Melanoma in a carcinoma ex pleomorphic adenoma of the parotid gland: a case report and putative histogenesis.

abstract：:We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750...

journal_title：Human pathology

authors： Weissferdt A,Kalhor N,Bishop JA,Jang SJ,Ro J,Petersson F,Wu B,Langman G,Bancroft H,Bi Y,Meng Y,Medeiros F,Brunnstrom H,Spagnolo D,Chai SM,Laycock A,Wakely PE Jr,Elmberger G,Soares FA,Campos AH,Gumurdulu D,Alvara

更新日期：2018-03-01 00:00:00

abstract：:Automatic quantification of cardinal histologic features of nonalcoholic fatty liver disease (NAFLD) may reduce human variability and allow continuous rather than semiquantitative assessment of injury. We recently developed an automated classifier that can detect and quantify macrosteatosis with greater than or equal ...

journal_title：Human pathology

authors： Vanderbeck S,Bockhorst J,Kleiner D,Komorowski R,Chalasani N,Gawrieh S

更新日期：2015-05-01 00:00:00

abstract：:Preeclampsia is a leading cause for maternal and perinatal mortality and morbidity. Microarray-based transcriptional profiling has been widely used for identifying genes responsible for preeclampsia. These studies deliver multiple pictures of gene signatures, implying the complicated pathophysiology. In the present wo...

journal_title：Human pathology

authors： Louwen F,Muschol-Steinmetz C,Friemel A,Kämpf AK,Töttel E,Reinhard J,Yuan J

更新日期：2014-06-01 00:00:00

abstract：:A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletio...

journal_title：Human pathology

authors： Park WS,Vortmeyer AO,Pack S,Duray PH,Böni R,Guerami AA,Emmert-Buck MR,Liotta LA,Zhuang Z

更新日期：1998-02-01 00:00:00

abstract：:CpG island methylator phenotype (CIMP) pathway in colorectal cancer is characterized by methylation of promoter regions of multiple putative tumor suppressor genes. Aberrant methylation also occurs in serrated and adenomatous polyps. We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS m...

journal_title：Human pathology

authors： Kakar S,Deng G,Cun L,Sahai V,Kim YS

更新日期：2008-01-01 00:00:00

abstract：:The canals of Hering (CoH), converging from the hepatic lobule onto the portal tract, connect bile canaliculi to the interlobular bile ducts, and represent the most proximal portion of the bile drainage pathway with a cholangiocyte lining. In this study we sought to ascertain whether this proximal pathway is involved ...

journal_title：Human pathology

authors： Saxena R,Hytiroglou P,Thung SN,Theise ND

更新日期：2002-10-01 00:00:00

abstract：:High cathepsin D (cath-D) concentration in breast cancer cytosol is associated with increased risk of metastasis. To specify the relative contribution of the different cells types responsible for cath-D level in cytosol, we validated semiquantitative cath-D immunoperoxidase staining on formalin-fixed, paraffin-embedde...

journal_title：Human pathology

authors： Roger P,Montcourrier P,Maudelonde T,Brouillet JP,Pages A,Laffargue F,Rochefort H

更新日期：1994-09-01 00:00:00

abstract：:Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy,...

journal_title：Human pathology

authors： Annan AC,Stevens KA,Osunkoya AO

更新日期：2017-07-01 00:00:00

abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...

journal_title：Human pathology

authors： Katz B,Tropé CG,Reich R,Davidson B

更新日期：2015-09-01 00:00:00

abstract：:Human immunodeficiency virus-associated nephropathy (HI-VAN) is a common form of nephropathy present in HIV-infected individuals that clinically presents with proteinuria that is frequently in the nephrotic range, less often with hematuria, and with a course that may evolve to irreversible azotemia ultimately resultin...

journal_title：Human pathology

authors： Rey L,Viciana A,Ruiz P

更新日期：1995-04-01 00:00:00

abstract：:Biopsy specimens of sarcoid skin lesions from nine patients with sarcoidosis were examined for the presence of immunoglobulins, complement (C3 and C4), and fibrinogen. Granulomas in all skin lesions were positive only for fibrinogen. The literature relating to the immunohistochemistry of sarcoidosis is reviewed and it...

journal_title：Human pathology

authors： Kataria YP,Zafranas A,Sharma HM

更新日期：1978-09-01 00:00:00

abstract：:Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...

journal_title：Human pathology

authors： Gokden M,Mrak RE

更新日期：2009-08-01 00:00:00

abstract：:We investigated whether histological chorioamnionitis (HCA) is a risk factor predisposing to leukemoid reaction (LR) and whether LR is associated with the preterm parturition syndrome and the systemic fetal inflammation response syndrome. A prospective histological study on placentas was performed in preterm infants (...

journal_title：Human pathology

authors： Zanardo V,Vedovato S,Trevisanuto DD,Suppiej A,Cosmi E,Fais GF,Chiarelli S

更新日期：2006-01-01 00:00:00

abstract：:We report a case of a newborn female with a rare tumor, a congenital sarcoma, presenting as an abdominal mass. Laparotomy demonstrated the tumor arising from the wall of the terminal ileum. Histologically, the tumor tissue was indistinguishable from clear cell sarcoma of the kidney and was composed of proliferating ce...

journal_title：Human pathology

authors： Kataoka Y,Shimada H,Sugimoto T,Mine H,Hachitanda Y,Doi Y,Sawada T,Weeks DA

更新日期：1993-09-01 00:00:00

abstract：:Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with Epstein-Barr virus occurring most frequently in the upper aerodigestive tract. There are limited reports on cellular origin and prognostic factors. We retrospectively investigated 73 cases with a median a...

journal_title：Human pathology

authors： Jhuang JY,Chang ST,Weng SF,Pan ST,Chu PY,Hsieh PP,Wei CH,Chou SC,Koo CL,Chen CJ,Hsu JD,Chuang SS

更新日期：2015-02-01 00:00:00

abstract：:Previous studies have proven that the lepidic component of lung adenocarcinoma is an independent prognostic factor and has a favorable effect on patient prognosis; however, no studies have reported the specific distribution of the lepidic component in lung cancer. In this study, we focused mainly on whether the lepidi...

journal_title：Human pathology

authors： Bian T,Jiang D,Feng J,Liu J,Qian L,Zhang Q,Li X,Liu Y,Zhang J

更新日期：2019-01-01 00:00:00

abstract：:Topoisomerase IIalpha (topoIIalpha) is an enzyme required for DNA replication and a molecular target for drugs called anthracyclines. The topoIIalpha gene (TOP2A) is located close to the HER-2/neu oncogene (HER2). We assessed gastric cancers to (1) clarify the relationship between gene amplification and protein overex...

journal_title：Human pathology

authors： Kanta SY,Yamane T,Dobashi Y,Mitsui F,Kono K,Ooi A

更新日期：2006-10-01 00:00:00

abstract：:In a series of approximately 80,000 lymph nodes, amyloid deposition was found in 18; 12 of those nodes were selected, on the basis of availability of specimens, for investigation by immunohistochemical typing to identify the protein of origin and by correlation with morphologic criteria and clinical information. Four ...

journal_title：Human pathology

authors： Newland JR,Linke RP,Lennert K

更新日期：1986-12-01 00:00:00

abstract：:An increase in S100 protein-positive cells has been reported in inflammatory bowel diseases, mainly Crohn disease. These cells were interpreted as myeloid-derived dendritic cells, chiefly in follicular areas. We were prompted to assess the nature of these cells in interfollicular areas of inflamed colonic mucosa in ul...

journal_title：Human pathology

authors： Mosnier JF,Jarry A,Camdessanché JP,Antoine JC,Laboisse CL

更新日期：2009-08-01 00:00:00

abstract：:Immunoreactivity to LN2 and LN3, monoclonal antibodies that recognize components of the class II major histocompatibility complex, was assessed in 72 cases of non-small cell lung carcinoma (NSCLC) (32 biopsy specimens, 40 resection specimens) and 64 cases of small cell carcinoma (56 biopsy specimens, 8 resections) of ...

journal_title：Human pathology

authors： Hua ZX,Tanaka KE,Tazelaar HD,Myers J,Markowitz GS,Borczuk AC

更新日期：1998-12-01 00:00:00

abstract：:Breast cancer is the leading form of cancer diagnosed in women, and the second leading cause of cancer mortality in this group. A commonly accepted grading system for breast cancer that has proven useful for guiding treatment strategy is the modified Bloom-Richardson system. However, this system is subject to interobs...

journal_title：Human pathology

authors： Tambasco M,Magliocco AM

更新日期：2008-05-01 00:00:00

abstract：:GATA3 immunostaining is a sensitive marker for mammary and urothelial carcinomas. It is routinely used in surgical pathology during workup of carcinomas of unknown origin. To the best of our knowledge, this is the first focused study of GATA3 expression in gallbladder adenocarcinomas. In this study, we evaluated GATA3...

journal_title：Human pathology

authors： Guo W,Lee W,Lu Y,Li X,Chandan VS

更新日期：2020-12-01 00:00:00

abstract：:It has been proposed that an epithelial injury may be one of the multiple primary events in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to characterize the tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis. W...

journal_title：Human pathology

authors： Lappi-Blanco E,Lehtonen ST,Sormunen R,Merikallio HM,Soini Y,Kaarteenaho RL

更新日期：2013-05-01 00:00:00

abstract：:The precise regulation and maintenance of balance between cell proliferation and cell death in multicellular organisms is critical for tissue homeostasis. bcl-2 initiates a new gene family involved in the regulation of cell death and survival without affecting cell proliferation. Expression of Bcl-2 has been reported ...

journal_title：Human pathology

authors： Lu QL,Abel P,Foster CS,Lalani EN

更新日期：1996-02-01 00:00:00

abstract：:Transitional cell (urothelial) carcinoma of the bladder is the second most common urologic malignancy and is one of the best understood neoplasms, with relatively well-defined pathogenetic pathways, natural history, and tumor biology. Conventional clinical and pathologic parameters are widely used to grade and stage t...

journal_title：Human pathology

authors： Cheng L,Zhang S,MacLennan GT,Williamson SR,Lopez-Beltran A,Montironi R

更新日期：2011-04-01 00:00:00

abstract：:Studies on melanoma cell lines indicate the expression of actin-binding protein (ABP), a peripheral cytoplasmic protein that crosslinks actin, is important for melanoma cell motility. We used an ABP-specific monoclonal antibody to characterize ABP expression in 18 benign nevi and 28 primary and metastatic malignant me...

journal_title：Human pathology

authors： Bouffard D,Duncan LM,Howard CA,Mihm MC Jr,Byers HR

更新日期：1994-07-01 00:00:00

abstract：:Giant cell tumor of tendon sheath (GCTS) and pigmented villonodular synovitis (PVNS) are common synovial "tumors." Their immunohistochemical profile, however, has not been well characterized, and uncertainty exists regarding their histogenesis and relationship to fibroma of tendon sheath. In an effort to clarify these...

journal_title：Human pathology

authors： O'Connell JX,Fanburg JC,Rosenberg AE

更新日期：1995-07-01 00:00:00

abstract：:A distinctive variant of basal cell adenoma called membranous basal cell adenoma is well recognized in salivary glands. It appears identical to cutaneous cylindroma, hence the synonym dermal analogue tumor. We present a case of a tumor involving the parotid gland that appeared identical to cutaneous spiradenoma. In ad...

journal_title：Human pathology

authors： Kazakov DV,Benkova K,Michal M,Vanecek T,Kacerovska D,Skalova A

更新日期：2009-10-01 00:00:00

abstract：:Endothelial cell injury may contribute to the progression of various glomerular diseases. In the present study, we examined glomerular capillary injury in acute and chronic glomerular lesions in patients with Immunoglobulin A nephropathy (IgAN). We selected renal biopsy samples of IgAN (n = 200), and glomerular capill...

journal_title：Human pathology

authors： Kusano T,Takano H,Kang D,Nagahama K,Aoki M,Morita M,Kaneko T,Tsuruoka S,Shimizu A

更新日期：2016-03-01 00:00:00

abstract：:A 75 year old man presented with metastatic carcinoma of the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver di...

journal_title：Human pathology

authors： Michel RP,Limacher JJ,Kimoff RJ

更新日期：1982-01-01 00:00:00