Abstract：
:A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ-light chains (LCs) were revealed by serum protein immunoelectrophoresis. Bone marrow aspiration with karyotype analysis and skeletal radiologic survey were normal. Kidney biopsy revealed a peculiar pattern of proximal tubular cells with hypertrophy and clarification initially diagnosed as an osmotic nephrosis. Immunofluorescence study, including immunoglobulin LCs conjugates was normal. Immunoelectron microscopy finally revealed a crystalline LC proximal tubulopathy κ. Our case presents some peculiarities: the absence of hematologic malignancy sign and the young patient's age. The silicone breast implants have been reported to be involved in the generation of monoclonal gammopathy.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Figueres ML,Beaume J,Vuiblet V,Rabant M,Bassilios N,Herody M,Touchard G,Noël LHdoi
10.1016/j.humpath.2014.10.008subject
Has Abstractpub_date
2015-01-01 00:00:00pages
165-8issue
1eissn
0046-8177issn
1532-8392pii
S0046-8177(14)00415-8journal_volume
46pub_type
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