Colloid cysts of the third ventricle: immunohistochemical evidence for nonneuroepithelial differentiation.

Abstract:

:The histogenesis of colloid cysts (CCs) of the third ventricle has been a subject of controversy. We examined, using immunohistochemical techniques, four CCs for the presence of cytokeratins (CKs), glutathione S-transferase isoenzymes (GST-pi, GST-mu), and glial fibrillary acidic protein. Antibodies to both low molecular weight CKs (anti-CK8) and to a mixture of CKs (AE1/AE3) were used. For comparison, normal fetal and adult choroid plexus, ependyma, and nasal mucosa were also examined. The epithelium lining all four CCs showed positive immunostaining for the CKs and GST-pi but not for GST-mu or glial fibrillary acidic protein. Fetal and adult nasal mucosa showed a pattern of immunohistochemical staining almost identical to that of CCs. In contrast, fetal and adult choroid plexus tissue showed positive immunostaining for GST-pi and low molecular weight CKs but not for the CK mixture (AE1/AE3). Fetal and adult ependyma were negative for both CKs and GST-pi. These results suggest that CCs differentiate along nonneural lines distinct from the neuroepithelial differentiation of the choroid plexus and ependyma.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Tsuchida T,Hruban RH,Carson BS,Phillips PC

doi

10.1016/0046-8177(92)90352-4

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

811-6

issue

7

eissn

0046-8177

issn

1532-8392

pii

0046-8177(92)90352-4

journal_volume

23

pub_type

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