Abstract：
:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is depostied in areas of vascular basement membrane degeneration. The initiating degenerative change is thickening of basement membrane with accumulation of debris. Inflammation, when present, tends to accelerate amyloid deposition locally. Amyloid transport from the vascular wall into the brain parenchyma proceeds by overflow when perivascular astroglial end-feet are disarranged. Structures of perivascular amyloid plaques are similar to the neuritic (senile) plaques in Alzheimer's disease, which were used as control, except that the amyloid core of the plaques in Alzheimer's disease is not related to blood vessels.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Okoye MI,Watanabe Idoi
10.1016/s0046-8177(82)80251-7subject
Has Abstractpub_date
1982-12-01 00:00:00pages
1127-32issue
12eissn
0046-8177issn
1532-8392pii
S0046-8177(82)80251-7journal_volume
13pub_type
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