Organotropism and prognostic marker discordance in distant metastases of breast carcinoma: fact or fiction? A clinicopathologic analysis.

abstract：:CD44 is an integral membrane glycoprotein that is a principal receptor for hyaluronan and plays a role in cell-extracellular matrix interactions. Recent studies of melanomas in mouse models have suggested that increased CD44 expression by these tumors may relate to metastatic potential. Immunohistochemical expression ...

journal_title：Human pathology

authors： Leigh CJ,Palechek PL,Knutson JR,McCarthy JB,Cohen MB,Argenyi ZB

更新日期：1996-12-01 00:00:00

abstract：:Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...

journal_title：Human pathology

authors： Lu Z,Al-Obaidy K,Cheng L,Perry KD,Grignon DJ,Williamson SR

更新日期：2018-12-01 00:00:00

abstract：:The National Cancer Institute sponsored a Borderline Ovarian Tumor Workshop held in August 2003 in Bethesda, MD. This report was developed from discussions at the Workshop. The participants acknowledged several areas of disagreement on basic terminology issues and agreed that a glossary with example images would help ...

journal_title：Human pathology

authors： Seidman JD,Soslow RA,Vang R,Berman JJ,Stoler MH,Sherman ME,Oliva E,Kajdacsy-Balla A,Berman DM,Copeland LJ

更新日期：2004-08-01 00:00:00

abstract：:The distinction of malignant mesothelioma from non-small-cell lung carcinoma (NSCLC) usually requires immunohistochemistry, but some broad-spectrum carcinoma markers stain mesotheliomas, and it remains unclear which broad-spectrum markers are most valuable for distinguishing these malignancies. Here, we directly compa...

journal_title：Human pathology

authors： Naso JR,Churg A

更新日期：2020-06-01 00:00:00

abstract：:A cytogenetic study of an eccrine spiradenoma and two lymph node metastases, with a growth pattern and microscopic appearance typical for benign eccrine spiradenoma, revealed a 46,XY-5,del(16)(q22),+mar(t(?;5)(?::5q13----5qter)) karyotype. The finding of the same abnormal karyotype in the tumor and the metastases sugg...

journal_title：Human pathology

authors： Dijkhuizen T,van den Berg E,Nikkels PG,Hoekstra HJ,de Jong B

更新日期：1992-09-01 00:00:00

abstract：:Deposits found intrauterine contraceptive devices (IUDs) were studied by scanning electron microscopy, x-ray diffraction, and energy dispersive x-ray microanalysis. All seven devices, including five plastic and two copper IUDs, were coated with a crust containing cellular, acellular, and fibrillar material. The cellul...

journal_title：Human pathology

authors： Khan SR,Wilkinson EJ

更新日期：1985-07-01 00:00:00

abstract：:Patients with small cell lung carcinoma (SCLC) rarely demonstrate long-term survival. We previously reported that gene expression profiling identified a subset of SCLC with good prognosis in surgical cases. To find an easier way to routinely identify SCLC belonging to this subset, we conducted the present study with a...

journal_title：Human pathology

authors： Hamanaka W,Motoi N,Ishikawa S,Ushijima M,Inamura K,Hatano S,Uehara H,Okumura S,Nakagawa K,Nishio M,Horai T,Aburatani H,Matsuura M,Iwasaki A,Ishikawa Y

更新日期：2014-05-01 00:00:00

abstract：:It has been suggested that inferences about fetal karyotype can be made from examination of placental and decidual histology in early, spontaneous abortions (SABs). We assessed the reproducibility and predictive value of histologic features in 75 karyotyped, first trimester SABs; 32% (24 of 75) had normal male karyoty...

journal_title：Human pathology

authors： Genest DR,Roberts D,Boyd T,Bieber FR

更新日期：1995-02-01 00:00:00

abstract：:Carcinoma ex-pleomorphic adenoma (CA ex-PA) is a malignant salivary gland tumor that arises in association with pleomorphic adenoma (PA). Both PA and CA ex-PA have a broad spectrum of histology, and distinction from their histologic mimics may be difficult based on morphology alone. PLAG1 and HMGA2 abnormalities are t...

journal_title：Human pathology

authors： Katabi N,Ghossein R,Ho A,Dogan S,Zhang L,Sung YS,Antonescu CR

更新日期：2015-01-01 00:00:00

abstract：:Neuronal intranuclear inclusion disease (NIID) is a progressive, usually fatal degenerative neurologic condition characterized by eosinophilic, intranuclear inclusions in neurons of the central and peripheral nervous system. We report a boy with onset of disease manifestations at age 3 and death at age 9, who showed c...

journal_title：Human pathology

authors： Oyer CE,Cortez S,O'Shea P,Popovic M

更新日期：1991-07-01 00:00:00

abstract：:Encapsulated thyroid tumors of follicular cell origin with high-grade features (EFHG) are unusual neoplasms. In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma. When noninvasive, EFHG create a major therapeutic/diagnostic dilemma stemming f...

journal_title：Human pathology

authors： Rivera M,Ricarte-Filho J,Patel S,Tuttle M,Shaha A,Shah JP,Fagin JA,Ghossein RA

更新日期：2010-02-01 00:00:00

abstract：:Interferon-induced protein with tetratricopeptide repeat 1 (IFIT1) plays a key role in growth suppression and apoptosis promotion in cancer cells. Interferon was reported to induce the expression of IFIT1 and inhibit the expression of O-6-methylguanine-DNA methyltransferase (MGMT).This study aimed to investigate the e...

journal_title：Human pathology

authors： Zhang JF,Chen Y,Lin GS,Zhang JD,Tang WL,Huang JH,Chen JS,Wang XF,Lin ZX

更新日期：2016-06-01 00:00:00

abstract：:Merkel cell polyomavirus is of oncogenic significance in approximately 80% of Merkel cell carcinomas. Morphological subcategories of the tumor differ in regard to viral status, the rare combined type being uniformly virus negative and the predominant pure type being mainly virus positive. Indications that different bi...

journal_title：Human pathology

authors： Lai JH,Fleming KE,Ly TY,Pasternak S,Godlewski M,Doucette S,Walsh NM

更新日期：2015-09-01 00:00:00

abstract：:In an attempt to identify patients best suited for limited surgery as well as those at risk for recurrence and increased mortality, the authors reviewed the clinical and pathologic features of 130 patients who had undergone partial mastectomy as primary treatment for breast cancer (adjuvant therapy was administered on...

journal_title：Human pathology

authors： Lash RH,Bauer TW,Hermann RE,Esselstyn CB

更新日期：1986-08-01 00:00:00

abstract：:Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...

journal_title：Human pathology

authors： Tobi M,Kaila V,Hassan N,Gallinger S,Fligiel S,Hatfield J,Gesell M,Sakr W,Luk G,Odze RD

更新日期：1999-04-01 00:00:00

abstract：:Pleomorphic adenomas of the breast (PAB) are uncommon tumors. We studied the clinicopathologic features of 10 cases of PAB, seven of which were assessed immunohistochemically. Nine patients were women, with a median age at diagnosis of 65 years. Eight patients presented with a palpable mass; two had a nipple discharge...

journal_title：Human pathology

authors： Diaz NM,McDivitt RW,Wick MR

更新日期：1991-12-01 00:00:00

abstract：:Although the Revised European-American Lymphoma Classification does not utilize the term monocytoid B-cell Lymphoma, there are numerous reasons to support its use in classifying lymphomas of so-called marginal zone B-cell type that contain a distinct population of malignant monocytoid B-cells. In addition, there are o...

journal_title：Human pathology

authors： Nathwani BN,Hernandez AM,Deol I,Taylor CR

更新日期：1997-01-01 00:00:00

abstract：:Fifty-three pure mucinous carcinomas of breast were studied, with long-term follow-up evaluation (average, 15 years) for 37. The mean age of the patients was 63 years. Long-term survival (Kaplan-Meier method) was 68 per cent, excluding non-tumor-related deaths. Median survival for the patients with fatal carcinomas wa...

journal_title：Human pathology

authors： Clayton F

更新日期：1986-01-01 00:00:00

abstract：:To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...

journal_title：Human pathology

authors： Yu JB,Zuo Z,Zhang WY,Yang QP,Zhang YC,Tang Y,Zhao S,Mo XM,Liu WP

更新日期：2014-11-01 00:00:00

abstract：:Semaphorins (SEMAs) compete with vascular endothelial growth factor (VEGF) for receptor neuropilin 1 (NP1) and 2 (NP2) and suppress angiogenesis. To clarify the involvement of SEMA and VEGF in the development and progression of ovarian carcinoma, we analyzed the immunohistochemical expression of SEMA, VEGF, NP1, and N...

journal_title：Human pathology

authors： Osada R,Horiuchi A,Kikuchi N,Ohira S,Ota M,Katsuyama Y,Konishi I

更新日期：2006-11-01 00:00:00

abstract：:Aberrations of the long arm of chromosome 13 are common in prostate cancer and were initially attributed to alterations of the RB1 gene in band q14 of the chromosome. However, prostate tumors generally yield normal p110RB1 nuclear staining despite loss of heterozygosity (LOH) at the RB1 locus. Our previous analysis of...

journal_title：Human pathology

authors： Latil A,Bièche I,Pesche S,Volant A,Valèri A,Fournier G,Cussenot O,Lidereau R

更新日期：1999-07-01 00:00:00

abstract：:This study tested whether concordance could be achieved for abnormal inflammation in the basal decidua of placental specimens among 6 pathologists experienced in placental pathology. Thirty microscope slides were evaluated by the pathologists for chronic deciduitis. They also scored the severity and extent of inflamma...

journal_title：Human pathology

authors： Khong TY,Bendon RW,Qureshi F,Redline RW,Gould S,Stallmach T,Lipsett J,Staples A

更新日期：2000-03-01 00:00:00

abstract：:Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...

journal_title：Human pathology

authors： García JJ,Jin L,Jackson SB,Larsen BT,Lewis JE,Sukov WR,Roden AC

更新日期：2015-03-01 00:00:00

abstract：:Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...

journal_title：Human pathology

authors： Yamamoto H,Kojima A,Miyasaka Y,Imamura M,Nakamura N,Yao T,Tsuneyoshi M,Oda Y

更新日期：2010-10-01 00:00:00

abstract：:A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...

journal_title：Human pathology

authors： Bubendorf L,Tapia C,Gasser TC,Casella R,Grunder B,Moch H,Mihatsch MJ,Sauter G

更新日期：1998-09-01 00:00:00

abstract：:In a review of pediatric autopsies from 1951 to 1985, we identified 40 cases in which pancreatitis was diagnosed pathologically. Twenty-six of these patients were under 4 years of age, and the male-to-female ratio was 1.5. Six groups of patients were identified: 10 with hepatobiliary disease, including 9 with biliary ...

journal_title：Human pathology

authors： Nguyen T,Abramowsky C,Ashenburg C,Rothstein F

更新日期：1988-03-01 00:00:00

abstract：:T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PL...

journal_title：Human pathology

authors： Hu Z,Li S,Medeiros LJ,Sun T

更新日期：2017-07-01 00:00:00

abstract：:Epithelial inclusions in the axillary lymph nodes are very rare and have even less commonly been reported with either benign or malignant changes. We present a case of synchronous high-grade micropapillary ductal carcinoma in situ arising in the breast and in an epithelial inclusion in an ipsilateral sentinel lymph no...

journal_title：Human pathology

authors： Fitzpatrick-Swallow VL,Helin H,Cane P,Pinder SE

更新日期：2013-01-01 00:00:00

abstract：:Fluorescent (FISH) and chromogenic (CISH) in situ hybridization have recently become part of the diagnostic armamentarium of breast pathologists. HER2 gene testing by FISH and/or CISH has become an integral part of the diagnostic workup for patients with breast cancer. In this era of high throughput technologies, thes...

journal_title：Human pathology

authors： Lambros MB,Natrajan R,Reis-Filho JS

更新日期：2007-08-01 00:00:00

abstract：:Fibrillar proteins with a role in cellular shape and motility are present in the cytoplasm of most animal cells. They vary greatly in size, organization, and reactivity according to cell type and can be separately identified by the use of recently developed monospecific antisera and indirect immunofluorescence stainin...

journal_title：Human pathology

authors： Sieinski W,Dorsett B,Ioachim HL

更新日期：1981-05-01 00:00:00