Abstract：
:Viruses have long been held to be of pathogenetic importance in the evolution of autoimmune connective tissue disease. We describe 7 adults who developed cutaneous connective tissue disease stigmata in temporal association with recent cytomegalovirus (CMV) infection but without the classic cytopathic changes of CMV infection. We examined 7 adults with clinical presentations encompassing cutaneous vasculitis in 4 and scleroderma in 3. In all 7 patients, there was either IgM seropositivity for CMV and/or CMV DNA isolation from peripheral blood. Although no CMV inclusions were seen, in situ hybridization studies revealed very focal CMV RNA transcript expression with localization mainly to the endothelium. The patients with vasculitis treated with ganciclovir had improvement or resolution of symptoms, whereas only 1 patient with scleroderma received antiviral therapy, without benefit. Another scleroderma patient responded to infliximab therapy. Abortive/partial CMV reactivation can be associated with a syndrome complex mimicking and/or triggering a primary immune-based cutaneous microvascular injury syndrome. Antiviral therapy appears to be of therapeutic value in those cases associated with active necrotizing vasculitic changes. The role of tumor necrosis factor alpha blockers in scleroderma cases temporally associated with CMV infection requires further evaluation.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Magro CM,Crowson AN,Ferri Cdoi
10.1016/j.humpath.2006.06.002subject
Has Abstractpub_date
2007-01-01 00:00:00pages
42-9issue
1eissn
0046-8177issn
1532-8392pii
S0046-8177(06)00355-8journal_volume
38pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:The clinicopathologic features and immunohistochemical profiles of 14 cases of a distinctive mesenchymal tumor that arises in the superficial lamina propria of the cervix and vagina and is histologically distinguishable from mesodermal (fibroepithelial) stromal polyp, including the cellular (pseudosarcomatous) variant...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.25588
更新日期：2001-07-01 00:00:00
abstract：:Basal cell proliferation is a common finding in a benign hyperplastic prostate gland. Occasionally, basal cell hyperplasia is so florid that it can be mistaken for prostatic adenocarcinoma. We characterized histological, ultrastructural, and immunohistochemical features of florid basal cell hyperplasia from transureth...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00121-7
更新日期：2003-05-01 00:00:00
abstract：:Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90161-h
更新日期：1991-03-01 00:00:00
abstract：:Giant cell tumor of tendon sheath (GCTS) and pigmented villonodular synovitis (PVNS) are common synovial "tumors." Their immunohistochemical profile, however, has not been well characterized, and uncertainty exists regarding their histogenesis and relationship to fibroma of tendon sheath. In an effort to clarify these...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90226-0
更新日期：1995-07-01 00:00:00
abstract：:To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.04.024
更新日期：2014-11-01 00:00:00
abstract：:Fibrillar proteins with a role in cellular shape and motility are present in the cytoplasm of most animal cells. They vary greatly in size, organization, and reactivity according to cell type and can be separately identified by the use of recently developed monospecific antisera and indirect immunofluorescence stainin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80026-3
更新日期：1981-05-01 00:00:00
abstract：:Malignant gastrointestinal neuroectodermal tumor (MGNET) is a very rare, aggressive malignant neoplasm that may occur in any location in the gastrointestinal tract. Malignant gastrointestinal neuroectodermal tumors typically consist of sheet-like to pseudopapillary proliferation of primitive-appearing epithelioid cell...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.05.026
更新日期：2016-11-01 00:00:00
abstract：:Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.11.010
更新日期：2015-03-01 00:00:00
abstract：:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80251-7
更新日期：1982-12-01 00:00:00
abstract：:The previously unreported association of granulomatous gastritis and mononeuritis multiplex occurring in the setting of a vasculitic syndrome is described. The two conditions are considered to be associated and to be immune mediated. The previously accepted concept of isolated granulomatous gastritis is disputed. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90018-k
更新日期：1991-10-01 00:00:00
abstract：:In this series of 3,432 cases of malignant melanoma of the choroid and ciliary body, mortality from metastasis 15 years after enucleation was 46 per cent. This mortality was at least ten times greater than has been observed with tumors of the iris, probably owing to the greater size and more malignant cytology of chor...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80116-0
更新日期：1982-02-01 00:00:00
abstract：:We present a rare case of unilateral intratesticular cystadenocarcinoma with mucinous differentiation in a 71-year-old male patient. The orchiectomy specimen revealed a 3.5-cm well to moderately differentiated cystic neoplasm with elongated fine papillary structures lined by columnar epithelium with alternating goblet...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.11.021
更新日期：2011-09-01 00:00:00
abstract：:Epithelial inclusions in the axillary lymph nodes are very rare and have even less commonly been reported with either benign or malignant changes. We present a case of synchronous high-grade micropapillary ductal carcinoma in situ arising in the breast and in an epithelial inclusion in an ipsilateral sentinel lymph no...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.07.012
更新日期：2013-01-01 00:00:00
abstract：:Atrial fibrillation becomes a self-perpetuating arrhythmia as a consequence of electrophysiologic and structural remodeling involving the atrium. Oxidative stress may be a link between this rhythm disturbance and electrophysiologic remodeling. The aim of this study was to evaluate whether the heme oxygenase-1 (HO-1) m...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.12.007
更新日期：2008-08-01 00:00:00
abstract：:Cell growth in the normal prostate is regulated by a delicate balance between cell death and cell proliferation (ie, apoptotic v proliferative activity). Disruption of the molecular mechanisms that regulate these two processes may underline the abnormal growth of the gland leading to benign prostatic hyperplasia (BPH)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90396-2
更新日期：1996-07-01 00:00:00
abstract：:Cellular crescents are typically inflammatory and associated with rapidly progressive glomerulonephritis. Their pathogenesis involves glomerular basement membrane rupture due to circulating or intrinsic factors. Crescents associated with diabetic glomerulosclerosis are rarely reported. Furthermore, the nature of cells...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.10.030
更新日期：2014-03-01 00:00:00
abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.017
更新日期：2014-07-01 00:00:00
abstract：:A case of mucin-positive giant cell carcinoma of the pancreas is presented. Clear cells were a prominent feature of the primary tumor and constituted the majority of the metastatic deposits, a finding not usually associated with pancreatic carcinoma. Results of ultrastructural and histochemical studies are presented, ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80099-3
更新日期：1982-11-01 00:00:00
abstract：:The mucin profile of 24 endoscopic biopsies of heterotopic gastric mucosa (HGM) of the upper esophagus in adults and a control group of ten cases of Meckel's diverticula containing heterotopic gastric mucosa were studied with two combined histochemical methods: alcian blue pH 2.5/PAS and high iron diamine/alcian blue ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80285-5
更新日期：1988-11-01 00:00:00
abstract：:Congenital cystic adenomatoid malformation (CCAM) of the lung is a congenital lesion that is sometimes complicated by bronchioloalveolar adenocarcinoma (BAC). In some cases foci of atypical goblet cell hyperplasia (AGCH) can be found within the cysts. It has been proposed that CCAM and AGCH predispose to the developme...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.01.008
更新日期：2004-05-01 00:00:00
abstract：:Retrovenous perfusion of the myocardium via the coronary sinus and cardiac veins was one of the earliest attempted forms of myocardial revascularization. Although coronary artery revascularization has almost completely replaced venous revascularization as the procedure of choice, the latter approach is still occasiona...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90073-7
更新日期：1989-08-01 00:00:00
abstract：:In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.12.008
更新日期：2008-08-01 00:00:00
abstract：:GATA-3 and estrogen receptor (ER) are involved in a positive cross-regulatory loop and are frequently coexpressed in breast cancers. GATA-3 expression was shown to be an independent predictor of overall and disease-free survival in some studies, whereas others showed no difference. However, the studies used different ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.05.022
更新日期：2013-11-01 00:00:00
abstract：:We report novel renal histopathologic features in a patient with hemolytic uremic syndrome after allogeneic bone marrow transplantation who survived with plasma exchange therapy. This distribution of vascular lesions within the kidney differed from previously described cases, which were uniformly fatal, in that there ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90210-4
更新日期：1989-01-01 00:00:00
abstract：:Our previous investigations of transforming growth factor types beta 1 and beta 2 (TGF beta s) showed negative or positive autocrine growth regulation of gliomas in vitro. Near-diploid gliomas were inhibited by the TGF beta s, whereas a stimulatory response correlated with progressive anaplasia and karyotypic divergen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90118-x
更新日期：1994-05-01 00:00:00
abstract：:Recently, we reported 2 mixed endometrioid endometrial carcinomas with a "low-grade serous"-like component, which does not fit into any of the 4 molecular groups described by The Cancer Genome Atlas. To understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these 2 ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.10.016
更新日期：2018-01-01 00:00:00
abstract：:Pathologists are frequently asked to evaluate gastric mucosal biopsy specimens for the presence of Helicobacter pylori infection and for potentially important changes such as intestinal metaplasia. No agreed-on system is both available and prospectively shown to provide reliable estimates of the underlying pathologica...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90303-9
更新日期：1999-01-01 00:00:00
abstract：:The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.07.002
更新日期：2017-09-01 00:00:00
abstract：:The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.09.027
更新日期：2016-02-01 00:00:00
abstract：:Follicular lymphoma with MYC and BCL2 translocations, so-called double-hit follicular lymphoma (DH-FL), is rare. Here, we report the clinicopathological features of 7 cases of DH-FL. All neoplasms had a follicular pattern (1 partially diffuse). Five cases were predominantly low grade, 4 of which had focal (≤20%) grade...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2016.07.025
更新日期：2016-12-01 00:00:00
