当前位置： SCI文献检索 > HUMAN PATHOLOGY期刊下所有文献 > Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma.

Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma.

Abstract：

:We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required to differentiate primary MM from colonic metastasis of melanoma, including the absence of past history of other primary melanoma, a unique colonic and abdominal lesion with predominant features of in situ lentiginous MM and a very focal and unique invasive area without other digestive tract or abdominal localization. This tumor displayed a KIT exon 11 mutation leading to a unique combination of p.I571M and p.D572G deleterious amino acid changes. Such pattern also favors the diagnosis as KIT appears as a master oncogenic player in MM oncogenesis.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Furudoï A,Caumont C,Dutriaux C,Cappellen D,Goussot JF,Vergier B,Merlio C,Barberis C,Merlio JP,Gros A

doi

10.1016/j.humpath.2015.09.025

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

167-71

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(15)00371-8

journal_volume

48

pub_type

杂志文章

相关文献

HUMAN PATHOLOGY文献大全
  • Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood.

    abstract：:Mucosal addressin cell adhesion molecule 1, expressed on gut endothelial cells, in conjunction with integrin alpha(4)beta(7), expressed on lymphocytes, is critical in lymphocyte homing to the gut. The mucosal addressin cell adhesion molecule 1/integrin alpha(4)beta(7) pathway is involved in the pathogenesis of chronic...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2008.10.014

    authors： Di Sabatino A,Rovedatti L,Rosado MM,Carsetti R,Corazza GR,MacDonald TT

    更新日期：2009-05-01 00:00:00

  • Epithelial-lined (true) cyst of the adrenal gland: a case report.

    abstract：:A case of an epithelial-lined (true) adrenal cyst is reported. Although over 300 adrenal cysts have been reported in the literature, true cysts are rare. In this case, a 4.0 cm cyst lined by cuboidal to flattened cells with bland cytologic features was incidentally found at autopsy. Immunologic studies performed on fo...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(89)90017-8

    authors： Medeiros LJ,Weiss LM,Vickery AL Jr

    更新日期：1989-05-01 00:00:00

  • Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview.

    abstract：:Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime. Prediction of transformation, typically from plexiform neurofibroma, is clinically and histologically challenging. In this overview, aft...

    journal_title：Human pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humpath.2017.05.010

    authors： Miettinen MM,Antonescu CR,Fletcher CDM,Kim A,Lazar AJ,Quezado MM,Reilly KM,Stemmer-Rachamimov A,Stewart DR,Viskochil D,Widemann B,Perry A

    更新日期：2017-09-01 00:00:00

  • The correlation of NLRC3 expression with the progression and prognosis of hepatocellular carcinoma.

    abstract：:NLRC3 is a member of the nucleotide-binding domain and leucine-rich repeat (NLR) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, NLRC3 expression correlation with the development and prognosis of hepatocellular carcinoma (HCC) is...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2018.07.031

    authors： Ma YY,Zhang GH,Li J,Wang SB,Hu ZM,Zhang CW,Li E

    更新日期：2018-12-01 00:00:00

  • Pulmonary endodermal tumor resembling fetal lung: a clinicopathologic study of five cases with immunohistochemical and ultrastructural characterization.

    abstract：:Pulmonary endodermal tumor resembling fetal lung describes an uncommon neoplasm of the lung which also has been referred to as pulmonary blastoma and adenocarcinoma of fetal lung type. We describe five cases which fall within a narrow band on the spectrum of pulmonary neoplasms with both epithelial and mesenchymal fea...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(90)90145-u

    authors： Nakatani Y,Dickersin GR,Mark EJ

    更新日期：1990-11-01 00:00:00

  • "Hey! Whatever happened to hemangiopericytoma and fibrosarcoma?" An update on selected conceptual advances in soft tissue pathology which have occurred over the past 50 years.

    abstract：:Hemangiopericytoma and fibrosarcoma represented at one time two of the most common diagnoses in soft tissue pathology. Both terms are now largely extinct. This article will review the clinicopathologic, immunohistochemical and molecular genetic advances that have led to these changes, and review the pathologic feature...

    journal_title：Human pathology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.humpath.2019.10.001

    authors： Folpe AL

    更新日期：2020-01-01 00:00:00

  • A prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2, based on simple clinical parameters.

    abstract：:This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2016.09.012

    authors： Koeneman MM,van Lint FHM,van Kuijk SMJ,Smits LJM,Kooreman LFS,Kruitwagen RFPM,Kruse AJ

    更新日期：2017-01-01 00:00:00

  • Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability.

    abstract：:Histone methyltransferase (HMT), which catalyzes a histone methylation, is frequently altered in cancers at mutation and expression levels. The aims of this study were to explore whether SETD1B, SETDB2, and SETD2, SET domain-containing HMT genes, are mutated and expressionally altered in gastric (GC) and colorectal ca...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2014.04.013

    authors： Choi YJ,Oh HR,Choi MR,Gwak M,An CH,Chung YJ,Yoo NJ,Lee SH

    更新日期：2014-08-01 00:00:00

  • Recurrent hepatitis B, hepatitis C, and combined hepatitis B and C in liver allografts: a comparative pathological study.

    abstract：:Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(00)80205-1

    authors： Khettry U,Anand N,Gordon FD,Jenkins RL,Tahan SR,Loda M,Lewis WD

    更新日期：2000-01-01 00:00:00

  • Infiltrating cribriform carcinoma of the breast: a distinctive clinicopathologic entity.

    abstract：:All cases of primary breast carcinoma seen at the George Washington University Medical Center between 1971 and 1975 and between 1981 and 1986 were reviewed, and examples of pure and mixed infiltrating cribriform carcinoma (ICC) were identified. The relative frequency of ICC did not change significantly from the earlie...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(90)90235-w

    authors： Venable JG,Schwartz AM,Silverberg SG

    更新日期：1990-03-01 00:00:00

  • Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features.

    abstract：:Most human papillomavirus-associated squamous intraepithelial lesions of the uterine cervix are flat; some have papillary architecture that shows a spectrum of differentiation from low-grade squamous intraepithelial lesions to high-grade squamous intraepithelial lesions. For this subset of lesions, there are few data ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2009.05.015

    authors： Liang CW,Lin MC,Hsiao CH,Lin YT,Kuo KT

    更新日期：2010-03-01 00:00:00

  • Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis.

    abstract：:Twenty-one cases were selected from 236 thyroidectomies with a diagnosis of Hashimoto's disease for detailed clinicopathologic study on the basis of "early" changes in three cases and an unusually heavy lymphoplasmacytic infiltrate in 18 cases. These cases were studied in conjunction with ten cases of high-grade non-H...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(88)80287-9

    authors： Hyjek E,Isaacson PG

    更新日期：1988-11-01 00:00:00

  • Co-occurrence of neuroblastoma and nephroblastoma in an infant with Fanconi's anemia.

    abstract：:We report the clinical, histologic, and genetic findings of concurrent neuroblastoma and nephroblastoma in an infant with Fanconi's anemia (FA). Both tumors had characteristic chromosomal aberrations. In particular, the neuroblastoma showed a gain of chromosome 17q, considered an important factor for prognosis. But un...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/hupa.2002.128062

    authors： Bissig H,Staehelin F,Tolnay M,Avoledo P,Richter J,Betts D,Bruder E,Kühne T

    更新日期：2002-10-01 00:00:00

  • Male breast cancer: a case of apocrine carcinoma with psammoma bodies.

    abstract：:A case of apocrine carcinoma of the breast with psammoma bodies is described in a 69 year old man. The report emphasizes the rarity of this lesion and supports currently held beliefs about the formation of psammoma bodies. ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(81)80178-5

    authors： Bryant J

    更新日期：1981-08-01 00:00:00

  • Intratumoral c-Met expression is associated with vascular endothelial growth factor C expression, lymphangiogenesis, and lymph node metastasis in oral squamous cell carcinoma: implications for use as a prognostic marker.

    abstract：:Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lympha...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2010.03.012

    authors： Zhao D,Wang SH,Feng Y,Hua CG,Zhao J,Tang XF

    更新日期：2011-10-01 00:00:00

  • Aging changes in the human aortic valve in relation to dystrophic calcification.

    abstract：:To elucidate the pathogenesis of aging changes and their relation to age associated calcification, a morphological study of 27 human aortic valves was carried out. Nine valves were obtained from immediate autopsies and 18 valves from routine autopsies done within four hours after death. Calcium deposition was present ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(76)80005-6

    authors： Kim KM,Valigorsky JM,Mergner WJ,Jones RT,Pendergrass RF,Trump BF

    更新日期：1976-01-01 00:00:00

  • Fibrosis is worse in HIV-HCV patients with low-level immunodepression referred for HCV treatment than in HCV-matched patients.

    abstract：:Hepatitis C virus (HCV) infection is frequent in human immunodeficiency virus (HIV)-infected patients. It is known to have an aggressive course in significantly immunosuppressed patients, and cirrhosis C has become one of the main causes of mortality in HIV-HCV coinfected patients since the improvement of antiretrovir...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2004.05.009

    authors： Rullier A,Trimoulet P,Neau D,Bernard PH,Foucher J,Lacoste D,Winnock M,Urbaniak R,Ballardini G,Balabaud C,Bioulac-Sage P,Le Bail B

    更新日期：2004-09-01 00:00:00

  • Diagnostic contribution of left ventricular endomyocardial biopsy in patients with clinical phenotype of hypertrophic cardiomyopathy.

    abstract：:Hypertrophic cardiomyopathy phenotype is shared by heterogeneous entities. The purpose of the study was to evaluate the diagnostic role of left ventricular endomyocardial biopsy. One hundred fifty-one consecutive patients with unexplained left ventricular hypertrophy and normal/elevated QRS voltages or left bundle-bra...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2012.04.023

    authors： Frustaci A,Russo MA,Chimenti C

    更新日期：2013-01-01 00:00:00

  • Estrogen receptor expression in giant cell tumors of the bone.

    abstract：:Giant cell tumors (GCTs) of the bone are primary skeletal neoplasms that behave intermediately between a true benign and an overtly malignant neoplasm. For two decades, controversial reports have found estrogen receptor (ER) expression in isolated cells or small numbers of samples from these tumors. In this report, we...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/hupa.2002.31476

    authors： Olivera P,Perez E,Ortega A,Terual R,Gomes C,Moreno LF,Dueñas A,De La Garza J,Melendez-Zajgla J,Maldonado V

    更新日期：2002-02-01 00:00:00

  • Destruction of canals of Hering in primary biliary cirrhosis.

    abstract：:The canals of Hering (CoH), converging from the hepatic lobule onto the portal tract, connect bile canaliculi to the interlobular bile ducts, and represent the most proximal portion of the bile drainage pathway with a cholangiocyte lining. In this study we sought to ascertain whether this proximal pathway is involved ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/hupa.2002.128060

    authors： Saxena R,Hytiroglou P,Thung SN,Theise ND

    更新日期：2002-10-01 00:00:00

  • Spindle cell squamous carcinoma of the esophagus: analysis of ploidy and tumor proliferative activity in a series of 13 cases.

    abstract：:Spindle cell squamous esophageal carcinomas are distinctive polypoid "biphasic" tumors in which the sarcoma-like phenotype usually predominates over the epithelial component. To biologically assess both phenotypes, we compared the tumoral proliferative activity and DNA ploidy between the two histological components of...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(98)90458-0

    authors： Lauwers GY,Grant LD,Scott GV,Carr NJ,Sobin LH

    更新日期：1998-08-01 00:00:00

  • PhD graduate training programs in pathology: 2003 report from the American Society for Investigative Pathology workshop on pathology graduate education.

    abstract：:Graduate training is one of the most important activities in which we engage. Through PhD training programs in pathology, we continually renew the intellectual vigor of our discipline and assure its position as a vibrant force in the life sciences. To focus on this important issue, the Education Committee of the Ameri...

    journal_title：Human pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humpath.2004.03.014

    authors： Kemp JD,Bowser R,American Society for Investigative Pathology workshop.

    更新日期：2004-07-01 00:00:00

  • Multifocal benign chondroblastomas: report of a case.

    abstract：:Benign chondroblastoma is an unusual solitary bone tumor occurring usually in the second decade in a long bone. The tumor is often sited on epiphyseal cartilages. Very few examples of malignant variants have been documented, although local recurrence of benign tumors is not unusual. We wish to report a patient who dev...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(80)80014-1

    authors： Roberts PF,Taylor JG

    更新日期：1980-05-01 00:00:00

  • Expression of vascular endothelial growth factor, placental growth factor, and their receptors Flt-1 and KDR in human placenta under pathologic conditions.

    abstract：:The vascular endothelial growth factor (VEGF) family and its receptors have multifunctional activities besides angiogenesis, and some of these molecules are induced by hypoxia/ischemia. They are known to be expressed in human placenta, but little is known about their involvement in pathologic conditions. We have inves...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/hupa.2002.129420

    authors： Kumazaki K,Nakayama M,Suehara N,Wada Y

    更新日期：2002-11-01 00:00:00

  • Increased angiogenesis in papillary thyroid carcinoma but lack of prognostic importance.

    abstract：:Angiogenesis is important for tumor growth and progress, and the intratumor density of microvessels is a significant prognostic factor in many tumor types. The role in thyroid cancer has not been well studied, and we therefore examined a series of 128 papillary carcinomas with respect to microvessel density (MVD) and ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/1-ip.2000.6548

    authors： Akslen LA,Livolsi VA

    更新日期：2000-04-01 00:00:00

  • Overexpression of clusterin in human hepatocellular carcinoma.

    abstract：:Clusterin has been reported to play a significant role in tumorigenesis, and its overexpression occurs in various human malignancies. We examine the clusterin overexpression in human hepatocellular carcinoma (HCC) and verify its clinical usefulness as a candidate biomarker by clinicopathologic and survival analysis. W...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2004.07.021

    authors： Kang YK,Hong SW,Lee H,Kim WH

    更新日期：2004-11-01 00:00:00

  • Two case reports of childhood liver cell adenomas harboring beta-catenin abnormalities.

    abstract：:The benign epithelial neoplasm liver cell adenoma is rare, especially in childhood. We report 2 such cases, 1 of which was associated with Prader-Willi syndrome. Differential diagnosis of the liver cell adenomas on the basis of histopathologic findings proved difficult and was based on the absence of cellular and nucl...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/hupa.2002.125771

    authors： Takayasu H,Motoi T,Kanamori Y,Kitano Y,Nakanishi H,Tange T,Nakagawara A,Hashizume K

    更新日期：2002-08-01 00:00:00

  • Applications of electron microscopy to diagnostic pulmonary pathology.

    abstract：:Viruses and other possible causative agents should be sought light and electron microscopically in all cases of ill-defined diseases including "sarcoid." Ideally, tissue should be prepared for electron microscopic examination as soon as a specimen is obtained; however, when this has not been done, tissue preserved in ...

    journal_title：Human pathology

    pub_type： 杂志文章,评审

    doi：10.1016/s0046-8177(83)80164-6

    authors： Wang NS

    更新日期：1983-10-01 00:00:00

  • The relationship between the extent of surgical margin positivity and prostate specific antigen recurrence in radical prostatectomy specimens.

    abstract：:The presence of positive surgical margins is a negative prognostic indicator in patients undergoing prostatectomy for prostate cancer; whether the extent of the positive margins affects the clinical outcome with regards to prostate-specific antigen (PSA) recurrence remains uncertain. We evaluated the linear extent of ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2007.01.006

    authors： Marks RA,Koch MO,Lopez-Beltran A,Montironi R,Juliar BE,Cheng L

    更新日期：2007-08-01 00:00:00

  • CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.

    abstract：:CpG island methylator phenotype (CIMP) pathway in colorectal cancer is characterized by methylation of promoter regions of multiple putative tumor suppressor genes. Aberrant methylation also occurs in serrated and adenomatous polyps. We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS m...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2007.06.002

    authors： Kakar S,Deng G,Cun L,Sahai V,Kim YS

    更新日期：2008-01-01 00:00:00