A metastasis of an adenocarcinoma in a BRCA1 mutation carrier, a diagnostic problem not solved by morphology alone.

Abstract:

:To increase awareness of the possible coexistence of an ovarian and breast carcinoma in a BRCA1 mutation carrier, we describe a patient with primary ovarian cancer who developed distant metastases after 3 years and again after 6 years. Surprisingly, at that time an occult breast carcinoma was identified to be the origin of the 2 metastatic locations as confirmed by molecular analysis. Eventually the patient could be treated accordingly.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Kuenen-Boumeester V,Den Bakker M,Dinjens WN,Seynaeve C

doi

10.1016/j.humpath.2003.11.008

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

629-32

issue

5

eissn

0046-8177

issn

1532-8392

pii

S0046817703006725

journal_volume

35

pub_type

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