Abstract:
:A recent publication described 5 unusual clear cell renal tumors with prominent smooth muscle stroma that were characterized only by immunostaining. We report 3 additional tumors composed of clear cell renal cell carcinoma intimately admixed with abundant smooth muscle stroma. Epithelial differentiation of the malignant clear cell components and smooth muscle differentiation of the benign spindle cell stroma was confirmed by the immunostaining profiles and by electron microscopy. Fluorescence in situ hybridization analysis of chromosome 3 showed loss of the entire chromosome in 2 cases and loss of 3p in the third case. We therefore interpret these tumors as unique low-grade variants of clear cell renal cell carcinoma that have induced a prolific metaplastic stromal reaction. Extensive tissue sampling and immunostaining are recommended to distinguish cases with an extensive smooth muscle component from morphologically similar but benign lesions including angiomyolipoma, leiomyoma, or mixed epithelial and stromal tumor of the kidney.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Shannon BA,Cohen RJ,Segal A,Baker EG,Murch ARdoi
10.1016/j.humpath.2008.05.021subject
Has Abstractpub_date
2009-03-01 00:00:00pages
425-9issue
3eissn
0046-8177issn
1532-8392pii
S0046-8177(08)00291-8journal_volume
40pub_type
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