Cardiomyopathy and myocyte intranuclear inclusions in neuronal intranuclear inclusion disease: a case report.

abstract：:Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...

journal_title：Human pathology

authors： Wang J,Li G,Ma H,Bao Y,Wang X,Zhou H,Sheng Z,Sugimura H,Jin J,Zhou X

更新日期：2007-11-01 00:00:00

abstract：:Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examina...

journal_title：Human pathology

authors： Saw D,Chan JK,Jagirdar J,Greco MA,Lee M

更新日期：1992-08-01 00:00:00

abstract：:Primary dermal melanoma (PDM) is a rare variant of melanoma which simulates metastatic melanoma to the skin. Diagnosis of PDM cannot be established on histologic grounds alone but requires absence of evidence of melanoma elsewhere by clinical history and/or imaging studies. Despite this entity being clinically well do...

journal_title：Human pathology

authors： Shaigany S,Tessier-Cloutier B,Busam KJ,Horst BA

更新日期：2020-12-01 00:00:00

abstract：:Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is comm...

journal_title：Human pathology

authors： Xing D,Banet N,Sharma R,Vang R,Ronnett BM,Illei PB

更新日期：2018-02-01 00:00:00

abstract：:The radiosensitivities of lymphocytes of peripheral blood origin obtained from two healthy 45 year old male donors were studied simultaneously at yearly intervals over a three year period. Hypaque-Ficoll purified cells were exposed in vitro to 0, 5, 50, and 500 rads and then evaluated serially for viability of T and B...

journal_title：Human pathology

authors： Olson GB,Anderson RE,Bartels PH

更新日期：1979-03-01 00:00:00

abstract：:This report describes the biopsy findings in four of 30 patients treated with cadaver osteochondral shell allografts for osteoarthritis in the knee. This study demonstrates that graft cartilage cells can survive in excess of 25 months, and that host bone can completely replace graft bone by creeping substitution. An i...

journal_title：Human pathology

authors： Pritzker KP,Gross AE,Langer F,Luk SC,Houpt JB

更新日期：1977-11-01 00:00:00

abstract：:Refractile foreign particles within clear vacuoles were observed in capillaries of 17 patients who underwent cardiopulmonary bypass surgery, died, and were autopsied at the George Washington University Hospital from December 1978 through April 1981. The postoperative survival time ranged from less than one day to more...

journal_title：Human pathology

authors： Orenstein JM,Sato N,Aaron B,Buchholz B,Bloom S

更新日期：1982-12-01 00:00:00

abstract：:Telomerase is a ribonucleoprotein that consists of a RNA component for synthesizing telomeric DNA repeats onto chromosome ends, so that telomere length can be maintained; telomerase activation in general signifies immortalization of cells. Because the telomerase activity of only a few cases of nonastrocytic gliomas an...

journal_title：Human pathology

authors： Chong EY,Lam PY,Poon WS,Ng HK

更新日期：1998-06-01 00:00:00

abstract：:Fifty-three surgically resected small cell carcinomas of the lung were studied morphometrically, electron microscopically, immunohistochemically, and in terms of possible site of origin. Four subtypes of small cell carcinomas were identified: oat cell carcinoma (OAT), small cell carcinoma of the intermediate cell type...

journal_title：Human pathology

authors： Nomori H,Shimosato Y,Kodama T,Morinaga S,Nakajima T,Watanabe S

更新日期：1986-06-01 00:00:00

abstract：:Ki-67 proliferative index (Ki-67 index) is suggested to be an important prognostic variable and is included as one of the grading parameters for neuroendocrine tumors. The present study was undertaken to determine the usefulness of the Ki-67 index and the corresponding tumor grade in predicting progression-free surviv...

journal_title：Human pathology

authors： Dhall D,Mertens R,Bresee C,Parakh R,Wang HL,Li M,Dhall G,Colquhoun SD,Ines D,Chung F,Yu R,Nissen NN,Wolin E

更新日期：2012-04-01 00:00:00

abstract：:We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...

journal_title：Human pathology

authors： Kataoka Y,Shimada H,Sugimoto T,Mine H,Hachitanda Y,Doi Y,Sawada T,Weeks DA

更新日期：1993-09-01 00:00:00

abstract：:The canals of Hering (CoH), converging from the hepatic lobule onto the portal tract, connect bile canaliculi to the interlobular bile ducts, and represent the most proximal portion of the bile drainage pathway with a cholangiocyte lining. In this study we sought to ascertain whether this proximal pathway is involved ...

journal_title：Human pathology

authors： Saxena R,Hytiroglou P,Thung SN,Theise ND

更新日期：2002-10-01 00:00:00

abstract：:Grb2-associated binder 2 protein (Gab2) is a member of scaffold proteins, playing crucial roles in (receptor-) tyrosine kinase and cytokine signaling. Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which interacts with Grb2 and Gab2 signaling, thereby triggering hematopoietic ...

journal_title：Human pathology

authors： Aumann K,Lassmann S,Schöpflin A,May AM,Wöhrle FU,Zeiser R,Waller CF,Hauschke D,Werner M,Brummer T

更新日期：2011-05-01 00:00:00

abstract：:Loss of the NF1 allele, coding for the protein neurofibromin, and polymorphism in the proto-oncogene RET (RETp) are purportedly common in desmoplastic melanoma (DM). DM is categorized into pure (PDM) and mixed (MDM) subtypes, which differ in prognosis. Most NF1 mutations result in a truncated/absent protein, making im...

journal_title：Human pathology

authors： Kadokura A,Frydenlund N,Leone DA,Yang S,Hoang MP,Deng A,Hernandez-Perez M,Biswas A,Singh R,Yaar R,Mahalingam M

更新日期：2016-07-01 00:00:00

abstract：:We reviewed open lung biopsies from 35 patients with Wegener's (pathergic) granulomatosis in order to study the histogenesis of the pulmonary lesions and to identify the early lesions. The process of pathergic necrosis is fundamental in the production of extravascular and vascular lesions and was divided into micronec...

journal_title：Human pathology

authors： Mark EJ,Matsubara O,Tan-Liu NS,Fienberg R

更新日期：1988-09-01 00:00:00

abstract：:An accurate diagnosis between leiomyoma and leiomyosarcoma is essential for patient management. IMP3 is a member of the insulin-like growth factor (IGF-II) mRNA binding protein (IMP) family that consist of IMP1, IMP2, and IMP3. IMP3 is an oncofetal protein associated with aggressive and advanced tumors and is specific...

journal_title：Human pathology

authors： Cornejo K,Shi M,Jiang Z

更新日期：2012-10-01 00:00:00

abstract：:We developed a procedure based on computerized image analysis to establish objective criteria for the differential diagnosis between mesothelial hyperplasia and cancer in peritoneal tissue samples obtained at second-look operations for ovarian cancer. The tumor tissue after chemotherapy was classified as "nonresponsiv...

journal_title：Human pathology

authors： Deligdisch L,Kerner H,Cohen CJ,Dargent D,Gil J

更新日期：1993-02-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (CD166) is a member of the immunoglobulin superfamily and is aberrantly expressed in different tumors, including prostate cancer. To learn more on the prevalence and clinical significance of activated leukocyte cell adhesion molecule expression in prostate cancer, a tissue mi...

journal_title：Human pathology

authors： Minner S,Kraetzig F,Tachezy M,Kilic E,Graefen M,Wilczak W,Bokemeyer C,Huland H,Sauter G,Schlomm T

更新日期：2011-12-01 00:00:00

abstract：:Cystic hygroma of the neck was observed in seven spontaneously aborted, severely autolyzed female fetuses. Four of five karyotyped cases had the 45,XO karyotype; one was a normal female, 46,XX. Diagnostic features associated with monosomy X in fetuses, which were observed in six of these cases, include large cystic hy...

journal_title：Human pathology

authors： Byrne J,Blanc WA,Warburton D,Wigger J

更新日期：1984-01-01 00:00:00

abstract：:Preserving small pieces of frozen tissue for possible future ancillary studies ("tumor banking") usually involves either placing a small piece of tissue in a cryovial and snap freezing it in liquid nitrogen or embedding and freezing the tissue in a block of cryopreservation medium, such as optimal cutting temperature ...

journal_title：Human pathology

authors： Loken SD,Demetrick DJ

更新日期：2005-09-01 00:00:00

abstract：:Patients undergoing treatment of acute lymphoblastic leukemia are at risk for fungal infections including disseminated candidiasis. We describe a case of systemic Candida albicans infection associated with life-threatening gastrointestinal hemorrhage due to unusual necrotizing vasculitis involving the gastrointestinal...

journal_title：Human pathology

authors： Sargent J,O'Marcaigh A,Smith O,Butler K,Gavin P,O'Sullivan M

更新日期：2010-04-01 00:00:00

abstract：:A series of 36 cases of chondromyxoid fibroma (CMF) of bone, a rare benign tumor that may be confused with chondrosarcoma, is presented to aid in correctly identifying and diagnosing these neoplasms. In this series, CMFs were found in patients of all age groups, with no predominance between sexes. Long bone tumors wer...

journal_title：Human pathology

authors： Zillmer DA,Dorfman HD

更新日期：1989-10-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typically characterized by t(11;14), which places the IGH@ enhancer elements upstream of CCND1. This fusion results in up-regulation of CCND1 and consequently its protein product cyclin D1. Recent studies have shown that in MCL, mutations or translocations occurring within the 3' untransl...

journal_title：Human pathology

authors： Menke JR,Vasmatzis G,Murphy S,Yang L,Menke DM,Tun HW,King RL,Smoley SA,Ketterling RP,Sukov WR

更新日期：2017-06-01 00:00:00

abstract：:Only 8 cases of hamartomas of mature cardiac myocytes have been reported. The aim of the study was to describe 7 new cases and provide clinicopathologic correlation. Our anatomical pathology database was searched for all cases of cardiac hamartoma, of which 7 represented mature myocyte type. Medical records were revie...

journal_title：Human pathology

authors： Fealey ME,Edwards WD,Miller DV,Menon SC,Dearani JA

更新日期：2008-07-01 00:00:00

abstract：:Nuclear pore complexes (NPCs) are elaborate macromolecular structures that regulate the bidirectional nucleocytoplasmic traffic system. In vertebrate cells, NPCs include a family of 50 to 100 proteins termed nucleoporins (Nups). The 88-kD Nup has been found to be linked in a dynamic subcomplex with the oncogenic CAN/N...

journal_title：Human pathology

authors： Gould VE,Orucevic A,Zentgraf H,Gattuso P,Martinez N,Alonso A

更新日期：2002-05-01 00:00:00

abstract：:The pertinent clinical data and histologic features of the testes in 57 autopsied acquired immunodeficiency syndrome (AIDS) patients were analyzed and compared with those of 55 age-matched control patients without AIDS. The testes of the AIDS patients showed a significantly lower degree of spermatogenesis (determined ...

journal_title：Human pathology

authors： De Paepe ME,Waxman M

更新日期：1989-03-01 00:00:00

abstract：:Plasma cells are the hallmark of chronic endometritis but are not specific for upper tract infection. Plasma cells have also been noted in hormonally mediated endometrial disorders in association with gland architectural changes ("disordered proliferative" and "anovulatory" patterns), and stromal breakdown. We reviewe...

journal_title：Human pathology

authors： Gilmore H,Fleischhacker D,Hecht JL

更新日期：2007-04-01 00:00:00

abstract：:We report two cases of allergic bronchopulmonary fungal disease (ABPFD) caused by Curvularia sp and associated with allergic fungal sinusitis (AFS). Curvularia lunata was cultured in one case and Curvularia senegalensis was cultured in the other. Based on these cases and a review of the literature, we discuss unusual ...

journal_title：Human pathology

authors： Travis WD,Kwon-Chung KJ,Kleiner DE,Geber A,Lawson W,Pass HI,Henderson D

更新日期：1991-12-01 00:00:00

abstract：:Anti-tumor necrosis factor α (anti-TNF-α) therapy can result in endoscopic healing, reduction of symptoms, and reduced need for surgery and hospitalization in many patients with Crohn's disease (CD). Earlier data suggested that anti-TNF-α therapy may be associated with fibrosis and stricturing. We sought to determine ...

journal_title：Human pathology

authors： Schaeffer DF,Walsh JC,Kirsch R,Waterman M,Silverberg MS,Riddell RH

更新日期：2014-09-01 00:00:00

abstract：:There is considerable interest in the role of the human wart virus in the pathogenesis of squamous cell carcinoma. Mucosal wart virus infections may produce considerable epithelial atypia and have eventuated in carcinoma in "normal" individuals in some instances. The verruciform lesions of patients with epidermodyspla...

journal_title：Human pathology

authors： Gisser SD

更新日期：1981-02-01 00:00:00