Abstract：
:Endothelial cell injury may contribute to the progression of various glomerular diseases. In the present study, we examined glomerular capillary injury in acute and chronic glomerular lesions in patients with Immunoglobulin A nephropathy (IgAN). We selected renal biopsy samples of IgAN (n = 200), and glomerular capillary injury in the acute and chronic glomerular lesions was assessed using immunohistochemistry for CD34 and electron microscopy. We examined the correlations between acute and chronic glomerular lesions and proteinuria, hematuria, and the renal function. The injured glomerular capillaries in the acute glomerular lesions were characterized morphologically by the separation of CD34+ endothelial cells from the glomerular basement membrane and the loss of glomerular endothelial cells and capillaries, together with inflammatory cell infiltration, fibrin exudation, rupture of the glomerular basement membrane, and/or crescent formation. In addition, the injured capillaries in the chronic glomerular lesions were characterized by the loss of CD34+ glomerular endothelial cells and capillaries exhibiting segmental and global glomerular sclerosis with or without fibrous crescents. In the acute glomerular lesions, the presence of endocapillary hypercellularity, fibrinoid necrosis, and cellular and fibrocellular crescents correlated significantly with hematuria, with or without proteinuria. In the chronic glomerular lesions, a significant relationship was evident between segmental or global sclerosis and proteinuria and/or the serum creatinine level. In conclusion, injuries of glomerular capillaries and the loss of endothelial cells occurred in the acute and chronic glomerular lesions in IgAN and may contribute to the development of hematuria, proteinuria, and renal dysfunction.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Kusano T,Takano H,Kang D,Nagahama K,Aoki M,Morita M,Kaneko T,Tsuruoka S,Shimizu Adoi
10.1016/j.humpath.2015.10.013subject
Has Abstractpub_date
2016-03-01 00:00:00pages
135-44eissn
0046-8177issn
1532-8392pii
S0046-8177(15)00443-8journal_volume
49pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Most histopathologic descriptions of influenza pneumonia are based on autopsy findings in fatal cases during epidemics and pandemics of influenza. We describe the histologic findings of influenza pneumonia observed in biopsy material derived from six sporadic cases of influenza (influenza A, four cases; influenza B, o...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90170-8
更新日期：1994-01-01 00:00:00
abstract：:In the normal liver, the transforming growth factor beta (TGF-beta) signaling pathway plays an important role in inhibiting hepatocyte growth. This effect is mediated through Smad4 (or Dpc4), a tumor-suppressor gene that affects gene transcription and controls cell growth. A loss of Smad4 is associated with carcinoma ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.128061
更新日期：2002-09-01 00:00:00
abstract：:This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinicopathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.09.012
更新日期：2017-01-01 00:00:00
abstract：:Four monoclonal antibodies (MoAbs), 60.15, 61.3, 105.10, and 2.16, directed to different proteins of Mycobacterium tuberculosis were used by an indirect avidin-biotin complex peroxidase-antiperoxidase method to detect mycobacterial antigens in lung, lymph node, and joint tissue specimens of tuberculous patients. Using...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(89)90226-8
更新日期：1989-11-01 00:00:00
abstract：:Parakeratosis refers to incomplete maturation of epidermal keratinocytes, resulting in abnormal retention of nuclei in the stratum corneum. It occurs in many diseases of the skin, particularly in psoriasis. Down-regulation of inhibitor of differentiation 4 messenger RNA has been demonstrated in psoriatic skin, but the...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.02.005
更新日期：2011-12-01 00:00:00
abstract：:The approach to the collection and transport of meaningful and accurate microbiologic specimens depends upon the nature of the suspected infectious entity and upon the location of the pathogenic process, as well as the possession of appropriate instrumentation and containers. New information and newly developed collec...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(76)80040-8
更新日期：1976-05-01 00:00:00
abstract：:Myopericytoma is a rare, histologically distinctive tumor that shows evidence of differentiation toward perivascular myoid cells. Myopericytoma is largely considered a neoplasm of skin and soft tissues, with examples of this lesion involving visceral sites being extremely limited. We present the clinical and pathologi...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.02.014
更新日期：2010-10-01 00:00:00
abstract：:The pathology of cytomegalovirus (CMV) encephalitis was studied at autopsy in thirty patients with acquired immunodeficiency syndrome. Lesions could be segregated into five major categories: microglial nodules, isolated inclusion-bearing cells, focal parenchymal necrosis, necrotizing ventriculo-encephalitis, and necro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80012-6
更新日期：1987-03-01 00:00:00
abstract：:Previously used only as a screening tool, cytology now emerges as a powerful diagnostic technique, especially since the advent of the fine needle aspiration (FNA) biopsy. This article highlights the use of ancillary techniques, primarily electron microscopy (EM), and immunohistochemistry (IHC). When coupled with routi...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(98)90003-x
更新日期：1998-12-01 00:00:00
abstract：:Tissue specimens obtained at autopsy from seven childhood cases of malignant histiocytosis were studied by immunohistochemistry. Clinically, the majority of the cases showed sustained fever, hepatosplenomegaly, pancytopenia, and DIC. The pretreatment diagnosis was based on their typical clinical manifestations and bon...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(88)80178-3
更新日期：1988-06-01 00:00:00
abstract：:Congenital syphilis is often a presumptive diagnosis (based on serologies), because confirmation requires identification of Treponema pallidum in fetal/neonatal tissues or in the placenta. Placental histological features associated with congenital syphilis include the triad of enlarged hypercellular villi, proliferati...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90110-0
更新日期：1996-04-01 00:00:00
abstract：:This study investigate the expression of the mitogen-activated protein kinases (MAPKs) in normal prostate, benign prostatic hyperplasia (BPH), and prostatic cancer (PC), and also the possible relationship between the activity of these MAPKs and the apoptosis/proliferation index. Immunochemical techniques were carried ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.32227
更新日期：2002-03-01 00:00:00
abstract：:Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. Th...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：:Adenomatous hyperplasia, a hyperplastic parenchymal nodule in the cirrhotic liver, has been presumed to be a preneoplastic lesion in human hepatocarcinogenesis. In this study, phenotypes of the sinusoidal endothelium were examined in adenomatous hyperplasia, hepatocellular carcinoma, cirrhosis, chronic active hepatiti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(91)90136-d
更新日期：1991-05-01 00:00:00
abstract：:Patients undergoing treatment of acute lymphoblastic leukemia are at risk for fungal infections including disseminated candidiasis. We describe a case of systemic Candida albicans infection associated with life-threatening gastrointestinal hemorrhage due to unusual necrotizing vasculitis involving the gastrointestinal...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.09.015
更新日期：2010-04-01 00:00:00
abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.017
更新日期：2014-07-01 00:00:00
abstract：:Giant cell tumor of tendon sheath (GCTTS) is a common soft tissue tumor. Immunophenotypical evidence suggests it is of synovial cell origin. There is controversy regarding the underlying nature of this lesion, specifically whether it is a neoplastic or nonneoplastic (ie, reactive or hyperplastic) process. Karyotypic a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90155-6
更新日期：1997-07-01 00:00:00
abstract：:In 1999, the World Health Organization (WHO) published a new classification of papillary urothelial tumors of the urinary bladder. Intended to represent a reproducible, easy-to-use classification system that better separates patients with true malignancies (bladder cancer) from those patients who are at an increased r...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.8224
更新日期：2000-06-01 00:00:00
abstract：:A recent publication described 5 unusual clear cell renal tumors with prominent smooth muscle stroma that were characterized only by immunostaining. We report 3 additional tumors composed of clear cell renal cell carcinoma intimately admixed with abundant smooth muscle stroma. Epithelial differentiation of the maligna...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.05.021
更新日期：2009-03-01 00:00:00
abstract：:Cystic hygroma of the neck was observed in seven spontaneously aborted, severely autolyzed female fetuses. Four of five karyotyped cases had the 45,XO karyotype; one was a normal female, 46,XX. Diagnostic features associated with monosomy X in fetuses, which were observed in six of these cases, include large cystic hy...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(84)80331-7
更新日期：1984-01-01 00:00:00
abstract：:Unlike colorectal cancer, risk markers for adenocarcinoma of the small intestine (ASI) have not been identified. Because the demographic and pathological features of both of these diseases are similar, immunohistochemistry was performed using monoclonal antibodies for three colonic premalignant markers, Adnab-9 (recog...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(99)90124-7
更新日期：1999-04-01 00:00:00
abstract：:A case of myocardial hyperplasia with numerous mitotic figures, caterpillar nuclei, and an abnormal DNA ploidy pattern is described in an 8-day-old full-term baby with uneventful gestation and sudden death. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90064-a
更新日期：1992-12-01 00:00:00
abstract：:We describe the pathology of 5 patients with germline PRKACA copy number gain and Cushing syndrome: 4 males and 1 female, aged 2 to 43 years, including a mother and son. Imaging showed normal or slightly enlarged adrenal glands in 4 patients and a unilateral mass in the fifth. Biochemically, the patients had corticotr...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.09.005
更新日期：2015-01-01 00:00:00
abstract：:Recently, we reported 2 mixed endometrioid endometrial carcinomas with a "low-grade serous"-like component, which does not fit into any of the 4 molecular groups described by The Cancer Genome Atlas. To understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these 2 ca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.10.016
更新日期：2018-01-01 00:00:00
abstract：:Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.02.007
更新日期：2009-08-01 00:00:00
abstract：:This report describes a 47-year-old man with Erdheim-Chester disease (EC), the second case reported in Japan. The patient complained of knee pain, and the roentgenogram of the bilateral legs revealed symmetric osteolytic lesions with sclerosis of the metaphyseal regions of the long bones. Histological examination of t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90145-8
更新日期：1996-01-01 00:00:00
abstract：:The peroxidase-antiperoxidase immunohistochemical technique was employed to stain formalin fixed, paraffin embedded tissue sections from three cases of encephalitis caused by Toxoplasma gondii. We studied two cases of congenital infection and one case of acquired toxoplasmosis occurring in an immunocompromised host. T...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80170-0
更新日期：1981-08-01 00:00:00
abstract：:Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult tes...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2015.10.003
更新日期：2016-03-01 00:00:00
abstract：:A primary neoplasm of the proximal humerus in a 68-year-old woman was unique histologically in that it contained both malignant cartilaginous and squamous cell components. The epithelial differentiation was confirmed by the demonstration of keratin by immunohistochemical techniques and of basement membrane, tonofilame...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80227-5
更新日期：1986-03-01 00:00:00
abstract：:We present a rare case of unilateral intratesticular cystadenocarcinoma with mucinous differentiation in a 71-year-old male patient. The orchiectomy specimen revealed a 3.5-cm well to moderately differentiated cystic neoplasm with elongated fine papillary structures lined by columnar epithelium with alternating goblet...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.11.021
更新日期：2011-09-01 00:00:00
