Abstract：
:T-lymphocyte subsets in peripheral blood, bronchoalveolar lavage fluid, and prescalenic lymph nodes from eight patients with sarcoidosis were evaluated with monoclonal antibodies. Both in lung and lymph nodes significant increases in helper T cells were demonstrated, except in patients with stage III pulmonary disease or with unaffected lymph nodes. A good statistical correlation was observed between the activity of the disease (expressed by an increased ratio of helper to suppressor/cytotoxic T cells) in bronchoalveolar fluid and in lymph node cell suspensions from each patient. A three-step immunoperoxidase staining reaction, performed on lymph node frozen sections, showed a prevalence of helper T cells both inside and around the granulomas. These findings confirm that sarcoidosis is characterized by increased activity of cell-mediated immunity in its different localizations.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Viale G,Codecasa L,Bulgheroni P,Giobbi A,Madonini E,Dell'Orto P,Coggi Gdoi
10.1016/s0046-8177(86)80037-5subject
Has Abstractpub_date
1986-05-01 00:00:00pages
476-81issue
5eissn
0046-8177issn
1532-8392pii
S0046-8177(86)80037-5journal_volume
17pub_type
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