Kearns-Sayre syndrome with features of Pearson's marrow-pancreas syndrome and a novel 2905-base pair mitochondrial DNA deletion.

abstract：:Immunofluorescent staining of tissue from a lung tumor detected 12 years after excision of a primary malignant melanoma of the skin was negative for prekeratin and positive for vimentin, indicating that the tumor was not epithelial in origin and excluding carcinoma from the differential diagnosis. Complementary conven...

journal_title：Human pathology

authors： Huszar M,Halkin H,Herczeg E,Bubis J,Geiger B

更新日期：1983-11-01 00:00:00

abstract：:In general, the large cell lymphomas are a cytogenetically heterogeneous group of diseases, and the cytogenetic findings do not correlate with morphological findings in this group of malignant lymphomas. The CD30-positive anaplastic large cell lymphomas, however, are thought to be an exception, with the t(2;5) reporte...

journal_title：Human pathology

authors： Arber DA,Sun LH,Weiss LM

更新日期：1996-06-01 00:00:00

abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...

journal_title：Human pathology

authors： Katz B,Tropé CG,Reich R,Davidson B

更新日期：2015-09-01 00:00:00

abstract：:Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...

journal_title：Human pathology

authors： Slebos RJ,Baas IO,Clement MJ,Offerhaus GJ,Askin FB,Hruban RH,Westra WH

更新日期：1998-08-01 00:00:00

abstract：:A renal biopsy of a 57-year-old man with nephrotic syndrome revealed marked glomerular deposition of Congo red-positive, bire-fringent material characteristic for amyloid. Ultrastructurally, however, this material is composed of nonbranching, haphazardly arranged fibrils of approximately three times the thickness of t...

journal_title：Human pathology

authors： Yoshikawa Y,Truong LD,Mattioli C,Cartwright J Jr

更新日期：1990-08-01 00:00:00

abstract：:Mucus-filled cystic tumors of low or borderline malignant potential, well recognized in ovary and appendix, have received little attention in the lung. We present data on 11 patients, all of whom had solitary pulmonary nodules resected in which mucus was the major histologic component. Prognosis appears good; no patie...

journal_title：Human pathology

authors： Graeme-Cook F,Mark EJ

更新日期：1991-02-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (CD166) is a member of the immunoglobulin superfamily and is aberrantly expressed in different tumors, including prostate cancer. To learn more on the prevalence and clinical significance of activated leukocyte cell adhesion molecule expression in prostate cancer, a tissue mi...

journal_title：Human pathology

authors： Minner S,Kraetzig F,Tachezy M,Kilic E,Graefen M,Wilczak W,Bokemeyer C,Huland H,Sauter G,Schlomm T

更新日期：2011-12-01 00:00:00

abstract：:This study explored the importance of hepatitis B virus infection in cholangiocarcinoma pathogenesis in northern China. The clinical data of 66 patients with cholangiocarcinoma were analyzed. The hepatitis B virus gene was amplified using nested polymerase chain reaction, and the hepatitis B virus-related antigen was ...

journal_title：Human pathology

authors： Wu Y,Wang T,Ye S,Zhao R,Bai X,Wu Y,Abe K,Jin X

更新日期：2012-01-01 00:00:00

abstract：:This article reviews 281 malignant germ cell tumors of the ovary from the Armed Forces Institute of Pathology and highlights their distinctive clinical and pathologic features. Emphasis is placed on the importance of a combined therapeutic approach utilizing surgery, chemotherapy, and radiation. The rationale for unil...

journal_title：Human pathology

authors： Kurman RJ,Norris HJ

更新日期：1977-09-01 00:00:00

abstract：:Endometrial carcinoma is the most common malignant tumor of the female genital tract in the Western world. Approximately 80% of cases are well- to moderately differentiated (endometrioid) adenocarcinomas, which are confined to the uterine corpus at diagnosis, and thus most can be cured. Conversely, high-grade (ie, cle...

journal_title：Human pathology

authors： Prat J

更新日期：2004-06-01 00:00:00

abstract：:Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study t...

journal_title：Human pathology

authors： Fukutomi T,Hayashi Y,Emoto K,Kamiya K,Kohno M,Sakamoto M

更新日期：2013-09-01 00:00:00

abstract：:As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GISTs), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor ...

journal_title：Human pathology

authors： Fletcher CD,Berman JJ,Corless C,Gorstein F,Lasota J,Longley BJ,Miettinen M,O'Leary TJ,Remotti H,Rubin BP,Shmookler B,Sobin LH,Weiss SW

更新日期：2002-05-01 00:00:00

abstract：:Peritoneal involvement in colorectal cancer (CRC) has prognostic significance and is an important parameter in pathologic tumor staging. Restaging of tumors based on peritoneal elastic lamina invasion (ELI) has prognostic significance in CRCs classified as pathologic stage 3 tumors without regional lymph node metastas...

journal_title：Human pathology

authors： Liang WY,Wang YC,Hsu CY,Yang SH

更新日期：2019-03-01 00:00:00

abstract：:There is considerable interest in the role of the human wart virus in the pathogenesis of squamous cell carcinoma. Mucosal wart virus infections may produce considerable epithelial atypia and have eventuated in carcinoma in "normal" individuals in some instances. The verruciform lesions of patients with epidermodyspla...

journal_title：Human pathology

authors： Gisser SD

更新日期：1981-02-01 00:00:00

abstract：:It is currently thought that most clear cell and endometrioid carcinomas arise from ovarian endometriosis. We recently suggested that, besides their origin in the ovary, reduction of CDC42 messenger RNA (a member of the RHO GTPase family) may contribute to explain why clear cell carcinomas are not uncommonly found lim...

journal_title：Human pathology

authors： Canet B,Pons C,Espinosa I,Prat J

更新日期：2012-05-01 00:00:00

abstract：:The current World Health Organization classification considers myelodysplastic syndrome with isolated del(5q) a distinct entity owing to its characteristic clinical and pathologic features. Recently, several studies have examined survival, leukemic transformation, and various prognostic factors in these patients. Howe...

journal_title：Human pathology

authors： Geyer JT,Verma S,Mathew S,Wang YL,Racchumi J,Espinal-Witter R,Subramaniyam S,Knowles DM,Orazi A

更新日期：2013-03-01 00:00:00

abstract：:We studied the histopathology and clinicopathologic correlates of invasive cavitary pulmonary aspergillosis in 11 immunosuppressed patients with disseminated malignancy. In most patients cavities were produced by separation of necrotic from viable lung, resulting in an intracavitary sequestrum ("lung ball"). Central d...

journal_title：Human pathology

authors： Pai U,Blinkhorn RJ Jr,Tomashefski JF Jr

更新日期：1994-03-01 00:00:00

abstract：:We received the clinical records and pathologic material of 20 patients with biopsy proven hepatic focal nodular hyperplasia. The majority of the patients were females of child bearing age, five of whom had a history of oral use of contraceptives. In every instance focal nodular hyperplasia was an incidental finding; ...

journal_title：Human pathology

authors： Knowles DM,Wolff M

更新日期：1976-09-01 00:00:00

abstract：:A 61-year-old woman was admitted to the hospital because of general fatigue. Laboratory examinations showed hyponatremia, plasma hypo-osmolarity, and inappropriate increased concentration of the plasma antidiuretic hormone (ADH) in the presence of concentrated urine. Magnetic resonance imaging revealed a mass lesion i...

journal_title：Human pathology

authors： Asada Y,Marutsuka K,Mitsukawa T,Kuribayashi T,Taniguchi S,Sumiyoshi A

更新日期：1996-05-01 00:00:00

abstract：:Most esophageal intraepithelial lymphocytes (IELs) express T-cell markers. Increased numbers of esophageal IELs have been shown in reflux esophagitis. The cytotoxic potential and activity of esophageal IELs have not as yet been examined. Our objectives were to determine whether esophageal IELs express the recently des...

journal_title：Human pathology

authors： Resnick MB,Finkelstein Y,Weissler A,Levy J,Yakirevich E

更新日期：1999-04-01 00:00:00

abstract：:Analogous to mixed tumors of salivary glands (" pleomorphic adenomas" ), cutaneous mixed tumors (" chondroid syringomas" ) contain a ductal (epithelial) component and a variably prominent myoepithelial component. Tumors showing purely myoepithelial differentiation (myoepitheliomas) have only recently been recognized t...

journal_title：Human pathology

authors： Hornick JL,Fletcher CD

更新日期：2004-01-01 00:00:00

abstract：:An immunohistochemical survey of X-linked inhibitor of apoptosis (XIAP) expression in mammary carcinoma was performed. XIAP, the most potent of the inhibitor of apoptosis family of caspase inhibitors, has been linked to tumor aggressiveness and therapeutic resistance in several malignancies and is considered an attrac...

journal_title：Human pathology

authors： Jaffer S,Orta L,Sunkara S,Sabo E,Burstein DE

更新日期：2007-06-01 00:00:00

abstract：:A six year old boy with bilateral breast enlargement was found to have a normal endocrine status. Resected tissue revealed the features of pseudogynecomastia due to a proliferation of fibrous tissue traversed by neuroid structures. Multinucleated giant cells were present within the fibrous tissue. Ultrastructural stud...

journal_title：Human pathology

authors： Lipper S,Willson CF,Copeland KC

更新日期：1981-08-01 00:00:00

abstract：:Recently, the fusion gene EML4-ALK was identified in non-small cell lung carcinoma, which could be a potential therapeutic target. We investigated the prevalence of anaplastic lymphoma kinase protein expression in these tumors by immunohistochemistry and correlated the results with data from ALK molecular studies. Gen...

journal_title：Human pathology

authors： Boland JM,Erdogan S,Vasmatzis G,Yang P,Tillmans LS,Johnson MR,Wang X,Peterson LM,Halling KC,Oliveira AM,Aubry MC,Yi ES

更新日期：2009-08-01 00:00:00

abstract：:Although T-lineage large granular lymphocyte (LGL) leukemia has been described for over 20 years, many patients with this neoplasm go unrecognized. Chief among the difficulties in diagnosing this entity is that the morphologic features are nonspecific and that it is difficult to distinguish it from reactive processes....

journal_title：Human pathology

authors： Evans HL,Burks E,Viswanatha D,Larson RS

更新日期：2000-10-01 00:00:00

abstract：:The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the...

journal_title：Human pathology

authors： Lorenzato M,Caudroy S,Bronner C,Evrard G,Simon M,Durlach A,Birembaut P,Clavel C

更新日期：2005-10-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC) is a common salivary gland neoplasm with a lengthy clinical course and often late local recurrences after surgical resection. This is accounted for histologically by its infiltrative capacity and distinct propensity for perineural invasion. The expression of biological markers may help e...

journal_title：Human pathology

authors： Kowalski PJ,Paulino AF

更新日期：2002-09-01 00:00:00

abstract：:Pancreatic cancer (PaCA) is a deadly disease with few systemic therapeutic options. The head of the pancreas is the most innervated part and most common location of cancer. However, little is known about the contribution of the nerve-cancer interaction to facilitate pancreatic progression. To quantify PaCA axonogenesi...

journal_title：Human pathology

authors： He D,Manzoni A,Florentin D,Fisher W,Ding Y,Lee M,Ayala G

更新日期：2016-06-01 00:00:00

abstract：:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a B-cell neoplasm that is typically CD5 negative. We describe the clinicopathologic, immunophenotypic, and cytogenetic features of 14 cases of CD5+ MALT lymphoma. There were 9 men and 5 women (median age, 68 years; range, 34-87 y...

journal_title：Human pathology

authors： Jaso J,Chen L,Li S,Lin P,Chen W,Miranda RN,Konoplev S,Medeiros LJ,Yin CC

更新日期：2012-09-01 00:00:00

abstract：:NLRC3 is a member of the nucleotide-binding domain and leucine-rich repeat (NLR) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, NLRC3 expression correlation with the development and prognosis of hepatocellular carcinoma (HCC) is...

journal_title：Human pathology

authors： Ma YY,Zhang GH,Li J,Wang SB,Hu ZM,Zhang CW,Li E

更新日期：2018-12-01 00:00:00