Hepatoid adenocarcinoma of the stomach: histogenesis and progression in association with intestinal phenotype.

abstract：:The aim of the study was to evaluate the impact of the updated 2018 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline on human epidermal growth factor receptor 2 (HER2) interpretation in breast cancer compared with that of the previous guidelines and also the significance of...

journal_title：Human pathology

authors： Woo JW,Lee K,Chung YR,Jang MH,Ahn S,Park SY

更新日期：2020-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is an angiogenic factor that plays important roles in tumor growth. Angiogenesis studies on VEGF deal with various types of malignant tumors, but very little is known about the role or significance of VEGF in human thyroid neo...

journal_title：Human pathology

authors： Katoh R,Miyagi E,Kawaoi A,Hemmi A,Komiyama A,Oyama T,Shibuya M

更新日期：1999-08-01 00:00:00

abstract：:Anti-tumor necrosis factor α (anti-TNF-α) therapy can result in endoscopic healing, reduction of symptoms, and reduced need for surgery and hospitalization in many patients with Crohn's disease (CD). Earlier data suggested that anti-TNF-α therapy may be associated with fibrosis and stricturing. We sought to determine ...

journal_title：Human pathology

authors： Schaeffer DF,Walsh JC,Kirsch R,Waterman M,Silverberg MS,Riddell RH

更新日期：2014-09-01 00:00:00

abstract：:A study of so-called gelatinous transformation of the bone marrow in 14 patients is presented. The condition is characterized by the presence of extracellular "gelatinous" material, fat atrophy, and associated focal marrow hypoplasia and is often mistaken as representing edema, necrosis, or amyloid. Histochemical stud...

journal_title：Human pathology

authors： Seaman JP,Kjeldsberg CR,Linker A

更新日期：1978-11-01 00:00:00

abstract：:A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparen...

journal_title：Human pathology

authors： Pecorella I,Ciardi A,Amadeo G,Baiocchini A,Marasco A,Di Tondo U

更新日期：2000-12-01 00:00:00

abstract：:Demonstration of identical allelic loss on chromosome 11q13 in synchronous in situ (DCIS) and invasive ductal (IDC) breast carcinoma has provided molecular evidence of the progression of DCIS to IDC. We investigated loss of heterozygosity (LOH) at chromosome 11q13 in the spectrum of "marker/premalignant" and "malignan...

journal_title：Human pathology

authors： Nayar R,Zhuang Z,Merino MJ,Silverberg SG

更新日期：1997-03-01 00:00:00

abstract：:To elucidate the putative role of human papillomavirus (HPV) infection in the etiology of esophageal cancer, 121 formalin-fixed, paraffin-embedded specimens originating from a non-high-incidence area for this carcinoma, from Slovenia, were screened for HPV infection using eight different polymerase chain reactions (PC...

journal_title：Human pathology

authors： Poljak M,Cerar A,Seme K

更新日期：1998-03-01 00:00:00

abstract：:Complete age-related regression of mammary epithelium, often termed postmenopausal involution, is associated with decreased breast cancer risk. However, most studies have qualitatively assessed involution. We quantitatively analyzed epithelium, stroma, and adipose tissue from histologically normal breast tissue of 454...

journal_title：Human pathology

authors： Sandhu R,Chollet-Hinton L,Kirk EL,Midkiff B,Troester MA

更新日期：2016-02-01 00:00:00

abstract：:Tubular carcinoma of the breast is a well-differentiated variant of invasive ductal carcinoma and has been shown to have an exceptionally favorable prognosis, as manifested by a low incidence of lymph node metastases and an excellent overall survival. It is unknown whether this subtype represents an early step along t...

journal_title：Human pathology

authors： Waldman FM,Hwang ES,Etzell J,Eng C,DeVries S,Bennington J,Thor A

更新日期：2001-02-01 00:00:00

abstract：:Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes. Occas...

journal_title：Human pathology

authors： Matias-Guiu X,Catasus L,Bussaglia E,Lagarda H,Garcia A,Pons C,Muñoz J,Argüelles R,Machin P,Prat J

更新日期：2001-06-01 00:00:00

abstract：:Recent evidence has invoked immunohistochemical expression of p63 in Merkel cell carcinoma as an adverse prognostic factor. Conflicting data led us to evaluate this. An Eastern Canadian cohort diagnosed between 1990 and 2012 was studied. Demographic and clinical data were obtained from pathology records and Provincial...

journal_title：Human pathology

authors： Fleming KE,Ly TY,Pasternak S,Godlewski M,Doucette S,Walsh NM

更新日期：2014-05-01 00:00:00

abstract：:Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interacti...

journal_title：Human pathology

authors： Tsang JY,Mendoza P,Putti TC,Karim RZ,Scolyer RA,Lee CS,Pang AL,Tse GM

更新日期：2012-12-01 00:00:00

abstract：:Acute rejection is an extremely common complication of lung transplantation. (1) To appreciate the interobserver variation in the interpretation of histologic findings and (2) to assess the efficacy of transbronchial biopsy (TBB) for acute rejection diagnosis and associated diseases, particularly infection, we perform...

journal_title：Human pathology

authors： Colombat M,Groussard O,Lautrette A,Thabut G,Marrash-Chahla R,Brugière O,Mal H,Lesèche G,Fournier M,Degott C

更新日期：2005-04-01 00:00:00

abstract：:Langerhans' cell histiocytosis (LCH) is a proliferative histiocytic disorder of unknown etiology. We previously reported that Epstein-Barr virus (EBV) infects and proliferates in macrophages, and investigated the possibility that EBV exhibits etiologic effects in LCH. To detect EBV expression, paraffin sections from 1...

journal_title：Human pathology

authors： Shimakage M,Sasagawa T,Kimura M,Shimakage T,Seto S,Kodama K,Sakamoto H

更新日期：2004-07-01 00:00:00

abstract：:Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of p...

journal_title：Human pathology

authors： Karnik T,Ozawa MG,Lefterova M,Luna-Fineman S,Alvarez E,Link M,Zehnder JL,Arber DA,Ohgami RS

更新日期：2015-04-01 00:00:00

abstract：:Recent studies have indicated that some cases of fulminant hepatitis that were ostensibly type B were actually acute viral hepatitis, types B and delta, or persistent hepatitis, type B with superimposed acute delta infection. Histologic characterization of the various types has not yet been undertaken. Within ten to 3...

journal_title：Human pathology

authors： Govindarajan S,de Cock KM,Peters RL

更新日期：1985-03-01 00:00:00

abstract：:Although rare, synovial sarcoma (SS) is one of the most common soft tissue sarcomas affecting young adults. To investigate potential tumor markers related to synovial sarcoma prognosis, we carried out a single-institution retrospective analysis of 103 patients diagnosed with SS between 1980 and 2009. Clinical outcome ...

journal_title：Human pathology

authors： Charbonneau B,Vogel RI,Manivel JC,Rizzardi A,Schmechel SC,Ognjanovic S,Subramanian S,Largaespada D,Weigel B

更新日期：2013-09-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a group of granulomatous disorders in which abnormal Langerhans cells proliferate as either a localized lesion in a single bone or disseminated disease involving two or more organs or systems. Because the different LCH forms exhibit significantly elevated levels of inflammatory m...

journal_title：Human pathology

authors： Murakami I,Matsushita M,Iwasaki T,Kuwamoto S,Kato M,Horie Y,Hayashi K,Imamura T,Morimoto A,Imashuku S,Gogusev J,Jaubert F,Takata K,Oka T,Yoshino T

更新日期：2014-01-01 00:00:00

abstract：:The mucin profile of 24 endoscopic biopsies of heterotopic gastric mucosa (HGM) of the upper esophagus in adults and a control group of ten cases of Meckel's diverticula containing heterotopic gastric mucosa were studied with two combined histochemical methods: alcian blue pH 2.5/PAS and high iron diamine/alcian blue ...

journal_title：Human pathology

authors： Bogomoletz WV,Geboes K,Feydy P,Nasca S,Ectors N,Rigaud C

更新日期：1988-11-01 00:00:00

abstract：:We aimed to study the expression of phosphorylated vascular endothelial growth factor receptor 2 (pVEGFR-2), a membrane-bound tyrosine kinase receptor to vascular endothelial growth factor, in 76 cases of leukemia and nonneoplastic myeloproliferative disease and in 8 reactive bone marrows. The microvessel density (MVD...

journal_title：Human pathology

authors： Zhang Y,Pillai G,Gatter K,Blázquez C,Turley H,Pezzella F,Watt SM

更新日期：2005-07-01 00:00:00

abstract：:SMARCA4-deficient thoracic sarcoma is a recently proposed new entity of soft tissue sarcomas with an undifferentiated round cell morphology that is diagnostically challenging. Here we report a case of this tumor where the diagnosis was established using limited samples and resources. A woman in her early 30s developed...

journal_title：Human pathology

authors： Kuwamoto S,Matsushita M,Takeda K,Tanaka N,Endo Y,Yamasaki A,Kohashi K,Oda Y,Horie Y

更新日期：2017-12-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) exon 18-21 mutations were shown to be highly predictive of response to gefitinib (Iressa) therapy in lung cancer. Studies on Western and Japanese lung cancers have indicated substantial differences in the EGFR mutation frequency between these populations. To investigate the prev...

journal_title：Human pathology

authors： Al-Kuraya K,Siraj AK,Bavi P,Al-Jommah N,Ezzat A,Sheikh S,Amr S,Al-Dayel F,Simon R,Guido S

更新日期：2006-04-01 00:00:00

abstract：:High bone marrow mast cell counts before and after marrow transplantation have been reported to predict graft rejection in aplastic anemia. We tested this association by studying marrow specimens from 73 consecutive patients allografted for severe aplastic anemia, 21 of whom rejected. Mast cell counts per unit area we...

journal_title：Human pathology

authors： Sale GE,Marmont P

更新日期：1981-07-01 00:00:00

abstract：:A case of an epithelial-lined (true) adrenal cyst is reported. Although over 300 adrenal cysts have been reported in the literature, true cysts are rare. In this case, a 4.0 cm cyst lined by cuboidal to flattened cells with bland cytologic features was incidentally found at autopsy. Immunologic studies performed on fo...

journal_title：Human pathology

authors： Medeiros LJ,Weiss LM,Vickery AL Jr

更新日期：1989-05-01 00:00:00

abstract：:Esophageal and colorectal adenocarcinomas overexpress Fas ligand (FasL), which can protect them from immune surveillance. The aim of this work was to determine whether FasL expression, and therefore FasL-dependent immune evasion, occurs early during malignant transformation in Barrett's metaplasia (BM) of the esophagu...

journal_title：Human pathology

authors： Younes M,Schwartz MR,Finnie D,Younes A

更新日期：1999-11-01 00:00:00

abstract：:We introduce a novel hybrid telepathology system providing simultaneous transmission of both real-time microscopy and static imagery at a reasonable cost. It is capable of capturing static, true color images at resolution of 1,520 x 1,144 pixels and providing live transmission of real-time video images of the glass sl...

journal_title：Human pathology

authors： Zhou J,Hogarth MA,Walters RF,Green R,Nesbitt TS

更新日期：2000-07-01 00:00:00

abstract：:The spectrum of neuroendocrine (NE) tumors in the genitourinary tract ranges from the aggressive large and small cell carcinomas to the often benign paraganglioma and well-differentiated neuroendocrine tumor (WD-NET). At least 15 pure lower urinary tract (LUT) WD-NETs have been described. Owing to the rarity of WD-NET...

journal_title：Human pathology

authors： Rodriguez Pena MDC,Salles DC,Epstein JI,Canete-Portillo S,Tregnago AC,Ramirez J,Meliti A,Netto GJ

更新日期：2020-12-08 00:00:00

abstract：:Fluorescence in situ hybridization, loss of heterozygosity testing, and comparative genomic hybridization have been used to detect NF2 gene alterations in both sporadic and neurofibromatosis type 2 (NF2)-associated central nervous system tumors. In this study, we performed chromogenic in situ hybridization (CISH) and ...

journal_title：Human pathology

authors： Begnami MD,Palau M,Rushing EJ,Santi M,Quezado M

更新日期：2007-09-01 00:00:00

abstract：:Human papilloma virus (HPV) has emerged as the key etiologic driver in the majority of cancers at head and neck mucosal sites. First described in the uterine cervix and subsequently in oropharyngeal squamous cell carcinomas, the morphologic and clinical spectrum of HPV-related neoplasia has continued to expand and now...

journal_title：Human pathology

authors： Devins KM,Tetzlaff MT,Baloch Z,LiVolsi VA

更新日期：2019-12-01 00:00:00

abstract：:CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization...

journal_title：Human pathology

authors： Ohmori S,Shiraki K,Sugimoto K,Sakai T,Fujikawa K,Wagayama H,Takase K,Nakano T

更新日期：2001-12-01 00:00:00