Abstract：
:Basal cell carcinoma (also referred to as adenoid cystic carcinoma) is a rare tumor of the prostate. Although largely characterized as indolent, poor outcomes have been reported in a considerable fraction of cases. As yet, optimum treatment strategies for this cancer have not been developed. This study investigates protein expression of common or potential molecular therapeutic targets and reports on the clinicopathological features of 9 new cases. We evaluated the expression of ERBB2, KIT, androgen receptor, PTEN, EGFR, ERG, and p53 via immunohistochemistry. We also examined EGFR amplification and TMPRSS2-ERG gene rearrangement by fluorescence in situ hybridization. The mean clinical follow-up was 44 months. We found that basal cell carcinoma behaved aggressively with almost one-half of the cases displaying high-risk pathologic features or local recurrence (44%). One patient died as a result of metastatic disease. The most consistent abnormalities included a loss of PTEN expression (56% of cases) and EGFR overexpression (67% of cases). EGFR overexpression occurred in the absence of gene amplification. The TMPRSS2-ERG rearrangement was not detected in any of the tumors studied, nor was ERG protein positivity identified by immunostaining. In addition, ERBB2, KIT, p53, and androgen receptor expressions were either absent or showed only weak, limited reactivity. Our results suggest that there is a high morbidity associated with this tumor, and more intense follow-up and additional treatment may be indicated. Furthermore, targeted therapies directed against the EGFR and PTEN proteins or their constitutive pathways may be promising for future clinical management.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Simper NB,Jones CL,MacLennan GT,Montironi R,Williamson SR,Osunkoya AO,Wang M,Zhang S,Grignon DJ,Eble JN,Tran T,Wang L,Baldrige LA,Cheng Ldoi
10.1016/j.humpath.2015.02.004subject
Has Abstractpub_date
2015-06-01 00:00:00pages
805-12issue
6eissn
0046-8177issn
1532-8392pii
S0046-8177(15)00068-4journal_volume
46pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Although mast cell proliferation in the bone marrow frequently occurs in systemic mastocytosis and is often associated with radiographically detectable bone lesions, the pathologic correlates of the skeletal abnormalities are poorly characterized. We therefore examined three nondecalcified transiliac crest biopsy spec...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80084-6
更新日期：1981-09-01 00:00:00
abstract：:The presence of positive surgical margins is a negative prognostic indicator in patients undergoing prostatectomy for prostate cancer; whether the extent of the positive margins affects the clinical outcome with regards to prostate-specific antigen (PSA) recurrence remains uncertain. We evaluated the linear extent of ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.006
更新日期：2007-08-01 00:00:00
abstract：:In order to study the granular transformation of Sertoli cells the following testicular specimens were reviewed: 58 postmortem biopsies from 21 children and 37 young adult males with normal histologic pattern; 165 biopsies from prepubertal cryptorchid testes; 38 biopsies and 18 surgical specimens from postpubertal-cry...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90034-m
更新日期：1991-02-01 00:00:00
abstract：:Hydrophilic polymers are commonly applied as surface coatings on vascular devices and have been shown to dissociate during endovascular use, causing hydrophilic polymer embolism (HPE). Adverse effects related to this phenomenon have been recognized and reported. The prevalence of this complication is unknown. We condu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.09.011
更新日期：2015-02-01 00:00:00
abstract：:C- kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been identified in several types of human neoplasms. Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma. However, expression of this molecule has not been adequately studied in ot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.01.011
更新日期：2005-03-01 00:00:00
abstract：:Five hundred consecutive breast carcinomas from the first screening round of the Breast Cancer Detection Demonstration Project were studied quantitatively and semiquantitatively for features relevant to the diagnosis of tubular carcinoma. Tubularity was defined as the proportion of tumor cells that were adjacent to an...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hp.2000.6699
更新日期：2000-05-01 00:00:00
abstract：:This study assessed squamous cell papillomas of the human esophagus for the presence of human papillomavirus (HPV) and correlated the results with histological features. Twenty-three lesions obtained by endoscopic biopsy from 17 patients were studied, first by in situ hybridization (ISH) for HPV types 6-11, 16-18, 18,...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(94)90128-7
更新日期：1994-05-01 00:00:00
abstract：:Mucin core proteins (MUCs) are expressed in tissue-specific patterns in the gastrointestinal tract and expression is deregulated in Barrett's metaplasia. Based on differential expression, MUCs have been used to classify adenocarcinomas into distinct phenotypes (eg, intestinal, gastric, pancreaticobiliary, etc). Becaus...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.10.020
更新日期：2014-03-01 00:00:00
abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2015.06.013
更新日期：2015-09-01 00:00:00
abstract：:Cytochrome P-450 specific for steroid 17 alpha-hydroxylation (P-45017 alpha) was immunolocalized in normal and hyperfunctioning adrenal glands of pigs, bovines, and humans, using a specific IgG fraction raised against the enzyme. P-45017 alpha was present in the zona fasciculata (ZF) and zona reticularis (ZR), but not...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90174-3
更新日期：1989-02-01 00:00:00
abstract：:There is limited published data regarding the significance of the number or position of nucleoli and the presence of apoptotic bodies in diagnostically challenging cases of adenocarcinoma of the prostate on needle biopsy material. One hundred consecutive prostate cancers on needle biopsy were sent because of diagnosti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.09.001
更新日期：2005-11-01 00:00:00
abstract：:Hypertrophic cardiomyopathy phenotype is shared by heterogeneous entities. The purpose of the study was to evaluate the diagnostic role of left ventricular endomyocardial biopsy. One hundred fifty-one consecutive patients with unexplained left ventricular hypertrophy and normal/elevated QRS voltages or left bundle-bra...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.04.023
更新日期：2013-01-01 00:00:00
abstract：:Most failures of bioprosthetic heart valves in children are due to stenosis secondary to thrombus, calcific deposits, or tissue ingrowth. Valve failures due to regurgitation typically involve cuspal detachment, tears, or perforations. We present four cases of prosthetic valve regurgitation in children caused by cuspal...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80341-1
更新日期：1988-02-01 00:00:00
abstract：:Human papilloma virus (HPV) has emerged as the key etiologic driver in the majority of cancers at head and neck mucosal sites. First described in the uterine cervix and subsequently in oropharyngeal squamous cell carcinomas, the morphologic and clinical spectrum of HPV-related neoplasia has continued to expand and now...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2019.09.001
更新日期：2019-12-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.08.004
更新日期：2008-03-01 00:00:00
abstract：:Two cases of lymphadenopathy resulting from a lymph node foreign body reaction to silicone are presented. In each case lymph node biopsy was performed because of the clinical suspicion of neoplastic disease. Histologic study in both cases revealed no evidence of malignant disease, but rather demonstrated multinucleate...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(80)80005-0
更新日期：1980-05-01 00:00:00
abstract：:A case of a tail in a 2-week-old infant is reported, and findings from a review of 33 previously reported cases of true tails and pseudotails are summarized. The true, or persistent, vestigial tail of humans arises from the most distal remnant of the embryonic tail. It contains adipose and connective tissue, central b...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80079-9
更新日期：1984-05-01 00:00:00
abstract：:Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(89)90249-9
更新日期：1989-06-01 00:00:00
abstract：:Fetal vessels in the placentas of 11 of 15 infants with cerebral palsy contained thrombi. An alternate basis for the injury was identified in the four placentas without thrombi. Autopsy findings in one infant who died at age 1 month confirmed the presence of cerebral thrombi and infarcts. It is concluded that thrombot...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90114-3
更新日期：1997-02-01 00:00:00
abstract：:The histologic classification of pulmonary neoplasms can have important implications regarding appropriate management of patients. Although the histologic classification of lung tumors is predominantly based on morphology, ancillary studies such as immunohistochemistry can be used in difficult cases, and the diagnosis...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.9076
更新日期：2000-08-01 00:00:00
abstract：:Renal cell carcinoma (RCC) with sarcomatoid changes and rhabdoid features has shown poor outcomes. Several immune checkpoint inhibitors including programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors have been approved for the treatment of RCC. Combination therapy using PD-1/PD-L1 and ind...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.04.003
更新日期：2020-07-01 00:00:00
abstract：:GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The cop...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.11.014
更新日期：2010-07-01 00:00:00
abstract：:Metallothionein is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. Metallothionein has been shown to regulate apoptosis and proliferation. Overexpression of metallothionein frequently occurs in human tumors and is related to prognosis as well as therapy response. However, me...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.01.026
更新日期：2009-12-01 00:00:00
abstract：:Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. The clonal and genetic relationship between each component has not been investigated b...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.05.022
更新日期：2016-10-01 00:00:00
abstract：:Literature on BRCA1-associated protein 1 (BAP1) expression status in well-differentiated papillary mesothelioma (WDPM) is limited. In the present study, we examined the prevalence of BAP1 loss in WDPM by immunohistochemistry with clinical correlation, along with CDKN2A deletion status by fluorescence in situ hybridiza...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.05.001
更新日期：2018-09-01 00:00:00
abstract：:A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ-light chains (LCs) were revealed by se...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.10.008
更新日期：2015-01-01 00:00:00
abstract：:Human papillomavirus-related oropharyngeal squamous cell carcinoma has a unique biology and improved prognosis. A new focus is to identify prognostic biomarkers specifically in this human papillomavirus-positive cohort. We analyzed cyclin D1 immunostaining on a tissue microarray of patients with known clinical follow-...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.01.021
更新日期：2013-08-01 00:00:00
abstract：:Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs). We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.012
更新日期：2006-06-01 00:00:00
abstract：:Twelve cases of bizarre parosteal osteochondromatous proliferation (BPOP), also known as Nora's lesion, are reported. Ten lesions were located in the small bones of the hands, and 2 were located in long bones (femur and proximal tibia). Patient age ranged from 12 to 63 years (average, 30.3 years). Radiography of the l...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.130103
更新日期：2002-12-01 00:00:00
abstract：:Germ cell tumors arising within the central nervous system are rare neoplasms that typically occur along midline structures in children and young adults. Although isochromosome 12p is established as a frequent chromosomal abnormality in testicular germ cell tumors, studies examining isochromosome 12p in primary centra...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.07.017
更新日期：2010-02-01 00:00:00
