Abstract：
:Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study the histopathologic and clinicopathologic characteristics. In the lepidic component of invasive adenocarcinoma, we have identified a morphologically unique structure characterized by proliferation of low papillae, consisting of neoplastic cells piling up toward the alveolar space, and we defined this architecture as "low papillary structure." There were 18 cases with the low papillary structure in the lepidic components, whereas 73 cases did not have the structure. In the lepidic component, the cases with the low papillary structure had higher Ki-67 labeling index (15.7%) and more frequent p53 overexpression (50.0%) than did those without the structure (9.4% and 16.4%, respectively). Based on clinicopathologic findings, the presence of low papillary structure was significantly associated with lymphatic invasion (P = .023) and lymph node metastasis (P = .001). Furthermore, the patients with the low papillary structure in the lepidic components demonstrated significantly shorter disease-free and overall survival than did those without the structure (P = .001 and P = .010, respectively). We conclude that the low papillary structure is a significant histologic feature in a lepidic component and is associated with aggressive cancer behavior in lung adenocarcinoma.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Fukutomi T,Hayashi Y,Emoto K,Kamiya K,Kohno M,Sakamoto Mdoi
10.1016/j.humpath.2013.02.008subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1849-58issue
9eissn
0046-8177issn
1532-8392pii
S0046-8177(13)00092-0journal_volume
44pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:A study of so-called gelatinous transformation of the bone marrow in 14 patients is presented. The condition is characterized by the presence of extracellular "gelatinous" material, fat atrophy, and associated focal marrow hypoplasia and is often mistaken as representing edema, necrosis, or amyloid. Histochemical stud...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80051-3
更新日期：1978-11-01 00:00:00
abstract：:A solitary fibrous tumor (SFT) is a rare, NAB2-STAT6 fusion gene-associated mesenchymal neoplasm. It most commonly arises in the pleural site, but it can occur at many other sites, and rarely also in the head and neck (H&N) region. STFs may show many growth patterns and therefore can be easily mistaken for other more ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2020.03.007
更新日期：2020-05-01 00:00:00
abstract：:Recently, the fusion gene EML4-ALK was identified in non-small cell lung carcinoma, which could be a potential therapeutic target. We investigated the prevalence of anaplastic lymphoma kinase protein expression in these tumors by immunohistochemistry and correlated the results with data from ALK molecular studies. Gen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.01.012
更新日期：2009-08-01 00:00:00
abstract：:Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90015-9
更新日期：1994-09-01 00:00:00
abstract：:The ontogeny and distribution of the epidermal growth factor (EGF) receptor and lipocortin-1, a major cellular substrate of the EGF receptor, were evaluated in a developmental series of fetal and neonatal human lungs (8 to 41 weeks' gestation and stillborn to 16 days' postnatal age). The peroxidase anti-peroxidase tec...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90127-q
更新日期：1990-02-01 00:00:00
abstract：:Malignant mesotheliomas are highly aggressive tumors that develop most frequently in the pleura of patients chronically exposed to asbestos. The distinction between malignant mesotheliomas and tumors of epithelial origin, particularly peripheral lung adenocarcinoma, can be difficult despite the use of immunocytochemic...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90302-x
更新日期：1995-12-01 00:00:00
abstract：:Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs). We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.012
更新日期：2006-06-01 00:00:00
abstract：:Arginase-1 has been demonstrated as a marker for hepatocellular carcinoma (HCC) with higher sensitivity and specificity than HepPar-1 and glypican-3. However, its sensitivity is diminished in moderately and poorly differentiated HCCs. In the current study, we evaluated the utility of AGXT1 as a diagnostic marker. Immu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.05.025
更新日期：2018-10-01 00:00:00
abstract：:Micropapillary carcinoma is a histologic pattern, rather than an independent entity, that has an aggressive clinical behavior regardless of location. Histologically, it is characterized by papillary cell groups in clear spaces. The micropapillary pattern in the thyroid gland has not been studied until recently but und...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.027
更新日期：2012-10-01 00:00:00
abstract：:Lymphocytic colitis (LC) and LC incomplete (LCi) are common causes of chronic watery diarrhea. The diagnosis relies on clinical findings and histopathologic evaluation. The diagnostic criteria of LC are based on hematoxylin and eosin (HE) staining. However, supplementary immunohistochemical staining for highlighting t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.08.031
更新日期：2019-02-01 00:00:00
abstract：:Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that th...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.017
更新日期：2012-09-01 00:00:00
abstract：:Tumor cell adhesion, detachment, and aggregation play an important part in tumor invasion and metastasis, and a variety of cell adhesion molecules have been found on tumor cells. Cell adhesion molecules, including those of the immunoglobulin superfamily, are associated with the development of metastatic behavior in cu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90191-4
更新日期：1995-11-01 00:00:00
abstract：:We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting island...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.03.011
更新日期：2012-03-01 00:00:00
abstract：:The aims of this investigation were to compare quantitative with qualitative analysis of fluorescent in situ hybridization (FISH) centromere signals in interphase breast cancer cell nuclei and to evaluate the possible clinical utility of detecting numerical abnormalities of chromosomes 11 and 17 by FISH in the preoper...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90267-8
更新日期：1999-02-01 00:00:00
abstract：:Strategies for cost containment in the clinical laboratory have been proposed and some are being tested. An approach is described and illustrated in this article for estimating the size of a cost reduction that might be observed in response to hypothetical changes in the utilization of the clinical laboratory. The var...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(80)80051-7
更新日期：1980-09-01 00:00:00
abstract：:Adenomatous hyperplasia, a hyperplastic parenchymal nodule in the cirrhotic liver, has been presumed to be a preneoplastic lesion in human hepatocarcinogenesis. In this study, phenotypes of the sinusoidal endothelium were examined in adenomatous hyperplasia, hepatocellular carcinoma, cirrhosis, chronic active hepatiti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90136-d
更新日期：1991-05-01 00:00:00
abstract：:Human epidermal growth factor receptor 2 (HER2) status is useful for predicting response to trastuzumab. Fluorescence in situ hybridization (FISH) for HER2 gene amplification is accurate but limited because of cost, the need for fluorescence microscopy, the limited assessment of histology, and the fading of its signal...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.07.005
更新日期：2013-11-01 00:00:00
abstract：:A primary neoplasm of the proximal humerus in a 68-year-old woman was unique histologically in that it contained both malignant cartilaginous and squamous cell components. The epithelial differentiation was confirmed by the demonstration of keratin by immunohistochemical techniques and of basement membrane, tonofilame...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80227-5
更新日期：1986-03-01 00:00:00
abstract：:Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.016
更新日期：2012-09-01 00:00:00
abstract：:Pathologists are frequently asked to evaluate gastric mucosal biopsy specimens for the presence of Helicobacter pylori infection and for potentially important changes such as intestinal metaplasia. No agreed-on system is both available and prospectively shown to provide reliable estimates of the underlying pathologica...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90303-9
更新日期：1999-01-01 00:00:00
abstract：:Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations pr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.06.003
更新日期：2014-09-01 00:00:00
abstract：:Cancer-related axonogenesis and neurogenesis are recently described biologic phenomena. Our previously published data showed that nerve density and the number of neurons in the parasympathetic ganglia are increased in prostate cancer (PCa) and associated with aggressive disease. Tissue microarrays were constructed fro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.009
更新日期：2014-07-01 00:00:00
abstract：:Five cases of persistent neonatal hyperinsulinemic hypoglycemia (PNHH) were studied by a combined immunofluorescent and Feulgen technique under a computerized microscope which was used to measure the area and absorbance of beta cell nuclei. An increase of 16% was found in the nuclear area and absorbance of the beta ce...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80154-0
更新日期：1988-10-01 00:00:00
abstract：:Immunofluorescence of formalin-fixed, paraffin-embedded tissues was performed to study the plasma cell population in 114 colonic specimens from 58 patients. Correlation of the histopathologic stage of disease activity with the isotypes and numbers of immunoglobulin-containing cells in the lamina propria demonstrated h...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80167-7
更新日期：1984-08-01 00:00:00
abstract：:The Sydney classification for gastritis provides guidelines for histological grading of gastric biopsies. In an ongoing study of gastric preneoplastic lesions in Chiapas, Mexico, 7 biopsies from 150 patients (4 from the antrum and 3 from the body) were obtained during endoscopy and studied histologically. The first 74...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90164-8
更新日期：1999-12-01 00:00:00
abstract：:Giant cell pneumonia associated with parainfluenza virus type 3 infection and chronic poliovirus type 2 meningoencephalomyelitis are documented in an infant with combined immunologic deficiency (Swiss type). Caution should be exercised in attributing cases of giant cell pneumonia to measles virus without serologic or ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80032-9
更新日期：1981-05-01 00:00:00
abstract：:The concept of minimal deviation melanoma is presented in diagrammatic form. In this approach, the precursors of melanoma are presented as having two dimensions and melanomas as having three dimensions. In turn, the relativity between dimensionalities and recommendations for treatment (as indirect correlates of progno...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(99)90194-6
更新日期：1999-05-01 00:00:00
abstract：:Literature on BRCA1-associated protein 1 (BAP1) expression status in well-differentiated papillary mesothelioma (WDPM) is limited. In the present study, we examined the prevalence of BAP1 loss in WDPM by immunohistochemistry with clinical correlation, along with CDKN2A deletion status by fluorescence in situ hybridiza...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.05.001
更新日期：2018-09-01 00:00:00
abstract：:Sneddon's syndrome is a potentially fatal arterio-occlusive disorder characterized by generalized livedo racemosa and cerebrovascular lesions. Skin biopsies often fail to yield diagnostic arterial lesions. In the present series, affected vessels were found in skin biopsies from 12 of 15 patients with Sneddon's syndrom...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90323-u
更新日期：1992-06-01 00:00:00
abstract：:Immunoglobulin G4-related sclerosing cholangitis is histologically characterized by the infiltration of immunoglobulin G4-positive plasma cells and sclerosing change. Moreover, several cases of carcinoma accompanied by immunoglobulin G4-positive cells in tissue and increased serum immunoglobulin G4 levels have been re...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.03.001
更新日期：2012-12-01 00:00:00
