Abstract：
:SPARC (secreted protein acidic and rich in cysteine, also called osteonectin, BM-40, and 43K protein) is a matricellular protein and is associated with cell-matrix interactions during cell proliferation and extracellular remodeling. It is also implicated in the neovascularization, invasion, and metastasis of human malignancies. To investigate a potential role of the SPARC in renal tumorigenesis, we examined primary renal cell carcinomas (RCCs) for SPARC expression by Northern blot analysis and for protein distribution by immunohistochemistry. We found that 6 (100%) of 6 sarcomatoid and 25 (70%) of 36 clear-cell carcinomas had enhanced SPARC transcription compared with that of the corresponding normal kidney tissue. In contrast, papillary and chromophobe RCCs characterized by a hypovascular or avascular tumor phenotype had undetectable SPARC expression. Immunohistochemical analysis showed that SPARC was strongly stained in the cytoplasm of the sarcomatoid neoplastic cells in sarcomatoid RCCs, whereas it was expressed only in the vascular endothelial cells and fibroblasts in clear-cell RCCs. SPARC staining intensity in the stromal cells was increased in the invading portion in some clear-cell RCCs. These findings suggest that tumor development, including neovascularization and invasion in clear-cell RCCs, might be regulated by SPARC from stromal endothelial cells and fibroblasts and that sarcomatoid transformation from common-type RCCs is associated with upregulation of SPARC expression; SPARC may contribute to its aggressive tumor phenotype.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Sakai N,Baba M,Nagasima Y,Kato Y,Hirai K,Kondo K,Kobayashi K,Yoshida M,Kaneko S,Kishida T,Kawakami S,Hosaka M,Inayama Y,Yao Mdoi
10.1053/hupa.2001.28244subject
Has Abstractpub_date
2001-10-01 00:00:00pages
1064-70issue
10eissn
0046-8177issn
1532-8392pii
S0046817701815033journal_volume
32pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Galectins, a family of beta-galactoside-binding animal lectins, might be involved in tumor progression. In this study, the expression patterns of galectin-1 and -3 were examined immunohistochemically in intrahepatic cholangiocarcinoma (ICC), with emphasis on its development and progression as well as its histopatholog...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.22767
更新日期：2001-03-01 00:00:00
abstract：:Kikuchi's histiocytic necrotizing lymphadenitis is a self-limited disorder that typically involves the cervical lymph nodes of young women. Although a viral etiology has been postulated, a definitive viral agent has not been identified. Recent reports have suggested that human herpesvirus 8 (HHV 8) or Epstein-Barr vir...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2003.11
更新日期：2003-02-01 00:00:00
abstract：:Mucin core proteins (MUCs) are expressed in tissue-specific patterns in the gastrointestinal tract and expression is deregulated in Barrett's metaplasia. Based on differential expression, MUCs have been used to classify adenocarcinomas into distinct phenotypes (eg, intestinal, gastric, pancreaticobiliary, etc). Becaus...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.10.020
更新日期：2014-03-01 00:00:00
abstract：:Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：:Histone methyltransferase (HMT), which catalyzes a histone methylation, is frequently altered in cancers at mutation and expression levels. The aims of this study were to explore whether SETD1B, SETDB2, and SETD2, SET domain-containing HMT genes, are mutated and expressionally altered in gastric (GC) and colorectal ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.04.013
更新日期：2014-08-01 00:00:00
abstract：:Basal cell proliferation is a common finding in a benign hyperplastic prostate gland. Occasionally, basal cell hyperplasia is so florid that it can be mistaken for prostatic adenocarcinoma. We characterized histological, ultrastructural, and immunohistochemical features of florid basal cell hyperplasia from transureth...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00121-7
更新日期：2003-05-01 00:00:00
abstract：:A mixed gangliocytoma-adenoma occurring in the pituitary fossa of a patient who presented with acromegaly, galactorrhea, and headaches is described. Immunohistochemical studies demonstrated the gangliocytic portion of the tumor to be composed nearly entirely of ganglion cells enmeshed in their neuritic processes and d...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(89)80012-7
更新日期：1989-12-01 00:00:00
abstract：:Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.016
更新日期：2012-09-01 00:00:00
abstract：:Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy with a poor prognosis, and pathologically, it is a diagnosis of exclusion. Rendering this diagnosis can be challenging in practice because of the large number of diverse entities in the differential diagnosis. We encountered an index case of a sin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.05.002
更新日期：2020-07-01 00:00:00
abstract：:Breast cancer is the leading form of cancer diagnosed in women, and the second leading cause of cancer mortality in this group. A commonly accepted grading system for breast cancer that has proven useful for guiding treatment strategy is the modified Bloom-Richardson system. However, this system is subject to interobs...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.10.001
更新日期：2008-05-01 00:00:00
abstract：:A renal biopsy of a 57-year-old man with nephrotic syndrome revealed marked glomerular deposition of Congo red-positive, bire-fringent material characteristic for amyloid. Ultrastructurally, however, this material is composed of nonbranching, haphazardly arranged fibrils of approximately three times the thickness of t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90059-e
更新日期：1990-08-01 00:00:00
abstract：:Eight cases of primary mesenchymal renal tumor in infants under one year of age were studied. The patients' ages ranged from one day to seven months; all but one were diagnosed within the first three months of life. There were four typical congenital mesoblastic nephromas. Two malignant mesenchymal, one intermediate c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80244-4
更新日期：1981-01-01 00:00:00
abstract：:Insulin-like growth factor-II messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is a biomarker whose expression has been found to be a negative prognostic factor in several neoplasms including ovarian clear cell carcinoma (CCC). In this study, we analyzed the frequency and clinicopathologic significance of IMP3 expres...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.12.003
更新日期：2013-08-01 00:00:00
abstract：:We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a v...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2006.10.006
更新日期：2007-04-01 00:00:00
abstract：:Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expressi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.006
更新日期：2013-10-01 00:00:00
abstract：:Pathologists are frequently asked to evaluate gastric mucosal biopsy specimens for the presence of Helicobacter pylori infection and for potentially important changes such as intestinal metaplasia. No agreed-on system is both available and prospectively shown to provide reliable estimates of the underlying pathologica...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90303-9
更新日期：1999-01-01 00:00:00
abstract：:The diagnosis of metastatic adenocarcinoma to the brain of unknown primary is problematic, and the role of immunohistochemistry in identifying a source has not been fully characterized. Sixty-eight metastatic adenocarcinomas of the brain with known primaries were immunostained with antibodies to cytokeratin 7 (CK7), c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90009-5
更新日期：1997-08-01 00:00:00
abstract：:Biopsy specimens of sarcoid skin lesions from nine patients with sarcoidosis were examined for the presence of immunoglobulins, complement (C3 and C4), and fibrinogen. Granulomas in all skin lesions were positive only for fibrinogen. The literature relating to the immunohistochemistry of sarcoidosis is reviewed and it...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80132-4
更新日期：1978-09-01 00:00:00
abstract：:Arginase-1 has been demonstrated as a marker for hepatocellular carcinoma (HCC) with higher sensitivity and specificity than HepPar-1 and glypican-3. However, its sensitivity is diminished in moderately and poorly differentiated HCCs. In the current study, we evaluated the utility of AGXT1 as a diagnostic marker. Immu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.05.025
更新日期：2018-10-01 00:00:00
abstract：:Histopathologic diagnosis of adrenocortical tumors is based on adverse features that indicate malignant potential. Proliferation index has served as a supplemental tool in assessing the malignant potential of adrenocortical tumors. None of the current histologic classification systems can sufficiently accurately predi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.11.015
更新日期：2015-03-01 00:00:00
abstract：:Platelet stimulus-activation-contraction-secretion coupling is linked to fundamental modifications in the biochemistry and ultrastructure of the platelet surface and the membranes enclosing storage organelles. It is not surprising, therefore, that membrane defects are common in platelets from patients with inherited h...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(87)80331-3
更新日期：1987-02-01 00:00:00
abstract：:Three of eight female patients with cytomegalovirus disease had evidence of ovarian infection at autopsy. All three patients with ovarian lesions were postmenopausal; the remaining five were premenopausal. The lesions, which may be bilateral and may occur without evidence of cytomegalovirus infection elsewhere, are di...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(77)80025-7
更新日期：1977-05-01 00:00:00
abstract：:We examined the infection of herpes simplex virus (HSV), human cytomegalovirus (HCMV), and Epstein-Barr virus (EBV) in 61 autopsy cases with secondary diffuse interstitial pneumonia (SDIP) by immunohistochemistry and compared our findings with those in 46 individuals without lung complications. There was no significan...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90065-5
更新日期：1994-10-01 00:00:00
abstract：:Gene amplification is a common event in breast cancer, and identifies actual and potential targets of molecular therapy. The aim of the present study was to determine the amplification status of 22 genes that are reportedly frequently amplified in breast cancers. An archive of 322 formalin-fixed and paraffin-embedded ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.10.017
更新日期：2019-03-01 00:00:00
abstract：:Four cases of radiation cystitis that caused diagnostic difficulty because of an epithelial proliferation with architectural complexity and reactive cytologic atypia are described. The patients, 2 male, 2 female, were from 43 to 77 years of age. Two presented with hematuria. Cystoscopy disclosed abnormalities in 3 pat...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.7894
更新日期：2000-06-01 00:00:00
abstract：:Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examina...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90401-n
更新日期：1992-08-01 00:00:00
abstract：:Cellular crescents are typically inflammatory and associated with rapidly progressive glomerulonephritis. Their pathogenesis involves glomerular basement membrane rupture due to circulating or intrinsic factors. Crescents associated with diabetic glomerulosclerosis are rarely reported. Furthermore, the nature of cells...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.10.030
更新日期：2014-03-01 00:00:00
abstract：:Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic nephroma....
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.24323
更新日期：2001-05-01 00:00:00
abstract：:Substantial agreement has previously been demonstrated between qualitative and morphometric grading of gastric dysplasia. In the present study, a further attempt is made to quantitatively define the dysplastic changes in relation to associated benign or malignant changes of gastric mucosa. In total, 232 cases were stu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90094-4
更新日期：1989-09-01 00:00:00
abstract：:Hydatidiform moles are classified as partial or complete by histologic criteria (Am J Obstet Gynecol 131:665-671, 1978 and Am J Obstet Gynecol 132:20-27, 1978). While persistent gestational trophoblastic tumors follow both types, there remains controversy as to whether the malignant extreme of gestational trophoblasti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90096-l
更新日期：1992-04-01 00:00:00
