Abstract：
:We studied the histopathology and clinicopathologic correlates of invasive cavitary pulmonary aspergillosis in 11 immunosuppressed patients with disseminated malignancy. In most patients cavities were produced by separation of necrotic from viable lung, resulting in an intracavitary sequestrum ("lung ball"). Central dissolution of large necrotic areas and suppurative granulomatous aspergillary pneumonia were additional causes of cavities in three patients. In four patients with chronic cavities sequestra had been replaced by intracavitary mycetomas ("fungus balls"). Neutrophils usually were numerous at the interface of the sequestrum and adjacent lung, but were minimally present in three patients with prolonged severe neutropenia. The lack of neutrophils in some patients suggests that factors other than neutrophil-derived proteases may be important in cavity formation. A prominent giant cell reaction was seen in three patients with chronic cavities. Hemoptysis occurred in five patients and massive hemoptysis due to a bronchoarterial fistula caused the death of one patient. The "air-crescent" sign was not observed radiographically in any patient and is therefore considered to be an insensitive marker for lung cavitation in invasive aspergillosis. Persistent intracavitary fungal growth may serve as a reservoir for recurrent fungal invasion in patients with prolonged or repeated episodes of severe neutropenia.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Pai U,Blinkhorn RJ Jr,Tomashefski JF Jrdoi
10.1016/0046-8177(94)90202-xsubject
Has Abstractpub_date
1994-03-01 00:00:00pages
293-303issue
3eissn
0046-8177issn
1532-8392pii
0046-8177(94)90202-Xjournal_volume
25pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.016
更新日期：2012-09-01 00:00:00
abstract：:Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.01.020
更新日期：2013-08-01 00:00:00
abstract：:Basal cells of benign prostate glands are typically p63 positive, whereas malignant glands are usually p63 negative. A rare subset of prostatic adenocarcinoma (PCa) demonstrates aberrant diffuse p63 expression but is negative for high-molecular-weight cytokeratin. Strong p63 staining of the tumor cells can obscure the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.11.011
更新日期：2015-03-01 00:00:00
abstract：:The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.022
更新日期：2007-09-01 00:00:00
abstract：:Loss of the NF1 allele, coding for the protein neurofibromin, and polymorphism in the proto-oncogene RET (RETp) are purportedly common in desmoplastic melanoma (DM). DM is categorized into pure (PDM) and mixed (MDM) subtypes, which differ in prognosis. Most NF1 mutations result in a truncated/absent protein, making im...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.02.012
更新日期：2016-07-01 00:00:00
abstract：:Ewing sarcoma (ES) is an aggressive malignant small round cell tumor that arises in bone or soft tissue of adolescents and young adults. A characteristic molecular finding in ES is EWSR1 gene fusion with ETS (erythroblast transformation-specific) family genes including FLI1 (~90%) and ERG (>5%). Here we report our exp...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.003
更新日期：2013-10-01 00:00:00
abstract：:In this autopsy series of cryptococcal meningoencephalitis (CME), the authors analyzed neuropathologic lesions in 13 human immunodeficiency virus (HIV) and 14 non-HIV-related cases. Most non-HIV patients did not have immunosuppressive predisposing illness. Analysis of pathological findings revealed significant differe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90459-1
更新日期：1996-08-01 00:00:00
abstract：:A recent publication described 5 unusual clear cell renal tumors with prominent smooth muscle stroma that were characterized only by immunostaining. We report 3 additional tumors composed of clear cell renal cell carcinoma intimately admixed with abundant smooth muscle stroma. Epithelial differentiation of the maligna...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.05.021
更新日期：2009-03-01 00:00:00
abstract：:Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.03.005
更新日期：2006-08-01 00:00:00
abstract：:We evaluated 173 consecutive breast carcinomas for c-erbB-2 using a combination of immunohistochemistry (IHC) with a commercial polyclonal antibody (Nitirei) and dual-color fluorescence in situ hybridization (FISH) using the c-erbB-2-specific probe and the chromosome 17 centromere-specific probe from Vysis (Downers Gr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.30185
更新日期：2002-01-01 00:00:00
abstract：:Pilocytic astrocytoma is an infrequently encountered, generally low-grade neoplasm. No study has extensively looked at both cyclin D1 and MIB-1 labeling indices in pilocytic astrocytoma and their relation to clinical outcome. This study retrospectively examines the clinicopathologic features of 48 patients with pilocy...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90023-5
更新日期：1998-12-01 00:00:00
abstract：:Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes. Occas...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1053/hupa.2001.25929
更新日期：2001-06-01 00:00:00
abstract：:Hemangiopericytoma and fibrosarcoma represented at one time two of the most common diagnoses in soft tissue pathology. Both terms are now largely extinct. This article will review the clinicopathologic, immunohistochemical and molecular genetic advances that have led to these changes, and review the pathologic feature...
journal_title：Human pathology
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.humpath.2019.10.001
更新日期：2020-01-01 00:00:00
abstract：:Posttransplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV), and may clinically resemble acute allograft rejection. Three methods to show EBV in tissue were evaluated in 15 liver allograft biopsies from 12 patients including four with PTLD: (1) semiquantitative polymerase chain react...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90074-5
更新日期：1997-05-01 00:00:00
abstract：:Refractile foreign particles within clear vacuoles were observed in capillaries of 17 patients who underwent cardiopulmonary bypass surgery, died, and were autopsied at the George Washington University Hospital from December 1978 through April 1981. The postoperative survival time ranged from less than one day to more...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80243-8
更新日期：1982-12-01 00:00:00
abstract：:Carbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in oral cavity cancer and the corresponding normal tissues. We aimed to assess the prevalence of CA9 expression and its prognostic implications in patients with oral cavity sq...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.10.026
更新日期：2008-09-01 00:00:00
abstract：:The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.033
更新日期：2018-12-01 00:00:00
abstract：:Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(00)80205-1
更新日期：2000-01-01 00:00:00
abstract：:To investigate the roles of matrix metalloproteinases (MMPs) in thymic epithelial tumors, we examined the expression of MMP-2, -7, and -9; membrane-type 1 (MT1)-MMP; and tissue inhibitor of metalloproteinase-2 (TIMP-2) in 57 tumors by immunohistochemistry and in selected 15 cases by in situ hybridization. The tumors c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.07.013
更新日期：2003-12-01 00:00:00
abstract：:We have previously reported that the drs gene has the ability to suppress transformation by v-src and v-K-ras in the rat cell line F2808. We have also shown that the expression of drs mRNA is markedly reduced in a variety of human cancer cell lines, suggesting that down-regulation of drs mRNA is correlated with the de...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00240-5
更新日期：2003-07-01 00:00:00
abstract：:To examine the hypothesis that malpositions of cardiac ventricles could be explained by altered development of the interventricular septum, we studied hearts from the Johns Hopkins Hospital autopsy files with double inlet left ventricle (16 cases) or corrected transposition (nine cases). In double inlet left ventricle...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80125-6
更新日期：1981-03-01 00:00:00
abstract：:A young male with Buerger's disease who had previously required a left leg amputation died in renal failure and sepsis. Postmortem examination revealed an obliterative lesion of the celiac artery, which resulted in hepatic, splenic, and pancreatic infarctions. Celiac artery involvement represents an unusual manifestat...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(79)80080-5
更新日期：1979-01-01 00:00:00
abstract：:Tumor cell adhesion, detachment, and aggregation play an important part in tumor invasion and metastasis, and a variety of cell adhesion molecules have been found on tumor cells. Cell adhesion molecules, including those of the immunoglobulin superfamily, are associated with the development of metastatic behavior in cu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90191-4
更新日期：1995-11-01 00:00:00
abstract：:C- kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been identified in several types of human neoplasms. Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma. However, expression of this molecule has not been adequately studied in ot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.01.011
更新日期：2005-03-01 00:00:00
abstract：:This article describes a case of lymphomatoid granulomatosis without active pulmonary involvement of stigmata of healed granulomatous lesions in the lungs. The patient had ischemic segmental colitis due to mesenteric arterial intimal fibrosis, which we interpreted as spontaneously regressed granulomatous involvement o...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80096-3
更新日期：1978-05-01 00:00:00
abstract：:Lymphangioleiomyomatosis (LAM) is a rare disease which afflicts young women of childbearing age. Recently, it has been listed as an indication for lung transplantation. We describe a case of recurrent LAM in a 31-year-old woman occurring in the allograft of a male donor after single lung transplantation. Nonisotopic i...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90233-1
更新日期：1997-12-01 00:00:00
abstract：:The introduction of chemotherapeutic agents directly into the proper hepatic artery via an indwelling catheter results in perfusion of the gallbladder, because the cystic artery is usually a branch of the right hepatic artery. Five gallbladders, removed two to 16 months after insertion of permanently implanted Infusai...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80275-6
更新日期：1985-10-01 00:00:00
abstract：:Adenoid cystic carcinoma (ACC) is a common salivary gland neoplasm with a lengthy clinical course and often late local recurrences after surgical resection. This is accounted for histologically by its infiltrative capacity and distinct propensity for perineural invasion. The expression of biological markers may help e...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.128249
更新日期：2002-09-01 00:00:00
abstract：:A subset of endometrial polyps recurs after resection. The clinicopathologic significance of the phenomenon is evaluated herein. Consecutive cases of recurrent polyps (index polyp removed by hysteroscopy-directed polypectomy or by curettage; at least one more polyp diagnosed ≤12 months after) were compared with an age...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.03.005
更新日期：2020-06-01 00:00:00
abstract：:We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in a...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2020.02.005
更新日期：2020-04-01 00:00:00
