Abstract：
:The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression was analyzed in 262 HGSC effusions using immunohistochemistry. HUR mRNA was detected in all 66 effusions. HUR mRNA levels were unrelated to clinicopathological parameters. However, higher HUR mRNA levels were significantly related to poor overall survival in the entire cohort (P=.023), as well as in analysis limited to patients with prechemotherapy primary diagnosis specimens (P=.001) in univariate analysis. Cox multivariate analysis showed an independent prognostic role for HUR mRNA in the entire cohort (P=.033) and in patients with prechemotherapy primary diagnosis specimens (P=.002). HuR protein was detected in the nucleus and cytoplasm of tumor cells in 258 (98%) of 262 and 153 (58%) of 262 effusions, respectively. Higher HuR protein expression was associated with higher serum Cancer Antigen (CA) 125 levels at diagnosis (P=.01), but its presence at both cellular compartments was otherwise unrelated to clinicopathological parameters or survival. In conclusion, HuR is widely expressed in metastatic HGSC at both the mRNA and protein level. Higher HUR mRNA levels are associated with poor survival in metastatic HGSC, whereas protein expression has no prognostic value.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Davidson B,Holth A,Hellesylt E,Hadar R,Katz B,Tropé CG,Reich Rdoi
10.1016/j.humpath.2015.09.027subject
Has Abstractpub_date
2016-02-01 00:00:00pages
95-101eissn
0046-8177issn
1532-8392pii
S0046-8177(15)00389-5journal_volume
48pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:The case of a 65-year-old female patient with a pedunculated left atrial angiosarcoma is presented. Histologically, the tumor was composed of vascular spaces lined by atypical cells with similar cells in the solid portion of the tumor. Immunohistochemical stain for factor VIII-related antigen was positive in the cells...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90250-5
更新日期：1989-06-01 00:00:00
abstract：:Surfactant-associated (SA) glycoproteins are lung-specific proteins produced in the human lung by alveolar type II cells and Clara cells. The distribution of these proteins was studied immunohistochemically in lung tissue obtained postmortem from 12 stillborn fetuses and 49 infants with hyaline membrane disease (HMD)....
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90200-o
更新日期：1990-04-01 00:00:00
abstract：:The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.12.024
更新日期：2016-05-01 00:00:00
abstract：:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80251-7
更新日期：1982-12-01 00:00:00
abstract：:Extratubal secondary trophoblastic implants (ESTI) are a rare complication of conservative laparoscopic procedures for tubal ectopic pregnancies. These implants present with persistent beta-hCG titers postoperatively and are probably the result of disruption of the ectopic pregnancy at salpingostomy or morcellation of...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90231-3
更新日期：1998-02-01 00:00:00
abstract：:Although the term "thyroiditis" suggests inflammation, many disorders of the thyroid that are of unknown etiology are also currently included under this heading. Thus, only infective thyroiditis and subacute thyroiditis are clearly inflammatory; autoimmune thyroiditis is a result of lymphocytic and fibroblastic infilt...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80028-8
更新日期：1978-07-01 00:00:00
abstract：:Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its clinicopathological and genetic features are poorly understood. The aim of our study was to elucidate the frequency and prognostic significance of molecular subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with DLBCL-li...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.09.003
更新日期：2020-02-01 00:00:00
abstract：:This study reports clinicopathologic and biological analysis of 45 stage IVS neuroblastomas (IVS-NBs). All IVS-NB cases had small or undetectable primary tumors associated with disease involving the liver, skin, or bone marrow. Their ages at diagnosis ranged from 1 day to 12 months, with a median age of 4 months. The ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90304-4
更新日期：1996-11-01 00:00:00
abstract：:A case of a primary carcinoid islet cell tumor of the duodenum is reported, demonstrated by histochemistry, electron microscopy, and immunofluorescence to be composed of alpha cells containing glucagon-like material. The patient was found on admission to have hyperglycemia and a diffuse skin rash. Primary duodenal glu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(79)80032-5
更新日期：1979-05-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.08.004
更新日期：2008-03-01 00:00:00
abstract：:Current regulations require that departments of pathology have a structured and active program of quality assurance (QA) and quality improvement (QI), with the goals of enhancing patient safety, minimizing error, ensuring timely delivery of reports, and monitoring physician competence. Types of potential error may evo...
journal_title：Human pathology
pub_type： 指南,杂志文章
doi：10.1016/j.humpath.2006.03.010
更新日期：2006-08-01 00:00:00
abstract：:Heavy proteinuria after bone marrow transplantation (BMT) is rare. Pathology shows membranous glomerulonephritis (MGN) in most cases. After BMT, focal segmental glomerulosclerosis (FSGS) after resolution of MGN has not been reported. We describe a 13-year-old boy who had matched unrelated donor allogeneic BMT for rela...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.07.011
更新日期：2006-12-01 00:00:00
abstract：:The absence of keratin staining in tumor cells from localized fibrous mesotheliomas in both paraffin-embedded and frozen sections with sensitive peroxidase-antiperoxidase and avidin-biotin techniques is described. In addition ot the absence of staining for whole-stratum corneum keratin proteins, sections were negative...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80077-5
更新日期：1984-05-01 00:00:00
abstract：:Parakeratosis refers to incomplete maturation of epidermal keratinocytes, resulting in abnormal retention of nuclei in the stratum corneum. It occurs in many diseases of the skin, particularly in psoriasis. Down-regulation of inhibitor of differentiation 4 messenger RNA has been demonstrated in psoriatic skin, but the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.02.005
更新日期：2011-12-01 00:00:00
abstract：:Loss or reduced expression of E-cadherin has been shown to be associated with poor survival in patients with bladder cancer. In numerous cases, loss of E-cadherin expression in bladder tumors has been accompanied by continued association of catenins with the membrane, suggestive of the expression of an alternative cad...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.21140
更新日期：2001-01-01 00:00:00
abstract：:Retrovenous perfusion of the myocardium via the coronary sinus and cardiac veins was one of the earliest attempted forms of myocardial revascularization. Although coronary artery revascularization has almost completely replaced venous revascularization as the procedure of choice, the latter approach is still occasiona...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90073-7
更新日期：1989-08-01 00:00:00
abstract：:The reticulin stain is a critical diagnostic aide used to differentiate benign hepatocellular proliferations from well differentiated hepatocellular carcinoma (HCC). Rarely, however, hepatocellular carcinomas do not show definitive loss of reticulin in liver biopsy specimens. To study this group of tumors, 11 HCC with...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.09.015
更新日期：2021-01-01 00:00:00
abstract：:We describe a case of simultaneous nodular sclerosing Hodgkin's disease and a granulocytic sarcoma in a cervical lymph node without any previous therapy. The condition evolved into acute myelogenous leukemia approximately 8 months after the initial diagnosis of the granulocytic sarcoma. The unexpected presence of a gr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90293-2
更新日期：1996-10-01 00:00:00
abstract：:The significance of the quantity of acidophil bodies (AB) in nonalcoholic steatohepatitis (NASH) is not certain. We quantified AB in liver biopsies and examined the association with the diagnosis of NASH and other histologic features. We reviewed 157 liver biopsies from the NASH Clinical Research Network Database coll...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2016.01.001
更新日期：2016-06-01 00:00:00
abstract：:The expression of the proteins encoded by the ras, myc, and erb B-2 oncogenes was examined in 63 paraffin-embedded human cholangiocarcinomas of Thai and English origin using immunohistochemistry. The observed distributions were compared with oncogene expression in a series of human hepatocellular carcinomas. In an att...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(89)80006-1
更新日期：1989-12-01 00:00:00
abstract：:In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.12.008
更新日期：2008-08-01 00:00:00
abstract：:A subset of endometrial polyps recurs after resection. The clinicopathologic significance of the phenomenon is evaluated herein. Consecutive cases of recurrent polyps (index polyp removed by hysteroscopy-directed polypectomy or by curettage; at least one more polyp diagnosed ≤12 months after) were compared with an age...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.03.005
更新日期：2020-06-01 00:00:00
abstract：:Cytochrome P-450 specific for steroid 17 alpha-hydroxylation (P-45017 alpha) was immunolocalized in normal and hyperfunctioning adrenal glands of pigs, bovines, and humans, using a specific IgG fraction raised against the enzyme. P-45017 alpha was present in the zona fasciculata (ZF) and zona reticularis (ZR), but not...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90174-3
更新日期：1989-02-01 00:00:00
abstract：:Pulmonary endodermal tumor resembling fetal lung describes an uncommon neoplasm of the lung which also has been referred to as pulmonary blastoma and adenocarcinoma of fetal lung type. We describe five cases which fall within a narrow band on the spectrum of pulmonary neoplasms with both epithelial and mesenchymal fea...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90145-u
更新日期：1990-11-01 00:00:00
abstract：:Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma. The lesions contain a tubular adenocarcinoma that seems to develop "hepatoid" features, but the relation between the tubular adenocarcinomatous and the hepatoid components remains unclear. We compa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.10.020
更新日期：2007-06-01 00:00:00
abstract：:Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90251-3
更新日期：1997-10-01 00:00:00
abstract：:B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 subtypes with either somatically mutated or unmutated immunoglobulin heavy-chain variable region (IgVH) genes. A prognostic significance of the infiltration pattern in bone marrow trephine biopsy has been described before. The combined pattern analysis...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.04.016
更新日期：2006-09-01 00:00:00
abstract：:Oral contraceptive-associated sinusoidal ectasia is a rare lesion of unknown pathogenesis. We describe the case of a 31-year-old woman who had used oral contraceptives for 10 years and was found to have abnormal liver function tests on "routine" examination. A single 9 x 5 x 4 cm hypervascular lesion was demonstrated ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90411-u
更新日期：1992-08-01 00:00:00
abstract：:Sneddon's syndrome is a potentially fatal arterio-occlusive disorder characterized by generalized livedo racemosa and cerebrovascular lesions. Skin biopsies often fail to yield diagnostic arterial lesions. In the present series, affected vessels were found in skin biopsies from 12 of 15 patients with Sneddon's syndrom...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90323-u
更新日期：1992-06-01 00:00:00
abstract：:Glypican 3 is a heparin sulfate proteoglycan bound to the cell surface that is theorized to participate in cell signaling, resulting in embryonic cell growth and differentiation. The GPC3 gene is mutated in Simpson-Golabi-Behmel syndrome, whose features include numerous developmental abnormalities, tissue overgrowth, ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.06.006
更新日期：2008-02-01 00:00:00
