Abstract:
:The reticulin stain is a critical diagnostic aide used to differentiate benign hepatocellular proliferations from well differentiated hepatocellular carcinoma (HCC). Rarely, however, hepatocellular carcinomas do not show definitive loss of reticulin in liver biopsy specimens. To study this group of tumors, 11 HCC with no reticulin loss in 10 patients were collected and studied. Analysis of demographics showed a typical enrichment for men with a typical age for HCC presentation of 69 ± 7 years for adults. The background livers showed advanced fibrosis or cirrhosis in 6 of 6 cases with available information. The tumors were all well differentiated. Cytological atypia was mild and consisted of very mild nuclear atypia (8 cases), mild increase in N:C ratio (3 cases), and pseudorosette formation (4 cases). The cytological/architectural atypia was insufficient in isolation to diagnose HCC. Additional studies, however, showed an increased Ki-67 proliferative rate (N = 10/10 stained cases). The Ki-67 proliferative rate was estimated to be between 5 and 10% in all tested cases and was clearly increased from adjacent liver at low power. Glypican 3 positivity (4 tumors) and alpha fetoprotein (AFP) (1/8 stained cases) positivity also helped make the diagnosis of HCC. Morphologically, the HCC had conventional morphology with five showing steatosis/steatohepatitic features and one showing intratumoral fibrosis. A control group of macroregenerative/dysplastic nodules showed no increase in Ki-67 proliferation and no staining for glypican 3. These findings highlight an important diagnostic pitfall: rare HCC show no reticulin loss on biopsy. In these challenging cases, additional findings are useful to make a diagnosis of HCC: increased Ki-67 and positive staining for aberrant expression of proteins such as glypican 3 or AFP.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Yasir S,Chen ZE,Said S,Wu TT,Torbenson Mdoi
10.1016/j.humpath.2020.09.015subject
Has Abstractpub_date
2021-01-01 00:00:00pages
20-28eissn
0046-8177issn
1532-8392pii
S0046-8177(20)30196-9journal_volume
107pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::A case of a tail in a 2-week-old infant is reported, and findings from a review of 33 previously reported cases of true tails and pseudotails are summarized. The true, or persistent, vestigial tail of humans arises from the most distal remnant of the embryonic tail. It contains adipose and connective tissue, central b...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80079-9
更新日期:1984-05-01 00:00:00
abstract::Demonstration of identical allelic loss on chromosome 11q13 in synchronous in situ (DCIS) and invasive ductal (IDC) breast carcinoma has provided molecular evidence of the progression of DCIS to IDC. We investigated loss of heterozygosity (LOH) at chromosome 11q13 in the spectrum of "marker/premalignant" and "malignan...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90124-6
更新日期:1997-03-01 00:00:00
abstract::Altered expression of oncogenes and tumor suppressor genes, the normal function of which is to regulate cell growth and differentiation, represents a central event in the pathogenesis of human cancer. Aberrant expression of these genes is often a result of a mutational event. In vitro amplification of DNA with the pol...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(94)90220-8
更新日期:1994-06-01 00:00:00
abstract::Schistosoma haematobium infection is a common occurrence in Africa and the Middle East and is the world's leading cause of hematuria. Since more North Americans are venturing into endemic areas and more residents of endemic areas are seeking medical care in North America, pathologists must be able not only to diagnose...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80456-7
更新日期:1986-04-01 00:00:00
abstract::Parakeratosis refers to incomplete maturation of epidermal keratinocytes, resulting in abnormal retention of nuclei in the stratum corneum. It occurs in many diseases of the skin, particularly in psoriasis. Down-regulation of inhibitor of differentiation 4 messenger RNA has been demonstrated in psoriatic skin, but the...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.02.005
更新日期:2011-12-01 00:00:00
abstract::Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.013
更新日期:2007-05-01 00:00:00
abstract::In 1821 Napoleon died in exile on the Island of St. Helena. Although the autopsy had suggested stomach cancer as the cause of death, in 1961 an elevated arsenic concentration was found in Napoleon's hair. This finding elicited numerous theories of conspiracy, treachery, and poisoning. Most recent reports even suggeste...
journal_title:Human pathology
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.humpath.2005.02.001
更新日期:2005-04-01 00:00:00
abstract::Abnormalities of the cell cycle are present in all neoplasms. Cyclin E, which regulates the G1/S phase transition of the cell cycle, plays an important role in many different cancers. To further investigate the role of cyclin E in invasive breast ductal carcinomas in South African women, representative sections from 1...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.21141
更新日期:2001-01-01 00:00:00
abstract::Cancer-related axonogenesis and neurogenesis are recently described biologic phenomena. Our previously published data showed that nerve density and the number of neurons in the parasympathetic ganglia are increased in prostate cancer (PCa) and associated with aggressive disease. Tissue microarrays were constructed fro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.02.009
更新日期:2014-07-01 00:00:00
abstract::After endoscopic resection of early gastric cancer (EGC), it is imperative to accurately determine whether follow-up surgery is indicated, since this technique is used as a first line of treatment. Herein, we developed a scoring system to indicate the risk of lymph node metastasis in submucosal EGC (smEGC), and presen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.07.037
更新日期:2013-12-01 00:00:00
abstract::We describe a patient with adenosquamous carcinoma of the prostate. His history suggests a common histogenesis of the glandular and squamous elements of the tumor. A 60-year-old white man had adenocarcinoma of the prostate diagnosed by biopsy and then underwent radical prostatectomy, which showed adenosquamous carcino...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90125-6
更新日期:1995-01-01 00:00:00
abstract::We developed a procedure based on computerized image analysis to establish objective criteria for the differential diagnosis between mesothelial hyperplasia and cancer in peritoneal tissue samples obtained at second-look operations for ovarian cancer. The tumor tissue after chemotherapy was classified as "nonresponsiv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90292-o
更新日期:1993-02-01 00:00:00
abstract::SPARC (secreted protein acidic and rich in cysteine, also called osteonectin, BM-40, and 43K protein) is a matricellular protein and is associated with cell-matrix interactions during cell proliferation and extracellular remodeling. It is also implicated in the neovascularization, invasion, and metastasis of human mal...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.28244
更新日期:2001-10-01 00:00:00
abstract::Explants from paraspinal muscles of patients with scoliosis were cultured in Millipore diffusion chambers placed in peritoneal cavities of mice. Three and four weeks of incubation produced a predominantly myogenic growth. Cell counts done on paraffin sections and on dissociated cells from the chambers showed that expl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80046-9
更新日期:1981-07-01 00:00:00
abstract::Ten cases of reactive follicular hyperplasia and 31 cases of B-cell non-Hodgkin's malignant lymphoma were studied using multiparameter flow cytometry. A bimodal distribution for HLA-DR expression, but not for surface immunoglobulin or B cell-specific antigens CD19 and CD20, was observed commonly in mixed cell type and...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(06)80042-0
更新日期:1990-12-01 00:00:00
abstract::A 64-year-old man with pseudosarcoma of the esophagus is described. Morphologic examinations of this rare tumor were made, and the origin of the sarcoma-like cells of the tumor is discussed. The findings for the sarcoma-like cells of the tumor support the idea that the sarcoma-like elements arose through transformatio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80036-1
更新日期:1982-05-01 00:00:00
abstract::The present report is a neuropathologic study of three patients who died from a severe form of necrotizing encephalopathy following intrathecal methotrexate therapy and craniospinal irradiation for acute lymphoblastic leukemia. During the early phase the lesion presented as multifocal coalescing areas of coagulation n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(78)80047-1
更新日期:1978-11-01 00:00:00
abstract::Kikuchi's histiocytic necrotizing lymphadenitis is a self-limited disorder that typically involves the cervical lymph nodes of young women. Although a viral etiology has been postulated, a definitive viral agent has not been identified. Recent reports have suggested that human herpesvirus 8 (HHV 8) or Epstein-Barr vir...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2003.11
更新日期:2003-02-01 00:00:00
abstract::Acinar cell carcinoma (ACC) is a rare tumor that differentiates toward pancreatic acinar cells and shows evidence of pancreatic enzyme production. Mixed acinar-neuroendocrine carcinoma (MANC) is defined as having more than 30% of both acinar and neuroendocrine cell types as per immunohistochemistry analysis. Trypsin i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2020.07.019
更新日期:2020-09-01 00:00:00
abstract::Histopathologic lesions in the central nervous system (CNS) of 400 autopsy cases of the acquired immunodeficiency syndrome (AIDS) collected from 1982 to 1990 were studied. Lesions most closely associated with human immunodeficiency virus (HIV) infection in the CNS (perivascular macrophages, nodular encephalomyelitis, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90215-3
更新日期:1993-11-01 00:00:00
abstract::Clear cell renal cell carcinoma is a complex disease with only partial response to therapy and scarce reliable clinical parameters indicative of progression and survival. Fibroblast activation protein expression has been correlated with prognosis in several malignancies but never in renal cancer. We aim to analyze the...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2016.03.009
更新日期:2016-08-01 00:00:00
abstract::K homology domain containing protein overexpressed in cancer (KOC) is a member of the insulin-like growth factor (IGF) messenger RNA-binding protein family and is expressed during embryogenesis and in certain malignancies. KOC, known as L523S and IGF messenger RNA-binding protein 3, was shown to be frequently expresse...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.011
更新日期:2007-04-01 00:00:00
abstract::Grb2-associated binder 2 protein (Gab2) is a member of scaffold proteins, playing crucial roles in (receptor-) tyrosine kinase and cytokine signaling. Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which interacts with Grb2 and Gab2 signaling, thereby triggering hematopoietic ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.09.012
更新日期:2011-05-01 00:00:00
abstract::Urethral caruncle is a benign polypoid mass of the urethral meatus in primarily postmenopausal women. Although a conclusive association with malignancy, urologic disorder, or systemic disease has not been established, often the lesion carries a challenging clinical differential diagnosis that includes malignancy. Conv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.015
更新日期:2012-09-01 00:00:00
abstract::To assess the proliferative activity of renal cell carcinoma (RCC-A) in patients with acquired cystic disease of the kidney (ACDK) after long-term hemodialysis, we analyzed cell cycle, DNA ploidy, and S-phase fraction by flow cytometry (FCM) and proliferating cell nuclear antigen (PCNA) labeling index by immunohistoch...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.30188
更新日期:2002-02-01 00:00:00
abstract::Although rare, synovial sarcoma (SS) is one of the most common soft tissue sarcomas affecting young adults. To investigate potential tumor markers related to synovial sarcoma prognosis, we carried out a single-institution retrospective analysis of 103 patients diagnosed with SS between 1980 and 2009. Clinical outcome ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.001
更新日期:2013-09-01 00:00:00
abstract::Congenital syphilis is often a presumptive diagnosis (based on serologies), because confirmation requires identification of Treponema pallidum in fetal/neonatal tissues or in the placenta. Placental histological features associated with congenital syphilis include the triad of enlarged hypercellular villi, proliferati...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90110-0
更新日期:1996-04-01 00:00:00
abstract::Heat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the pre...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.09.039
更新日期:2017-03-01 00:00:00
abstract::A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90221-0
更新日期:1998-02-01 00:00:00
abstract::Tumor proliferation in bladder cancer is associated with tumor behavior. To assess the association between Ki-67 labeling index (LI), p53, and c-erbB-2 overexpression, formalin-fixed tissue samples of 160 patients with transitional cell carcinoma (TCC) of the urinary bladder were studied by immunohistochemistry. Ki-67...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90096-5
更新日期:1994-12-01 00:00:00