Abstract:
:Focal apocrine metaplasia was studied in 293 whole human breasts by a subgross sampling technique with histologic confirmation. There were 186 breasts obtained from random autopsies. Another 107 breasts were obtained that were cancer-associated; these breasts either contained an invasive cancer or were situated contralateral to a cancer-containing breast. The observations support a lobular origin for most if not all apocrine metaplasia and demonstrate some correlation between the presence of apocrine metaplasia and coincident invasive breast cancer on either the contralateral or ipsilateral side. When extensive, apocrine metaplasia appears to be a useful phenotypic marker for tissue at a modestly increased risk for breast cancer. There were no breast carcinomas of the apocrine type in this series, supporting the belief that apocrine metaplastic epithelium has little intrinsic malignant potential. Finally, the data support the hypothesis that most breast cysts arise from apocrine metaplastic lobules.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Wellings SR,Alpers CEdoi
10.1016/s0046-8177(87)80169-7subject
Has Abstractpub_date
1987-04-01 00:00:00pages
381-6issue
4eissn
0046-8177issn
1532-8392pii
S0046-8177(87)80169-7journal_volume
18pub_type
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