Abstract：
:Angiogenesis is important for tumor growth and progress, and the intratumor density of microvessels is a significant prognostic factor in many tumor types. The role in thyroid cancer has not been well studied, and we therefore examined a series of 128 papillary carcinomas with respect to microvessel density (MVD) and patient survival. Follow-up was obtained for all cases (median, 145 months). We found a mean MVD of 216 per mm2 (range, 35-751), and there was an average of 3.14 times more vessels in the tumors, when compared with surrounding non-neoplastic thyroid tissue. MVD was inversely related to age, tumor diameter, histological grade, and primary tumor extent. Furthermore, increasing MVD tended to be associated with improved survival (P = .056). In conclusion, our data indicate that angiogenesis is important for the development and maintenance of papillary thyroid carcinomas, although it was not identified as a prognostic factor.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Akslen LA,Livolsi VAdoi
10.1053/1-ip.2000.6548subject
Has Abstractpub_date
2000-04-01 00:00:00pages
439-42issue
4eissn
0046-8177issn
1532-8392pii
S0046-8177(05)80028-0journal_volume
31pub_type
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