Metastatic amelanotic melanoma simulating giant-cell tumor of bone.

abstract：:Epstein-Barr virus (EBV) is a member of the human herpesvirus family that was initially isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964. Subsequent studies have proven that it is the causative agent in most cases of infectious mononucleosis. Primary infection is usually asymptomatic in chi...

journal_title：Human pathology

authors： Rezk SA,Weiss LM

更新日期：2007-09-01 00:00:00

abstract：:Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its clinicopathological and genetic features are poorly understood. The aim of our study was to elucidate the frequency and prognostic significance of molecular subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with DLBCL-li...

journal_title：Human pathology

authors： Hori Y,Yamamoto H,Nozaki Y,Torisu T,Fujiwara M,Taguchi K,Nishiyama K,Nakamura S,Kitazono T,Oda Y

更新日期：2020-02-01 00:00:00

abstract：:In a review of pediatric autopsies from 1951 to 1985, we identified 40 cases in which pancreatitis was diagnosed pathologically. Twenty-six of these patients were under 4 years of age, and the male-to-female ratio was 1.5. Six groups of patients were identified: 10 with hepatobiliary disease, including 9 with biliary ...

journal_title：Human pathology

authors： Nguyen T,Abramowsky C,Ashenburg C,Rothstein F

更新日期：1988-03-01 00:00:00

abstract：:Cribriform and/or papillary prostatic lesions observed on limited tissue, such as needle biopsy, can pose diagnostic dilemmas. One such area of difficulty is the distinction between papillary and/or cribriform prostatic high-grade prostatic intraepithelial neoplasia (HG-PIN) and ductal adenocarcinoma. Over 48 months, ...

journal_title：Human pathology

authors： Rioux-Leclercq N,Leray E,Patard JJ,Lobel B,Guillé F,Jouan F,Bellaud P,Epstein JI

更新日期：2005-05-01 00:00:00

abstract：:The HER-2/neu oncogene is localized to chromosome 17q and shares significant homology with the epidermal growth factor receptor. HER-2/neu protein overexpression has been associated with poor prognosis in a variety of tumors, but its significance in Barrett's esophagus-associated adenocarcinoma (BEAd) is unknown. Ther...

journal_title：Human pathology

authors： Brien TP,Odze RD,Sheehan CE,McKenna BJ,Ross JS

更新日期：2000-01-01 00:00:00

abstract：:Endometrial carcinoma is the most common malignant tumor of the female genital tract in the Western world. Approximately 80% of cases are well- to moderately differentiated (endometrioid) adenocarcinomas, which are confined to the uterine corpus at diagnosis, and thus most can be cured. Conversely, high-grade (ie, cle...

journal_title：Human pathology

authors： Prat J

更新日期：2004-06-01 00:00:00

abstract：:We reviewed open lung biopsies from 35 patients with Wegener's (pathergic) granulomatosis in order to study the histogenesis of the pulmonary lesions and to identify the early lesions. The process of pathergic necrosis is fundamental in the production of extravascular and vascular lesions and was divided into micronec...

journal_title：Human pathology

authors： Mark EJ,Matsubara O,Tan-Liu NS,Fienberg R

更新日期：1988-09-01 00:00:00

abstract：:Telomerase, the enzyme that stabilizes telomere length, is reactivated with almost all cancer types, and it may be necessary for unlimited cell proliferation. Assessment of malignancy in ordinary meningiomas is inconclusive because no clear-cut correlation exists between aggressive clinical behavior and histological f...

journal_title：Human pathology

authors： Langford LA,Piatyszek MA,Xu R,Schold SC Jr,Wright WE,Shay JW

更新日期：1997-04-01 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) and c-myc p62 oncoprotein are two nuclear proteins expressed in proliferating and transformed cells. They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively. On the other hand, nucleolar organizer regi...

journal_title：Human pathology

authors： Korkolopoulou P,Patsouris E,Pangalis G,Tsenga A,Elemenoglou J,Thomas-Tsangli E,Spandidos D,Kittas C

更新日期：1993-04-01 00:00:00

abstract：:A small number (4% to 6%) of primary malignant lymphomas arising in the intestines express the EBV genome. However, in these tumors, the viral genotype and the role of tumor suppressor gene p53 have not been investigated. We sought to determine what genotype of EBV is frequently involved and whether the expression of ...

journal_title：Human pathology

authors： Kim YS,Kim JB,Kang YK,Nam ES,Park SH,Kim I

更新日期：1999-10-01 00:00:00

abstract：:To investigate the roles of matrix metalloproteinases (MMPs) in thymic epithelial tumors, we examined the expression of MMP-2, -7, and -9; membrane-type 1 (MT1)-MMP; and tissue inhibitor of metalloproteinase-2 (TIMP-2) in 57 tumors by immunohistochemistry and in selected 15 cases by in situ hybridization. The tumors c...

journal_title：Human pathology

authors： Takahashi E,Tateyama H,Akatsu H,Fukai I,Yamakawa Y,Fujii Y,Eimoto T

更新日期：2003-12-01 00:00:00

abstract：:We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting island...

journal_title：Human pathology

authors： Hennell C,Jamison J,Wells M,McCluggage WG

更新日期：2012-03-01 00:00:00

abstract：:Ultrastructural studies of the brain in three cases of cerebral amyloid angiopathy demonstrated that the vascular amyloid in this disease is composed of fibrils identical to those in systemic amyloid disease, mixed with a large amount of vesicular debris. Amyloid appears to be derived from circulating protein and is d...

journal_title：Human pathology

authors： Okoye MI,Watanabe I

更新日期：1982-12-01 00:00:00

abstract：:This presentation reports the light and electron microscopic findings relating to the vascular and glomerular changes in the kidney in a series of 25 patients having malignant hypertension, the hemolytic-uremic syndrome, scleroderma, or toxemia of pregnancy. The pathologic changes were generally similar in each of the...

journal_title：Human pathology

authors： Sinclair RA,Antonovych TT,Mostofi FK

更新日期：1976-09-01 00:00:00

abstract：:Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in lung adenocarcinoma ra...

journal_title：Human pathology

authors： Tan J,Sidhu G,Greco MA,Ballard H,Wieczorek R

更新日期：1998-04-01 00:00:00

abstract：:The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...

journal_title：Human pathology

authors： Dobashi Y,Suzuki S,Kimura M,Matsubara H,Tsubochi H,Imoto I,Ooi A

更新日期：2011-02-01 00:00:00

abstract：:IMP3, an oncofetal protein, is a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein family. Its relevance as a novel biomarker in lung, pancreatic, renal, and cervical adenocarcinoma was recently revealed. However, its role in breast carcinogenesis and tumor progression is not yet established. B...

journal_title：Human pathology

authors： Walter O,Prasad M,Lu S,Quinlan RM,Edmiston KL,Khan A

更新日期：2009-11-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in the development and progression of many tumors, but data for primary neuroendocrine carcinoma (PNC) of the skin are lacking. The aim of the study was to assess the expression of MMPs and TIMPs in PNC and to evaluate their prog...

journal_title：Human pathology

authors： Massi D,Franchi A,Ketabchi S,Paglierani M,Pimpinelli N,Santucci M

更新日期：2003-01-01 00:00:00

abstract：:Among 236 aortic valves surgically excised at the Mayo Clinic in 1990 (mean patient age, 66 years; age range, 10 to 92 years), 154 (65%) were stenotic, 58 (25%) were insufficient, and 24 (10%) were both stenotic and insufficient. Pure stenosis was related to calcification, and causes included degenerative (51%), bicus...

journal_title：Human pathology

authors： Dare AJ,Veinot JP,Edwards WD,Tazelaar HD,Schaff HV

更新日期：1993-12-01 00:00:00

abstract：:We applied a panel of antibodies to formalin-fixed, paraffin-embedded sections of 55 renal cell carcinomas using a three-stage immunoperoxidase technique. The antibody panel included two anti-keratins, AE1 and CAM5.2, anti-epithelial membrane antigen (EMA), anti-vimentin, anti-S100 protein, and the anti-leukocyte mark...

journal_title：Human pathology

authors： Medeiros LJ,Michie SA,Johnson DE,Warnke RA,Weiss LM

更新日期：1988-08-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is known to have a wide variation in clinical outcome despite the use of conventional prognostic factors, such as staging or grading. A better knowledge of the biologic aggressiveness of RCC could facilitate the selection of patients at high risk of tumor progression. The aim of this study w...

journal_title：Human pathology

authors： Rioux-Leclercq N,Epstein JI,Bansard JY,Turlin B,Patard JJ,Manunta A,Chan T,Ramee MP,Lobel B,Moulinoux JP

更新日期：2001-11-01 00:00:00

abstract：:CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...

journal_title：Human pathology

authors： Ohmori S,Shiraki K,Sugimoto K,Sakai T,Fujikawa K,Wagayama H,Takase K,Nakano T

更新日期：2001-12-01 00:00:00

abstract：:Although the term "thyroiditis" suggests inflammation, many disorders of the thyroid that are of unknown etiology are also currently included under this heading. Thus, only infective thyroiditis and subacute thyroiditis are clearly inflammatory; autoimmune thyroiditis is a result of lymphocytic and fibroblastic infilt...

journal_title：Human pathology

authors： Volpé R

更新日期：1978-07-01 00:00:00

abstract：:Breast cancer is the leading form of cancer diagnosed in women, and the second leading cause of cancer mortality in this group. A commonly accepted grading system for breast cancer that has proven useful for guiding treatment strategy is the modified Bloom-Richardson system. However, this system is subject to interobs...

journal_title：Human pathology

authors： Tambasco M,Magliocco AM

更新日期：2008-05-01 00:00:00

abstract：:Abnormal nuclear megakaryocytic staining for phospho-STAT5 (pSTAT5) correlates with JAK2 V617F mutational status in non-chronic myelogenous leukemia chronic myeloproliferative disorders. However, a proportion of wild-type JAK2 non-chronic myelogenous leukemia chronic myeloproliferative disorders cases also demonstrate...

journal_title：Human pathology

authors： Gibson SE,Schade AE,Szpurka H,Bak B,Maciejewski JP,Hsi ED

更新日期：2008-07-01 00:00:00

abstract：:Tissue specimens obtained at autopsy from seven childhood cases of malignant histiocytosis were studied by immunohistochemistry. Clinically, the majority of the cases showed sustained fever, hepatosplenomegaly, pancytopenia, and DIC. The pretreatment diagnosis was based on their typical clinical manifestations and bon...

journal_title：Human pathology

authors： Hibi S,Esumi N,Todo S,Imashuku S

更新日期：1988-06-01 00:00:00

abstract：:Myopericytoma is a rare, histologically distinctive tumor that shows evidence of differentiation toward perivascular myoid cells. Myopericytoma is largely considered a neoplasm of skin and soft tissues, with examples of this lesion involving visceral sites being extremely limited. We present the clinical and pathologi...

journal_title：Human pathology

authors： Lau SK,Klein R,Jiang Z,Weiss LM,Chu PG

更新日期：2010-10-01 00:00:00

abstract：:An unusual case of multiple myeloma in an 88-year-old patient is described. Besides skeletal involvement, there was myeloma of the thoracic and abdominal lymph nodes and of the liver and pancreas. In the pancreas, the myeloma extensively involved the head and body, and on computerized tomography scan was suggestive of...

journal_title：Human pathology

authors： Bell HG,David R,Shamsuddin AM

更新日期：1982-10-01 00:00:00

abstract：:Oncogenes, growth factors, cell surface receptors, and cell-cycle and apoptotic regulatory proteins have been implicated in the growth regulation and progression of Barrett's-associated neoplasia. Among these, insulin-like growth factor 1 receptor (IGF1-R) and c-Src are reported to be key regulators of mitogenesis and...

journal_title：Human pathology

authors： Iravani S,Zhang HQ,Yuan ZQ,Cheng JQ,Karl RC,Jove R,Coppola D

更新日期：2003-10-01 00:00:00

abstract：:RBM (RNA-binding motif) protein is a marker of male germ cells. This protein is encoded by the Azoospermia factor region-b (AZF-b) of the human Y chromosome and is expressed exclusively in the male germ cell line, that is, spermatogonia, spermatocytes, and round spermatids. The authors analyzed the expression of the R...

journal_title：Human pathology

authors： Lifschitz-Mercer B,Elliott DJ,Leider-Trejo L,Schreiber-Bramante L,Hassner A,Eisenthal A,Maymon BB

更新日期：2000-09-01 00:00:00