Metastatic amelanotic melanoma simulating giant-cell tumor of bone.


:A case of metastatic malignant melanoma simulating a giant cell tumor of bone is reported. This case typifies the diversity of expression of malignant melanoma. Osteoclast-like giant cells were present only in the femoral head metastasis and were not present in the primary lesion. The giant cell component may be reflective of an inherent and indiscriminant expression which may be seen in a variety of neoplastic bone lesions.


Hum Pathol


Human pathology


Daroca PJ Jr,Reed RJ,Martin PC




Has Abstract


1990-09-01 00:00:00














  • Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas.

    abstract::The histologic classification of pulmonary neoplasms can have important implications regarding appropriate management of patients. Although the histologic classification of lung tumors is predominantly based on morphology, ancillary studies such as immunohistochemistry can be used in difficult cases, and the diagnosis...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Lyda MH,Weiss LM

    更新日期:2000-08-01 00:00:00

  • The significance of prohibitin and c-Met/hepatocyte growth factor receptor in the progression of cervical adenocarcinoma.

    abstract::To examine the importance of prohibitin 1 and c-Met/hepatocyte growth factor receptor (HGFR) expression in human cervical adenocarcinomas, 85 patients (69 with invasive adenocarcinoma [ACA] and 16 with adenocarcinoma in situ [AIS]) were studied using immunohistochemistry. High prohibitin 1 expression was found in 51 (...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Tsai HW,Chow NH,Lin CP,Chan SH,Chou CY,Ho CL

    更新日期:2006-02-01 00:00:00

  • High IFIT1 expression predicts improved clinical outcome, and IFIT1 along with MGMT more accurately predicts prognosis in newly diagnosed glioblastoma.

    abstract::Interferon-induced protein with tetratricopeptide repeat 1 (IFIT1) plays a key role in growth suppression and apoptosis promotion in cancer cells. Interferon was reported to induce the expression of IFIT1 and inhibit the expression of O-6-methylguanine-DNA methyltransferase (MGMT).This study aimed to investigate the e...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Zhang JF,Chen Y,Lin GS,Zhang JD,Tang WL,Huang JH,Chen JS,Wang XF,Lin ZX

    更新日期:2016-06-01 00:00:00

  • Polymerase chain reaction-based methods for the detection of mutations in oncogenes and tumor suppressor genes.

    abstract::Altered expression of oncogenes and tumor suppressor genes, the normal function of which is to regulate cell growth and differentiation, represents a central event in the pathogenesis of human cancer. Aberrant expression of these genes is often a result of a mutational event. In vitro amplification of DNA with the pol...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Loda M

    更新日期:1994-06-01 00:00:00

  • Visceral botryomycosis in a case of Erysipelothrix rhusiopathiae endocarditis.

    abstract::Botryomycosis is a rare bacterial infection of the skin and, rarely, viscera that is characterized by the formation of characteristic hyaline grains. We encountered a patient with Erysipelothrix rhusiopathiae endocarditis who developed visceral botryomycosis. He was a 54-year-old black man who presented in sepsis with...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Carson HJ,Perkins JT

    更新日期:2005-01-01 00:00:00

  • Role of SATB2 in distinguishing the site of origin in glandular lesions of the bladder/urinary tract.

    abstract::The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Giannico GA,Gown AM,Epstein JI,Revetta F,Bishop JA

    更新日期:2017-09-01 00:00:00

  • Angiotropic large-cell lymphoma presenting as pulmonary small vessel occlusive disease.

    abstract::Angiotropic lymphoma (AL) is an unusual variant of extranodal lymphoma, characterized by massive proliferation of neoplastic lymphoid cells almost exclusively within blood vessels. Whereas the lymphoid origin of this disease is widely accepted it still remains unclear whether AL is a distinct entity that originates in...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Evert M,Lehringer-Polzin M,Möbius W,Pfeifer U

    更新日期:2000-07-01 00:00:00

  • prostatic xanthoma: a mimic of prostatic adenocarcinoma.

    abstract::Xanthoma is a localized collection of cholesterol-laden histiocytes that is usually idiopathic, but may be seen in patients with hyperlipidemia. We report seven cases of xanthoma involving the prostate, including one arising in a patient with mild hyperlipidemia. Prostatic xanthoma appeared as a solitary microscopic l...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Sebo TJ,Bostwick DG,Farrow GM,Eble JN

    更新日期:1994-04-01 00:00:00

  • Adenocarcinoma of the lung: a comparative diagnostic study using light and electron microscopy.

    abstract::Several techniques for diagnosing adenocarcinoma of the lung are commonly available, but the frequency of their use and diagnostic sensitivity may vary. Twenty cases of primary lung adenocarcinoma obtained at surgery were studied by the following four routine techniques: light microscopy (LM) using hematoxylin-eosin (...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: McGregor DH,Dixon AY,McGregor DK

    更新日期:1988-08-01 00:00:00

  • Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma.

    abstract::Focal adhesion kinase (FAK) is one of the central signaling molecules found at focal adhesion sites, which are specific areas on the cell membrane where cells attach to extracellular matrix proteins. Focal adhesion kinase interacts with multiple signaling and adaptor molecules and effects several signaling pathways. O...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Madan R,Smolkin MB,Cocker R,Fayyad R,Oktay MH

    更新日期:2006-01-01 00:00:00

  • Computerized morphonuclear characteristics and DNA content of adenocarcinoma of the pancreas, chronic pancreatitis, and normal tissues: relationship with histopathologic grading.

    abstract::We report the morphonuclear characteristics of normal (13 cases), benign (ie, chronic) pancreatitis (six cases), and neoplastic (ie, ductal) adenocarcinoma (22 cases) tissues of the pancreas. This description is based on computerized cell image analysis, which permits the determination of parameters related to the mor...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Rickaert F,Gelin M,van Gansbeke D,Lambilliotte JP,Verhest A,Pasteels JL,Kloppel G,Kiss R

    更新日期:1992-11-01 00:00:00

  • Pseudogynecomastia due to neurofibromatosis--a light microscopic and ultrastructural study.

    abstract::A six year old boy with bilateral breast enlargement was found to have a normal endocrine status. Resected tissue revealed the features of pseudogynecomastia due to a proliferation of fibrous tissue traversed by neuroid structures. Multinucleated giant cells were present within the fibrous tissue. Ultrastructural stud...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Lipper S,Willson CF,Copeland KC

    更新日期:1981-08-01 00:00:00

  • Goals of residency training in pathology. An analysis of the initial two conferences for pathology program directors.

    abstract::This report reviews the goals and objectives of residency training in pathology as defined during the initial two conferences of program directors. Specific emphasis is given to future needs and in particular the background and capabilities of the persons who will be practicing pathology in the 1980's and 1990's. In t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Anderson RE

    更新日期:1980-09-01 00:00:00

  • Persistence of high-grade prostatic intra-epithelial neoplasia under combined androgen blockade therapy.

    abstract::The presence and morphology of high-grade prostatic intraepithelial neoplasia (H-PIN) was blindly evaluated in 40 totally embedded radical prostatectomy specimens of patients with prostate cancer randomized to either a 3 (n = 18) or 6 months (n = 22) combined androgen blockade regimen before surgery. In 5 cases, neo-a...

    journal_title:Human pathology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: van der Kwast TH,Labrie F,Tetu B

    更新日期:1999-12-01 00:00:00

  • Ultrastructure and immunohistochemical localization of estradiol in three thecomas.

    abstract::Three ovarian thecomas were studied by ultrastructural and immunohistochemical techniques. In each tumor, a small number of tumor cells stained for estradiol. Vacuolated as well as plump non-vacuolated tumor cells were positive, but spindle-shaped cells were negative. Ultrastructural examination showed two principle c...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Gaffney EF,Majmudar B,Hewan-Lowe K

    更新日期:1984-02-01 00:00:00

  • Renal amyloidosis characterized by abnormally thick fibrils.

    abstract::A renal biopsy of a 57-year-old man with nephrotic syndrome revealed marked glomerular deposition of Congo red-positive, bire-fringent material characteristic for amyloid. Ultrastructurally, however, this material is composed of nonbranching, haphazardly arranged fibrils of approximately three times the thickness of t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yoshikawa Y,Truong LD,Mattioli C,Cartwright J Jr

    更新日期:1990-08-01 00:00:00

  • Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm.

    abstract::Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for invasive cholangiocarcinoma: biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. How the carcinogenetic process differs between biliary intr...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Nakanishi Y,Zen Y,Kondo S,Itoh T,Itatsu K,Nakanuma Y

    更新日期:2008-08-01 00:00:00

  • Hemosiderin deposition in portal endothelial cells: a novel hepatic hemosiderosis frequent in chronic viral hepatitis B and C.

    abstract::We have recently noted a hitherto undescribed hepatic hemosiderosis confined to endothelial cells of the portal tract in chronic viral hepatitis. In this study, this lesion was surveyed in 156 liver biopsy specimens from patients with chronic hepatitis C and in 21 liver biopsy specimens from patients with chronic hepa...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Kaji K,Nakanuma Y,Sasaki M,Unoura M,Kobayashi K,Nonomura A

    更新日期:1995-10-01 00:00:00

  • Small cell undifferentiated carcinoma of the colon associated with hepatocellular carcinoma in an immunodeficient patient.

    abstract::Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Zirkin HJ,Levy J,Katchko L

    更新日期:1996-09-01 00:00:00

  • TCL-1-positive hematogones in a patient with T-cell prolymphocytic leukemia after therapy.

    abstract::T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PL...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Hu Z,Li S,Medeiros LJ,Sun T

    更新日期:2017-07-01 00:00:00

  • Incidence and significance of GATA3 positivity in gallbladder adenocarcinoma.

    abstract::GATA3 immunostaining is a sensitive marker for mammary and urothelial carcinomas. It is routinely used in surgical pathology during workup of carcinomas of unknown origin. To the best of our knowledge, this is the first focused study of GATA3 expression in gallbladder adenocarcinomas. In this study, we evaluated GATA3...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Guo W,Lee W,Lu Y,Li X,Chandan VS

    更新日期:2020-12-01 00:00:00

  • Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma.

    abstract::Pseudovascular adenoid squamous cell carcinoma (PASCC) is a variant epithelial neoplasm with the ability to simulate the growth pattern of angiosarcoma. It has been documented in the breast, skin, and, recently, lung. We describe three additional examples of pulmonary PASCC occurring in two men and one woman. The pati...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Nappi O,Swanson PE,Wick MR

    更新日期:1994-04-01 00:00:00

  • MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients.

    abstract::We have previously reported that MUC2 apomucin was highly expressed in noninvasive tumors of the pancreas (intraductal papillary tumor [IdPT]) and liver (bile duct cystadenocarcinoma [BdCC]), which show more favorable outcomes than invasive carcinomas. In contrast, MUC2 was rarely expressed in invasive carcinomas of t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yonezawa S,Sueyoshi K,Nomoto M,Kitamura H,Nagata K,Arimura Y,Tanaka S,Hollingsworth MA,Siddiki B,Kim YS,Sato E

    更新日期:1997-03-01 00:00:00

  • Relationships between histology, monoclonal antibody reactivity, and prognosis in breast cancer.

    abstract::Infiltrating ductal carcinoma of the breast is histologically heterogeneous and may be subdivided into three main types (A, B, and C) which correlate with the likelihood of long-term survival. Examples of each type were tested against three monoclonal antibodies (H59, H71, and H72) prepared against the breast cancer c...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yuan D,Dawson PJ

    更新日期:1987-11-01 00:00:00

  • Duodenal epithelioid gastrointestinal stromal tumor with prominent granular cell features.

    abstract::Gastrointestinal stromal tumors are a group of mesenchymal tumors arising from the wall of the gastrointestinal tract that are characterized by activating mutations in KIT or PDGFRA. Their proper recognition is important clinically because of their potential responsiveness to targeted therapies. We report a case of du...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Adamiak A,Lee CH,Nielsen TO,Webber D,O'Connell JX

    更新日期:2009-04-01 00:00:00

  • Genomic alterations in tubular breast carcinomas.

    abstract::Tubular carcinoma of the breast is a well-differentiated variant of invasive ductal carcinoma and has been shown to have an exceptionally favorable prognosis, as manifested by a low incidence of lymph node metastases and an excellent overall survival. It is unknown whether this subtype represents an early step along t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Waldman FM,Hwang ES,Etzell J,Eng C,DeVries S,Bennington J,Thor A

    更新日期:2001-02-01 00:00:00

  • Dimensionalities: borderline and intermediate melanocytic neoplasia.

    abstract::The concept of minimal deviation melanoma is presented in diagrammatic form. In this approach, the precursors of melanoma are presented as having two dimensions and melanomas as having three dimensions. In turn, the relativity between dimensionalities and recommendations for treatment (as indirect correlates of progno...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Reed RJ

    更新日期:1999-05-01 00:00:00

  • Significance of GATA-3 expression in outcomes of patients with breast cancer who received systemic chemotherapy and/or hormonal therapy and clinicopathologic features of GATA-3-positive tumors.

    abstract::GATA-3 and estrogen receptor (ER) are involved in a positive cross-regulatory loop and are frequently coexpressed in breast cancers. GATA-3 expression was shown to be an independent predictor of overall and disease-free survival in some studies, whereas others showed no difference. However, the studies used different ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Gulbahce HE,Sweeney C,Surowiecka M,Knapp D,Varghese L,Blair CK

    更新日期:2013-11-01 00:00:00

  • Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma.

    abstract::Several matrix metalloproteinases (MMPs) are implicated in the degradation of the epithelial basement membrane (BM), invasiveness, and malignancy of endometrial and ovarian carcinomas. We have recently proposed a cooperative role for RUNX1/AML1 and ETV5/ERM in myometrial infiltration during endometrioid endometrial in...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Planagumà J,Liljeström M,Alameda F,Bützow R,Virtanen I,Reventós J,Hukkanen M

    更新日期:2011-01-01 00:00:00

  • Epithelial-to-mesenchymal transition-related transcription factors are up-regulated in ependymomas and correlate with a poor prognosis.

    abstract::Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Malgulwar PB,Nambirajan A,Pathak P,Rajeshwari M,Suri V,Sarkar C,Singh M,Sharma MC

    更新日期:2018-12-01 00:00:00