Abstract：
:Autopsy studies of three premature siblings who died soon after birth with the neonatal myotonic dystrophy syndrome revealed pulmonary hypoplasia and congenital pleural effusions. Neither of these findings has been described previously in this condition. New ultrastructural findings include focal diaphragmatic myofiber degeneration and necrosis, which were attributed to over-stretching of the fetal diaphragm. In addition, abnormally small stores of free and intravesicular glycogen were observed in skeletal muscle fibers. The morphometric features of control fetal and neonatal skeletal muscle were recorded for comparison with muscle fiber measurements in the three infants. Fiber diameters in the latter were much smaller than expected for body weights. The morphologic and morphometric findings support the concept that fetal muscle maturation is severely retarded in this syndrome.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Silver MM,Vilos GA,Silver MD,Shaheed WS,Turner KLdoi
10.1016/s0046-8177(84)80312-3subject
Has Abstractpub_date
1984-12-01 00:00:00pages
1171-82issue
12eissn
0046-8177issn
1532-8392pii
S0046-8177(84)80312-3journal_volume
15pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Substantial agreement has previously been demonstrated between qualitative and morphometric grading of gastric dysplasia. In the present study, a further attempt is made to quantitatively define the dysplastic changes in relation to associated benign or malignant changes of gastric mucosa. In total, 232 cases were stu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90094-4
更新日期：1989-09-01 00:00:00
abstract：:Fibrillar proteins with a role in cellular shape and motility are present in the cytoplasm of most animal cells. They vary greatly in size, organization, and reactivity according to cell type and can be separately identified by the use of recently developed monospecific antisera and indirect immunofluorescence stainin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80026-3
更新日期：1981-05-01 00:00:00
abstract：:Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.10.023
更新日期：2018-01-01 00:00:00
abstract：:Abnormalities of the cell cycle are present in all neoplasms. Cyclin E, which regulates the G1/S phase transition of the cell cycle, plays an important role in many different cancers. To further investigate the role of cyclin E in invasive breast ductal carcinomas in South African women, representative sections from 1...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.21141
更新日期：2001-01-01 00:00:00
abstract：:Sixteen cases of intermediate lymphocytic lymphoma (ILL), including eight cases with mantle zone architecture, were studied using cryostat sections, a biotin-avidin immunoperoxidase technique, and a large panel of monoclonal antibodies. The neoplastic cells invariably expressed IgM, most B lineage antigens (B1, TO15, ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80203-x
更新日期：1988-05-01 00:00:00
abstract：:Clinical stage I seminomas are effectively treated with surgery raising concerns as to when to give adjuvant radiation therapy given the risk of secondary malignancies. A recent randomized trial found tumor size and rete testis invasion to be the strongest predictors of relapse in clinical stage I seminomas. These 2 p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.03.011
更新日期：2005-06-01 00:00:00
abstract：:A case of recurrent Hodgkin's disease of the "sarcomatoid" or "syncytial variant" type was seen that occurred as an extension from the mediastinum to a previously uninvolved extranodal site (breast) and pericardium after treatment of classical nodular sclerosing Hodgkin's disease based in the lymph nodes. This histolo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80247-2
更新日期：1987-07-01 00:00:00
abstract：:Monocytoid B-cell lymphoma (MBCL) is a newly recognized, morphologically and immunologically distinct, low-grade B-cell neoplasm that may exist as a pure morphologic entity or as a component of a composite lymphoma. To determine whether cytogenetic abnormalities exist in cases of MBCL, fresh tissue from four lymphoma ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90188-m
更新日期：1993-10-01 00:00:00
abstract：:Current regulations require that departments of pathology have a structured and active program of quality assurance (QA) and quality improvement (QI), with the goals of enhancing patient safety, minimizing error, ensuring timely delivery of reports, and monitoring physician competence. Types of potential error may evo...
journal_title：Human pathology
pub_type： 指南,杂志文章
doi：10.1016/j.humpath.2006.03.010
更新日期：2006-08-01 00:00:00
abstract：:Hyaline globules (HG) have been observed in a large variety of unrelated categories of tumors and benign tissues. Different explanations for their formation have been proposed, varying according to tumor type and anatomic location. We have studied 80 tumor cases containing HG, by light microscopy, electron microscopy,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.20376
更新日期：2000-12-01 00:00:00
abstract：:Although adipophilin has been reported to be a sensitive marker for sebaceous carcinoma, others have noted its expression in squamous cell carcinoma and a variety of noncutaneous tumors, suggesting that lipid droplet accumulation is a frequent feature of neoplastic cells. We investigated the expression of adipophilin ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.02.003
更新日期：2013-09-01 00:00:00
abstract：:This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(78)80005-7
更新日期：1978-01-01 00:00:00
abstract：:Cytochrome P-450 specific for steroid 17 alpha-hydroxylation (P-45017 alpha) was immunolocalized in normal and hyperfunctioning adrenal glands of pigs, bovines, and humans, using a specific IgG fraction raised against the enzyme. P-45017 alpha was present in the zona fasciculata (ZF) and zona reticularis (ZR), but not...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90174-3
更新日期：1989-02-01 00:00:00
abstract：:Focal apocrine metaplasia was studied in 293 whole human breasts by a subgross sampling technique with histologic confirmation. There were 186 breasts obtained from random autopsies. Another 107 breasts were obtained that were cancer-associated; these breasts either contained an invasive cancer or were situated contra...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80169-7
更新日期：1987-04-01 00:00:00
abstract：:Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but the understanding of placental and fetal aspects of the disease is limited. We report the pregnancy outcome in and placental path...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2011.07.020
更新日期：2012-04-01 00:00:00
abstract：:Fluorescence in situ hybridization, loss of heterozygosity testing, and comparative genomic hybridization have been used to detect NF2 gene alterations in both sporadic and neurofibromatosis type 2 (NF2)-associated central nervous system tumors. In this study, we performed chromogenic in situ hybridization (CISH) and ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.027
更新日期：2007-09-01 00:00:00
abstract：:Congenital subclavian steal may result from various anomalies of the aortic arch. The most common predisposing type is the right aortic arch with an isolated left subclavian artery arising from a left ductus arteriosus. A rare variant includes isolation of the left common carotid as well as the left subclavian arterie...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80200-6
更新日期：1981-10-01 00:00:00
abstract：:Cardiac myxoma is the most common primary tumor of the heart. A detailed evaluation of cell types in 41 cardiac myxomas by light microscopy and in 30 cases by immunohistochemistry was made. Reactivity to the various antisera were observed in the surface lining cells, the stromal myxoma cells and the cells in the periv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90283-x
更新日期：1996-10-01 00:00:00
abstract：:Combined small cell and non-small cell carcinoma is relatively rare in the lung. Examination of the clonal relationship of different components in this type of tumor may give a clue to the rarity. We retrieved 6 such tumors; all 6 had small cell carcinoma and adenocarcinoma components, and 3 had an additional squamous...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/j.humpath.2003.05.001
更新日期：2003-11-01 00:00:00
abstract：:We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces wer...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.09.020
更新日期：2017-03-01 00:00:00
abstract：:To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.04.024
更新日期：2014-11-01 00:00:00
abstract：:Twelve cases of pure adenoid cystic carcinoma of the breast were reviewed. Patients ranged in age from 34 to 69 years. Seven carcinomas were in the right breast, and five in the left; five of the 12 were located in the central region of the breast, five in the upper outer quadrant, and the two in the upper inner and l...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(87)80413-6
更新日期：1987-12-01 00:00:00
abstract：:T-lymphocyte subsets in peripheral blood, bronchoalveolar lavage fluid, and prescalenic lymph nodes from eight patients with sarcoidosis were evaluated with monoclonal antibodies. Both in lung and lymph nodes significant increases in helper T cells were demonstrated, except in patients with stage III pulmonary disease...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80037-5
更新日期：1986-05-01 00:00:00
abstract：:CD10 is common in B-precursor acute lymphoblastic leukemia (ALL) but is rare in acute myeloid leukemia (AML). However, until recently, analysis for CD10 has generally required fresh or frozen tissue. 56C6 is a monoclonal antibody that is now commercially available for the detection of CD10 in routinely processed paraf...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.6276
更新日期：2000-09-01 00:00:00
abstract：:A 61-year-old white woman was found to have disseminated abdominal carcinoma at autopsy. The primary site proved to be a bile duct carcinoma arising from ductal epithelium of multiple von Meyenburg complexes of the liver. No other neoplastic lesion was found elsewhere after careful, gross, microscopic examination. Thi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(86)80575-5
更新日期：1986-12-01 00:00:00
abstract：:A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90199-x
更新日期：1998-09-01 00:00:00
abstract：:Two cases of lymphadenopathy resulting from a lymph node foreign body reaction to silicone are presented. In each case lymph node biopsy was performed because of the clinical suspicion of neoplastic disease. Histologic study in both cases revealed no evidence of malignant disease, but rather demonstrated multinucleate...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(80)80005-0
更新日期：1980-05-01 00:00:00
abstract：:Most human papillomavirus-associated squamous intraepithelial lesions of the uterine cervix are flat; some have papillary architecture that shows a spectrum of differentiation from low-grade squamous intraepithelial lesions to high-grade squamous intraepithelial lesions. For this subset of lesions, there are few data ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.05.015
更新日期：2010-03-01 00:00:00
abstract：:Laminin and collagen have been studied in several tumor types and their immunomorphological expression correlated with tumor morphogenesis, local invasiveness, and metastatic behavior. In a series of 53 cases of pleomorphic adenomas (PA) and 16 cases of carcinomas ex-pleomorphic adenoma (Ca ex-PA), we investigated by ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90251-4
更新日期：1999-08-01 00:00:00
abstract：:To investigate the roles of matrix metalloproteinases (MMPs) in thymic epithelial tumors, we examined the expression of MMP-2, -7, and -9; membrane-type 1 (MT1)-MMP; and tissue inhibitor of metalloproteinase-2 (TIMP-2) in 57 tumors by immunohistochemistry and in selected 15 cases by in situ hybridization. The tumors c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.07.013
更新日期：2003-12-01 00:00:00
