Abstract:
:Platelet stimulus-activation-contraction-secretion coupling is linked to fundamental modifications in the biochemistry and ultrastructure of the platelet surface and the membranes enclosing storage organelles. It is not surprising, therefore, that membrane defects are common in platelets from patients with inherited hemorrhagic disorders caused by platelet dysfunction. In fact, it might be stated that all inherited disorders of platelet function are related directly or indirectly to abnormalities of membranes. The current review discusses the state of knowledge on inherited platelet membrane defects of the cell surface and storage organelles.
journal_name
Hum Patholjournal_title
Human pathologyauthors
White JGdoi
10.1016/s0046-8177(87)80331-3subject
Has Abstractpub_date
1987-02-01 00:00:00pages
123-39issue
2eissn
0046-8177issn
1532-8392pii
S0046-8177(87)80331-3journal_volume
18pub_type
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