-01 00:00:00

abstract：:Invasive squamous cell carcinoma (SCC) of the cervix involves the progression of premalignant cervical intraepithelial neoplasia (CIN) and is associated with persistent human papillomavirus infection. Most CINs will regress, and the challenge is to identify the lesions likely to progress to invasive cancer. We evaluat...

journal_title：Human pathology

authors： Velez-Perez A,Wang XI,Li M,Zhang S

更新日期：2017-01-01 00:00:00

abstract：:The distribution and amplification patterns of human papillomavirus were studied in 15 human papillomavirus (HPV) 16- and six HPV18-positive cervical carcinomas by colorimetric in situ hybridization (ISH). The findings were correlated with the viral copy number and status of E1/E2 viral genes in the tumor DNA, as stud...

journal_title：Human pathology

authors： Berumen J,Unger ER,Casas L,Figueroa P

更新日期：1995-06-01 00:00:00

abstract：:Endolymphatic sac tumor (ELST) is a low-grade adenocarcinoma of the temporal bone that is presumed to originate from the endolymphatic system. Although ELSTs are extremely rare in the general population, a significant number of studies have documented the occurrence of ELST among patients with von Hippel-Lindau (VHL) ...

journal_title：Human pathology

authors： Hamazaki S,Yoshida M,Yao M,Nagashima Y,Taguchi K,Nakashima H,Okada S

更新日期：2001-11-01 00:00:00

abstract：:The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblas...

journal_title：Human pathology

authors： Akmal SN,Yun K,MacLay J,Higami Y,Ikeda T

更新日期：1995-08-01 00:00:00

abstract：:Epithelioid hemangioendotheliomas are uncommon vascular tumors, mainly observed in lung and soft tissues. Liver involvement is infrequent and, in contrast to the extrahepatic localizations of the tumor, has not been subjected to detailed ultrastructural analysis. This prompted us to report the results of the ultrastru...

journal_title：Human pathology

authors： Scoazec JY,Degott C,Reynes M,Benhamou JP,Feldmann G

更新日期：1989-07-01 00:00:00

abstract：:The pathology of cytomegalovirus (CMV) encephalitis was studied at autopsy in thirty patients with acquired immunodeficiency syndrome. Lesions could be segregated into five major categories: microglial nodules, isolated inclusion-bearing cells, focal parenchymal necrosis, necrotizing ventriculo-encephalitis, and necro...

journal_title：Human pathology

authors： Morgello S,Cho ES,Nielsen S,Devinsky O,Petito CK

更新日期：1987-03-01 00:00:00

abstract：:Recent evidence has invoked immunohistochemical expression of p63 in Merkel cell carcinoma as an adverse prognostic factor. Conflicting data led us to evaluate this. An Eastern Canadian cohort diagnosed between 1990 and 2012 was studied. Demographic and clinical data were obtained from pathology records and Provincial...

journal_title：Human pathology

authors： Fleming KE,Ly TY,Pasternak S,Godlewski M,Doucette S,Walsh NM

更新日期：2014-05-01 00:00:00

abstract：:Intraductal papillary mucinous neoplasm is characterized by cystically dilated main and/or branch pancreatic duct with mucus. According to the degree of atypia, intraductal papillary mucinous neoplasm is classified into 3 groups: adenoma, borderline, and carcinoma. Furthermore, intraductal papillary mucinous neoplasm ...

journal_title：Human pathology

authors： Hayashi A,Aishima S,Miyasaka Y,Nakata K,Morimatsu K,Oda Y,Nagai E,Oda Y,Tanaka M,Tsuneyoshi M

更新日期：2010-11-01 00:00:00

abstract：:PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expressi...

journal_title：Human pathology

authors： Dang DN,Raj G,Sarode V,Molberg KH,Vadlamudi RK,Peng Y

更新日期：2015-12-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in the development and progression of many tumors, but data for primary neuroendocrine carcinoma (PNC) of the skin are lacking. The aim of the study was to assess the expression of MMPs and TIMPs in PNC and to evaluate their prog...

journal_title：Human pathology

authors： Massi D,Franchi A,Ketabchi S,Paglierani M,Pimpinelli N,Santucci M

更新日期：2003-01-01 00:00:00

abstract：:Pauci-immune necrotizing crescentic glomerulonephritis is the histologic substrate of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Several studies in animal models have demonstrated the crucial role of complement activation in the pathogenesis of ANCA-associated vasculitis, but only small series h...

journal_title：Human pathology

authors： Villacorta J,Diaz-Crespo F,Acevedo M,Guerrero C,Campos-Martin Y,García-Díaz E,Mollejo M,Fernandez-Juarez G

更新日期：2016-10-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end-stage renal disease in children and young adults. Approximately 60% of patients with a known genetic etiology of nephronophthisis are due to homozygous deletion of the NPHP1 gene. We identified a total o...

journal_title：Human pathology

authors： Larsen CP,Bonsib SM,Beggs ML,Wilson JD

更新日期：2018-11-01 00:00:00

abstract：:Oral cancer overexpressed 1 (ORAOV1) has been reported to exhibit high amplification levels in esophageal squamous cell cancer (ESCC) and in premalignant lesions. However, ORAOV1 protein expression levels in ESCC and esophageal squamous intraepithelial neoplasia (ESIN) have not yet been reported. We have explored the ...

journal_title：Human pathology

authors： Li M,Cui X,Shen Y,Dong H,Liang W,Chen Y,Hu J,Li S,Kong J,Li H,Zhao J,Li F

更新日期：2015-05-01 00:00:00

abstract：:Ovarian ependymomas are rare glial neoplasms that typically occur in women on their third to fourth decades of life. They are histologically similar to ependymomas of the central nervous system but may have a broader immunophenotype. We describe a 27-year-old woman who presented to the emergency department with a 3-we...

journal_title：Human pathology

authors： Lopez LV,Bhattacharyya S,Carlsen ED,Bartlett D,Rao UNM

更新日期：2019-01-01 00:00:00

abstract：:One hundred six liver biopsy specimens from 34 orthotopic liver transplant (OLT) patients were examined and the histologic findings correlated with the clinical course of the patients to determine if specific morphologic patterns were associated with specific causes of acute allograft dysfunction. The principle causes...

journal_title：Human pathology

authors： Ray RA,Lewin KJ,Colonna J,Goldstein LI,Busuttil RW

更新日期：1988-07-01 00:00:00

abstract：:The diagnosis of microscopic colitis (MC) relies on specific histopathological findings in colon biopsies. The number of biopsies needed to diagnose MC remains disputed. The aim of the study was to determine the number and site of biopsies necessary for the diagnosis and the effect of perpendicular orientation when em...

journal_title：Human pathology

authors： Kanstrup Fiehn AM,Heiberg Engel PJ,Lanzarotto F,Goudkade D,Landolfi S,Munck LK,Villanacci V

更新日期：2020-09-01 00:00:00

abstract：:We have previously reported that MUC2 apomucin was highly expressed in noninvasive tumors of the pancreas (intraductal papillary tumor [IdPT]) and liver (bile duct cystadenocarcinoma [BdCC]), which show more favorable outcomes than invasive carcinomas. In contrast, MUC2 was rarely expressed in invasive carcinomas of t...

journal_title：Human pathology

authors： Yonezawa S,Sueyoshi K,Nomoto M,Kitamura H,Nagata K,Arimura Y,Tanaka S,Hollingsworth MA,Siddiki B,Kim YS,Sato E

更新日期：1997-03-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a rare disease which afflicts young women of childbearing age. Recently, it has been listed as an indication for lung transplantation. We describe a case of recurrent LAM in a 31-year-old woman occurring in the allograft of a male donor after single lung transplantation. Nonisotopic i...

journal_title：Human pathology

authors： Bittmann I,Dose TB,Müller C,Dienemann H,Vogelmeier C,Löhrs U

更新日期：1997-12-01 00:00:00

abstract：:Neoglycoproteins are readily available conjugates of a histochemically inert carrier protein and histochemically crucial carbohydrate moieties which are covalently attached to the carrier protein by chemical synthesis. Biotinylation renders these conjugates detectable in formalin-fixed, paraffin-embedded tissue sectio...

journal_title：Human pathology

authors： Kayser K,Gabius HJ,Ciesiolka T,Ebert W,Bach S

更新日期：1989-04-01 00:00:00

abstract：:Our aim was to investigate the expression of micro-RNA-200b (miR-200b) and cAMP-responsive element-binding protein 1 (CREB-1) in astrocytoma and its efficacy for predicting outcome. Both miR-200b and CREB-1 messenger RNA expression was measured in 122 astrocytomas and 30 nonneoplastic brain specimens by quantitative r...

journal_title：Human pathology

authors： Zhang JQ,Yao QH,Kuang YQ,Ma Y,Yang LB,Huang HD,Cheng JM,Yang T,Liu EY,Liang L,Fan KX,Zhao K,Xia X,Gu JW

更新日期：2014-10-01 00:00:00

abstract：:The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32...

journal_title：Human pathology

authors： Giannico GA,Gown AM,Epstein JI,Revetta F,Bishop JA

更新日期：2017-09-01 00:00:00