Abstract:
:A subset of endometrial polyps recurs after resection. The clinicopathologic significance of the phenomenon is evaluated herein. Consecutive cases of recurrent polyps (index polyp removed by hysteroscopy-directed polypectomy or by curettage; at least one more polyp diagnosed ≤12 months after) were compared with an age-matched control group of nonrecurrent polyps regarding 15 clinicopathologic features. A total of 107 (5.6%) of the 1908 polyps diagnosed in a sampling specimen during the study period was a recurrence, and 102 (6.9%) of the 1478 patients who were diagnosed with an endometrial polyp in a sampling specimen had at least 1 recurrence. Eighty-six percent of patients with any recurrences had only one recurrence, with a mean duration between the index polyp and the first recurrence of 4.36 months. On univariate analyses, the recurrent polyps were, compared with controls, significantly larger, had a higher stromal mitotic index, and more frequently displayed prominent thick-walled vessels in most fragments of the polyp. However, on Cox regression multivariate analyses, no single clinicopathologic feature was significantly associated with a recurrence. No malignancies were diagnosed during the follow-up of the study and control group patients at median follow-up durations of 23 and 34 months, respectively. In conclusion, the recurrence of an endometrial polyp is relatively uncommon (5.6% of polyps) and does not portend an increased risk of malignancy. We could not identify any clinicopathologic features that conclusively predict a recurrence.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Ciscato A,Zare SY,Fadare Odoi
10.1016/j.humpath.2020.03.005subject
Has Abstractpub_date
2020-06-01 00:00:00pages
38-44eissn
0046-8177issn
1532-8392pii
S0046-8177(20)30054-Xjournal_volume
100pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofibe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80312-3
更新日期:1984-12-01 00:00:00
abstract::In the past decade most studies of coronary arterial aneurysms have been clinical; few have focused on morphology and etiopathogenesis. The subjects of the present autopsy study were 52 patients, 5 months to 80 years of age, with coronary arterial aneurysms. Patients were divided into two groups: 38 with atherosclerot...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(86)80129-0
更新日期:1986-06-01 00:00:00
abstract::Telomerase, the enzyme that stabilizes telomere length, is reactivated with almost all cancer types, and it may be necessary for unlimited cell proliferation. Assessment of malignancy in ordinary meningiomas is inconclusive because no clear-cut correlation exists between aggressive clinical behavior and histological f...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90029-0
更新日期:1997-04-01 00:00:00
abstract::We report the morphonuclear characteristics of normal (13 cases), benign (ie, chronic) pancreatitis (six cases), and neoplastic (ie, ductal) adenocarcinoma (22 cases) tissues of the pancreas. This description is based on computerized cell image analysis, which permits the determination of parameters related to the mor...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90287-d
更新日期:1992-11-01 00:00:00
abstract::Infantile hemiparesis may be associated with significant morbidity and may have a profound impact on a child's physical and social development. There are little published data evaluating the clinicopathologic features of patients with infantile hemiparesis. The present study retrospectively examines these clinicopatho...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.02.013
更新日期:2004-06-01 00:00:00
abstract::The current World Health Organization classification considers myelodysplastic syndrome with isolated del(5q) a distinct entity owing to its characteristic clinical and pathologic features. Recently, several studies have examined survival, leukemic transformation, and various prognostic factors in these patients. Howe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.05.022
更新日期:2013-03-01 00:00:00
abstract::The synovium in two well-documented cases of alkaptonuric ochronosis was studied by transmission electron and light microscopy. A feature of alkaptonuria previously unreported in the English-language literature was the presence of phagocytosis of large collagen fibrils by synovial macrophages in both cases. The origin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80385-4
更新日期:1987-11-01 00:00:00
abstract::It is currently thought that most clear cell and endometrioid carcinomas arise from ovarian endometriosis. We recently suggested that, besides their origin in the ovary, reduction of CDC42 messenger RNA (a member of the RHO GTPase family) may contribute to explain why clear cell carcinomas are not uncommonly found lim...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.06.020
更新日期:2012-05-01 00:00:00
abstract::The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2009.12.017
更新日期:2010-11-01 00:00:00
abstract::Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90232-4
更新日期:1996-09-01 00:00:00
abstract::We describe a case of simultaneous nodular sclerosing Hodgkin's disease and a granulocytic sarcoma in a cervical lymph node without any previous therapy. The condition evolved into acute myelogenous leukemia approximately 8 months after the initial diagnosis of the granulocytic sarcoma. The unexpected presence of a gr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90293-2
更新日期:1996-10-01 00:00:00
abstract::Pleomorphic adenomas of the breast (PAB) are uncommon tumors. We studied the clinicopathologic features of 10 cases of PAB, seven of which were assessed immunohistochemically. Nine patients were women, with a median age at diagnosis of 65 years. Eight patients presented with a palpable mass; two had a nipple discharge...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(91)90102-u
更新日期:1991-12-01 00:00:00
abstract::Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes. Occas...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1053/hupa.2001.25929
更新日期:2001-06-01 00:00:00
abstract::In metastatic breast cancer (MBC), it can be difficult to establish the origin if the primary tumor is triple negative or if there is a loss of biomarker expression. SOX10 expression has been reported in primary triple-negative breast cancer but is poorly studied in metastatic lesions. In this study, the diagnostic ut...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.11.005
更新日期:2019-03-01 00:00:00
abstract::Carcinoma ex-pleomorphic adenoma (CA ex-PA) is a malignant salivary gland tumor that arises in association with pleomorphic adenoma (PA). Both PA and CA ex-PA have a broad spectrum of histology, and distinction from their histologic mimics may be difficult based on morphology alone. PLAG1 and HMGA2 abnormalities are t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.08.017
更新日期:2015-01-01 00:00:00
abstract::In the normal liver, the transforming growth factor beta (TGF-beta) signaling pathway plays an important role in inhibiting hepatocyte growth. This effect is mediated through Smad4 (or Dpc4), a tumor-suppressor gene that affects gene transcription and controls cell growth. A loss of Smad4 is associated with carcinoma ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.128061
更新日期:2002-09-01 00:00:00
abstract::We introduce a novel hybrid telepathology system providing simultaneous transmission of both real-time microscopy and static imagery at a reasonable cost. It is capable of capturing static, true color images at resolution of 1,520 x 1,144 pixels and providing live transmission of real-time video images of the glass sl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2000.9196
更新日期:2000-07-01 00:00:00
abstract::Studies on melanoma cell lines indicate the expression of actin-binding protein (ABP), a peripheral cytoplasmic protein that crosslinks actin, is important for melanoma cell motility. We used an ABP-specific monoclonal antibody to characterize ABP expression in 18 benign nevi and 28 primary and metastatic malignant me...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(94)90305-0
更新日期:1994-07-01 00:00:00
abstract::Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expressi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.006
更新日期:2013-10-01 00:00:00
abstract::Previously used only as a screening tool, cytology now emerges as a powerful diagnostic technique, especially since the advent of the fine needle aspiration (FNA) biopsy. This article highlights the use of ancillary techniques, primarily electron microscopy (EM), and immunohistochemistry (IHC). When coupled with routi...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(98)90003-x
更新日期:1998-12-01 00:00:00
abstract::Pulmonary vein stenosis (PVS) is a rare disorder. Accurate diagnosis often requires anatomical examination. We report four children with pulmonary vein stenosis. Autopsy showed bilateral lesions in two patients who were thought clinically to have unilateral disease. A diagnosis of PVS was made at autopsy in the third ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90011-x
更新日期:1995-08-01 00:00:00
abstract::Mucoepidermoid carcinoma of the breast is a rare entity with specific morphologic and immunohistochemical features similar to its salivary gland counterpart. In the 28 reported cases to date, there has not been a comparison of the molecular characteristics of this tumor with salivary gland mucoepidermoid carcinomas. H...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2008.11.004
更新日期:2009-06-01 00:00:00
abstract::A recent publication described 5 unusual clear cell renal tumors with prominent smooth muscle stroma that were characterized only by immunostaining. We report 3 additional tumors composed of clear cell renal cell carcinoma intimately admixed with abundant smooth muscle stroma. Epithelial differentiation of the maligna...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.05.021
更新日期:2009-03-01 00:00:00
abstract::Human papillomavirus (HPV) types 16 and 18 are strongly implicated in the generation of progressive cervical neoplasms. The viruses produce complex families of overlapping messenger RNAs that are linked to differentiation, making it necessary to analyze gene expression in the context of morphology. We have developed H...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90232-r
更新日期:1992-02-01 00:00:00
abstract::A 60-year-old man developed a widely metastatic spindle cell neoplasm with admixed osteoclast-like giant cells indistinguishable from malignant giant cell tumor of soft parts. Autopsy revealed a bronchogenic sarcomatoid squamous cell carcinoma that was the primary source of the sarcomatoid metastases. The osteoclast-l...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80181-6
更新日期:1983-11-01 00:00:00
abstract::Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.013
更新日期:2010-10-01 00:00:00
abstract::Wild type p53 plays a crucial role in maintaining genomic stability in both normal and tumor cells in vitro. When DNA damage occurs, p53 acts as a cell cycle checkpoint and induces a cellular response that aims at restoring genomic integrity. p53 may either allow the repair of damaged DNA by inducing a transient G1 ar...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90292-9
更新日期:1995-12-01 00:00:00
abstract::A case of myocardial hyperplasia with numerous mitotic figures, caterpillar nuclei, and an abnormal DNA ploidy pattern is described in an 8-day-old full-term baby with uneventful gestation and sudden death. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90064-a
更新日期:1992-12-01 00:00:00
abstract::Rosette-forming glioneuronal tumors of the fourth ventricle are rare brain tumors, and only 19 such lesions have been previously reported. This report presents the first case of a rosette-forming glioneuronal tumors arising from the spinal cord. A 44-year-old woman presented with a 15-year history of dissociated senso...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.11.010
更新日期:2009-06-01 00:00:00
abstract::Previous studies indicated that microRNA (miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role. To investigate the involvement of miR-675 in gliomas and its underlying mechanisms, we here collected candidate target genes of miR-675-5p from miRTarBase (ht...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.09.006
更新日期:2017-11-01 00:00:00