Abstract：
:Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carcinomas (SqCCs; n = 40); colorectal, pancreatic, and prostate adenocarcinomas (n = 31), and hepatocellular carcinomas (HCCs; n = 8). In SqCCs, PKP 1 and PKP 3 revealed common desmosome-type immunostaining, their expression level being inversely correlated with the degree of malignancy. Instead, staining for PKP 2 was limited. In contrast, all adenocarcinomas contained PKP 2 and-often abundantly-PKP 3 in desmosome-typical pattern, whereas PKP 1 was expressed only in prostate tumors. The presence of PKP 3 in adenocarcinomas was confirmed by immunoblotting. In HCCs, only PKP 2 was detected. Under certain staining conditions, focal nuclear immunoreactivity for PKP 1 was observed in some SqCCs and HCCs. Our results, which are inconsistent with previously published data to some extent, indicate a principal preservation of the cell type and differentiation-related expression patterns of PKPs in normal epithelia. For PKP 1, a suppressor function of malignant behavior seems conceivable, whereas the putative functional significance of its occurrence in tumor cell nuclei requires further studies.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Schwarz J,Ayim A,Schmidt A,Jäger S,Koch S,Baumann R,Dünne AA,Moll Rdoi
10.1016/j.humpath.2006.01.013subject
Has Abstractpub_date
2006-05-01 00:00:00pages
613-22issue
5eissn
0046-8177issn
1532-8392pii
S0046-8177(06)00021-9journal_volume
37pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Although recurrence of viral hepatitis in liver transplants is common, data comparing recurrent hepatitis B (HB), hepatitis C (HC), and co-existing dual hepatitis B and C (HB&C) are sparse. Posttransplantation liver biopsies, along with molecular, serological, immunohistochemical, and clinical data from 27 patients wi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(00)80205-1
更新日期：2000-01-01 00:00:00
abstract：:The Sydney classification for gastritis provides guidelines for histological grading of gastric biopsies. In an ongoing study of gastric preneoplastic lesions in Chiapas, Mexico, 7 biopsies from 150 patients (4 from the antrum and 3 from the body) were obtained during endoscopy and studied histologically. The first 74...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90164-8
更新日期：1999-12-01 00:00:00
abstract：:Acute rejection is an extremely common complication of lung transplantation. (1) To appreciate the interobserver variation in the interpretation of histologic findings and (2) to assess the efficacy of transbronchial biopsy (TBB) for acute rejection diagnosis and associated diseases, particularly infection, we perform...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2005.01.022
更新日期：2005-04-01 00:00:00
abstract：:High cathepsin D (cath-D) concentration in breast cancer cytosol is associated with increased risk of metastasis. To specify the relative contribution of the different cells types responsible for cath-D level in cytosol, we validated semiquantitative cath-D immunoperoxidase staining on formalin-fixed, paraffin-embedde...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90004-3
更新日期：1994-09-01 00:00:00
abstract：:Clinicopathological studies of 181 patients with liver cirrhosis undergoing autopsy in the pathology department of a municipal hospital between 1973 and 1976 are reported. The main etiological types were alcoholic (25.4 per cent), HBsAg positive (14.9 per cent), and cryptogenic cirrhosis (54.7 per cent). Four patients...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80082-2
更新日期：1981-09-01 00:00:00
abstract：:Although rare, synovial sarcoma (SS) is one of the most common soft tissue sarcomas affecting young adults. To investigate potential tumor markers related to synovial sarcoma prognosis, we carried out a single-institution retrospective analysis of 103 patients diagnosed with SS between 1980 and 2009. Clinical outcome ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.001
更新日期：2013-09-01 00:00:00
abstract：:This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.09.012
更新日期：2017-01-01 00:00:00
abstract：:Bioassay of hormones has a small but important role in defining the physiologic status of selected patients in whom immunoassay results do not correlate with clinical signs and symptoms. This article reviews three sensitive bioassays for hormones, which are based on 1) stimulation of adenylate cyclase in membrane prep...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(84)80050-7
更新日期：1984-02-01 00:00:00
abstract：:Esophageal cancer is one of the most fatal cancers worldwide and is characterized by great variation in rates among different populations. Linxian, a county in Henan Province, located in north-central China, has one of the highest rates of esophageal squamous cell carcinoma in the world. Most squamous cell carcinomas ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90260-x
更新日期：1998-11-01 00:00:00
abstract：:The radiosensitivities of lymphocytes of peripheral blood origin obtained from two healthy 45 year old male donors were studied simultaneously at yearly intervals over a three year period. Hypaque-Ficoll purified cells were exposed in vitro to 0, 5, 50, and 500 rads and then evaluated serially for viability of T and B...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(79)80007-6
更新日期：1979-03-01 00:00:00
abstract：:Cell adhesion molecule expression has been linked to disease outcome in prostatic adenocarcinomas (PACs). We evaluated the coordinated expression of catenin-related proteins, E-cadherin, N-cadherin, and CD44s in PACs. Archival sections from 112 PACs were immunostained by an automated method (Ventana Medical Systems, T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.26463
更新日期：2001-08-01 00:00:00
abstract：:An accurate diagnosis between leiomyoma and leiomyosarcoma is essential for patient management. IMP3 is a member of the insulin-like growth factor (IGF-II) mRNA binding protein (IMP) family that consist of IMP1, IMP2, and IMP3. IMP3 is an oncofetal protein associated with aggressive and advanced tumors and is specific...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.12.020
更新日期：2012-10-01 00:00:00
abstract：:Previous studies indicated that microRNA (miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role. To investigate the involvement of miR-675 in gliomas and its underlying mechanisms, we here collected candidate target genes of miR-675-5p from miRTarBase (ht...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.09.006
更新日期：2017-11-01 00:00:00
abstract：:We investigated the use of remote video microscopy (telepathology) to assist in the diagnosis of 52 neurosurgical frozen section cases. The TelMed system (Discovery Medical Systems, Overland Park, KS), in which the referring pathologist selects appropriate fields for transmission to the consultant, was used for the st...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90142-4
更新日期：1993-08-01 00:00:00
abstract：:In this autopsy series of cryptococcal meningoencephalitis (CME), the authors analyzed neuropathologic lesions in 13 human immunodeficiency virus (HIV) and 14 non-HIV-related cases. Most non-HIV patients did not have immunosuppressive predisposing illness. Analysis of pathological findings revealed significant differe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90459-1
更新日期：1996-08-01 00:00:00
abstract：:The distinction between Spitz nevus and melanoma is currently possible, applying a set of definite histological criteria. However, in certain lesions deviating from the stereotypical morphology of classic Spitz nevi ("atypical Spitz tumors"), the differentiation between benign and malignant cases appears problematic b...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.02.001
更新日期：2006-07-01 00:00:00
abstract：:Geotrichum candidum was identified as an invasive organism in the terminal ileum of a man with "hairy cell" leukemia. The organism was identified on the basis of histologic and cultural characteristics. The diagnostic features of G. candidum infection are compared to those of Aspergillus and Candida species. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80055-x
更新日期：1981-07-01 00:00:00
abstract：:Both individual patient treatment and cancer registries depend on adequate histopathology reports. To ensure the quality of these reports, professional organizations have published guidelines on minimum data sets for various cancer types. Norway has a population of 4.6 million, and all individuals have a unique identi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.06.019
更新日期：2008-03-01 00:00:00
abstract：:Previous immunohistochemical (IHC) studies showed controversial data about the prognostic value of tumor-infiltrating lymphocytes (TILs) in follicular lymphoma (FL). To clarify this issue, a large series of FL samples from rituximab-treated patients enrolled in the randomized PRIMA trial was examined. IHC was quantifi...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.humpath.2017.03.023
更新日期：2017-06-01 00:00:00
abstract：:CRABP-II, a retinoic acid binding protein, shuffles retinoic acid from cytoplasm into nucleus and forms a complex with nuclear retinoic acid receptor to facilitate transcriptional activities of retinoic acid. In this study, we studied the expression patterns of CRABP-II in pancreatic ductal adenocarcinoma (PDAC) compa...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.01.014
更新日期：2014-06-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) promotes growth of blood or lymphatic vessels. The aim of the current study is to identify relationships between VEGF-A and VEGF-C, and their impact in angiogenesis and metastases in thyroid cancers. VEGF-A and VEGF-C mRNA and protein expression was investigated in 136 thyroid...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.04.014
更新日期：2013-10-01 00:00:00
abstract：:A young male with Buerger's disease who had previously required a left leg amputation died in renal failure and sepsis. Postmortem examination revealed an obliterative lesion of the celiac artery, which resulted in hepatic, splenic, and pancreatic infarctions. Celiac artery involvement represents an unusual manifestat...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(79)80080-5
更新日期：1979-01-01 00:00:00
abstract：:Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.03.005
更新日期：2006-08-01 00:00:00
abstract：:This presentation reports the light and electron microscopic findings relating to the vascular and glomerular changes in the kidney in a series of 25 patients having malignant hypertension, the hemolytic-uremic syndrome, scleroderma, or toxemia of pregnancy. The pathologic changes were generally similar in each of the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(76)80103-7
更新日期：1976-09-01 00:00:00
abstract：:Calcitonin and calcitonin gene-related peptide (CGRP) have been localized immunohistochemically in neuroendocrine cells of normal and diseased human lungs. Cells immunoreactive for calcitonin and CGRP first appeared in immature bronchi in the 27th gestational week. Thereafter, both peptides were found in the same bron...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90103-2
更新日期：1989-09-01 00:00:00
abstract：:The objective of this cohort study was to evaluate whether the immunohistochemical expression of tissue inhibitor of metalloprotease 2, matrix metalloproteinase (MMP) 2, and MMP-9 could predict the occurrence of death and progression in women with ovarian high-grade serous carcinoma (HGSC). A total of 100 women with p...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.01.014
更新日期：2015-05-01 00:00:00
abstract：:A 51-year-old man presented with a paratracheal tumor. He had undergone resection of a thyroid tumor 15 years previously; at that time, the histologic diagnosis had been anaplastic carcinoma. When the tumor recurred, the presumptive clinical diagnosis was medullary thyroid carcinoma. Histologic examination revealed a ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80242-9
更新日期：1988-12-01 00:00:00
abstract：:The objective of this study was to analyze the expression and clinical role of the RNA-binding molecule HuR in metastatic high-grade ovarian serous carcinoma (HGSC). HUR mRNA expression by reverse-transcription polymerase chain reaction was analyzed in 66 effusions from patients diagnosed with HGSC. Protein expression...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.09.027
更新日期：2016-02-01 00:00:00
abstract：:The diagnosis of microscopic colitis (MC) relies on specific histopathological findings in colon biopsies. The number of biopsies needed to diagnose MC remains disputed. The aim of the study was to determine the number and site of biopsies necessary for the diagnosis and the effect of perpendicular orientation when em...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.07.011
更新日期：2020-09-01 00:00:00
abstract：:Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.04.009
更新日期：2006-09-01 00:00:00
