Abstract:
:Hydatidiform moles are classified as partial or complete by histologic criteria (Am J Obstet Gynecol 131:665-671, 1978 and Am J Obstet Gynecol 132:20-27, 1978). While persistent gestational trophoblastic tumors follow both types, there remains controversy as to whether the malignant extreme of gestational trophoblastic tumors, choriocarcinoma, can follow a partial hydatidiform mole (Am J Obstet Gynecol 127:167-170, 1977 and Arch Gynecol 234:161-166, 1984). In this instance, a 37-year-old woman presented with a partial hydatidiform mole that persisted and was treated with one course of chemotherapy. She attained a remission for 10 months, when a routine follow-up examination revealed an asymptomatic rise in serum beta-human chorionic gonadotropin from baseline to 14,600 mIU/mL. Dilatation and curettage revealed abundant avillous cytotrophoblast and syncytiotrophoblast with marked atypia, diagnostic of choriocarcinoma. Flow cytometry of paraffin blocks of both specimens showed the partial hydatidiform mole to be triploid and the choriocarcinoma diploid. The patient had no evidence of metastatic disease and was successfully treated with multiple-agent chemotherapy.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Gardner HA,Lage JMdoi
10.1016/0046-8177(92)90096-lsubject
Has Abstractpub_date
1992-04-01 00:00:00pages
468-71issue
4eissn
0046-8177issn
1532-8392pii
0046-8177(92)90096-Ljournal_volume
23pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract::Immunoreactivity to LN2 and LN3, monoclonal antibodies that recognize components of the class II major histocompatibility complex, was assessed in 72 cases of non-small cell lung carcinoma (NSCLC) (32 biopsy specimens, 40 resection specimens) and 64 cases of small cell carcinoma (56 biopsy specimens, 8 resections) of ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90013-2
更新日期:1998-12-01 00:00:00
abstract::Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2011.10.017
更新日期:2012-09-01 00:00:00
abstract::The control of colorectal cancer is currently dependent on early detection, and its prevention requires the recognition and treatment of its precursor lesions. The adenoma has been established as the precursor of colorectal carcinoma in the general population. Among patients with inflammatory bowel disease (IBD), dysp...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(94)90032-9
更新日期:1994-11-01 00:00:00
abstract::Oncogenes, growth factors, cell surface receptors, and cell-cycle and apoptotic regulatory proteins have been implicated in the growth regulation and progression of Barrett's-associated neoplasia. Among these, insulin-like growth factor 1 receptor (IGF1-R) and c-Src are reported to be key regulators of mitogenesis and...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/s0046-8177(03)00354-x
更新日期:2003-10-01 00:00:00
abstract::The intraoperative diagnosis of pulmonary neuroendocrine tumors can be difficult. Frozen section diagnosis was requested on 87 neuroendocrine tumors including 58 typical carcinoids, 8 atypical carcinoids, 18 large cell neuroendocrine carcinomas, and 3 small cell carcinomas from 2405 patients that underwent frozen sect...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.07.017
更新日期:2009-01-01 00:00:00
abstract::An increase in S100 protein-positive cells has been reported in inflammatory bowel diseases, mainly Crohn disease. These cells were interpreted as myeloid-derived dendritic cells, chiefly in follicular areas. We were prompted to assess the nature of these cells in interfollicular areas of inflamed colonic mucosa in ul...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.11.017
更新日期:2009-08-01 00:00:00
abstract::Bone Marrow Transplant (BMT) is a critical therapeutic intervention for a variety of diseases occurring in the pediatric patient. Complications of allogeneic BMT include graft-versus-host disease (GVHD), infection, drug toxicity, thrombotic microangiopathy, and veno-occlusive disease. With solid organ transplantation,...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(99)90132-6
更新日期:1999-07-01 00:00:00
abstract::We have begun a systematic study of human papillomavirus (HPV) infection in colposcopically and/or morphologically normal epithelium of the uterine cervix. Paired biopsies were taken from the lesions (cervical intraepithelial neoplasia [CIN], condyloma, invasive carcinoma) and from the normal-appearing adjacent epithe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90039-7
更新日期:1989-04-01 00:00:00
abstract::A case of metastatic malignant melanoma simulating a giant cell tumor of bone is reported. This case typifies the diversity of expression of malignant melanoma. Osteoclast-like giant cells were present only in the femoral head metastasis and were not present in the primary lesion. The giant cell component may be refle...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(90)90183-6
更新日期:1990-09-01 00:00:00
abstract::Activating transcription factor 2 (ATF2) is a member of activator protein 1 superfamily, which can heterodimerize with other transcription factors regulating cell differentiation and survival. ATF2 assembles into a complex with the synovial sarcoma translocation, chromosome 18 (SS18)-synovial sarcoma, X breakpoint (SS...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.09.003
更新日期:2014-02-01 00:00:00
abstract::Chemokine receptor, CXCR3, has been increasingly reported to be involved in tumorigenesis and tumor progression, but limited data are available regarding the expression of CXCR3 in gastric cancer (GC). In the present study, the expressions of CXCR3 and its variants were detected in 96 GC and corresponding nontumor gas...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2015.08.004
更新日期:2015-12-01 00:00:00
abstract::Promyelocytic leukemia zinc finger is a zinc finger transcription factor that functions as a transcriptional repressor. Its expression has been shown to be down-regulated in hematopoietic, melanocytic, and mesothelial malignancies. Histone H1.5 is a variant of histone H1, a family of linker proteins that organizes chr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2012.11.014
更新日期:2013-07-01 00:00:00
abstract::Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(92)90110-o
更新日期:1992-03-01 00:00:00
abstract::Infantile hemiparesis may be associated with significant morbidity and may have a profound impact on a child's physical and social development. There are little published data evaluating the clinicopathologic features of patients with infantile hemiparesis. The present study retrospectively examines these clinicopatho...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2004.02.013
更新日期:2004-06-01 00:00:00
abstract::Explants from paraspinal muscles of patients with scoliosis were cultured in Millipore diffusion chambers placed in peritoneal cavities of mice. Three and four weeks of incubation produced a predominantly myogenic growth. Cell counts done on paraffin sections and on dissociated cells from the chambers showed that expl...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(81)80046-9
更新日期:1981-07-01 00:00:00
abstract::Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.01.013
更新日期:2006-05-01 00:00:00
abstract::Except for post-transfusion hepatitis (PTH), the transmission of disease by blood transfusion appears to be very limited. There are only a few case reports documenting the transmission of malaria and other parasitic diseases, syphilis, or bacterial infections. The ability to eradicate PTH will depend on the developmen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(83)80024-0
更新日期:1983-03-01 00:00:00
abstract::The pertinent clinical data and histologic features of the testes in 57 autopsied acquired immunodeficiency syndrome (AIDS) patients were analyzed and compared with those of 55 age-matched control patients without AIDS. The testes of the AIDS patients showed a significantly lower degree of spermatogenesis (determined ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(89)90125-1
更新日期:1989-03-01 00:00:00
abstract::Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90104-0
更新日期:1997-02-01 00:00:00
abstract::Adenocarcinomas of nonsalivary origin represent approximately 10% to 20% of all sinonasal malignancies and are characterized by varying histopathologic features and uncertain histogenesis. To better understand the histogenesis and phenotypic heterogeneity of these tumors, we performed immunohistochemical analyses for ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/j.humpath.2003.08.024
更新日期:2003-11-01 00:00:00
abstract::In 112 unselected autopsies of adult patients without known pancreatic disease (except adult-onset diabetes mellitus), the pancreas was examined to establish the incidence and degree of such minor pancreatic lesions as lipomatosis, fibrosis, alterations of ducts and ductal epithelium, inflammatory infiltrates, focal n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(84)80294-4
更新日期:1984-07-01 00:00:00
abstract::Massive chronic intervillositis (MCI) is an unusual placental lesion associated with poor fetal growth and adverse pregnancy outcome; it has not previously been associated with spontaneous abortion or recurrent pregnancy loss. This article reports a patient who had 10 spontaneous abortions with repetitious massive chr...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/0046-8177(95)90201-5
更新日期:1995-11-01 00:00:00
abstract::Renal cell carcinoma (RCC) is known to have a wide variation in clinical outcome despite the use of conventional prognostic factors, such as staging or grading. A better knowledge of the biologic aggressiveness of RCC could facilitate the selection of patients at high risk of tumor progression. The aim of this study w...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1053/hupa.2001.28957
更新日期:2001-11-01 00:00:00
abstract::Digitization of glass slides holds great promise for increasing workflow efficiency, but current applications have not gained widespread acceptance. Applications to date have not taken into consideration pathologists' workflow patterns, and as a result many find navigation cumbersome and interpretation more challengin...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2008.01.006
更新日期:2008-09-01 00:00:00
abstract::Carcinoma ex-pleomorphic adenoma (CA ex-PA) is a malignant salivary gland tumor that arises in association with pleomorphic adenoma (PA). Both PA and CA ex-PA have a broad spectrum of histology, and distinction from their histologic mimics may be difficult based on morphology alone. PLAG1 and HMGA2 abnormalities are t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.08.017
更新日期:2015-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a commonly occurring tumor in southern China. Although several causative factors have now been recognized, the genetic basis underlying its tumorigenesis is still unclear. To identify potential chromosomal aberrations for further investigations, comparative genomic hybridization (CGH)...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(00)80216-6
更新日期:2000-02-01 00:00:00
abstract::This presentation reports the light and electron microscopic findings relating to the vascular and glomerular changes in the kidney in a series of 25 patients having malignant hypertension, the hemolytic-uremic syndrome, scleroderma, or toxemia of pregnancy. The pathologic changes were generally similar in each of the...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(76)80103-7
更新日期:1976-09-01 00:00:00
abstract::In this study, we assessed the changes and prognostic relevance of syndecan-1 (SDC1) tissue and serum levels in bladder cancer (BC). SDC1 levels were analyzed in 213 samples (119 paraffin-embedded and 79 serum samples of BC patients and 15 controls) using immunohistochemistry and enzyme-linked immunosorbent assay. Res...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2013.10.036
更新日期:2014-04-01 00:00:00
abstract::A case of scrotal and penile extramammary Paget's disease (EMPD) and concurrent prostate adenocarcinoma in a 59-year-old patient is presented. Immunohistochemically, the tumor cells of both the EMPD and prostate stained positively for prostate-specific antigen. Six previously reported cases of EMPD associated with pro...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/0046-8177(94)90229-1
更新日期:1994-06-01 00:00:00
abstract::Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2014.12.002
更新日期:2015-03-01 00:00:00