Abstract：
:This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective cohort of 129 women with a histologic diagnosis of CIN 2 who were managed by watchful waiting for 6 to 24months. Five potential predictors for spontaneous regression were selected based on the literature and expert opinion and were analyzed in a multivariable logistic regression model, followed by backward stepwise deletion based on the Wald test. The prediction model was internally validated by the bootstrapping method. Discriminative capacity and accuracy were tested by assessing the area under the receiver operating characteristic curve (AUC) and a calibration plot. Disease regression within 24months was seen in 91 (71%) of 129 patients. A prediction model was developed including the following variables: smoking, Papanicolaou test outcome before the CIN 2 diagnosis, concomitant CIN 1 diagnosis in the same biopsy, and more than 1 biopsy containing CIN 2. Not smoking, Papanicolaou class <3, concomitant CIN 1, and no more than 1 biopsy containing CIN 2 were predictive of disease regression. The AUC was 69.2% (95% confidence interval, 58.5%-79.9%), indicating a moderate discriminative ability of the model. The calibration plot indicated good calibration of the predicted probabilities. This prediction model for spontaneous regression of CIN 2 may aid physicians in the personalized management of these lesions.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Koeneman MM,van Lint FHM,van Kuijk SMJ,Smits LJM,Kooreman LFS,Kruitwagen RFPM,Kruse AJdoi
10.1016/j.humpath.2016.09.012subject
Has Abstractpub_date
2017-01-01 00:00:00pages
62-69eissn
0046-8177issn
1532-8392pii
S0046-8177(16)30232-5journal_volume
59pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Endocrine-paracrine (APUD, neuroendocrine) cells are located in the prostatic ductal and acinar epithelium. These cells are of the open and closed type and have dendritic processes. There is a wide range of secretory granule morphology presumably indicating a variety of different cell "types." Secretory immunoreactive...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(92)90110-o
更新日期：1992-03-01 00:00:00
abstract：:Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonali...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.125381
更新日期：2002-08-01 00:00:00
abstract：:Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its clinicopathological and genetic features are poorly understood. The aim of our study was to elucidate the frequency and prognostic significance of molecular subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with DLBCL-li...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.09.003
更新日期：2020-02-01 00:00:00
abstract：:Tissue specimens obtained at autopsy from seven childhood cases of malignant histiocytosis were studied by immunohistochemistry. Clinically, the majority of the cases showed sustained fever, hepatosplenomegaly, pancytopenia, and DIC. The pretreatment diagnosis was based on their typical clinical manifestations and bon...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80178-3
更新日期：1988-06-01 00:00:00
abstract：:Dysplastic nevi are an important indicator of risk of cutaneous malignant melanoma. The study of and, particularly, international communication regarding this group of lesions have been hindered by a lack of precision in diagnosis. In an effort to broaden understanding, a panel of pathologists agreed upon a set of cri...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90078-4
更新日期：1991-04-01 00:00:00
abstract：:Blue nevus is an uncommon pigmented tumor of dermal melanocytes that has traditionally been classified into common and cellular variant. It is usually a skin tumor in adults but can become apparent in early childhood or even be present at birth. Malignant blue nevus is a rare melanocytic tumor of the skin arising from...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.07.012
更新日期：2004-10-01 00:00:00
abstract：:To investigate the expression and clinical significance of long noncoding RNA (lncRNA) in gastric cancer, we applied microarray analysis to obtain expression profiles of protein-coding genes and lncRNAs in tumor and paired adjacent nontumor tissues. We found that 41 lncRNAs were up-regulated and 31 lncRNAs were down-r...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.04.008
更新日期：2018-08-01 00:00:00
abstract：:Patients with small cell lung carcinoma (SCLC) rarely demonstrate long-term survival. We previously reported that gene expression profiling identified a subset of SCLC with good prognosis in surgical cases. To find an easier way to routinely identify SCLC belonging to this subset, we conducted the present study with a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.01.001
更新日期：2014-05-01 00:00:00
abstract：:Kidneys from 1864 necropsies performed in Brisbane, Australia, and from 397 necropsies performed in Christchurch, New Zealand, were examined macroscopically and microscopically. Three zonal and three focal patterns of renal medullary calcification were defined: (1) Outer medullary cortical calcification seen in hyperc...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(76)80057-3
更新日期：1976-07-01 00:00:00
abstract：:Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.08.004
更新日期：2012-05-01 00:00:00
abstract：:Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs). We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.01.012
更新日期：2006-06-01 00:00:00
abstract：:Endometrial carcinoma is the most common malignant tumor of the female genital tract in the Western world. Approximately 80% of cases are well- to moderately differentiated (endometrioid) adenocarcinomas, which are confined to the uterine corpus at diagnosis, and thus most can be cured. Conversely, high-grade (ie, cle...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2004.02.007
更新日期：2004-06-01 00:00:00
abstract：:Bioassay of hormones has a small but important role in defining the physiologic status of selected patients in whom immunoassay results do not correlate with clinical signs and symptoms. This article reviews three sensitive bioassays for hormones, which are based on 1) stimulation of adenylate cyclase in membrane prep...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(84)80050-7
更新日期：1984-02-01 00:00:00
abstract：:We have previously reported that MUC2 apomucin was highly expressed in noninvasive tumors of the pancreas (intraductal papillary tumor [IdPT]) and liver (bile duct cystadenocarcinoma [BdCC]), which show more favorable outcomes than invasive carcinomas. In contrast, MUC2 was rarely expressed in invasive carcinomas of t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90134-9
更新日期：1997-03-01 00:00:00
abstract：:Proliferative lesions of breast duct epithelium are associated with an increased risk of subsequent carcinoma. Fine-needle aspiration criteria for these lesions are poorly defined; most studies are retrospective and do not clearly use the classification of Page and Rogers. Suggested criteria for "atypia" include crowd...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90243-a
更新日期：1993-06-01 00:00:00
abstract：:The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.01.022
更新日期：2007-09-01 00:00:00
abstract：:Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis in various malignancies. ZEB2/SIP1 is an important EMT regulator and down-regulates E-cadherin expression. The present study was planned to explore status of EMT-associated markers ZEB2/SIP1 and E-cadherin in eyelid sebaceous...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.05.026
更新日期：2015-10-01 00:00:00
abstract：:CD10 is common in B-precursor acute lymphoblastic leukemia (ALL) but is rare in acute myeloid leukemia (AML). However, until recently, analysis for CD10 has generally required fresh or frozen tissue. 56C6 is a monoclonal antibody that is now commercially available for the detection of CD10 in routinely processed paraf...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.6276
更新日期：2000-09-01 00:00:00
abstract：:Platelet stimulus-activation-contraction-secretion coupling is linked to fundamental modifications in the biochemistry and ultrastructure of the platelet surface and the membranes enclosing storage organelles. It is not surprising, therefore, that membrane defects are common in platelets from patients with inherited h...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(87)80331-3
更新日期：1987-02-01 00:00:00
abstract：:Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90448-8
更新日期：1998-08-01 00:00:00
abstract：:To increase awareness of the possible coexistence of an ovarian and breast carcinoma in a BRCA1 mutation carrier, we describe a patient with primary ovarian cancer who developed distant metastases after 3 years and again after 6 years. Surprisingly, at that time an occult breast carcinoma was identified to be the orig...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.11.008
更新日期：2004-05-01 00:00:00
abstract：:An accurate diagnosis between leiomyoma and leiomyosarcoma is essential for patient management. IMP3 is a member of the insulin-like growth factor (IGF-II) mRNA binding protein (IMP) family that consist of IMP1, IMP2, and IMP3. IMP3 is an oncofetal protein associated with aggressive and advanced tumors and is specific...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.12.020
更新日期：2012-10-01 00:00:00
abstract：:To elucidate the pathogenesis of aging changes and their relation to age associated calcification, a morphological study of 27 human aortic valves was carried out. Nine valves were obtained from immediate autopsies and 18 valves from routine autopsies done within four hours after death. Calcium deposition was present ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(76)80005-6
更新日期：1976-01-01 00:00:00
abstract：:Pilocytic astrocytoma is an infrequently encountered, generally low-grade neoplasm. No study has extensively looked at both cyclin D1 and MIB-1 labeling indices in pilocytic astrocytoma and their relation to clinical outcome. This study retrospectively examines the clinicopathologic features of 48 patients with pilocy...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90023-5
更新日期：1998-12-01 00:00:00
abstract：:This article reviews 281 malignant germ cell tumors of the ovary from the Armed Forces Institute of Pathology and highlights their distinctive clinical and pathologic features. Emphasis is placed on the importance of a combined therapeutic approach utilizing surgery, chemotherapy, and radiation. The rationale for unil...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(77)80115-9
更新日期：1977-09-01 00:00:00
abstract：:PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expressi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.07.023
更新日期：2015-12-01 00:00:00
abstract：:A rare example of melanoma arising in carcinoma ex pleomorphic adenoma is presented. The diagnosis, differential diagnosis, and putative histogenesis of the melanoma component are discussed. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.12.002
更新日期：2011-09-01 00:00:00
abstract：:Abnormalities of the cell cycle are present in all neoplasms. Cyclin E, which regulates the G1/S phase transition of the cell cycle, plays an important role in many different cancers. To further investigate the role of cyclin E in invasive breast ductal carcinomas in South African women, representative sections from 1...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.21141
更新日期：2001-01-01 00:00:00
abstract：:To examine the hypothesis that malpositions of cardiac ventricles could be explained by altered development of the interventricular septum, we studied hearts from the Johns Hopkins Hospital autopsy files with double inlet left ventricle (16 cases) or corrected transposition (nine cases). In double inlet left ventricle...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80125-6
更新日期：1981-03-01 00:00:00
abstract：:Chondroblastoma (CBL) is a benign neoplasm of bone for which the genomic characteristics remain unclear. We compared the status of allelic losses of CBL with that seen in a set of chondrosarcomas (CS) to determine whether differences in their natural history and behavior are also reflected genetically. Eleven cases of...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.02.014
更新日期：2006-07-01 00:00:00
