Abstract：
:A primary neoplasm of the proximal humerus in a 68-year-old woman was unique histologically in that it contained both malignant cartilaginous and squamous cell components. The epithelial differentiation was confirmed by the demonstration of keratin by immunohistochemical techniques and of basement membrane, tonofilaments, and well-formed desmosomes by electron microscopy. The patient died 3 1/2 years after the onset of symptoms, without clinical evidence of either a primary tumor elsewhere or metastasis. The differential diagnosis from other bone tumors with epithelial differentiation, such as adamantinoma and "primitive multipotential primary sarcoma," is discussed. This is a rare primary neoplasm of bone of unknown histogenesis. Intermutability or metaplasia between mesenchymal and epithelial tissues is a possibility. The tumor probably originated from multipotential stem cells with the ability to undergo biphasic or dual differentiation toward mesenchymal and epithelial elements.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Ling LL,Steiner GCdoi
10.1016/s0046-8177(83)80227-5subject
Has Abstractpub_date
1986-03-01 00:00:00pages
317-20issue
3eissn
0046-8177issn
1532-8392pii
S0046-8177(83)80227-5journal_volume
17pub_type
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