Abstract:
:The diagnosis of microscopic colitis (MC) relies on specific histopathological findings in colon biopsies. The number of biopsies needed to diagnose MC remains disputed. The aim of the study was to determine the number and site of biopsies necessary for the diagnosis and the effect of perpendicular orientation when embedding the biopsies. This retrospective multicenter European study included 42 patients with a consensus diagnosis of collagenous colitis (CC), 51 patients with lymphocytic colitis (LC), and three patients with incomplete LC (LCi). The number of individual diagnostic biopsies from each patient was determined. The diagnostic rate of 744 individual biopsies from 96 patients with MC was 69.5% for the specific MC subgroup, 79.4% for MC and 93.4% for MC plus incomplete MC (MCi). The risk of missing a diagnosis of the specific subgroup of MC when analyzing four biopsies was 0.87%, decreasing to 0.18% for MC and 0.0019% for MC plus MCi. More biopsies from the right colon were diagnostic of the specific MC subgroup (76.3% vs. 64.0%, p = 0.0014). Perpendicular orientation of biopsies increased the diagnostic rate of the specific MC subgroup (73.1% vs. 65.0%, p = 0.0201). Histological changes diagnostic of MC were present in almost all biopsies from the right colon, with orientated biopsies more often being diagnostic of the specific MC subgroup. The results of this study indicate that four biopsies from the colon, rectum excluded, are sufficient to diagnose MC.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kanstrup Fiehn AM,Heiberg Engel PJ,Lanzarotto F,Goudkade D,Landolfi S,Munck LK,Villanacci Vdoi
10.1016/j.humpath.2020.07.011subject
Has Abstractpub_date
2020-09-01 00:00:00pages
63-71eissn
0046-8177issn
1532-8392pii
S0046-8177(20)30134-9journal_volume
103pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Merkel cell polyomavirus is of oncogenic significance in approximately 80% of Merkel cell carcinomas. Morphological subcategories of the tumor differ in regard to viral status, the rare combined type being uniformly virus negative and the predominant pure type being mainly virus positive. Indications that different bi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.008
更新日期:2015-09-01 00:00:00
abstract::Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.02.008
更新日期:2013-09-01 00:00:00
abstract::Primitive neuroectodermal tumors are morphologically similar malignant tumors arising in intracranial and peripheral sites of the nervous system, showing varying degrees of cellular differentiation with a tendency to disseminate along cerebrospinal fluid pathways. They occur primarily in children and young adults. Und...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(83)80006-9
更新日期:1983-06-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.01.032
更新日期:2011-04-17 00:00:00
abstract::Disheveled-axin (DIX) domain containing 1 (DIXDC1), a protein containing a coiled-coil domain and a DIX domain, is involved in the progression of multiple cancers. However, the role of DIXDC1 in human pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we investigated the role and prognostic value ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.07.015
更新日期:2016-11-01 00:00:00
abstract::Organ transplant recipients have an increased tumor incidence owing to their immunocompromised state. The origin of such tumors, whether donor or recipient, will have a clinical impact on decision-making concerning immunosuppressive therapy, retransplantation, and for recipients of other organs from the same donors. W...
journal_title:Human pathology
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::A small number (4% to 6%) of primary malignant lymphomas arising in the intestines express the EBV genome. However, in these tumors, the viral genotype and the role of tumor suppressor gene p53 have not been investigated. We sought to determine what genotype of EBV is frequently involved and whether the expression of ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90030-8
更新日期:1999-10-01 00:00:00
abstract::Lymphangioleiomyomatosis (LAM) is a rare disease which afflicts young women of childbearing age. Recently, it has been listed as an indication for lung transplantation. We describe a case of recurrent LAM in a 31-year-old woman occurring in the allograft of a male donor after single lung transplantation. Nonisotopic i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90233-1
更新日期:1997-12-01 00:00:00
abstract::Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the prese...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90165-5
更新日期:1995-06-01 00:00:00
abstract::Clinicopathological studies of 181 patients with liver cirrhosis undergoing autopsy in the pathology department of a municipal hospital between 1973 and 1976 are reported. The main etiological types were alcoholic (25.4 per cent), HBsAg positive (14.9 per cent), and cryptogenic cirrhosis (54.7 per cent). Four patients...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80082-2
更新日期:1981-09-01 00:00:00
abstract::The current World Health Organization classification considers myelodysplastic syndrome with isolated del(5q) a distinct entity owing to its characteristic clinical and pathologic features. Recently, several studies have examined survival, leukemic transformation, and various prognostic factors in these patients. Howe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.05.022
更新日期:2013-03-01 00:00:00
abstract::CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.29678
更新日期:2001-12-01 00:00:00
abstract::Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) generally confers poor prognosis; however, the clinical outcome remains heterogeneous. We sought to further stratify this subentity of AML by performing a retrospective analysis of 179 adult patients with AML-MRC diagnosed at our institution. Based o...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.08.003
更新日期:2020-10-01 00:00:00
abstract::Retroperitoneal cysts are uncommon diseases, and benign nonneoplastic Müllerian cysts are extremely rare among the known cases. We report a case of a 35-year-old woman with a retroperitoneal Müllerian cyst with the tubal type of epithelium. The patient presented with a large (20 cm in diameter), palpable abdominal mas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.12
更新日期:2003-02-01 00:00:00
abstract::Basaloid carcinoma (BC) and large-cell neuroendocrine carcinoma (LCNEC) are 2 recently recognized variants of large-cell lung carcinomas that may overlap in their morphology, and are discriminated by expression of neuroendocrine markers in LCNEC. Because thyroid transcription factor 1 (TTF-1) is expressed in lung aden...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.27110
更新日期:2001-09-01 00:00:00
abstract::Anti-tumor necrosis factor α (anti-TNF-α) therapy can result in endoscopic healing, reduction of symptoms, and reduced need for surgery and hospitalization in many patients with Crohn's disease (CD). Earlier data suggested that anti-TNF-α therapy may be associated with fibrosis and stricturing. We sought to determine ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.05.016
更新日期:2014-09-01 00:00:00
abstract::Three cases of primary thymic neuroendocrine tumors characterized by prominent angiomatoid features that resembled a vascular neoplasm are presented. The patients were all men between 52 and 59 years of age who presented with chest pain and shortness of breath attributable to a large anterior mediastinal mass. The les...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90087-4
更新日期:1999-06-01 00:00:00
abstract::Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.013
更新日期:2007-05-01 00:00:00
abstract::The shortage of pathologists is being created by a combination of three factors: inadequate trainee recruitment, high trainee attrition, and accelerating practitioner attrition. The current report provides comprehensive data on the first two factors. The third factor is, by every estimate, likely to become worse over ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90258-q
更新日期:1991-11-01 00:00:00
abstract::Although the term "thyroiditis" suggests inflammation, many disorders of the thyroid that are of unknown etiology are also currently included under this heading. Thus, only infective thyroiditis and subacute thyroiditis are clearly inflammatory; autoimmune thyroiditis is a result of lymphocytic and fibroblastic infilt...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80028-8
更新日期:1978-07-01 00:00:00
abstract::Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90251-3
更新日期:1997-10-01 00:00:00
abstract::Micropapillary carcinoma is a histologic pattern, rather than an independent entity, that has an aggressive clinical behavior regardless of location. Histologically, it is characterized by papillary cell groups in clear spaces. The micropapillary pattern in the thyroid gland has not been studied until recently but und...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.027
更新日期:2012-10-01 00:00:00
abstract::We evaluated 173 consecutive breast carcinomas for c-erbB-2 using a combination of immunohistochemistry (IHC) with a commercial polyclonal antibody (Nitirei) and dual-color fluorescence in situ hybridization (FISH) using the c-erbB-2-specific probe and the chromosome 17 centromere-specific probe from Vysis (Downers Gr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.30185
更新日期:2002-01-01 00:00:00
abstract::Pathological demonstration of varicella infection in first trimester aborted tissue is reported. A 24-year-old primigravida manifested chickenpox infection about 38 days after her last menstrual period or at 24 days age of the embryo. The conceptus survived another 4 to 5 weeks. The macerated embryo and placental tiss...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90396-3
更新日期:1998-01-01 00:00:00
abstract::The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.12.024
更新日期:2016-05-01 00:00:00
abstract::To establish whether an intramural left anterior descending coronary artery (LADA) is a simple anatomic or a singularly pathologic variant we studied 39 hearts, each with an intramural course of the LADA and no coronary artery disease, valvular derangement, cardiomyopathy, or congenital anomaly. Seventeen of the 39 he...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90004-z
更新日期:1993-07-01 00:00:00
abstract::Twenty-one cases were selected from 236 thyroidectomies with a diagnosis of Hashimoto's disease for detailed clinicopathologic study on the basis of "early" changes in three cases and an unusually heavy lymphoplasmacytic infiltrate in 18 cases. These cases were studied in conjunction with ten cases of high-grade non-H...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80287-9
更新日期:1988-11-01 00:00:00
abstract::Ten cases of reactive follicular hyperplasia and 31 cases of B-cell non-Hodgkin's malignant lymphoma were studied using multiparameter flow cytometry. A bimodal distribution for HLA-DR expression, but not for surface immunoglobulin or B cell-specific antigens CD19 and CD20, was observed commonly in mixed cell type and...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(06)80042-0
更新日期:1990-12-01 00:00:00
abstract::A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90199-x
更新日期:1998-09-01 00:00:00
abstract::This article describes a case of lymphomatoid granulomatosis without active pulmonary involvement of stigmata of healed granulomatous lesions in the lungs. The patient had ischemic segmental colitis due to mesenteric arterial intimal fibrosis, which we interpreted as spontaneously regressed granulomatous involvement o...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80096-3
更新日期:1978-05-01 00:00:00