当前位置： SCI文献检索 > HUMAN PATHOLOGY期刊下所有文献 > Metallothionein overexpression and its prognostic relevance in intrahepatic cholangiocarcinoma and extrahepatic hilar cholangiocarcinoma (Klatskin tumors).

Metallothionein overexpression and its prognostic relevance in intrahepatic cholangiocarcinoma and extrahepatic hilar cholangiocarcinoma (Klatskin tumors).

Abstract：

:Metallothionein is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. Metallothionein has been shown to regulate apoptosis and proliferation. Overexpression of metallothionein frequently occurs in human tumors and is related to prognosis as well as therapy response. However, metallothionein expression and its clinical relevance in cholangiocarcinoma have not been investigated. The present study aimed to analyze metallothionein over-expression and its possible prognostic impact in intrahepatic cholangiocarcinoma and hilar extrahepatic cholangiocarcinoma (Klatskin tumors). We investigated the relationship of immunohistochemically demonstrated metallothionein expression with various clinicopathological parameters in a series of 56 intrahepatic and 56 extrahepatic cholangiocarcinoma. In noncancerous bile duct epithelia metallothionein was only occasionally weakly expressed; strong metallothionein overexpression (>50% metallothionein -positive tumor cells) was noted in 7 (12.5%) of 56 intrahepatic cholangiocarcinoma and 14 (25%) of 56 Klatskin tumors, which was associated with poor clinical outcome in univariate Kaplan-Meier testing in both intrahepatic cholangiocarcinoma (P = .002) and Klatskin tumors (P = .034). Moreover, strong metallothionein expression was identified as an independent prognostic parameter in multivariate Cox regression analysis in both intrahepatic cholangiocarcinoma (P = .005) and Klatskin tumors (P = .035). In contrast, cholangiocarcinoma with a papillary phenotype (8/112; 7.1%) exhibited a significant lack of strong metallothionein expression in all 8 of 8 cases. Strong metallothionein expression is identified as an independent poor prognostic parameter, and determination of the metallothionein expression may serve as an additional tool for the therapeutic management of patients with cholangiocarcinoma. In comparison, lack of metallothionein expression seems to be associated with cholangiocarcinoma with a papillary phenotype, which is generally recognized to have a better prognosis.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Schmitz KJ,Lang H,Kaiser G,Wohlschlaeger J,Sotiropoulos GC,Baba HA,Jasani B,Schmid KW

doi

10.1016/j.humpath.2009.01.026

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1706-14

issue

12

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(09)00166-X

journal_volume

40

pub_type

杂志文章

相关文献

HUMAN PATHOLOGY文献大全
  • Amyloid deposits in lymph nodes: a morphologic and immunohistochemical study.

    abstract：:In a series of approximately 80,000 lymph nodes, amyloid deposition was found in 18; 12 of those nodes were selected, on the basis of availability of specimens, for investigation by immunohistochemical typing to identify the protein of origin and by correlation with morphologic criteria and clinical information. Four ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(86)80568-8

    authors： Newland JR,Linke RP,Lennert K

    更新日期：1986-12-01 00:00:00

  • Differential expression of EphA7 receptor tyrosine kinase in gastric carcinoma.

    abstract：:Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2007.01.030

    authors： Wang J,Li G,Ma H,Bao Y,Wang X,Zhou H,Sheng Z,Sugimura H,Jin J,Zhou X

    更新日期：2007-11-01 00:00:00

  • Ontogeny of epidermal growth factor receptor and lipocortin-1 in fetal and neonatal human lungs.

    abstract：:The ontogeny and distribution of the epidermal growth factor (EGF) receptor and lipocortin-1, a major cellular substrate of the EGF receptor, were evaluated in a developmental series of fetal and neonatal human lungs (8 to 41 weeks' gestation and stillborn to 16 days' postnatal age). The peroxidase anti-peroxidase tec...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(90)90127-q

    authors： Johnson MD,Gray ME,Carpenter G,Pepinsky RB,Stahlman MT

    更新日期：1990-02-01 00:00:00

  • Novel histopathologic findings in a surviving case of hemolytic uremic syndrome after bone marrow transplantation.

    abstract：:We report novel renal histopathologic features in a patient with hemolytic uremic syndrome after allogeneic bone marrow transplantation who survived with plasma exchange therapy. This distribution of vascular lesions within the kidney differed from previously described cases, which were uniformly fatal, in that there ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(89)90210-4

    authors： Arends MJ,Harrison DJ

    更新日期：1989-01-01 00:00:00

  • Expression of mTORC1/2-related proteins in primary and brain metastatic lung adenocarcinoma.

    abstract：:Brain metastases (BMs) are common complications of adenocarcinomas (ADCs) of the lung and are associated with a poor prognosis. Although an increasing amount of data indicates that dysregulated activity of mammalian target of rapamycin (mTOR) can influence the metastatic potential of various tumors, the role of mTOR c...

    journal_title：Human pathology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.humpath.2016.12.012

    authors： Krencz I,Sebestyén A,Fábián K,Márk Á,Moldvay J,Khoor A,Kopper L,Pápay J

    更新日期：2017-04-01 00:00:00

  • Detection of hepatitis delta virus RNA by a nonradioactive in situ hybridization procedure.

    abstract：:A digoxigenin-tailed, synthetic oligodeoxynucleotide was used to detect genomic hepatitis delta virus (HDV) RNA in formalin-fixed, paraffin-embedded liver sections by a nonisotopic in situ hybridization (NISH) procedure. Twenty-three liver samples from chronically HDV-infected patients were studied. Eight liver specim...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(92)90133-n

    authors： Pacchioni D,Negro F,Chiaberge E,Rizzetto M,Bonino F,Bussolati G

    更新日期：1992-05-01 00:00:00

  • Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features.

    abstract：:Papillary renal cell carcinoma (PRCC), a morphologically and genetically distinct subtype of RCC, is morphologically separated into 2 subtypes, type 1 and 2, for prognostic purposes. Type 1 PRCC (single layer of small cells, scant pale cytoplasm) is more common and has a favorable prognosis compared with type 2 (pseud...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2007.05.016

    authors： Kunju LP,Wojno K,Wolf JS Jr,Cheng L,Shah RB

    更新日期：2008-01-01 00:00:00

  • Cerebral palsy and thrombi in placental vessels of the fetus: insights from litigation.

    abstract：:Fetal vessels in the placentas of 11 of 15 infants with cerebral palsy contained thrombi. An alternate basis for the injury was identified in the four placentas without thrombi. Autopsy findings in one infant who died at age 1 month confirmed the presence of cerebral thrombi and infarcts. It is concluded that thrombot...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(97)90114-3

    authors： Kraus FT

    更新日期：1997-02-01 00:00:00

  • Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy.

    abstract：:ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2007.10.009

    authors： Larbcharoensub N,Leopairat J,Sirachainan E,Narkwong L,Bhongmakapat T,Rasmeepaisarn K,Janvilisri T

    更新日期：2008-06-01 00:00:00

  • Pleomorphic adenoma of the breast: a clinicopathologic and immunohistochemical study of 10 cases.

    abstract：:Pleomorphic adenomas of the breast (PAB) are uncommon tumors. We studied the clinicopathologic features of 10 cases of PAB, seven of which were assessed immunohistochemically. Nine patients were women, with a median age at diagnosis of 65 years. Eight patients presented with a palpable mass; two had a nipple discharge...

    journal_title：Human pathology

    pub_type： 杂志文章,评审

    doi：10.1016/0046-8177(91)90102-u

    authors： Diaz NM,McDivitt RW,Wick MR

    更新日期：1991-12-01 00:00:00

  • Semiquantitative assessment of cytomorphologic features can predict mutation status of thyroid nodules with indeterminate cytologic diagnosis.

    abstract：:Molecular diagnostics increasingly direct the management of thyroid nodules with an indeterminate cytologic diagnosis. This study was undertaken to correlate cytomorphologic features with the molecular profiles in an effort to identify features predictive of molecular aberrations. One hundred eighty-nine thyroid nodul...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2019.08.010

    authors： Shahi M,Bloechl SJ,Vogel RI,Shrestha R,Krigman HR,Evasovich M,Burmeister LA,Amin K

    更新日期：2019-11-01 00:00:00

  • EGFR and KRAS mutations in metastatic lung adenocarcinomas.

    abstract：:In primary lung adenocarcinoma, EGFR and KRAS mutations are found in approximately 10% to 20% and 20% to 30%, respectively. Few studies have investigated these mutations in metastases. Patients with EGFR mutations have a 70% to 80% response rate to tyrosine-kinase inhibitors therapy and a longer progression-free survi...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2010.12.011

    authors： Munfus-McCray D,Harada S,Adams C,Askin F,Clark D,Gabrielson E,Li QK

    更新日期：2011-10-01 00:00:00

  • Flow cytometric DNA analysis of carcinoid tumors of the ileum and appendix.

    abstract：:Although all carcinoid tumors are considered potentially malignant, the biologic behaviors of appendiceal and ileal carcinoids are distinctly different. Appendiceal carcinoids often behave in a benign fashion, whereas ileal carcinoids pursue an aggressive course with frequent metastasis. Whether differences in DNA plo...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(92)90052-5

    authors： Goolsby CL,Punyarit P,Mehl PJ,Rao MS

    更新日期：1992-12-01 00:00:00

  • The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma.

    abstract：:The objective of this study was to compare the expression of the nerve growth factor (NGF) receptors TrkA and p75 in ovarian borderline tumors, International Federation of Gynecology and Obstetrics (FIGO) stage I carcinomas and advanced-stage (FIGO stage III-IV) carcinomas, and to assess a possible association between...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2006.06.027

    authors： Ødegaard E,Staff AC,Abeler VM,Kopolovic J,Onsrud M,Lazarovici P,Davidson B

    更新日期：2007-01-01 00:00:00

  • A subset of small cell lung cancer with low neuroendocrine expression and good prognosis: a comparison study of surgical and inoperable cases with biopsy.

    abstract：:Patients with small cell lung carcinoma (SCLC) rarely demonstrate long-term survival. We previously reported that gene expression profiling identified a subset of SCLC with good prognosis in surgical cases. To find an easier way to routinely identify SCLC belonging to this subset, we conducted the present study with a...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2014.01.001

    authors： Hamanaka W,Motoi N,Ishikawa S,Ushijima M,Inamura K,Hatano S,Uehara H,Okumura S,Nakagawa K,Nishio M,Horai T,Aburatani H,Matsuura M,Iwasaki A,Ishikawa Y

    更新日期：2014-05-01 00:00:00

  • Two cases of concomitant acquired aplastic anemia and systemic mastocytosis.

    abstract：:Reactive bone marrow mast cells reliably lack the morphologic, immunophenotypic, and molecular features of systemic mastocytosis (SM). We report two unusual cases of acquired aplastic anemia (AA) in which multifocal aggregates of bone marrow mast cells fulfilled morphologic and immunophenotypic criteria for SM accordi...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2013.08.002

    authors： Golardi N,Sramek JE,Myers JB,Saffer H,George TI,Czuchlewski DR

    更新日期：2014-02-01 00:00:00

  • Immunohistochemical characteristics of renomedullary interstitial cell tumor: a study of 41 tumors with emphasis on differential diagnosis of mesenchymal neoplasms.

    abstract：:Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2018.07.010

    authors： Lu Z,Al-Obaidy K,Cheng L,Perry KD,Grignon DJ,Williamson SR

    更新日期：2018-12-01 00:00:00

  • Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR.

    abstract：:Basal cell carcinoma (also referred to as adenoid cystic carcinoma) is a rare tumor of the prostate. Although largely characterized as indolent, poor outcomes have been reported in a considerable fraction of cases. As yet, optimum treatment strategies for this cancer have not been developed. This study investigates pr...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2015.02.004

    authors： Simper NB,Jones CL,MacLennan GT,Montironi R,Williamson SR,Osunkoya AO,Wang M,Zhang S,Grignon DJ,Eble JN,Tran T,Wang L,Baldrige LA,Cheng L

    更新日期：2015-06-01 00:00:00

  • Immunohistochemistry of human cutaneous sarcoidosis: a study of nine cases.

    abstract：:Biopsy specimens of sarcoid skin lesions from nine patients with sarcoidosis were examined for the presence of immunoglobulins, complement (C3 and C4), and fibrinogen. Granulomas in all skin lesions were positive only for fibrinogen. The literature relating to the immunohistochemistry of sarcoidosis is reviewed and it...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(78)80132-4

    authors： Kataria YP,Zafranas A,Sharma HM

    更新日期：1978-09-01 00:00:00

  • Comparison between the location and the histomorphological/immunohistochemical characteristics of noninvasive neoplasms of the ampulla of Vater.

    abstract：:To determine useful factors when selecting an appropriate procedure for noninvasive ampullary neoplasia, we investigated the relationship between the location and the histomorphological/immunohistochemical characteristics of 56 noninvasive ampullary neoplasms obtained by endoscopic papillectomy (EP). All subjects were...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2014.05.013

    authors： Yamamoto Y,Nemoto T,Okubo Y,Nihonyanagi Y,Ishiwatari T,Takuma K,Tochigi N,Okano N,Wakayama M,Igarashi Y,Shibuya K

    更新日期：2014-09-01 00:00:00

  • Respiratory obstruction caused by a multicentric granular cell tumor of the laryngotracheobronchial tree.

    abstract：:An unusual case of acute respiratory obstruction caused by multicentric granular cell tumors of the laryngotracheobronchial tree is presented. The patient also had granular cell tumors in the tongue, vulva, and chest wall. Multiplicity of the lesions in the left lung and recurrent episodes of intercurrent pulmonary in...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(81)80132-3

    authors： Majmudar B,Thomas J,Gorelkin L,Symbas PN

    更新日期：1981-03-01 00:00:00

  • CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases.

    abstract：:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a B-cell neoplasm that is typically CD5 negative. We describe the clinicopathologic, immunophenotypic, and cytogenetic features of 14 cases of CD5+ MALT lymphoma. There were 9 men and 5 women (median age, 68 years; range, 34-87 y...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2011.11.004

    authors： Jaso J,Chen L,Li S,Lin P,Chen W,Miranda RN,Konoplev S,Medeiros LJ,Yin CC

    更新日期：2012-09-01 00:00:00

  • New observations on the etiology of aortic valve disease: a surgical pathologic study of 236 cases from 1990.

    abstract：:Among 236 aortic valves surgically excised at the Mayo Clinic in 1990 (mean patient age, 66 years; age range, 10 to 92 years), 154 (65%) were stenotic, 58 (25%) were insufficient, and 24 (10%) were both stenotic and insufficient. Pure stenosis was related to calcification, and causes included degenerative (51%), bicus...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(93)90267-k

    authors： Dare AJ,Veinot JP,Edwards WD,Tazelaar HD,Schaff HV

    更新日期：1993-12-01 00:00:00

  • Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma.

    abstract：:The immunohistochemical expression of cell adhesion molecules in colorectal serrated adenocarcinoma is still unknown. The immunostaining patterns of β-catenin, E-cadherin, P-cadherin, laminin 5γ2, and SMAD4 and their relationship to survival were studied in different tumor areas, namely, tumor center and invasive fron...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2011.08.020

    authors： García-Solano J,Conesa-Zamora P,Trujillo-Santos J,Torres-Moreno D,Mäkinen MJ,Pérez-Guillermo M

    更新日期：2012-07-01 00:00:00

  • Gain of hTERC: a genetic marker of malignancy in oral potentially malignant lesions.

    abstract：:Oral squamous cell carcinoma (OSCC) is the most common oral cancer, and major efforts is being made to identify molecular markers capable to differentiate oral potentially malignant lesions (OPMLs) with indolent course from lesions with aggressive behavior. We undertook a study to evaluate if gain of the human telomer...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2015.05.013

    authors： Dorji T,Monti V,Fellegara G,Gabba S,Grazioli V,Repetti E,Marcialis C,Peluso S,Di Ruzza D,Neri F,Foschini MP

    更新日期：2015-09-01 00:00:00

  • Relation of neurological marker expression and EWS gene fusion types in MIC2/CD99-positive tumors of the Ewing family.

    abstract：:The Ewing family of tumors (EFT) is characterized by high MIC2/CD99 expression and specific EWS/ETS gene rearrangements, resulting in different chimeric transcripts. Further division into peripheral primitive neuroectodermal tumors and Ewing's sarcoma is still debated and, in the absence of distinct morphological para...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/s0046-8177(99)90223-x

    authors： Amann G,Zoubek A,Salzer-Kuntschik M,Windhager R,Kovar H

    更新日期：1999-09-01 00:00:00

  • Co-regulatory potential of vascular endothelial growth factor-A and vascular endothelial growth factor-C in thyroid carcinoma.

    abstract：:Vascular endothelial growth factor (VEGF) promotes growth of blood or lymphatic vessels. The aim of the current study is to identify relationships between VEGF-A and VEGF-C, and their impact in angiogenesis and metastases in thyroid cancers. VEGF-A and VEGF-C mRNA and protein expression was investigated in 136 thyroid...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2013.04.014

    authors： Salajegheh A,Pakneshan S,Rahman A,Dolan-Evans E,Zhang S,Kwong E,Gopalan V,Lo CY,Smith RA,Lam AK

    更新日期：2013-10-01 00:00:00

  • Virtual microscopy: an evaluation of its validity and diagnostic performance in routine histologic diagnosis of skin tumors.

    abstract：:Digitization of histologic slides is associated with many advantages, and its use in routine diagnosis holds great promise. Nevertheless, few articles evaluate virtual microscopy in routine settings. This study is an evaluation of the validity and diagnostic performance of virtual microscopy in routine histologic diag...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/j.humpath.2010.05.015

    authors： Nielsen PS,Lindebjerg J,Rasmussen J,Starklint H,Waldstrøm M,Nielsen B

    更新日期：2010-12-01 00:00:00

  • Proliferative activity of renal cell carcinoma associated with acquired cystic disease of the kidney: comparison with typical renal cell carcinoma.

    abstract：:To assess the proliferative activity of renal cell carcinoma (RCC-A) in patients with acquired cystic disease of the kidney (ACDK) after long-term hemodialysis, we analyzed cell cycle, DNA ploidy, and S-phase fraction by flow cytometry (FCM) and proliferating cell nuclear antigen (PCNA) labeling index by immunohistoch...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1053/hupa.2002.30188

    authors： Ikeda R,Tanaka T,Moriyama MT,Kawamura K,Miyazawa K,Suzuki K

    更新日期：2002-02-01 00:00:00

  • Epithelial-lined (true) cyst of the adrenal gland: a case report.

    abstract：:A case of an epithelial-lined (true) adrenal cyst is reported. Although over 300 adrenal cysts have been reported in the literature, true cysts are rare. In this case, a 4.0 cm cyst lined by cuboidal to flattened cells with bland cytologic features was incidentally found at autopsy. Immunologic studies performed on fo...

    journal_title：Human pathology

    pub_type： 杂志文章

    doi：10.1016/0046-8177(89)90017-8

    authors： Medeiros LJ,Weiss LM,Vickery AL Jr

    更新日期：1989-05-01 00:00:00