Abstract：
:Immunoreactivity to LN2 and LN3, monoclonal antibodies that recognize components of the class II major histocompatibility complex, was assessed in 72 cases of non-small cell lung carcinoma (NSCLC) (32 biopsy specimens, 40 resection specimens) and 64 cases of small cell carcinoma (56 biopsy specimens, 8 resections) of the lung. All cases were reviewed independently by three pathologists for histological classification. Only 1 of the 64 small cell carcinomas showed immunoreactivity for LN2, and none of the 64 cases showed reactivity for LN3. Among the non-small cell carcinomas, 25 of 48 cases were positive for LN2 and 43 of 71 were positive for LN3; the sensitivity was greater for adenocarcinoma (78.5%) than for squamous cell carcinoma (37%). A combined sensitivity of 64.7% was observed when the results of LN2 and LN3 were combined, and this sensitivity was not significantly diminished in the biopsy subset of cases (59.4%). Differentiation within histological subtypes of NSCLC (ie, well, moderate, or poorly differentiated) did not alter test sensitivity. In conclusion, LN2 and LN3, used alone or in combination, appear highly specific for non-small cell carcinoma and moderately sensitive in both biopsy and resection specimens; therefore, these antibodies may be diagnostically useful in distinguishing small cell from non-small cell carcinoma of the lung.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Hua ZX,Tanaka KE,Tazelaar HD,Myers J,Markowitz GS,Borczuk ACdoi
10.1016/s0046-8177(98)90013-2subject
Has Abstractpub_date
1998-12-01 00:00:00pages
1441-6issue
12eissn
0046-8177issn
1532-8392pii
S0046-8177(98)90013-2journal_volume
29pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Adamantinoma of the long bones is a rare, typically low-grade malignant tumor that frequently involves the tibia. Radiographically, adamantinoma is characteristically a lytic, intracortical, and expansile lesion with variable margins. Histologically, adamantinoma is a bimorphic neoplasm, composed of epithelial and ost...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.11.018
更新日期：2019-09-01 00:00:00
abstract：:This article briefly describes the origin of one of the more common (food-related) pathologic terms--"bread and butter pericarditis." The eminent French physician, Laennec, the inventor of the stethoscope amongst several other important medical contributions, can be credited for having coined the term that is still in...
journal_title：Human pathology
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.humpath.2003.08.029
更新日期：2004-02-01 00:00:00
abstract：:The DNA content and proliferative indexes of seven cases of tenosynovial giant cell tumor of tendon sheath, diffuse type (TGCT-D); 11 cases of tenosynovial giant cell tumor of tendon sheath, localized type (TGCT-L); and seven cases of pigmented villonodular synovitis (PVNS) were analyzed by flow cytometry in an attemp...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90340-9
更新日期：1992-07-01 00:00:00
abstract：:The clinical and pathologic features of 15 new cases of the uncommon primary or granulomatous angiitis of the central nervous system (PACNS) are described. To date, only 108 such cases have been reported in the English literature. Clinically, most PACNS patients have been young or middle-aged (mean age, 45 years; rang...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(92)90238-x
更新日期：1992-02-01 00:00:00
abstract：:Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.09.001
更新日期：2016-12-01 00:00:00
abstract：:Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy,...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.04.018
更新日期：2017-07-01 00:00:00
abstract：:Refractile foreign particles within clear vacuoles were observed in capillaries of 17 patients who underwent cardiopulmonary bypass surgery, died, and were autopsied at the George Washington University Hospital from December 1978 through April 1981. The postoperative survival time ranged from less than one day to more...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80243-8
更新日期：1982-12-01 00:00:00
abstract：:Altered expression of oncogenes and tumor suppressor genes, the normal function of which is to regulate cell growth and differentiation, represents a central event in the pathogenesis of human cancer. Aberrant expression of these genes is often a result of a mutational event. In vitro amplification of DNA with the pol...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(94)90220-8
更新日期：1994-06-01 00:00:00
abstract：:CD10 is common in B-precursor acute lymphoblastic leukemia (ALL) but is rare in acute myeloid leukemia (AML). However, until recently, analysis for CD10 has generally required fresh or frozen tissue. 56C6 is a monoclonal antibody that is now commercially available for the detection of CD10 in routinely processed paraf...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.6276
更新日期：2000-09-01 00:00:00
abstract：:Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. The clonal and genetic relationship between each component has not been investigated b...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.05.022
更新日期：2016-10-01 00:00:00
abstract：:High cathepsin D (cath-D) concentration in breast cancer cytosol is associated with increased risk of metastasis. To specify the relative contribution of the different cells types responsible for cath-D level in cytosol, we validated semiquantitative cath-D immunoperoxidase staining on formalin-fixed, paraffin-embedde...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90004-3
更新日期：1994-09-01 00:00:00
abstract：:Endometrial carcinoma is the most common malignant tumor of the female genital tract in the Western world. Approximately 80% of cases are well- to moderately differentiated (endometrioid) adenocarcinomas, which are confined to the uterine corpus at diagnosis, and thus most can be cured. Conversely, high-grade (ie, cle...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2004.02.007
更新日期：2004-06-01 00:00:00
abstract：:Giant cell tumor of tendon sheath (GCTS) and pigmented villonodular synovitis (PVNS) are common synovial "tumors." Their immunohistochemical profile, however, has not been well characterized, and uncertainty exists regarding their histogenesis and relationship to fibroma of tendon sheath. In an effort to clarify these...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90226-0
更新日期：1995-07-01 00:00:00
abstract：:GATA3 immunostaining is a sensitive marker for mammary and urothelial carcinomas. It is routinely used in surgical pathology during workup of carcinomas of unknown origin. To the best of our knowledge, this is the first focused study of GATA3 expression in gallbladder adenocarcinomas. In this study, we evaluated GATA3...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2020.09.012
更新日期：2020-12-01 00:00:00
abstract：:Cell growth in the normal prostate is regulated by a delicate balance between cell death and cell proliferation (ie, apoptotic v proliferative activity). Disruption of the molecular mechanisms that regulate these two processes may underline the abnormal growth of the gland leading to benign prostatic hyperplasia (BPH)...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90396-2
更新日期：1996-07-01 00:00:00
abstract：:A digoxigenin-tailed, synthetic oligodeoxynucleotide was used to detect genomic hepatitis delta virus (HDV) RNA in formalin-fixed, paraffin-embedded liver sections by a nonisotopic in situ hybridization (NISH) procedure. Twenty-three liver samples from chronically HDV-infected patients were studied. Eight liver specim...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90133-n
更新日期：1992-05-01 00:00:00
abstract：:Cervical carcinoma is the most common cancer among Belizean women; however, data regarding the frequency of human papillomavirus (HPV) genotypes and their association with cervical cancer are nonexistent. We therefore included HPV genotyping as part of a week-long cervical cancer screening campaign conducted in Belize...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2008.12.015
更新日期：2009-07-01 00:00:00
abstract：:The pathogenesis of lacaziosis continues to be obscure, and works have investigated the blood systemic immune response or the dermal immune response in restricted lesions in different body regions. Some authors describe that the inflammatory infiltrate in lacaziosis lesions showed a predominance of macrophages followe...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.10.016
更新日期：2015-02-01 00:00:00
abstract：:Aberrant crypt foci (ACF) are one of the earliest putative preneoplastic, and in some cases, neoplastic lesions in human colons. These microscopic lesions, identified on methylene blue-stained mucosa with a low-power-magnification microscope, are thought to be closely related to the earliest steps in multistage coloni...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90062-4
更新日期：1998-05-01 00:00:00
abstract：:Ovarian cancer, consisting predominantly of ovarian carcinoma, is the eighth most common cancer in women and the most lethal gynecologic malignancy. Efforts focus on identifying biomarkers which may aid in early diagnosis and reduce mortality, as well as on characterizing therapeutic targets with the aim of circumvent...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2015.06.013
更新日期：2015-09-01 00:00:00
abstract：:A 61-year-old woman was admitted to the hospital because of general fatigue. Laboratory examinations showed hyponatremia, plasma hypo-osmolarity, and inappropriate increased concentration of the plasma antidiuretic hormone (ADH) in the presence of concentrated urine. Magnetic resonance imaging revealed a mass lesion i...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(96)90094-5
更新日期：1996-05-01 00:00:00
abstract：:We present a rare case of unilateral intratesticular cystadenocarcinoma with mucinous differentiation in a 71-year-old male patient. The orchiectomy specimen revealed a 3.5-cm well to moderately differentiated cystic neoplasm with elongated fine papillary structures lined by columnar epithelium with alternating goblet...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.11.021
更新日期：2011-09-01 00:00:00
abstract：:Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important ro...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2011.10.016
更新日期：2012-09-01 00:00:00
abstract：:Renal glomerular disease characterized by the deposition of immunoglobulin light chains or monoclonal immunoglobulins was demonstrated by immunofluorescence microscopy in 11 patients. The most common histopathologic findings were those of mesangiocapillary glomerulonephritis, but considerable variability was observed....
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(85)80017-4
更新日期：1985-03-01 00:00:00
abstract：:The present report is a neuropathologic study of three patients who died from a severe form of necrotizing encephalopathy following intrathecal methotrexate therapy and craniospinal irradiation for acute lymphoblastic leukemia. During the early phase the lesion presented as multifocal coalescing areas of coagulation n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(78)80047-1
更新日期：1978-11-01 00:00:00
abstract：:Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced n...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(83)80022-7
更新日期：1983-03-01 00:00:00
abstract：:Explants from paraspinal muscles of patients with scoliosis were cultured in Millipore diffusion chambers placed in peritoneal cavities of mice. Three and four weeks of incubation produced a predominantly myogenic growth. Cell counts done on paraffin sections and on dissociated cells from the chambers showed that expl...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80046-9
更新日期：1981-07-01 00:00:00
abstract：:Topoisomerases are ubiquitous nuclear enzymes that regulate DNA structure in eukaryotic cells. The role of topoisomerase IIIβ, the newest member of the topoisomerase family, in the clinical outcome of breast cancer is still poorly understood. This study aims to investigate the immunoexpression of topoisomerase IIIβ in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.01.027
更新日期：2010-11-01 00:00:00
abstract：:A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.05.002
更新日期：2009-11-01 00:00:00
abstract：:Sneddon's syndrome is a potentially fatal arterio-occlusive disorder characterized by generalized livedo racemosa and cerebrovascular lesions. Skin biopsies often fail to yield diagnostic arterial lesions. In the present series, affected vessels were found in skin biopsies from 12 of 15 patients with Sneddon's syndrom...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90323-u
更新日期：1992-06-01 00:00:00
