Abstract:
:Epidermal growth factor receptor (EGFR) exon 18-21 mutations were shown to be highly predictive of response to gefitinib (Iressa) therapy in lung cancer. Studies on Western and Japanese lung cancers have indicated substantial differences in the EGFR mutation frequency between these populations. To investigate the prevalence of EGFR in another distinct ethnic group, EGFR alterations were studied in 47 consecutive non small cell lung cancers from Saudi Arabia by immunohistochemistry, fluorescence in situ hybridization, and DNA sequencing. Detectable EGFR expression was seen in 69.8% of 43 interpretable cancers. Epidermal growth factor receptor amplification, present in 15.3% of 39 analyzable cancers, was strongly associated with high levels of EGFR expression (P = .0047). Only 1 exon 18-21 mutation was seen among 34 lung cancers that could be successfully sequenced. It is concluded that EGFR exon 18-21 mutations are rare in Middle East patients with lung cancer and occur in a similar range as in Western patients. The remarkable high rate of EGFR gene amplifications could potentially facilitate studies on the predictive role of gene copy number changes for response to anti-EGFR therapies in Middle East patient sets.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Al-Kuraya K,Siraj AK,Bavi P,Al-Jommah N,Ezzat A,Sheikh S,Amr S,Al-Dayel F,Simon R,Guido Sdoi
10.1016/j.humpath.2005.12.004subject
Has Abstractpub_date
2006-04-01 00:00:00pages
453-7issue
4eissn
0046-8177issn
1532-8392pii
S0046-8177(05)00709-4journal_volume
37pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial-mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor buddin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.06.012
更新日期:2018-10-01 00:00:00
abstract::Twelve cases of pure adenoid cystic carcinoma of the breast were reviewed. Patients ranged in age from 34 to 69 years. Seven carcinomas were in the right breast, and five in the left; five of the 12 were located in the central region of the breast, five in the upper outer quadrant, and the two in the upper inner and l...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(87)80413-6
更新日期:1987-12-01 00:00:00
abstract::CDX2 is a sensitive and specific marker of intestinal differentiation. It is routinely used in surgical pathology, as its expression within a tumor favors an origin within the gastrointestinal tract. We had anecdotally encountered occasional hepatocellular carcinomas (HCCs) that were CDX2 positive. CDX2 expression in ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.12.029
更新日期:2017-06-01 00:00:00
abstract::An immunohistochemical survey of X-linked inhibitor of apoptosis (XIAP) expression in mammary carcinoma was performed. XIAP, the most potent of the inhibitor of apoptosis family of caspase inhibitors, has been linked to tumor aggressiveness and therapeutic resistance in several malignancies and is considered an attrac...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.016
更新日期:2007-06-01 00:00:00
abstract::Monoclonal antibodies to somatostatin receptors 2A (SSTR2A, UMB-1) and 5 (SSTR5, UMB-4) were reported to be highly reliable for immunohistochemical detection of these receptors in neuroendocrine neoplasms. However, the standardization of either the immunohistochemical procedure and the methods of evaluation has yet to...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.11.008
更新日期:2018-02-01 00:00:00
abstract::Paracoccidioidomycosis is a systemic mycosis with a geographic distribution that is limited to Central and South America; Brazil has the highest number of cases. Severe disseminated disease caused by paracoccidioidomycosis was observed in acquired immunodeficiency syndrome patients who live or have resided in endemic ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.03.007
更新日期:2010-09-01 00:00:00
abstract::Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90448-8
更新日期:1998-08-01 00:00:00
abstract::Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90104-0
更新日期:1997-02-01 00:00:00
abstract::A case of recurrent Hodgkin's disease of the "sarcomatoid" or "syncytial variant" type was seen that occurred as an extension from the mediastinum to a previously uninvolved extranodal site (breast) and pericardium after treatment of classical nodular sclerosing Hodgkin's disease based in the lymph nodes. This histolo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(87)80247-2
更新日期:1987-07-01 00:00:00
abstract::Refractile foreign particles within clear vacuoles were observed in capillaries of 17 patients who underwent cardiopulmonary bypass surgery, died, and were autopsied at the George Washington University Hospital from December 1978 through April 1981. The postoperative survival time ranged from less than one day to more...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80243-8
更新日期:1982-12-01 00:00:00
abstract::A case of mucin-positive giant cell carcinoma of the pancreas is presented. Clear cells were a prominent feature of the primary tumor and constituted the majority of the metastatic deposits, a finding not usually associated with pancreatic carcinoma. Results of ultrastructural and histochemical studies are presented, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80099-3
更新日期:1982-11-01 00:00:00
abstract::Merkel cell polyomavirus is of oncogenic significance in approximately 80% of Merkel cell carcinomas. Morphological subcategories of the tumor differ in regard to viral status, the rare combined type being uniformly virus negative and the predominant pure type being mainly virus positive. Indications that different bi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.05.008
更新日期:2015-09-01 00:00:00
abstract::Twenty-six women with multiple human papillomavirus (HPV)-related lesions of the lower genital tract were investigated by immunohistochemistry for the internal genus-specific capsid antigen of HPV and by DNA-DNA in situ hybridization with 35S-radiolabeled probes for sequences of HPV-6/11, HPV-16, and HPV-18. The vulva...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90175-5
更新日期:1989-02-01 00:00:00
abstract::Malignant mixed tumors of the parotid gland are rare. Metastasizing lesions are even more rare. To the best of our knowledge, this is the first case reported in the English literature in which the scalp nodule was the primary manifestation of the malignant nature of the parotid tumor. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(77)80100-7
更新日期:1977-11-01 00:00:00
abstract::Histopathologic diagnosis of adrenocortical tumors is based on adverse features that indicate malignant potential. Proliferation index has served as a supplemental tool in assessing the malignant potential of adrenocortical tumors. None of the current histologic classification systems can sufficiently accurately predi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.015
更新日期:2015-03-01 00:00:00
abstract::Geotrichum candidum was identified as an invasive organism in the terminal ileum of a man with "hairy cell" leukemia. The organism was identified on the basis of histologic and cultural characteristics. The diagnostic features of G. candidum infection are compared to those of Aspergillus and Candida species. ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80055-x
更新日期:1981-07-01 00:00:00
abstract::Lipomatous lesions of the heart involving the atria and interatrial septum are not well known. Most such lesions do not become clinically significant; however, intractable arrhythmias, blood flow obstruction, and valvular disruption may result from extensive fatty infiltration of the atrial wall or from the mass effec...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.028
更新日期:2006-10-01 00:00:00
abstract::Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(96)90232-4
更新日期:1996-09-01 00:00:00
abstract::The natural history of pediatric nonalcoholic steatohepatitis is still unknown; however, there are differences between adult and pediatric presentation. Apoptosis may play an important role in pathophysiologic pathways involved in liver damage and progression. Our aim was to detect early apoptosis markers, activated c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.04.022
更新日期:2008-12-01 00:00:00
abstract::In 2012, the lower anogenital squamous terminology (LAST) project introduced new nomenclature for human papillomavirus-related squamous lesions of the lower genital tract: low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL). Biomarker p16(INK4a) immunohistochemistry (IHC) was also recommended to a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2016.04.010
更新日期:2016-09-01 00:00:00
abstract::Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy,...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.04.018
更新日期:2017-07-01 00:00:00
abstract::In 1821 Napoleon died in exile on the Island of St. Helena. Although the autopsy had suggested stomach cancer as the cause of death, in 1961 an elevated arsenic concentration was found in Napoleon's hair. This finding elicited numerous theories of conspiracy, treachery, and poisoning. Most recent reports even suggeste...
journal_title:Human pathology
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.humpath.2005.02.001
更新日期:2005-04-01 00:00:00
abstract::An unusual case of multiple myeloma in an 88-year-old patient is described. Besides skeletal involvement, there was myeloma of the thoracic and abdominal lymph nodes and of the liver and pancreas. In the pancreas, the myeloma extensively involved the head and body, and on computerized tomography scan was suggestive of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(82)80057-9
更新日期:1982-10-01 00:00:00
abstract::Ewing sarcoma (ES) is an aggressive malignant small round cell tumor that arises in bone or soft tissue of adolescents and young adults. A characteristic molecular finding in ES is EWSR1 gene fusion with ETS (erythroblast transformation-specific) family genes including FLI1 (~90%) and ERG (>5%). Here we report our exp...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.03.003
更新日期:2013-10-01 00:00:00
abstract::Women with breast cancer have an increased risk of developing primary ovarian tumors. Because a differential diagnosis between primary and metastatic tumors may be difficult in poorly differentiated ovarian neoplasms, breast carcinoma markers may be helpful in establishing the primary site of origin. Gross cystic dise...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(91)90084-3
更新日期:1991-04-01 00:00:00
abstract::In a review of pediatric autopsies from 1951 to 1985, we identified 40 cases in which pancreatitis was diagnosed pathologically. Twenty-six of these patients were under 4 years of age, and the male-to-female ratio was 1.5. Six groups of patients were identified: 10 with hepatobiliary disease, including 9 with biliary ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(88)80530-6
更新日期:1988-03-01 00:00:00
abstract::Myopericytoma is a rare, histologically distinctive tumor that shows evidence of differentiation toward perivascular myoid cells. Myopericytoma is largely considered a neoplasm of skin and soft tissues, with examples of this lesion involving visceral sites being extremely limited. We present the clinical and pathologi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2010.02.014
更新日期:2010-10-01 00:00:00
abstract::Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.016
更新日期:2012-09-01 00:00:00
abstract::Basal cell carcinoma (also referred to as adenoid cystic carcinoma) is a rare tumor of the prostate. Although largely characterized as indolent, poor outcomes have been reported in a considerable fraction of cases. As yet, optimum treatment strategies for this cancer have not been developed. This study investigates pr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.02.004
更新日期:2015-06-01 00:00:00
abstract::Mixed epithelial and stromal tumor of the kidney is a recently recognized neoplasm that occurs almost exclusively in perimenopausal women. Because it frequently contains areas of smooth muscle in which epithelial structures are embedded, some have concluded that it is the adult form of congenital mesoblastic nephroma....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.24323
更新日期:2001-05-01 00:00:00