N-myc amplification was rarely detected by fluorescence in situ hybridization in retinoblastoma.

abstract：:A case of mucin-positive giant cell carcinoma of the pancreas is presented. Clear cells were a prominent feature of the primary tumor and constituted the majority of the metastatic deposits, a finding not usually associated with pancreatic carcinoma. Results of ultrastructural and histochemical studies are presented, ...

journal_title：Human pathology

authors： Urbanski SJ,Medline A

更新日期：1982-11-01 00:00:00

abstract：:Plakophilins (PKPs) are members of the armadillo multigene family. Armadillo-related proteins function in both cell adhesion and signal transduction, and also play a central role in tumorigenesis. Here we report the immunohistochemical localization of PKPs in 37 cases of human primary squamous cell carcinoma of the or...

journal_title：Human pathology

authors： Papagerakis S,Shabana AH,Depondt J,Gehanno P,Forest N

更新日期：2003-06-01 00:00:00

abstract：:Polymer substances are commonly applied as surface coatings on endovascular catheters and vascular devices. Adverse effects related to their use have been reported, although the overall clinical significance and appropriate methods of detection of these complications have been unclear. In this analysis, we systematica...

journal_title：Human pathology

authors： Mehta RI,Mehta RI

更新日期：2016-07-01 00:00:00

abstract：:The case of a biliary cystadenoma containing foci of cystadenocarcinoma is reported, along with the first electron microscopic description of this lesion. Both neoplastic and congenital origins have been implicated in the pathogenesis of biliary cystadenomas. In this case hamartomatous bile ducts were found, supportin...

journal_title：Human pathology

authors： Devine P,Ucci AA

更新日期：1985-01-01 00:00:00

abstract：:Analogous to mixed tumors of salivary glands (" pleomorphic adenomas" ), cutaneous mixed tumors (" chondroid syringomas" ) contain a ductal (epithelial) component and a variably prominent myoepithelial component. Tumors showing purely myoepithelial differentiation (myoepitheliomas) have only recently been recognized t...

journal_title：Human pathology

authors： Hornick JL,Fletcher CD

更新日期：2004-01-01 00:00:00

abstract：:Three cases of primary thymic neuroendocrine tumors characterized by prominent angiomatoid features that resembled a vascular neoplasm are presented. The patients were all men between 52 and 59 years of age who presented with chest pain and shortness of breath attributable to a large anterior mediastinal mass. The les...

journal_title：Human pathology

authors： Moran CA,Suster S

更新日期：1999-06-01 00:00:00

abstract：:The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...

journal_title：Human pathology

authors： Mhawech P,Uchida T,Pelte MF

更新日期：2002-11-01 00:00:00

abstract：:Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...

journal_title：Human pathology

authors： Thurberg BL,Politei JM

更新日期：2012-04-01 00:00:00

abstract：:Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that th...

journal_title：Human pathology

authors： Matsuoka K,Hayashi S,Urano F,Zhu LJ,Okita H,Sago H,Nakazawa A

更新日期：2012-09-01 00:00:00

abstract：:Loss of the NF1 allele, coding for the protein neurofibromin, and polymorphism in the proto-oncogene RET (RETp) are purportedly common in desmoplastic melanoma (DM). DM is categorized into pure (PDM) and mixed (MDM) subtypes, which differ in prognosis. Most NF1 mutations result in a truncated/absent protein, making im...

journal_title：Human pathology

authors： Kadokura A,Frydenlund N,Leone DA,Yang S,Hoang MP,Deng A,Hernandez-Perez M,Biswas A,Singh R,Yaar R,Mahalingam M

更新日期：2016-07-01 00:00:00

abstract：:Lipomatous lesions of the heart involving the atria and interatrial septum are not well known. Most such lesions do not become clinically significant; however, intractable arrhythmias, blood flow obstruction, and valvular disruption may result from extensive fatty infiltration of the atrial wall or from the mass effec...

journal_title：Human pathology

authors： Cunningham KS,Veinot JP,Feindel CM,Butany J

更新日期：2006-10-01 00:00:00

abstract：:Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in lung adenocarcinoma ra...

journal_title：Human pathology

authors： Tan J,Sidhu G,Greco MA,Ballard H,Wieczorek R

更新日期：1998-04-01 00:00:00

abstract：:Paraffin-embedded sections of 99 human adrenal and extraadrenal paragangliomas were analyzed by the indirect immunoperoxidase technique for the presence of neuron-specific enolase (NSE) and 10 neuropeptides. Each showed diffuse staining for NSE. Most tumors were positive for [Leu5]-enkephalin (76 per cent), [Met5]-enk...

journal_title：Human pathology

authors： Linnoila RI,Lack EE,Steinberg SM,Keiser HR

更新日期：1988-01-01 00:00:00

abstract：:Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...

journal_title：Human pathology

authors： Seidl H,Richtig E,Tilz H,Stefan M,Schmidbauer U,Asslaber M,Zatloukal K,Herlyn M,Schaider H

更新日期：2007-05-01 00:00:00

abstract：:The objective of this cohort study was to evaluate whether the immunohistochemical expression of tissue inhibitor of metalloprotease 2, matrix metalloproteinase (MMP) 2, and MMP-9 could predict the occurrence of death and progression in women with ovarian high-grade serous carcinoma (HGSC). A total of 100 women with p...

journal_title：Human pathology

authors： Desmeules P,Trudel D,Turcotte S,Sirois J,Plante M,Grégoire J,Renaud MC,Orain M,Têtu B,Bairati I

更新日期：2015-05-01 00:00:00

abstract：:Ovarian ependymomas are rare glial neoplasms that typically occur in women on their third to fourth decades of life. They are histologically similar to ependymomas of the central nervous system but may have a broader immunophenotype. We describe a 27-year-old woman who presented to the emergency department with a 3-we...

journal_title：Human pathology

authors： Lopez LV,Bhattacharyya S,Carlsen ED,Bartlett D,Rao UNM

更新日期：2019-01-01 00:00:00

abstract：:A case of recurrent Hodgkin's disease of the "sarcomatoid" or "syncytial variant" type was seen that occurred as an extension from the mediastinum to a previously uninvolved extranodal site (breast) and pericardium after treatment of classical nodular sclerosing Hodgkin's disease based in the lymph nodes. This histolo...

journal_title：Human pathology

authors： Blaustein JC,Lewkow L

更新日期：1987-07-01 00:00:00

abstract：:The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...

journal_title：Human pathology

authors： Dobashi Y,Suzuki S,Kimura M,Matsubara H,Tsubochi H,Imoto I,Ooi A

更新日期：2011-02-01 00:00:00

abstract：:Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...

journal_title：Human pathology

authors： di Sant'Agnese PA

更新日期：1992-03-01 00:00:00

abstract：:The small, variously designated, primary atrioventricular node tumor has been considered to be of endothelial, endodermal, or mesothelial origin. To identify its derivation, we studied seven tumors using silver staining and immunocytochemical labeling with a variety of antibodies. Cytoplasmic argyrophil granules but n...

journal_title：Human pathology

authors： Fine G,Raju U

更新日期：1987-08-01 00:00:00

abstract：:Giant cell tumor of tendon sheath (GCTS) and pigmented villonodular synovitis (PVNS) are common synovial "tumors." Their immunohistochemical profile, however, has not been well characterized, and uncertainty exists regarding their histogenesis and relationship to fibroma of tendon sheath. In an effort to clarify these...

journal_title：Human pathology

authors： O'Connell JX,Fanburg JC,Rosenberg AE

更新日期：1995-07-01 00:00:00

abstract：:Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...

journal_title：Human pathology

authors： Khettry U,Anand N,Gordon FD,Jenkins RL,Tahan SR,Loda M,Lewis WD

更新日期：2000-01-01 00:00:00

abstract：:A practical approach to the interpretation of peroral small intestinal biopsy specimens is presented. Biopsy technique and tissure handling are described. Interpretation of normal and abnormal biopsy specimens is discussed. A practical classification of abnormal small intestinal biopsies is presented and illustrated. ...

journal_title：Human pathology

authors： Perera DR,Weinstein WM,Rubin CE

更新日期：1975-03-01 00:00:00

abstract：:A 57 year old man presented with a two week history of right sided chest pain. An admission chest x-ray examination revealed a 2 by 1 cm. lytic lesion of the ninth right rib and right sided pleural effusion. The patient underwent a right thoracotomy during which 700 cc. of blood tinged pleural fluid was drained and a ...

journal_title：Human pathology

authors： Pappas CA,Rheinlander HF,Stadecker MJ

更新日期：1980-11-01 00:00:00

abstract：:The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression...

journal_title：Human pathology

authors： Davidson B,Holth A,Hellesylt E,Hadar R,Katz B,Tropé CG,Reich R

更新日期：2016-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a member of the human herpesvirus family that was initially isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964. Subsequent studies have proven that it is the causative agent in most cases of infectious mononucleosis. Primary infection is usually asymptomatic in chi...

journal_title：Human pathology

authors： Rezk SA,Weiss LM

更新日期：2007-09-01 00:00:00

abstract：:Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a variant of anaplastic large cell lymphoma arising within seroma effusion associated with breast implants. BI-ALCL is a rare disease, recently recognized as a new provisional entity by the 2017 revised World Health Organization classification. All ...

journal_title：Human pathology

authors： Tabanelli V,Corsini C,Fiori S,Agostinelli C,Calleri A,Orecchioni S,Melle F,Motta G,Rotili A,Di Napoli A,Pileri SA

更新日期：2019-08-01 00:00:00

abstract：:Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...

journal_title：Human pathology

authors： Nasir A,Amateau SK,Khan S,Simpson RW,Snover DC,Amin K

更新日期：2018-04-01 00:00:00

abstract：:Focal apocrine metaplasia was studied in 293 whole human breasts by a subgross sampling technique with histologic confirmation. There were 186 breasts obtained from random autopsies. Another 107 breasts were obtained that were cancer-associated; these breasts either contained an invasive cancer or were situated contra...

journal_title：Human pathology

authors： Wellings SR,Alpers CE

更新日期：1987-04-01 00:00:00

abstract：:Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...

journal_title：Human pathology

authors： Park JH,Lee C,Suh JH,Chae JY,Kim HW,Moon KC

更新日期：2015-03-01 00:00:00