CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.

Abstract:

:CpG island methylator phenotype (CIMP) pathway in colorectal cancer is characterized by methylation of promoter regions of multiple putative tumor suppressor genes. Aberrant methylation also occurs in serrated and adenomatous polyps. We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS mutations and methylation at hMLH1, p16, HIC1, RASSF2, MGMT, MINT1, and MINT31. CIMP-positive status (methylation at 3 or more loci) was observed in 44% tubulovillous/villous adenomas compared with 8 (27%) of 30 tubular adenomas (P = .08). Tubulovillous/villous adenomas showed significantly higher methylation than tubular adenomas at MGMT (87% vs 37%, P < .01) and RASSF2 (94% vs 70%, P = .02). There was no significant difference in methylation of HIC1, MINT1, MINT31, and p16. hMLH1 methylation was absent in all tubulovillous/villous adenomas and seen in only 2 (7%) tubular adenomas. CIMP-positive status correlated with large size, right-sided location, and amount of villous component in tubulovillous/villous adenomas. BRAF V600E mutation was not observed in any tubular adenoma or tubulovillous/villous adenoma. KRAS mutations were seen in 9% of tubulovillous/villous adenomas and 10% of tubular adenomas. In conclusion, CIMP-positive phenotype is common in tubulovillous/villous adenomas and increases with large size, right-sided location, and amount of villous component. Methylation of MGMT and RASSF2 increases during the progression from tubular adenoma to tubulovillous/villous adenoma. BRAF mutations are absent in tubulovillous/villous adenomas.

journal_name

Hum Pathol

journal_title

Human pathology

authors

Kakar S,Deng G,Cun L,Sahai V,Kim YS

doi

10.1016/j.humpath.2007.06.002

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

30-6

issue

1

eissn

0046-8177

issn

1532-8392

pii

S0046-8177(07)00308-5

journal_volume

39

pub_type

杂志文章
  • Steroidogenesis in human adrenocortical carcinoma: biochemical activities, immunohistochemistry, and in situ hybridization of steroidogenic enzymes and histopathologic study in nine cases.

    abstract::To obtain a better understanding of steroid metabolism associated with adrenocortical malignancy we studied steroidogenesis in nine cases of adrenocortical carcinoma (six with Cushing's syndrome, two without clinically significant adrenocortical hormonal abnormalities, and one with primary aldosteronism) by analyzing ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(93)90088-x

    authors: Sasano H,Suzuki T,Nagura H,Nishikawa T

    更新日期:1993-04-01 00:00:00

  • The evolving landscape of HPV-related neoplasia in the head and neck.

    abstract::Human papilloma virus (HPV) has emerged as the key etiologic driver in the majority of cancers at head and neck mucosal sites. First described in the uterine cervix and subsequently in oropharyngeal squamous cell carcinomas, the morphologic and clinical spectrum of HPV-related neoplasia has continued to expand and now...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.humpath.2019.09.001

    authors: Devins KM,Tetzlaff MT,Baloch Z,LiVolsi VA

    更新日期:2019-12-01 00:00:00

  • Aging changes in the human aortic valve in relation to dystrophic calcification.

    abstract::To elucidate the pathogenesis of aging changes and their relation to age associated calcification, a morphological study of 27 human aortic valves was carried out. Nine valves were obtained from immediate autopsies and 18 valves from routine autopsies done within four hours after death. Calcium deposition was present ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(76)80005-6

    authors: Kim KM,Valigorsky JM,Mergner WJ,Jones RT,Pendergrass RF,Trump BF

    更新日期:1976-01-01 00:00:00

  • Loss of heterozygosity on chromosome 11q13 in lobular lesions of the breast using tissue microdissection and polymerase chain reaction.

    abstract::Demonstration of identical allelic loss on chromosome 11q13 in synchronous in situ (DCIS) and invasive ductal (IDC) breast carcinoma has provided molecular evidence of the progression of DCIS to IDC. We investigated loss of heterozygosity (LOH) at chromosome 11q13 in the spectrum of "marker/premalignant" and "malignan...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(97)90124-6

    authors: Nayar R,Zhuang Z,Merino MJ,Silverberg SG

    更新日期:1997-03-01 00:00:00

  • Chemical cholecystitis associated with hepatic arterial chemotherapy delivered by a permanently implanted pump.

    abstract::The introduction of chemotherapeutic agents directly into the proper hepatic artery via an indwelling catheter results in perfusion of the gallbladder, because the cystic artery is usually a branch of the right hepatic artery. Five gallbladders, removed two to 16 months after insertion of permanently implanted Infusai...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(85)80275-6

    authors: Marymont JV,Dakhil SR,Travers H,Housholder DF

    更新日期:1985-10-01 00:00:00

  • HMB-45, S-100, NK1/C3, and MART-1 in metastatic melanoma.

    abstract::The diagnosis of melanoma metastatic to lymph node remains a difficult problem given its histological diversity. We examined the staining patterns of S-100, NK1/C3, HMB-45, and MART-1 (DC10) in melanoma metastases to lymph nodes. Immunohistochemical stains were performed on tissue sections of 126 formalin-fixed lymph ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2003.09.019

    authors: Zubovits J,Buzney E,Yu L,Duncan LM

    更新日期:2004-02-01 00:00:00

  • Chronic myelogenous leukemia: molecular diagnostic considerations.

    abstract::Chronic myelogenous leukemia (CML) is associated in 95% of cases with the Philadelphia chromosome (Ph1) by cytogenetic analysis. This acquired karyotypic abnormality is the product of a balanced translocation between the c-abl oncogene on chromosome 9 and the breakpoint cluster region (BCR) gene on chromosome 22. The ...

    journal_title:Human pathology

    pub_type: 杂志文章,评审

    doi:10.1016/0046-8177(94)90225-9

    authors: McClure JS,Litz CE

    更新日期:1994-06-01 00:00:00

  • Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma.

    abstract::Using analysis of allelic loss (loss of heterozygosity [LOH]), we previously reported a putative progression pathway from germ cell neoplasia in situ (GCNIS) to seminoma and then to embryonal carcinoma in mixed-type testicular germ cell tumors. To identify the genetic backgrounds related to the progression of nonsemin...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2018.09.007

    authors: Miyai K,Ito K,Nakanishi K,Tsuda H

    更新日期:2019-02-01 00:00:00

  • Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis.

    abstract::We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2006.12.010

    authors: Milne AN,Sitarz R,Carvalho R,Polak MM,Ligtenberg M,Pauwels P,Offerhaus GJ,Weterman MA

    更新日期:2007-06-01 00:00:00

  • The ultrastructure of small-cell osteosarcoma, with a review of the light microscopy and differential diagnosis.

    abstract::Small-cell osteosarcoma is a rare form of osteosarcoma and often poses difficulty in differential diagnosis when tissue samples do not include any diagnostic osteoid. By light microscopy, it may be difficult to distinguish small-cell osteosarcoma from other small-cell neoplasms, especially Ewing's sarcoma and mesenchy...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/0046-8177(91)90161-h

    authors: Dickersin GR,Rosenberg AE

    更新日期:1991-03-01 00:00:00

  • Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis.

    abstract::Nuclear pore complexes (NPCs) are elaborate macromolecular structures that regulate the bidirectional nucleocytoplasmic traffic system. In vertebrate cells, NPCs include a family of 50 to 100 proteins termed nucleoporins (Nups). The 88-kD Nup has been found to be linked in a dynamic subcomplex with the oncogenic CAN/N...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2002.124785

    authors: Gould VE,Orucevic A,Zentgraf H,Gattuso P,Martinez N,Alonso A

    更新日期:2002-05-01 00:00:00

  • Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system.

    abstract::We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a v...

    journal_title:Human pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.humpath.2006.10.006

    authors: Massone C,Soyer HP,Lozzi GP,Di Stefani A,Leinweber B,Gabler G,Asgari M,Boldrini R,Bugatti L,Canzonieri V,Ferrara G,Kodama K,Mehregan D,Rongioletti F,Janjua SA,Mashayekhi V,Vassilaki I,Zelger B,Zgavec B,Cerroni L,K

    更新日期:2007-04-01 00:00:00

  • Transfusion therapy for renal transplant candidates.

    abstract::Improved graft survival was observed in cadaver-kidney recipients prepared with random donor blood transfusions and in selected living-related-kidney recipients primed with transfusions from the kidney donor. This seems to justify a purposeful transfusion policy in these patients. ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(83)80031-8

    authors: Polesky HF,Lasky LC

    更新日期:1983-03-01 00:00:00

  • Morphological and biological characteristics of mammogram-detected invasive breast cancer.

    abstract::Thirty-nine mammographically detected, (M-detected) small invasive carcinomas of the breast (< or = 5 mm) were compared with 78 consecutive clinical cancers (> or = 10 mm) for a variety of morphological and biological markers of prognostic importance. There were more tubular carcinomas in the M-detected group (12.8% v...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(96)90222-1

    authors: Moezzi M,Melamed J,Vamvakas E,Inghirami G,Mitnick J,Quish A,Bose S,Zelman G,Roses D,Harris M,Feiner H

    更新日期:1996-09-01 00:00:00

  • Mixed endometrial carcinomas with a "low-grade serous"-like component: a clinicopathologic, immunohistochemical, and molecular genetic study.

    abstract::Recently, we reported 2 mixed endometrioid endometrial carcinomas with a "low-grade serous"-like component, which does not fit into any of the 4 molecular groups described by The Cancer Genome Atlas. To understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these 2 ca...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2017.10.016

    authors: Espinosa I,D'Angelo E,Corominas M,Gonzalez A,Prat J

    更新日期:2018-01-01 00:00:00

  • Hepatic veno-occlusive disease after high-dose mitomycin C and autologous bone marrow transplantation therapy.

    abstract::Three cases of veno-occlusive disease of the liver were diagnosed in four autopsied patients who had received high-dose mitomycin C therapy followed by autologous bone marrow transplantation, and the pathologic finding are reported. Review of 27 liver, examined post mortem, of patients receiving other high-dose chemot...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(82)80008-7

    authors: Gottfried MR,Sudilovsky O

    更新日期:1982-07-01 00:00:00

  • Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases.

    abstract::Mesenchymal chondrosarcoma, a rare malignant round cell and hyaline cartilage tumor, is most commonly intraosseous but can occur in extraskeletal sites. We intensively observed the morphology and applied Sox9 (master regulator of chondrogenesis), beta-catenin (involved in bone formation, thought to inhibit chondrogene...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2009.11.006

    authors: Fanburg-Smith JC,Auerbach A,Marwaha JS,Wang Z,Rushing EJ

    更新日期:2010-05-01 00:00:00

  • Assessment of basal cell status and proliferative patterns in flat and papillary urothelial lesions: a contribution to the new WHO classification of the urothelial tumors of the urinary bladder.

    abstract::In 1999, the World Health Organization (WHO) published a new classification of papillary urothelial tumors of the urinary bladder. Intended to represent a reproducible, easy-to-use classification system that better separates patients with true malignancies (bladder cancer) from those patients who are at an increased r...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1053/hupa.2000.8224

    authors: Helpap B,Köllermann J

    更新日期:2000-06-01 00:00:00

  • Urothelial carcinoma involving the ureteral orifice: a clinicopathologic analysis of 93 cases.

    abstract::Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy,...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2017.04.018

    authors: Annan AC,Stevens KA,Osunkoya AO

    更新日期:2017-07-01 00:00:00

  • Identification of prekeratin by immunofluorescence staining in the differential diagnosis of tumors.

    abstract::Fibrillar proteins with a role in cellular shape and motility are present in the cytoplasm of most animal cells. They vary greatly in size, organization, and reactivity according to cell type and can be separately identified by the use of recently developed monospecific antisera and indirect immunofluorescence stainin...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(81)80026-3

    authors: Sieinski W,Dorsett B,Ioachim HL

    更新日期:1981-05-01 00:00:00

  • Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy.

    abstract::ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2007.10.009

    authors: Larbcharoensub N,Leopairat J,Sirachainan E,Narkwong L,Bhongmakapat T,Rasmeepaisarn K,Janvilisri T

    更新日期:2008-06-01 00:00:00

  • Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features.

    abstract::Most human papillomavirus-associated squamous intraepithelial lesions of the uterine cervix are flat; some have papillary architecture that shows a spectrum of differentiation from low-grade squamous intraepithelial lesions to high-grade squamous intraepithelial lesions. For this subset of lesions, there are few data ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2009.05.015

    authors: Liang CW,Lin MC,Hsiao CH,Lin YT,Kuo KT

    更新日期:2010-03-01 00:00:00

  • Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region.

    abstract::Partial monosomy 13q, a chromosomal alteration originally reported in spindle cell lipoma, has also been documented in a few cases of mammary myofibroblastoma. Subsequently, a monoallelic loss of RB1 and FOXO1, located on 13q14, was identified in some cases of cellular angiofibroma, a benign stromal tumor of the lower...

    journal_title:Human pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.humpath.2012.01.015

    authors: Magro G,Righi A,Casorzo L,Antonietta T,Salvatorelli L,Kacerovská D,Kazakov D,Michal M

    更新日期:2012-11-01 00:00:00

  • Exploration of BRAFV600E as a diagnostic adjuvant in the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).

    abstract::The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecu...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2018.06.033

    authors: Johnson DN,Sadow PM

    更新日期:2018-12-01 00:00:00

  • Coiled-coil domain-containing protein 8 inhibits the invasiveness and migration of non-small cell lung cancer cells.

    abstract::Lung cancer has always been the leading cause of death among patients with malignant tumors, and the majority of these patients die because of cancer cell invasion and metastasis. Previous studies have implicated coiled-coil domain-containing protein 8 (CCDC8) as a tumor suppressor in several types of cancer, such as ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2016.06.001

    authors: Jiang GY,Zhang XP,Zhang Y,Xu HT,Wang L,Li QC,Wang EH

    更新日期:2016-10-01 00:00:00

  • Retraction of bioprosthetic heart valve cusps: a cause of wide-open regurgitation in right-sided heart valves.

    abstract::Most failures of bioprosthetic heart valves in children are due to stenosis secondary to thrombus, calcific deposits, or tissue ingrowth. Valve failures due to regurgitation typically involve cuspal detachment, tears, or perforations. We present four cases of prosthetic valve regurgitation in children caused by cuspal...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(88)80341-1

    authors: Murphy SK,Rogler WC,Fleming WH,McManus BM

    更新日期:1988-02-01 00:00:00

  • Prognostic impact of blood vessel invasion in gastrointestinal stromal tumor of the stomach.

    abstract::Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important i...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2010.02.013

    authors: Yamamoto H,Kojima A,Miyasaka Y,Imamura M,Nakamura N,Yao T,Tsuneyoshi M,Oda Y

    更新日期:2010-10-01 00:00:00

  • Bone-marrow-derived CXCR4-positive tissue-committed stem cell recruitment in human right ventricular remodeling.

    abstract::The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/j.humpath.2009.12.017

    authors: Castellani C,Padalino M,China P,Fedrigo M,Frescura C,Milanesi O,Stellin G,Thiene G,Angelini A

    更新日期:2010-11-01 00:00:00

  • Chromosome 12p abnormalities and IMP3 expression in prepubertal pure testicular teratomas.

    abstract::Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...

    journal_title:Human pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.humpath.2015.10.003

    authors: Cornejo KM,Cheng L,Church A,Wang M,Jiang Z

    更新日期:2016-03-01 00:00:00

  • Morphologic and immunohistochemical features of fulminant delta hepatitis.

    abstract::Recent studies have indicated that some cases of fulminant hepatitis that were ostensibly type B were actually acute viral hepatitis, types B and delta, or persistent hepatitis, type B with superimposed acute delta infection. Histologic characterization of the various types has not yet been undertaken. Within ten to 3...

    journal_title:Human pathology

    pub_type: 杂志文章

    doi:10.1016/s0046-8177(85)80012-5

    authors: Govindarajan S,de Cock KM,Peters RL

    更新日期:1985-03-01 00:00:00