Abstract:
:Fetal vessels in the placentas of 11 of 15 infants with cerebral palsy contained thrombi. An alternate basis for the injury was identified in the four placentas without thrombi. Autopsy findings in one infant who died at age 1 month confirmed the presence of cerebral thrombi and infarcts. It is concluded that thrombotic events in utero may explain the pathogenesis of many instances of cerebral palsy and that identification of a coagulopathy in parents could potentially identify those at risk and provide a basis for preventive treatment during pregnancy.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kraus FTdoi
10.1016/s0046-8177(97)90114-3subject
Has Abstractpub_date
1997-02-01 00:00:00pages
246-8issue
2eissn
0046-8177issn
1532-8392pii
S0046-8177(97)90114-3journal_volume
28pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofibe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80312-3
更新日期:1984-12-01 00:00:00
abstract::Mucosal addressin cell adhesion molecule 1, expressed on gut endothelial cells, in conjunction with integrin alpha(4)beta(7), expressed on lymphocytes, is critical in lymphocyte homing to the gut. The mucosal addressin cell adhesion molecule 1/integrin alpha(4)beta(7) pathway is involved in the pathogenesis of chronic...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.10.014
更新日期:2009-05-01 00:00:00
abstract::Recently, we reported 2 mixed endometrioid endometrial carcinomas with a "low-grade serous"-like component, which does not fit into any of the 4 molecular groups described by The Cancer Genome Atlas. To understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these 2 ca...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2017.10.016
更新日期:2018-01-01 00:00:00
abstract::A case of a tail in a 2-week-old infant is reported, and findings from a review of 33 previously reported cases of true tails and pseudotails are summarized. The true, or persistent, vestigial tail of humans arises from the most distal remnant of the embryonic tail. It contains adipose and connective tissue, central b...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80079-9
更新日期:1984-05-01 00:00:00
abstract::Secretory carcinoma (SC) of the salivary gland is a low-grade malignancy associated with a well-defined clinical, histologic, immunohistochemical, and cytogenetic signature. Although the t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion is well documented, advances in molecular profiling in saliv...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.08.011
更新日期:2019-01-01 00:00:00
abstract::Literature on BRCA1-associated protein 1 (BAP1) expression status in well-differentiated papillary mesothelioma (WDPM) is limited. In the present study, we examined the prevalence of BAP1 loss in WDPM by immunohistochemistry with clinical correlation, along with CDKN2A deletion status by fluorescence in situ hybridiza...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.05.001
更新日期:2018-09-01 00:00:00
abstract::Decreases in true expenses in the hospital clinical laboratory consequent to reduced utilization were estimated from four models. Each category of direct expense was adjusted according to projections and confirmed to the extent possible by actual experience. No projections of reductions in indirect expenses were made....
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80002-7
更新日期:1984-06-01 00:00:00
abstract::Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80205-1
更新日期:2000-01-01 00:00:00
abstract::Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a variant of anaplastic large cell lymphoma arising within seroma effusion associated with breast implants. BI-ALCL is a rare disease, recently recognized as a new provisional entity by the 2017 revised World Health Organization classification. All ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.05.007
更新日期:2019-08-01 00:00:00
abstract::Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.02.017
更新日期:2014-07-01 00:00:00
abstract::α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are speci...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.04.025
更新日期:2013-10-01 00:00:00
abstract::We have previously reported that MUC2 apomucin was highly expressed in noninvasive tumors of the pancreas (intraductal papillary tumor [IdPT]) and liver (bile duct cystadenocarcinoma [BdCC]), which show more favorable outcomes than invasive carcinomas. In contrast, MUC2 was rarely expressed in invasive carcinomas of t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90134-9
更新日期:1997-03-01 00:00:00
abstract::We treated 36 women with laparoscopically proven endometriosis with danazol 600 mg/d (n = 17) or gestrinone 5.0 mg/wk (n = 19) for 6 months. Endometrial samples were obtained before and at 3 and 6 months of treatment and were studied by light, scanning, and transmission electron microscopy. At 3 months of treatment, t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(92)90011-q
更新日期:1992-01-01 00:00:00
abstract::Small-sized lung adenocarcinomas often contain a lepidic growth component in part. The term lepidic growth has recently been used to represent a growth pattern of neoplastic cells along preexisting alveolar structures. We reviewed 91 small-sized (≤3 cm) invasive lung adenocarcinomas with a lepidic component to study t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.02.008
更新日期:2013-09-01 00:00:00
abstract::Gastrointestinal stromal tumors are a group of mesenchymal tumors arising from the wall of the gastrointestinal tract that are characterized by activating mutations in KIT or PDGFRA. Their proper recognition is important clinically because of their potential responsiveness to targeted therapies. We report a case of du...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.09.017
更新日期:2009-04-01 00:00:00
abstract::The control of colorectal cancer is currently dependent on early detection, and its prevention requires the recognition and treatment of its precursor lesions. The adenoma has been established as the precursor of colorectal carcinoma in the general population. Among patients with inflammatory bowel disease (IBD), dysp...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(94)90032-9
更新日期:1994-11-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is an angiogenic factor that plays important roles in tumor growth. Angiogenesis studies on VEGF deal with various types of malignant tumors, but very little is known about the role or significance of VEGF in human thyroid neo...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90241-1
更新日期:1999-08-01 00:00:00
abstract::We investigated whether histological chorioamnionitis (HCA) is a risk factor predisposing to leukemoid reaction (LR) and whether LR is associated with the preterm parturition syndrome and the systemic fetal inflammation response syndrome. A prospective histological study on placentas was performed in preterm infants (...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2005.09.017
更新日期:2006-01-01 00:00:00
abstract::Previous studies have proven that the lepidic component of lung adenocarcinoma is an independent prognostic factor and has a favorable effect on patient prognosis; however, no studies have reported the specific distribution of the lepidic component in lung cancer. In this study, we focused mainly on whether the lepidi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2018.04.039
更新日期:2019-01-01 00:00:00
abstract::Pulmonary vein stenosis (PVS) is a rare disorder. Accurate diagnosis often requires anatomical examination. We report four children with pulmonary vein stenosis. Autopsy showed bilateral lesions in two patients who were thought clinically to have unilateral disease. A diagnosis of PVS was made at autopsy in the third ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90011-x
更新日期:1995-08-01 00:00:00
abstract::The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2002.129416
更新日期:2002-11-01 00:00:00
abstract::Langerhans' cell histiocytosis (LCH) is a proliferative histiocytic disorder of unknown etiology. We previously reported that Epstein-Barr virus (EBV) infects and proliferates in macrophages, and investigated the possibility that EBV exhibits etiologic effects in LCH. To detect EBV expression, paraffin sections from 1...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.03.017
更新日期:2004-07-01 00:00:00
abstract::We have recently noted a hitherto undescribed hepatic hemosiderosis confined to endothelial cells of the portal tract in chronic viral hepatitis. In this study, this lesion was surveyed in 156 liver biopsy specimens from patients with chronic hepatitis C and in 21 liver biopsy specimens from patients with chronic hepa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90269-4
更新日期:1995-10-01 00:00:00
abstract::We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(93)90120-6
更新日期:1993-09-01 00:00:00
abstract::Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with Epstein-Barr virus occurring most frequently in the upper aerodigestive tract. There are limited reports on cellular origin and prognostic factors. We retrospectively investigated 73 cases with a median a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.11.008
更新日期:2015-02-01 00:00:00
abstract::Sessile serrated adenomas and traditional serrated adenomas are pathogenetically related to inhibition of apoptosis. Survivin and hedgehog proteins, including sonic hedgehog, patched, and smoothened, inhibit apoptosis, with hedgehog proteins forming a signal transduction cascade implicated in digestive cancers. This s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.12.004
更新日期:2007-05-01 00:00:00
abstract::Anaplastic meningiomas (MIIIs) and meningeal hemangiopericytomas (HPCs) display significant morphologic and immunohistochemical overlap, including occasional cases of otherwise classic HPC with focal epithelial membrane antigen (EMA) positivity. The availability of several new biomarkers prompted us to examine the pot...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.07.017
更新日期:2004-11-01 00:00:00
abstract::Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.016
更新日期:2012-09-01 00:00:00
abstract::Esophageal adenocarcinoma often presents at an advanced stage and has a dismal prognosis. Current prognostic markers have limited utility. ARID1A is implicated as a tumor suppressor gene in esophageal adenocarcinoma. Loss of ARID1A expression correlates with DNA mismatch repair (MMR) protein deficiency in other tumors...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2019.09.004
更新日期:2019-12-01 00:00:00
abstract::Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90448-8
更新日期:1998-08-01 00:00:00